June, 2023

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ICYMI: PBM exec admits choosing profits over patients

PhRMA

With Congress discussing policy changes that would lower drug costs for patients and rein in powerful middlemen, insurers and their PBMs are dusting off their old playbook and once again threatening to increase costs for employers if required to do their job and actually provide meaningful coverage to patients. But recent remarks by one executive make clear that the PBM industry has a choice: protect its profits or lower costs for patients.

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The Cross-Roads Of Artificial Intelligence & Infectious Diseases Education: Witty Insights From ChatGPT

IDStewardship

In this article, ChatGPT provides witty insights into the cross-roads of artificial intelligence and infectious diseases. Interview with: ChatGPT by OpenAI Interview by: Timothy P. Gauthier, Pharm.D., BCPS, BCIDP Article Posted 7 June 2023 With the exception of the questions in bold, this entire text was written by ChatGPT. The only thing removed from the questions is the instruction “in a witty way” and a character limit was used in each of the questions.

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Pharmacists Will Play Critical Role in Helping Patients Navigate Digital Therapeutics

Drug Topics

With the rise of prescription digital therapeutics, pharmacists will need to prepare to manage the new paradigms of care.

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COVID-19 Infection Could Be Detected in Lungs, Heart, Causing Inflammatory Damage

Pharmacy Times

Investigators found thinner ventricular walls, disorganized and ruptured myocardial fiber, mild inflammatory infiltration, and mild epicardia or interstitial fibrosis in the hearts of mice infected with COVID-19.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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How the public health lessons of Covid can help Americans protect themselves from wildfire smoke

STAT

An unusually early and ferocious outbreak of forest fires across Canada has sent unprecedented amounts of smoke pollution to regions of the eastern United States unaccustomed to such hazards. Three years after the onset of the Covid-19 pandemic, the ensuing air pollution has once again put respiratory health at the forefront of many North Americans’ minds.

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Pharma giant Bayer moves deeper into digital health with new business unit

Fierce Healthcare

Pharma giant Bayer is launching a precision health unit as it ramps up its investment in consumer-facing digital health tools. | Pharma giant Bayer is launching a precision health unit as it ramps up its investment in consumer-facing digital health tools.

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Artificial Intelligence & Antimicrobial Stewardship: An Interview With ChatGPT

IDStewardship

In this article the artificial intelligence program ChatGPT is interviewed about antimicrobial stewardship. Interview with: ChatGPT by OpenAI Interview by: Timothy P. Gauthier, Pharm.D., BCPS, BCIDP Article posted 6 June 2023 Antimicrobial resistance (AMR) has emerged as a global healthcare crisis, threatening our ability to effectively treat infections and safeguard public health.

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Biosimilars Are Not Having a Big Impact on Insulin Prices

Drug Topics

Years of steady price increases have made access to the essential medicine more difficult for millions of Americans with diabetes.

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Why Choose a Career in Community Pharmacy?

Pharmacy Times

It’s imperative to redefine the future of pharmacy to help ensure a robust pipeline of future pharmacists and create a culture that helps ensure pharmacists live their purpose and passion.

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Opinion: When should hospitals require masks?

STAT

Is the pandemic over ? On the one hand, Covid-19 is clearly still with us. In the U.S., over the past month there was a weekly average of 557 deaths , though the numbers are dropping sharply, from 849 four weeks ago to 208 last week. On the other, for those who are not vulnerable or immune compromised, most facets of life have returned to normal, thanks to high levels of immunity from vaccines, boosters, and past infections.

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Medicare to broaden coverage of Alzheimer’s drugs after full FDA approval, but with some restrictions

Fierce Healthcare

The Centers for Medicare and Medicaid Services outlined plans Thursday to broadly cover a new class of Alzheimer’s drugs once the medications get full approval from the Food and Drug Administration | CMS outlined plans Thursday to broadly cover a new class of Alzheimer’s drugs once the medications get full approval from the Food and Drug Administration.

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ASCO: AstraZeneca, Daiichi's Enhertu delivers 'very compelling' pan-tumor activity, experts say

Fierce Pharma

AstraZeneca and Daiichi Sankyo’s Enhertu has already made waves in breast cancer treatment. | AstraZeneca and Daiichi Sankyo’s Enhertu has already made waves in breast cancer treatment. Now, the companies are positioning the HER2 antibody-drug conjugate for expansion into other tumor types with data that researchers view as very compelling.

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Alkeus raises funds to launch Stargardt disease therapy gildeuretinol

Pharmaceutical Technology

Alkeus Pharmaceuticals has raised $150m in Series B financing to support the registration and launch of gildeuretinol (ALK-001) to treat Stargardt disease, a genetic cause of blindness in children and young adults. Led by Bain Capital Life Sciences, the financing round has also seen participation from Sofinnova Investments, TCGX and Wellington Management.

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Efficacy of Therapeutic Cannabis in Patients With Medically Diagnosed Conditions

Drug Topics

A majority of patients say that taking cannabis helps them with chronic pain management and other conditions.

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FDA Approves Abrysvo to Prevent Respiratory Syncytial Virus in Older Adults

Pharmacy Times

Pfizer Inc’s bivalent respiratory syncytial virus (RSV) vaccine Abrysvo is indicated to prevent lower respiratory tract disease caused by RSV in individuals 60 years of age and older.

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STAT+: Coherus works with Mark Cuban to sell biosimilar Humira at steep discounts

STAT

In a bold move, Coherus BioSciences plans to sell a biosimilar version of Humira — one of the world’s best-selling medicines — at a steep discount, and will work with Mark Cuban’s generic drug company to make the medicine available directly to consumers for even less. Specifically, the Coherus medicine will carry a $995 list price for a carton of two autoinjectors, an 85% discount from the $6,922 that AbbVie charges for Humira, which is used to treat rheumatoid arthri

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Discrimination, racism, violence are common and weighing heavily on healthcare workers, surveys show

Fierce Healthcare

A pair of new healthcare workforce surveys outline widespread reports of discrimination, racism and workplace violence perpetuated by patients and coworkers alike. | A pair of polls released this week detail the interpersonal difficulties nurses and other healthcare workers face in the workplace.

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AZ, Merck's Lynparza wins FDA nod in prostate cancer subgroup following advisory committee vote

Fierce Pharma

After a panel of independent experts endorsed a narrow approval for AstraZeneca and Merck’s Lynparza in metastatic castration-resistant prostate cancer (mCRPC), the FDA has followed suit. | The drug is now approved to treat BRCA-mutated metastatic castration-resistant prostate cancer in combination with Johnson & Johnson’s Zytiga and a corticosteroid.

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Cybersecurity in pharma: Securing the future

Pharmaceutical Technology

Earlier this year, Sun Pharmaceutical Industries , one of India’s largest generic drug producers, reported a major cybersecurity breach , impacting its business operations. A ransomware group later claimed responsibility for the incident, which was one of several high-profile cybersecurity breaches in India over the past three years. Pharma companies around the world have also faced similar threats , some of which have impacted national security and public health.

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Exploring the Link Between Reduced Exercise Capacity and Cardiopulmonary Symptoms in Long COVID

Drug Topics

New research suggests that chronotropic incompetence contributes to exercise limitations in Long COVID.

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The Latest in the Role of Pharmacogenomics in Mental Health Treatment

Pharmacy Times

Pharmacogenomic testing in combination with therapeutic drug monitoring can be a cost effective and efficient way to advance psychiatric drug therapy.

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Academia’s postdoc system is teetering, imperiling efforts to diversify life sciences

STAT

For young life scientists hoping to land a prestigious faculty job in academia, postdoctoral research is practically a requirement. But it’s not a path equally open to everyone. Freshly minted life science Ph.D. graduates who have started families or have big loans, or are Black or female, say they plan to pursue postdoc positions at lower rates than their peers, according to a STAT analysis that includes previously unreported data from the National Center for Science and Engineering Stat

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Mayo Clinic, Google Cloud partner on generative AI to power enterprise search

Fierce Healthcare

Mayo Clinic is collaborating with Google Cloud to supercharge search tools with generative AI. | Mayo Clinic is collaborating with Google Cloud to supercharge search tools with generative AI. The health system aims to use the buzzy new technology to make it easier for doctors to get access to relevant medical notes, research papers or clinical guidelines.

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Novo Nordisk's obesity drug Wegovy to be provided to more patients under UK pilot program

Fierce Pharma

The rush to provide revolutionary weight-loss drugs to obese patients has reached the U.K. | The rush to provide revolutionary weight-loss drugs to obese patients has reached the U.K. On Wednesday, the government unveiled a two-year pilot program that will allow Novo Nordisk’s Wegovy to be given to more overweight participants, even though the treatment has yet to be launched there.

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Fosun Pharma and IFC to build new drug manufacturing plant in Africa

Pharmaceutical Technology

Shanghai Fosun Pharmaceutical (Group) is to collaborate with the International Finance Corporation (IFC) to construct a new pharmaceutical production facility and distribution hub near Abidjan, Côte d’Ivoire. The IFC will provide two loans totalling $53.49m (€50m) to Fosun Pharma’s subsidiaries. The funding will support the new production plant and distribution hub, which is aimed at enhancing access to high-quality medicines in Africa.

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Breaking: Merck Files Lawsuit to Halt Medicare Drug Price Negotiations

Drug Topics

According to a spokesperson, the company is prepared to take the lawsuit to the Supreme Court.

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Analysis of Gut Microbiome Did Not Show Significant Differences Relating to Immune Checkpoint Inhibition Resistance

Pharmacy Times

Fecal microbiota transplant from responders to non-responders was able to rescue immune checkpoint inhibition use in patients with melanoma, with 40% of patients showing clinical benefit.

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STAT+: Immunogen drug prolongs survival of women with advanced ovarian cancer

STAT

CHICAGO — An antibody that delivers chemotherapy directly to tumor cells extended the lives of women with a form of advanced ovarian cancer in a large study, researchers reported Sunday. The drug, called Elahere, is made by the biotech company Immunogen. It was granted conditional approval in the U.S. last November based on preliminary evidence showing it shrank tumors.

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Apple rolls out mental health tracking, vision assessment as new health app features

Fierce Healthcare

The roughly half of American smartphone users with iPhones will notice new health and pri | Apple brings its Health app to the iPad while offering new vision and mental health features to its suite of devices.

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ASCO: AstraZeneca guns for wider ovarian cancer market with Imfinzi-Lynparza combo. Will the FDA buy the plan?

Fierce Pharma

Lynparza may be the most popular PARP inhibitor, but a use restriction in ovarian cancer has been a thorn in AstraZeneca’s side. | AstraZeneca is bringing on Imfinzi to potentially help Lynparza reach a broader ovarian cancer population. But the lack of evidence for contribution from Imfinzi and a regulatory concern over the use of PARP inhibitors outside BRCA-mutant tumors could make it hard for AstraZeneca to win over the FDA.

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Amgen’s Lumakras data and research shows positive results across CodeBreaK clinical trial program

Outsourcing Pharma

Research has reinforced the efficacy of Lumakras (sotorasib), a small molecule inhibitor in advanced non-small cell lung cancer (NSCLC) and metastatic colorectal cancer (mCRC).

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Should We Welcome AI, Fear It, Or Both?

Drug Topics

A research article outlines the future of artificial intelligence in health care.

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Obstructive Sleep Apnea May Have Significant Impact on Cognitive Decline in Middle-Aged Individuals

Pharmacy Times

Recent debates have surrounded whether cognitive deficits, specifically in middle-aged patients, may be driven by cardiovascular and metabolic comorbidities instead of distinct obstructive sleep apnea processes.

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STAT+: Tempus launches an AI ‘assistant’ for thousands of oncologists

STAT

Tempus, a company that combines DNA sequencing for cancer with artificial intelligence, said Thursday that it is launching a voice-and-text assistant called Tempus One that will give physicians much easier access to patient data. The AI assistant is being launched ahead of the annual meeting of the American Society of Clinical Oncology in Chicago. Eric Lefkofsky, Tempus’ founder and CEO, told STAT Tempus will be rolling the product, called Tempus One, out to the 6,000 doctors that prescri

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Oak Street Health unveils expansion plans to open centers in 4 new states

Fierce Healthcare

Less than a month after CVS Health acquired Oak Street Health, the primary care provider plans to expand into four more states. | The company plans to open value-based primary care centers in Little Rock, Arkansas; Des Moines and Davenport, Iowa; Kansas City, Kansas and Richmond, Virginia, beginning this summer. Oak Street Health will operate centers in 25 states by the end of the year.

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ASCO: Merck bills Keytruda, used around surgery, as new standard in 'messy' early lung cancer realm

Fierce Pharma

As doctors weigh various immunotherapy strategies for the treatment of early-stage non-small cell lung cancer, Merck & Co. | As doctors navigate the "messy" early-stage non-small cell lung cancer landscape with various immunotherapy approaches, Merck & Co. has now unveiled new data that it hopes can establish Keytruda, used before and after surgery, as a new standard of care.

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