Wed.Aug 09, 2023

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Pre-Exposure Prophylaxis Continues to be Effective in Preventing HIV, Certain Populations Face Barriers

Pharmacy Times

Lack of information and access to health care, stigma, discrimination, criminalization, and privacy concerns are among the barriers some groups face when trying to obtain preventative HIV medications.

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High BMI in Breast Cancer Patients Linked With Increased Cardiotoxicity During Chemotherapy

Drug Topics

A recent study being presented at the American College of Cardiology Latin America 2023 conference found the prevalence of cardiotoxicity among patients with breast cancer undergoing chemotherapy was 11.94%.

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Predictive Model for Cervical Cancer Improved With Inclusion of Human Papillomavirus Genotypes

Pharmacy Times

Adding human papillomavirus genotypes to the predictive model had a significantly higher effect in improving accuracy compared to adding epidemiological factors and pelvic examination.

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Digital Health Interventions Could Help Improve Efficacy, Efficiency in Dermatology Care

Drug Topics

DHIs, first classified by the World Health Organization in 2018, include telemedicine, mobile health, wearable technologies, and artificial intelligence algorithms.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Chronic Immune-Related Adverse Effects Common in Patients With Resected Melanoma Treated With Anti-PD-1 Therapy

Pharmacy Times

Researchers found an increase in patients with melanoma who experience chronic immune-related adverse effects at 18 months compared to a previous study with a follow-up point of 6 months.

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Morning RX: August 9, 2023

Drug Topics

COVID-19 hospitalizations tick up, Wegovy shows cardiovascular benefit, and health care organizations team up to fight overdose deaths in New Jersey.

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Study mapping how SARS-CoV-2 disrupts mitochondria suggests a cause for long Covid

STAT

In yet another example of Covid’s seemingly limitless reach into our bodies, new research maps out how the SARS-CoV-2 virus disrupts mitochondria, the power plants in all our cells. The extent of the damage, spanning the lungs, heart, liver, kidneys, and brain, could potentially be one explanation for the lengthy list of persistent symptoms of long Covid , from fatigue to brain fog.

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Microbiology Quality Control Helps the Cell and Gene Therapy Segment Cure the Incurable

Pharmacy Times

With the continued advancement and approval of cell and gene therapies, the need for trustworthy microbiology quality control solutions is at an all-time high.

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Study shows autistic people are more likely to engage in self-harm — but not because of autism

STAT

Autistic people are at a much higher risk of self-harm leading to emergency care or suicide, according to a recent study published in JAMA Network Open. In particular, the study found, autistic females had an 83% increased risk of self-harm compared to non-autistic females, while for males, the increased risk compared to non-autistic individuals was 47%.

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Long-Term Intake of Probiotics Could Help to Improve Constipation, Increasing Positive Microbiome in Intestines

Pharmacy Times

The effects of probiotic strains on both constipation and cognition among all individuals involved in a meta-analysis remains difficult to determine.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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Eco-minded AstraZeneca doubles down on renewable energy push in Sweden

Fierce Pharma

AstraZeneca is often at the forefront when it comes to sustainability efforts among pharma companies. Now, the British drugmaker is doubling down on its clean energy commitments in Sweden.

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Barriers to Influenza Immunizations

Pharmacy Times

Chad Worz, PharmD, BCGP, FASCP, discusses how vaccine hesitancy and misinformation about flu vaccines create barriers to annual flu immunizations.

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Hospitals often charge commercial plans double or more than MA for same services, study finds

Fierce Healthcare

Hospitals nationwide charge payers more than double for healthcare services covered under commercial plans than they do for the same insurer’s Medicare Advantage (MA) plans, according to a recent J | A new analysis of hospitals' posted prices finds major differences in charged prices by plan, even when the hospital, insurer and service are all equivalent.

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Addressing Vaccine Hesitancy

Pharmacy Times

Randy McDonough, PharmD, MS, BCGP, BCPS, FAPhA, discusses his experience with vaccine hesitancy and factors that may lead to it.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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Babylon closes US business, lays off employees after MindMaze take-private deal collapses

Fierce Healthcare

Beleaguered digital health company Babylon Health shuttered its Austin, Texas, headquarters and laid off 94 employees as it struggled to secure more financing to continue operations. | Beleaguered digital health company Babylon Health shuttered its Austin, Texas, headquarters and laid off 94 employees as it has struggled to secure more financing to continue operations.

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‘Underwhelming’: NIH trials fail to test meaningful long Covid treatments — after 2.5 years and $1 billion

STAT

More than 2.5 years after the National Institutes of Health received a $1 billion mandate from Congress to study and treat long Covid , the agency has finally launched clinical trials for the often-debilitating condition. But both scientists who study long Covid and patients who have struggled with it say the trials are unlikely to deliver meaningful treatments, suggesting the federal government’s landmark Covid research effort may have been wasted.

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10 health benefits of yerba mate

The Checkup by Singlecare

With more than 1,000 varieties available, tea is one of the world’s oldest and most popular beverages. You’ve likely sipped the green, black, or oolong varieties but might not be as familiar with yerba mate. With potential benefits such as increased focus and energy and reduced cholesterol, this beverage dates back to 3,000 B.C. Yerba mate also contains nutrients like flavonoids , xanthines, polyphenols, saponins , amino acids, vitamins , and minerals.

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Opinion: Public pharma is the best solution to the ongoing problem of drug shortages

STAT

Drug shortages in the United States are at a record high. At least 14 essential generic cancer drugs are currently in shortage, forcing patients and doctors to make difficult decisions to delay or ration first-line treatments, or accept second-best treatments. ADHD treatments , antibiotics , children’s acetaminophen , and many other critical medicines are also in short supply.

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Takeda shells out $42M to settle Medicaid fraud claims in Texas

Fierce Pharma

After a whistleblower lawsuit accused Takeda and its subsidiaries of Medicaid fraud through illegal reimbursement arrangements and paid referrals in Texas, the company has agreed to pay more than $ | A whistleblower lawsuit accused the drugmaker of paying nurse educators to recommend ADHD drug Vyvanse to providers. Now, Takeda is paying tens of millions of dollars to resolve the case.

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GLP-1 Agonists and Gastroparesis

Med Ed 101

There’s always this voice in the back of my head that always cautions me that all that glitters is not gold. After being heralded as the next savior in weight loss by the media, the GLP-1 Agonists/GIP agonists have come under more scrutiny lately in the news. A recent article on CNN details patients who […] The post GLP-1 Agonists and Gastroparesis appeared first on Med Ed 101.

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Nonprofit naloxone maker celebrates FDA approval by donating 200,000 doses

STAT

A nonprofit naloxone manufacturer is celebrating its recent market approval by giving away 200,000 doses of its over-the-counter nasal spray. Harm Reduction Therapeutics said in a statement that it will donate nearly a quarter-million doses of its new product to the Remedy Alliance, an organization devoted to affordable naloxone access. The announcement comes on the heels of the Food and Drug Administration’s approval of Harm Reduction Therapeutics’ product RiVive , a new nasal nal

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With FDA approval for Elrexfio, Pfizer brings multiple myeloma battle to Johnson & Johnson

Fierce Pharma

Another off-the-shelf, BCMA-directed drug has arrived for the treatment of multiple myeloma. | Another off-the-shelf, BCMA-directed drug has arrived for the treatment of multiple myeloma. Pfizer's new Elrexfio will challenge Johnson & Johnson's entrenched position in the market.

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STAT+: Wegovy’s successful heart trial raises a vital question about weight loss

STAT

A landmark study that found the blockbuster obesity drug Wegovy reduces the chance of heart problems adds urgency to a basic question in medicine: what exactly is the relationship between weight and health? On its face, the result that Wegovy cut the risk of major cardiovascular complications by 20% lends credence to arguments by drugmakers, including Wegovy manufacturer Novo Nordisk, that obesity is a disease and weight loss makes people healthier.

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Despite recent sales growth, Mallinckrodt keeps financial options—including bankruptcy—on the table

Fierce Pharma

Despite a return to revenue growth in 2023’s second quarter, troubled Mallinckrodt continues to weigh its financial options, according to CEO Siggi Olafsson. | Despite a return to revenue growth in 2023’s second quarter, troubled Mallinckrodt continues to weigh its financial options, according to CEO Siggi Olafsson. Among them is a new bankruptcy bid that could get the company off the hook for more than $1 billion in opioid settlement payments.

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Meet the scientists trying to stop the next global pandemic from starting in Africa

STAT

Even experienced doctors could be fooled by this disease. A deadly hemorrhagic illness, it often looks like yellow fever, malaria, or typhoid. At first, an infected individual might feel weak, uneasy, and feverish; after a few days, headaches, sore throats, and nausea could begin. But in about 20% of infected individuals , patients start to feel like they’re suffocating as fluid leaks into their lungs; as the infection advances, they start bleeding out of their gums, eyes, and nose.

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Continuous Manufacturing of Small Molecule Drug Substances

ISPE

Continuous Manufacturing of Small Molecule Drug Substances Trudy Patterson Wed, 08/09/2023 - 14:36 Online Exclusives July / August 2023 Continuous Manufacturing of Small Molecule Drug Substances Daniel Griffin Martin D. Johnson Nicholas M. Thomson Clarence K. Wong 9 August 2023 The adoption of continuous manufacturing (CM) in the pharmaceutical industry is increasing because of the advantages and opportunities it offers, including the ability to handle hazardous reactions, a higher degree of pro

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Artificial Intelligence related patent filings increased in the pharmaceutical industry in Q2 2023

Pharmaceutical Technology

The global pharmaceutical industry experienced a 52% decline in the number of artificial intelligence related patent applications in Q2 2023 compared with the previous quarter, according to GlobalData's Patent Analytics.

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STAT+: ‘No data more personal’: Patients, digital health players weigh in on the FTC’s data privacy plan

STAT

This year has seen the Federal Trade Commission crack down on digital health companies’ irresponsible data use. Since February, it has charged four companies with improperly handling sensitive health information — starting with the first-ever enforcement of its long-stagnant Health Breach Notification Rule, against GoodRx. Now, the FTC is arming itself for even more aggressive enforcement.

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Moon Juice debuts Mini Dew

Drug Store News

Mini Dew is a 2-in-1 daily electrolyte and mineral powder supplement that features a microplastic-free Himalayan pink salt electrolyte and chelated forms of potassium and magnesium.

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CDC director overhauls leadership of center that oversaw response to Covid-19

STAT

The new director of the Centers for Disease Control and Prevention, Mandy Cohen , is overhauling the leadership of the CDC center that led the agency’s Covid-19 response. In an announcement to staff issued Tuesday, Cohen said José Romero, who headed the National Center for Immunization and Respiratory Diseases for the past 14 months, would be leaving the CDC at the end of August.

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Dental Disease, Oral Hygiene Important Determinants of Heart Failure in Patients With Type 2 Diabetes

Pharmacy Times

Study shows that as patients with type 2 diabetes lost more teeth, their risk of heart failure grew.

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Opinion: STAT+: One way to create resilient drug supply chains: incentivize predictive models

STAT

My first exposure to pharmaceutical shortages happened in 2017 as a new-to-practice nurse working on an inpatient oncology unit. A hurricane in Puerto Rico had left the U.S. short of sodium chloride minibags. Health care providers nationwide were tasked to modify standard medication preparation and administration practices, such as changing medications from IV to oral delivery, avoiding prepping IV lines with saline, or providing IV drugs by push rather than infusion.

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ADC oncology therapy market to value over $36b by 2029

European Pharmaceutical Review

According to research from GlobalData, the pharmaceutical industry is shifting towards development of antibody-drug conjugates (ADC) as oncology treatments. The data showed that Daiichi Sankyo , Seagen and Roche are currently three of the most important companies in the ADC market. Daiichi Sankyo was predicted to remain the dominant player in this market.

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Artificial Intelligence related patent filings increased in the pharmaceutical industry in Q2 2023

Pharmaceutical Technology

The global pharmaceutical industry experienced a 52% decline in the number of artificial intelligence related patent applications in Q2 2023 compared with the previous quarter, according to GlobalData's Patent Analytics.

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