Mon.Jul 24, 2023

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As Chemotherapy Drug Shortage Continues, Unimaginable Decisions and Lacking Accountability Reign

Pharmacy Times

Treatment providers have been forced to adapt and make potentially life-altering decisions for patients due to persistent chemotherapy drug shortages, all while solutions from the FDA and drug manufacturers remain scant.

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Consolidated hospitals leading to larger premiums and out-of-pocket spending, report finds

Fierce Healthcare

As hospitals acquire ambulatory care centers, consumers are more likely to be forced to pay outpatient facility fees for routine care traditionally covered by physician offices at lower costs. | Customers are being surprised with larger medical bills to cover a hospital's operational expenses, and hospital consolidation is major driving factor, a Georgetown University report uncovered.

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Exercise, Training May Improve Global Cognition in Older Patients With Mild Dementia

Pharmacy Times

Exercise alone or vitamin D supplementation did not clinically improve cognition in adults with mild cognitive impairment.

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Implementing Cloud-Based Plant Management Software: Data Security Considerations for Pharma Companies

ISPE

Implementing Cloud-Based Plant Management Software: Data Security Considerations for Pharma Companies Trudy Patterson Mon, 07/24/2023 - 11:13 iSpeak Blog iSpeak Implementing Cloud-Based Plant Management Software: Data Security Considerations for Pharma Companies Andreas Eschbach 24 July 2023 Cloud-based systems for plant process management (PPM) deliver significant benefits in terms of access, convenience and easy management.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Inside the hospital gardens that give respite from a world of ills

STAT

WILLOWBROOK, Calif. — In this neighborhood just north of Compton, Martin Luther King Jr. Community Hospital catches the light. Tall, sleek, all windows and silver finish, the hospital sits as a kind of promise to South Los Angeles. Not long ago, there was another hospital on the same property. Similar name, too: Martin Luther King Jr./Drew Medical Center.

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Labor shortages, Medicaid redeterminations: These are the headwinds facing payers, providers this year

Fierce Healthcare

While payers are facing headwinds going into the latter part of this year, the ongoing financial impacts of healthcare's labor shortage will be felt in the hospital sector far longer, according to | While payers are facing headwinds going into the latter part of this year, the ongoing financial impacts of healthcare's labor shortage will be felt in the hospital sector far longer, according to a new report from analysts at Moody's Investors Service.

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AstraZeneca enlists SK Chemicals to produce diabetes combo drug Sidapvia

Fierce Pharma

SK Chemicals of Korea has signed a deal with AstraZeneca to manufacture diabetes drug Sidapvia through the rest of the deca | SK Chemicals of Korea has signed a deal with AstraZeneca to manufacture type 2 diabetes drug Sidapvia through the rest of the decade, according to a regulatory filing. Sidapvia was approved in Korea last month.

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Single injection of zilebesiran for hypertension provides 24-week sustained reduction in blood pressure

Hospital Pharmacy Europe

A single subcutaneous injection of zilebesiran, which inhibits hepatic angiotensinogen synthesis, maintained a reduced 24-hour ambulatory blood pressure for 24 weeks, an international research team has found. If approved, the drug paves the way for a more convenient means of managing hypertension, which is normally treated with oral antihypertensive agents.

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Opinion: Drug pricing and the ‘impossible trinity’ for patients

STAT

You don’t have to be an economist to understand the law of demand: The higher the price, the less likely a customer is to buy a product. This, of course, limits how much companies can charge. The law of demand applies to pharmaceuticals, but with one big difference. It’s not always the customer who decides that the price is too high. Often, it’s the insurer.

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Is it safe to mix Benadryl and melatonin to sleep?

The Checkup by Singlecare

It’s 2 a.m. and you’re lying in bed, wide awake. Despite tucking in hours ago, you have yet to fall asleep. Or, perhaps you drifted off for a few hours, but now peaceful slumber eludes you. Trouble falling asleep—or staying asleep—is a fairly common problem. Insomnia affects 10% to 30% of the adult population, according to studies , mostly impacting women, older adults, and people with medical or mental health issues.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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STAT+: Rise in cancer among younger people worries and puzzles doctors

STAT

When both the nurse and the   doctor broke down in tears as they delivered the news, Chris Gosline knew that something difficult lay ahead. It was 5 a.m., after a long night in the emergency department at Beverly Hospital, where he’d gone for help with severe pain in his shoulder. A scan had detected tumors on his liver. Turns out, there’s a nerve connection that makes shoulder pain a possible   sign of liver disease.

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Dozens of studies paint private equity's provider purchases in a negative light

Fierce Healthcare

A body of published academic data suggest that private equity ownership of healthcare providers frequently comes with higher costs and reduced quality, according to a systematic literature review p | Evidence of private equity ownership's detrimental impact on healthcare providers is "robust enough" to warrant greater scrutiny and possibly new regulations, researchers wrote in a recent 55-study literature review.

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STAT+: Key House panel proposes lowering out-of-pocket drug costs in Medicare

STAT

WASHINGTON — A key House committee announced its own plans to increase health care transparency and reduce some health care costs for patients on Monday, according to bill text obtained by STAT. The House Ways & Means Committee package includes a new provision that would ensure that patients in the Medicare program pay for medicines they pick up at the pharmacy counter based on the discounted price that insurers negotiate with drugmakers, instead of higher sticker prices, starting in

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Joint Commission to revise another 200+ standards next month

Fierce Healthcare

The Joint Commission unveiled the second tranche of its planned accreditation standards reduction, which will become effective Aug. 27. | The second tranche of an ongoing standards review primarily focused on accreditation requirements for non-hospital programs.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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STAT+: Roche’s $3 billion Alnylam deal shows drug firms are interested in long-acting heart drugs

STAT

Roche’s announcement Monday that it would pay $310 million for rights to a hypertension treatment, zilebesiran, invented by the biotech firm Alnylam is evidence of a renewed interest on the part of large pharmaceutical companies for treatments for cardiovascular disease. If things go well, Roche could pay Alnylam up to $2.8 billion in total. Heart drugs were once the most lucrative category of pharmaceuticals, but they have been eclipsed by treatments for cancer and other diseases as drug

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Teva expands Alvotech collab with 2 more biosims, increased manufacturing oversight and a $40M investment

Fierce Pharma

After Teva’s Alvotech-partnered Humira biosimilar suffered its second FDA rejection, the generics giant is stepping up its role in their long-term collaboration with increased manufacturing involve | After Teva and Alvotech's proposed Humira biosimilar suffered a second FDA rejection because of issues at Alvotech's manufacturing plant, Teva is pledging increased involvement at the plant.

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STAT+: Gene therapy eyedrops restored a boy’s sight. Similar treatments could help millions

STAT

MIAMI — Dr. Alfonso Sabater pulled up two photos of Antonio Vento Carvajal’s eyes. One showed cloudy scars covering both eyeballs. The other, taken after months of gene therapy  given through eyedrops, revealed no scarring on either eye. Antonio, who’s been legally blind for much of his 14 years, can see again. The teen was born with dystrophic epidermolysis bullosa, a rare genetic condition that causes blisters all over his body and in his eyes.

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Pfizer, FDA ease shortage concerns as tornado relief efforts pick up at massive NC injectables plant

Fierce Pharma

Pfizer and the U.S. FDA are picking up the pieces after a violent tornado devastated the drugmaker’s massive North Carolina injectables plant last week. | Pfizer on Friday said it kicked off “immediate efforts” to provide relief and repair to the damage caused to its manufacturing facility in Rocky Mount, North Carolina. It noted crews are working around the clock to restore power, assess the structural integrity of the building and to relocate finished medicines to nearby sites for storage.

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STAT+: Roche’s $3 billion Alnylam deal shows drug firms are interested in long-acting heart drugs

STAT

Roche’s announcement Monday that it would pay $310 million for rights to a hypertension treatment, zilebesiran, invented by the biotech firm Alnylam is evidence of a renewed interest on the part of large pharmaceutical companies for treatments for cardiovascular disease. If things go well, Roche could pay Alnylam up to $2.8 billion in total. Heart drugs were once the most lucrative category of pharmaceuticals, but they have been eclipsed by treatments for cancer and other diseases as drug

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Virtual health can reduce industry’s carbon footprint, says Blue Shield of California

Fierce Healthcare

Virtual healthcare holds the key to not only increasing patient satisf | Virtual healthcare can not only improve outcomes and the patient experience, but it can also help reduce healthcare’s carbon footprint, according to Blue Shield of California.

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Opinion: How do doctors’ personal political affiliations affect how they care for their patients?

STAT

This essay is adapted from “ Random Acts of Medicine: The Hidden Forces That Sway Doctors, Impact Patients, and Shape Our Health ,” out now from Doubleday. “H oney, I forgot to duck,” Ronald Reagan said to his wife as he was wheeled to the operating room of George Washington University Hospital on March 30, 1981. He had just been shot and was bleeding into his left chest.

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Multiple Studies Reinforce Biktarvy as Treatment for Diverse Range of Patients With HIV

Pharmacy Times

The once-daily therapeutic agent is effective for pediatric patients and pregnant women with HIV.

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Watch: In a children’s hospital gardens, families find sanctuary

STAT

Boston Children’s Hospital is located in the heart of the city’s bustling Longwood medical area. But within this dense urban landscape, there are pockets of solace for patients, their families and hospital employees. The hospital has 10 dedicated garden spaces on site. Dotted with statuary of snails, foxes, and frogs, these facilities are specially designed to accommodate the complicated needs of their patients.

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With the neuro tide rising, could a breakthrough for Parkinson’s be next?

PharmaVoice

Amid a wave of neuro R&D, scientists are taking an Alzheimer’s-like approach to developing the first disease-modifying treatments for Parkinson’s.

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Handle With Care: Dispensing Controlled Substances in the Pharmacy

Drug Topics

Filling a prescription for a controlled substance requires more oversight than the average prescription.

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Will ESR1-mutated breast cancer treatment gain approval?

European Pharmaceutical Review

The Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has adopted a positive opinion on approving ORSERDU ® (elacestrant) for oestrogen receptor (ER)‑positive, HER2-negative, locally advanced or metastatic breast cancer (mBC) with an activating ESR1 mutation in patients with disease progression, following at least one line of endocrine therapy including a CDK 4/6 inhibitor.

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Verrica notches long-awaited FDA nod but shares plummet after loan revelation

Fierce Pharma

After two rejections from the FDA, Verrica has scored approval for Ycanth, the first therapeutic in the U.S. for molluscum, a viral skin infection.

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Verrica gains FDA approval for Verrica’s YCANTH to treat molluscum

Pharmaceutical Technology

Verrica has received approval from the US FDA for its YCANTH to treat molluscum in adult and paediatric patients aged two years and above.

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Amazon adds benefits to FamilyFlex program

Drug Store News

Amazon is adding new benefits to its FamilyFlex program that provides flexible scheduling and resources for employees and their family members.

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The Rise of AI in Pharmacy Practice Presents Benefits and Challenges

Pharmacy Times

Pharmacists must carefully consider safety concerns and patient privacy.

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Sofia Richie Grainge named K18 brand ambassador

Drug Store News

K18 is debuting its first national prime-time commercial with a campaign that features newly named brand ambassador Sofia Richie Grainge.

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Bavarian Nordic falls by RSV vaccine wayside after Phase III failure

Pharmaceutical Technology

Shares in the company dropped by 29% despite assurances the failure would not harm its 2023 financial outlook.

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Greenphire Study: Unified technology ‘essential’ for patient experience in clinical trials

Outsourcing Pharma

Greenphire, provider of clinical trial financial solutions, has released its global 2023 State of Clinical Trial Patient Convenience Market Trends survey.

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Establishing quality assurance in personalised preparations

European Pharmaceutical Review

Proficiency testing programmes aim to increase the product analysis and knowledge to contribute to overall improvement in drug product quality. A paper published in Pharmaceutics has proposed how a personalised preparation quality assurance programme can achieve this when these products are developed in compounding laboratories. Quality assurance for personalised preparations According to the authors, the personalised preparation quality assurance program (PACMI) was created in 2010 at the Facul