Tue.Nov 14, 2023

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Study Identifies Ketogenic Diet as Ideal Choice for IVF Success in Patients with PCOS

Drug Topics

For patients with polycystic ovary syndrome, 75% of whom have irregular or no ovulation, following a ketogenic diet improved IVF outcomes and metabolic health.

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Vitamin D Supplementation During Pregnancy Reduced Rates of Asthma, Wheezing in Children

Pharmacy Times

Compared to the standard prenatal vitamin alone, vitamin D supplementation with the prenatal vitamin reduced the risk of asthma and wheezing in children by approximately 50%.

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Trending Sources

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Paxlovid Associated With Virologic Rebound in Patients With Severe COVID-19

Drug Topics

Nirmatrelvir-ritonavir (Paxlovid) is an oral antiviral that inhibits the main protease of SARS-CoV-2 and is widely used in the United States.

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STAT+: UnitedHealth faces class action lawsuit over algorithmic care denials in Medicare Advantage plans

STAT

A class action lawsuit was filed Tuesday against UnitedHealth Group and a subsidiary alleging that they are illegally using an algorithm to deny rehabilitation care to seriously ill patients, even though the companies know the algorithm has a high error rate. The class action suit, filed on behalf of deceased patients who had a UnitedHealthcare Medicare Advantage plan and their families by the California-based Clarkson Law Firm, follows the publication of a STAT investigation Tuesday.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Pfizer's cost-cutting campaign hits Sandwich site in UK, where 500 workers will lose jobs

Fierce Pharma

Earlier this month, Pfizer’s $3.5 billion cost-cutting campaign crossed overseas to Ireland. Now, just a week later, Pfizer is announcing hundreds more job cuts in the U.K. | Pfizer plans to cut approximately 500 roles and ax its Pharmaceutical Sciences Small Molecule capabilities at its site in Sandwich in Kent in the U.K. The move is a consequence of Pfizer’s enterprisewide cost realignment program, which the drugmaker unveiled in mid-October.

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STAT+: UnitedHealth pushed employees to follow an algorithm to cut off Medicare patients’ rehab care

STAT

The nation’s largest health insurance company pressured its medical staff to cut off payments for seriously ill patients in lockstep with a computer algorithm’s calculations, denying rehabilitation care for older and disabled Americans as profits soared, a STAT investigation has found. UnitedHealth Group has repeatedly said its algorithm, which predicts how long patients will need to stay in rehab, is merely a guidepost for their recoveries.

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One-quarter of Americans have little to no confidence in scientists to act in public’s best interests, per report

STAT

America’s trust in scientists and positive views of science has continued to decline, according to a new report. The Pew Research Center, a nonpartisan think tank, asked a random sample of 8,842 American adults this fall about their views on science and scientists. They found that roughly a quarter of Americans — 27% — said they have not too much or no confidence in scientists to act in the public’s best interests, compared to 12% who said the same in April 2020.

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New York State proposes new cybersecurity regulations for hospitals

Fierce Healthcare

New York has proposed a slew of new cybersecurity regulations for the state’s hospitals and plans to funnel $500 million from its FY24 budget to help facilities upgrade their technology systems, Go | Should its proposal be finalized, the Empire State will give hospitals a year and access to a $500 million fund to bring their facilities into compliance.

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STAT+: New NIH head says government has fallen behind pharma on clinical trials

STAT

WASHINGTON — The new National Institutes of Health director, Monica Bertagnolli, said it’s a “failure” that enrollment in government-funded clinical trials has lagged behind those funded by the pharmaceutical industry. “If you just look at the number of patients who go on government-funded trials, it’s been completely flat over the last decade,” she said at a meeting of the advocacy group Friends of Cancer Research.

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Medicaid enrollment to decrease by 8.6% in 2024: KFF

Fierce Healthcare

Medicaid enrollment is projected to slide further next year, according to an annual budget survey of Medicaid officials conducted by KFF and Health Management Associates in collaboration with the N | State Medicaid directors once again see redeterminations as one of the biggest challenges they face heading into next year.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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Fresh produce access boosts health outcomes among diabetes patients and those on Medicaid in recent studies

STAT

In Stockton, California, almost 60% of the city’s 320,000 residents are prediabetic or living with diabetes. Shane Bailey, a 72-year-old longtime resident and U.S. Coast Guard veteran, is one of them. And because she lives in a neighborhood that is considered a food desert because it lacks nearby grocery stores, it can be a huge challenge to access healthy, affordable food.

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What is Type 3 diabetes? Understanding the diabetes-dementia link

The Checkup by Singlecare

You’ve likely heard of Type 1 and Type 2 diabetes, but you may not have heard of this third type. Type 3 diabetes is a term used by some researchers to refer to emerging data that shows a link between insulin resistance and dysfunction of a hormone called insulin-like growth factor (IGF-1), which may be a causal factor in Alzheimer’s disease. Here is what we know so far about the connection between blood sugar and dementia.

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STAT+: Pharmalittle: AMA calls for obesity drug coverage; Covid rebound may be more common with Paxlovid than without

STAT

Top of the morning to you. And a fine one it is. Lots of sunshine and clear blue skies are once again enveloping the Pharmalot campus, where the official mascots are bounding about the grounds in search of creatures to annoy and neighbors sleeping late. As for us, we are as busy as ever hunting and gathering items of interest. We trust you have your own hectic agendas.

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J&J and Bayer's Xarelto proves its worth across PAD subgroups in 2 new analyses

Fierce Pharma

Johnson & Johnson and Bayer’s wide-spanning VOYAGER PAD study continues to be a gold mine for proving its Xarelto’s worth in several subsets of patients with peripheral artery disease (PAD).

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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A letter from the executive editor: STAT’s investigation into a UnitedHealth algorithm

STAT

I want to bring your attention to a vitally important  investigation  STAT has published today. For more than a year, our reporters have documented how the use of artificial intelligence is driving denial of claims or delaying treatment for seriously ill patients. This latest story goes even deeper, establishing how the denial of claims was by design.

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'A lot of positives' across labor, volumes, payer mix backstop HCA's multi-year market share play, CFO says

Fierce Healthcare

HCA Healthcare’s priorities are to address immediate issues with its physician professional fee spending, capitalize on its unexpectedly strong payer mix and volumes, and increase its longer term, | CFO Bill Rutherford said plans to spend billions on new inpatient and outpatient facilities across HCA's existing markets arrive as the for-profit system exits COVID amid a flurry of tailwinds—though one clear roadblock remains in Valesco Physician Services and costly professional fees.

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STAT+: ‘I never realized what people go through’: Doctor and former hospital CEO with Stage 4 cancer calls for greater empathy in medicine

STAT

PROVIDENCE – In late August, Dr. James E. Fanale was trudging through the Falmouth Road Race — walking up the hills, running down them — for seven miles. Fellow runners encouraged him to “keep trying” whenever he slowed down. But they couldn’t have known — along with most of the people in Fanale’s professional orbit — that he was battling Stage 4 lung cancer.

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Merck KGaA's pharma unit joins the healthcare migration to Boston's Seaport innovation hub

Fierce Pharma

In little more than a decade, Boston’s transformed Seaport district—once littered with industrial buildings, warehouses and parking lots—has become an innovation hub and home to more than 25 health | Add another to the list of healthcare companies joining Boston's transformed Seaport district, as Merck KGaA's pharma subsidiary, EMD Serono, said it will move its U.S. headquarters from 25 miles south in Rockland to Seaport.

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Opinion: Patent buyouts could spur vital innovation in antibiotics, vaccines, and other medical fields

STAT

The announcement by the Center for Medicare and Medicaid Services that ten drugs will be subject to price negotiation under the Inflation Adjustment Act has unleashed a storm of debate. Most observers agree that the negotiations will reduce spending for both consumers and taxpayers. The real dispute centers on whether the prospect of price negotiations will reduce future innovation by shrinking the expected future profits for patented drugs.

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Karma Water launches Natural Energy Water

Drug Store News

Karma Energy Water is available in five flavors—raspberry peach, melon dragonfruit, blueberry watermelon, orange mango and pineapple coconut.

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What health policies could hitch a ride on a spending bill?

STAT

You’re reading the web edition of D.C. Diagnosis, STAT’s twice-weekly newsletter about the politics and policy of health and medicine. Sign up here to receive it in your inbox on Tuesdays and Thursdays. Bon apétit, offsets are served Whenever lawmakers get around to actually making decisions about funding the government, leaders try to balance measures that save the government money with those that cost the government money.

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How Your Pharmacy Can Celebrate Thanksgiving this Cold and Flu Season

PioneerRx

The most wonderful time of the year is slowly approaching. Temperatures are falling, days are getting shorter (thanks, daylight savings), and holiday lights are.

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Unified vision essential in UK advanced manufacturing

European Pharmaceutical Review

The Association of the British Pharmaceutical Industry (ABPI) has drawn attention to a new report , which has emphasised the importance of UK advanced manufacturing requiring a long-term strategy to ensure its continued success. This ‘manifesto for growth’, developed by the Manufacturing Five (M5), a coalition of the UK’s leading advanced trade associations, proposed the reforms necessary for the UK to close the gap with global competitors and growth of innovative manufacturing in the country.

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Data Show an Increased Risk of Skin Cancer in Patients with Lower Extremity Lymphedema

Pharmacy Times

According to the authors, these results contribute to developing information that associate lymphedema with localized changes in immunity and a susceptibility for cancer.

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AstraZeneca’s Imfinzi regimen misses the mark in setback for ambitious lung cancer 2030 goal

Fierce Pharma

One study in AstraZeneca’s elaborate R&D plan for lung cancer has reached a dead end. | One study in AstraZeneca’s elaborate R&D plan for lung cancer has reached a dead end. Failure of the Imfinzi-concurrent-chemoradiotherapy regimen deals a blow to AZ’s goal to target more than half of lung cancer patients by 2030.

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From the Pharmacy Counter to the World Stage: Public Speaking Champion Discusses Being a Go-Getter in Pharmacy

Pharmacy Times

Lessons from the pharmacy taught her about good communication. Now it’s her turn to educate pharmacists.

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Stagnant sales for Dermavant's Vtama cast doubt on its blockbuster potential

Fierce Pharma

In the clinic, Dermavant’s nonsteroidal topical treatment Vtama is progressing nicely as recent trial results have paved the way for it to be approved for atopic dermatitis (eczema) on top of its c | In the clinic, Dermavant’s Vtama is progressing nicely as trial results have paved the way for it to be approved for atopic dermatitis (eczema) on top of its current indication for plaque psoriasis.

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Legend Biotech’s deal with Novartis is a reminder that biotech’s bear market has a few haves, and many have-nots

STAT

Want to stay on top of the science and politics driving biotech today?  Sign up  to get our biotech newsletter in your inbox. Hello, everyone. Damian here with the latest twist in the Ozempic panic, polarizing data in genome editing, and another biotech in search of “strategic alternatives.

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Novo Nordisk to Discontinue Levemir for Diabetes Mellitus

PharmExec

Novo Nordisk said it will continue providing Levemir vials and the Levemir FlexPen for diabetes control while supplies last, until the full product discontinuation at the end of 2024.

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Clinical Updates On COVID-19 Treatments and Vaccines

Pharmacy Times

Even with the current available treatment options, it is important to recognize the importance of masking, particularly for those with immunocompromised conditions.

Vaccines 101
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Guide to Outsourcing 2023

European Pharmaceutical Review

Outsourcing regulatory activities in pharma Here, EPR’s Editor explores some key considerations, approaches and strategies for pharmaceutical companies looking to outsource regulatory activities. Accelerating drug development for simple and complex drug programmes Quotient Sciences leverages more than 30 years of drug development expertise to support small molecule and synthetic peptide drug programmes, in both simple drug programmes as well as complex cases where specialised formulation e

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Breath test can reveal signs of liver cirrhosis and portal hypertension

Outsourcing Pharma

Owlstone Medical's exegenous volatile organic compound (EVOC) breath test can reveal signs of liver cirrhosis and portal hypertension, a study has found.

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New acquisition to support global gene therapy manufacturing

European Pharmaceutical Review

Ajinomoto Co., Inc. is set to acquire Forge Biologics, a viral vector and plasmid contract development and manufacturing organisation (CDMO) and clinical-stage therapeutics company. According to Forge Biologics, the acquisition is an all-cash deal for $620 million, which is Forge’s enterprise value on a cash-free and debt-free basis. The equity value attributable to unitholders of Forge Biologics is approximately $554 million.

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Amazon provides same-day grocery delivery for Weis Markets

Drug Store News

Weis Markets now offers customers same-day grocery delivery in cities across New Jersey, Virginia, Pennsylvania and Maryland.

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