Sat.Dec 16, 2023 - Fri.Dec 22, 2023

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How Patient Characteristics, SDOH, Impact CLL, SLL Treatment Backdrop

Drug Topics

Social determinants of health (SDOH), such as financial disparities or lack of insurance, create barriers to accessing breakthrough therapies like BTK inhibitors among patients with CLL and SLL.

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Doxycycline for Treatment of Pneumococcal Infection Could Reduce Clostridioides difficile Infection

Pharmacy Times

Less than 1% of individuals developed Clostridioides difficile infection (CDI), but for those who previously had a CDI the year before, 12% developed a new infection.

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Health data breaches hit an all-time high in 2023

STAT

Odds are, you’ve gotten at least one of the unnerving letters in your mailbox this year: “We’re writing to inform you of a cybersecurity incident,” it might start. It’s the standard notice many health care organizations are required to provide when your protected health information gets exposed — and in 2023, data leaks, hacks, and mishandling led more of them to be delivered than ever before.

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2024 Outlook: Despite hurdles, stakeholders bullish on VR in behavioral health

Fierce Healthcare

Though often associated with gaming, virtual reality (VR) is a technology rapidly evolving in healthcare. | VR therapy is not a new concept, though it wasn’t until the last few years that the field became prominent. And as technology has improved and gotten more intuitive to use, it has also become less expensive.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Saturday Night Live Skit Met With Criticism for Tone-Deaf Take on Sickle Cell Disease

Drug Topics

A Saturday Night Live skit has been met with criticism for its caricatured portrayal of patients with sickle cell disease, especially as the performance cast a dark shadow over the recent breakthrough FDA treatment approvals.

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New Biomarker Shows Potential in Therapeutic Development for Alzheimer Disease

Pharmacy Times

Investigators analyzed the effects of harmful accumulation of HDAC6 in the brains of mouse models with Alzheimer disease to determine any changes in disease progression.

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How to avoid prednisone withdrawal

The Checkup by Singlecare

Millions of people are prescribed prednisone each year for conditions that range from psoriasis and eczema to multiple sclerosis and rheumatoid arthritis. Prednisone belongs to a class of drugs called corticosteroids (also sometimes called glucocorticoids)—steroids that reduce inflammation in the body by replacing cortisol, a hormone produced in the adrenal glands, and slowing down an overactive immune system.

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Patients Hospitalized with COVID-19, Flu at Increased Risk of Long-Term Health Effects

Drug Topics

Patients hospitalized for either virus had an increased risk of death, hospital readmission, and health problems in multiple organ systems over 18 months of follow-up.

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The Role of Pharmacists in HIV Care Continues to Expand

Pharmacy Times

Pharmacists play a vital role in HIV care by addressing social determinants of health, managing complex HIV medication regimens, and providing comprehensive patient counseling.

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After ‘SNL’ skit on sickle cell CRISPR therapy, advocates cite errors and stereotypes

STAT

Mary Brown was sipping coffee at home in Ontario, Calif., Sunday morning when a friend sent a video clip that ruined her breakfast. It contained a skit from “Saturday Night Live” the night before about the new gene therapies for sickle cell disease. In it, workers gather for an office white-elephant-style gift exchange. A white employee, played by Kate McKinnon, gives a Black employee with sickle cell, played by Kenan Thompson, enrollment in “Vertex Pharmaceutical and CRISPR

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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2024 forecast: M&A saw an uptick in 2023. Analysts expect the trend to continue

Fierce Pharma

Even with the Federal Trade Commission keeping a watchful eye on the biopharma industry and the economic landscape giving some players pause, mergers and acquisitions are back on the rise. | Even with the Federal Trade Commission keeping a watchful eye on the biopharma industry and the economic landscape giving some players pause, mergers and acquisitions are back on the rise.

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Assessing B-Cell Maturation Antigen Directed Therapies in Multiple Myeloma Treatment

Drug Topics

Three posters presented at the 65th American Society of Hematology Annual Meeting and Exposition looked into the efficacy and safety of the therapies.

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FDA Approves Eplontersen for the Treatment of Adult Patients With ATTRv-PN

Pharmacy Times

The drug is the first medicine to be approved for the treatment of adults with polyneuropathy of hereditary transthyretin-mediated amyloidosis that can be self-administered.

FDA 149
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U.S. government spent more on health care in 2022 than six countries with universal health care combined

STAT

American taxpayers footed the bill for at least $1.8 trillion in federal and state health care expenditures in 2022 — about 41% of the nearly $4.5 trillion in both public and private health care spending the U.S. recorded last year, according to the annual report released last week by the Centers for Medicare and Medicaid Services. On top of that $1.8 trillion, third-party programs, which are often government-funded, and public health programs accounted for another $600 billion in spendin

Insurance 145
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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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BCBS of Massachusetts faces backlash from docs over anesthesia coverage policy change

Fierce Healthcare

A new policy from Blue Cross Blue Shield Massachusetts, starting Jan. | Some patients needing a colonoscopy in Massachusetts won't be covered for monitored anesthesia care, or MAC, starting Jan. 1. Blue Cross Blue Shield Massachusetts is standing by the policy, which will save the insurer money but require the patient to remain awake for the operation.

Insurance 139
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After Amryt buyout, Chiesi scores with FDA nod for rare skin disease treatment Filsuvez

Fierce Pharma

Seven months after Krystal Biotech became the first company to gain FDA approval to treat the rare, devastating skin disease epidermolysis bullosa (EB), Chiesi Farmaceutici has followed suit. | Seven months after Krystal Biotech became the first company to gain FDA approval to treat the rare, devastating skin disease epidermolysis bullosa (EB), Chiesi Farmaceutici has followed suit.

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Study: Children with Private Insurance Are More Likely to Outgrow Food Allergies Than Publicly Insured Children

Pharmacy Times

Overtime, children can outgrow food allergies, like milk and eggs—however, children with private insurance are more likely to outgrow allergies than those with public insurance.

Insurance 145
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Inhaled vaccines could stop Covid infections, monkey studies show

STAT

Want to stay on top of the science and politics driving biotech today?  Sign up  to get our biotech newsletter in your inbox. Hey there. Today, we get into why Amy Abernethy is leaving Verily, and why the ongoing reckoning with AI doesn’t necessarily need the voice of Google to chime in. Plus, Jason Mast pops in to give an update on Uniqure’s puzzling approach to presenting trial results.

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Few health plans have dedicated Alzheimer’s and dementia care management strategy: survey

Fierce Healthcare

Health plans and value-based care organizations are ill-prepared to help patients with Alzheimer’s Disease or related dementia. | Only a small fraction of health plans and value-based care organizations have a fully developed care management model for its enrollees with dementia or Alzheimer's, a new survey shows.

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As Vertex and CRISPR build out Casgevy launch, doctor sees strong demand and warns of possible supply hitches

Fierce Pharma

As Vertex Pharmaceuticals and CRISPR Therapeutics lay the groundwork for the launch of their CRISPR-based gene-editing therapy Casgevy, one doctor who treats sickle cell disease patients is already | As Vertex Pharmaceuticals and CRISPR Therapeutics lay the groundwork for the launch of their world-first CRISPR-based gene therapy Casgevy, one doctor who treats sickle cell disease patients is already seeing strong demand.

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Experimental Pneumococcal Vaccine Successfully Prevents Disease in Animal Models

Pharmacy Times

Investigators aim to find a substitution for incomplete Freund adjuvant, which is not suitable for use in humans but shows a strong response to antigen-specific systemic immune responses.

Vaccines 145
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STAT+: In the U.S., scientists see barriers to the development of CAR-T therapies. In Spain, a hospital brews its own

STAT

BARCELONA, Spain — Some of the patients waiting in the oncology ward of a hospital here, with its green-tiled floor and white walls, had arrived for a newfangled remedy for blood cancers, what’s known as a CAR-T therapy. The patients were not here for one of the brand-name medicines — a Kymriah or Yescarta — that have shown the power of these cell-based approaches and helped reap their makers hundreds of millions of dollars.

Hospitals 144
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Most doctors have not yet tried AI but are 'cautiously optimistic' about the benefits

Fierce Healthcare

The hype around healthcare artificial intelligence has reached a fever pitch but most doctors are holding back from trying it out in their medical practice, for now. | Among those who are holding off, doctors report lack of confidence in accuracy and a lack of integration or access through existing tools — as key obstacles to adoption.

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2024 forecast: Big Pharma reworks China strategy, and job cuts are part of it

Fierce Pharma

Big Pharma companies have often talked about the major opportunities that await in China. | Big Pharma companies have often talked about the major opportunities that await in China. But as price cuts play out and internal priorities shift, multinational companies are reworking their business models in the country.

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Expert: The Evolution of HIV Care, Treatment Options, How Pharmacists Can Assist in Providing Care

Pharmacy Times

Using information from clinical studies and her experiences working in the field, Stephanie Kirk describes treatment options that are on the horizon, and how removing stigma is key in HIV care.

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Here are the worst biopharma CEOs of 2023

STAT

Pfizer is this year’s anti-Eli Lilly. If David Ricks is the best biopharma CEO of 2023 , then Pfizer CEO Albert Bourla is, unfortunately, the worst. My annual Worst Biopharma CEO list is typically populated with blockheads and scoundrels. That’s not why Bourla is here. The reason is accountability. Strategic missteps , financial miscalculations, and scientific setbacks have plunged Pfizer into a deep crisis.

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ChristianaCare pays $47M to resolve former compliance officer's kickback allegations

Fierce Healthcare

Wilmington, Delaware-based ChristianaCare has agreed to a $47.1 million settlement resolving illegal kickback allegations flagged by its former chief compliance officer, Ronald Sherman. | The agreement is the largest False Claims Act settlement in Delaware's history and paves the way for future cases against hospitals that provide private physician groups with free services from their employees, legal counsel said.

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To fight rare diseases, win the data battle first

pharmaphorum

To effectively combat rare diseases, it is essential to prioritise the collection and analysis of data. This article explores how pharmaceutical companies are leveraging AI and focusing on orphan drugs to tackle rare diseases.

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Formulated Toothpaste Could Improve Allergic Reactions to Peanut Allergy

Pharmacy Times

The results found that INT301 met both its primary and secondary endpoints and could be a safe and effective option for individuals that experience food allergies.

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3 issues to watch in global health in 2024

STAT

As we enter the fifth year of this challenging decade, life finally appears to be inching toward normal — a new normal — on the infectious diseases front. Humans and the SARS-CoV-2 virus seem to be making progress toward a detente with each other. Covid is still a major disruptor, a significant cause of illness and death. But the massive disease waves of the early 2020s have calmed down.

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2024 Outlook: 'Blurring of the lines' as providers, retailers and payers plotting primary care plays

Fierce Healthcare

Health systems, insurers, retailers like CVS and tech companies like Amazon are all scrambling for a bigger piece of the medical pie. | Patients are looking for easier access to medical services and more convenience and this is opening big opportunities for insurers, retailers, tech companies and nontraditional players to muscle their way into primary care.

Insurance 133
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Amid BioNTech legal fight, CureVac takes a loss as German court invalidates patent

Fierce Pharma

A German court has dealt the first blow against CureVac amid the company's heated COVID-19 vaccine patent fight with fellow German mRNA specialist BioNTech. | A German court has dealt the first blow against CureVac amid the company's heated COVID-19 vaccine patent fight with fellow German mRNA specialist BioNTech.

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Study: Neighborhoods With Lower Socioeconomic Status Linked to Lower Adherence Rates for Those With Heart Failure

Pharmacy Times

The results of the study show the importance of considering neighborhood-level disparities to address and improve medication adherence, according to investigators.

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STAT+: New Jersey’s telehealth restrictions cut off access to lifesaving care, lawsuit alleges

STAT

Since states started rolling back pandemic-inspired flexibilities that allowed physicians to easily practice telehealth across state lines, virtual health care providers have criticized state-based medical licensure rules as unnecessarily burdensome, expensive, and detrimental to patient care. Now, two of them are arguing in a lawsuit that they can also be unconstitutional.