Mon.Jul 31, 2023

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Patients With HIV Have Low Risk of End-Stage Renal Disease After Donating Kidney

Pharmacy Times

Patients with HIV can donate a kidney to others with HIV who have a low risk of developing end-stage renal disease or other kidney problems for 2 to 4 years following donation.

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Acute Myeloid Leukemia Therapy Approved by FDA

Drug Topics

Quizartinib (Vanflyta) is an oral inhibitor of FLT3, and it specifically targets FLT3-ITD mutations, which drive cancer growth and contribute to increased risk of relapse and shorter overall survival.

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The Not So New Role of Pharmacists: No Longer an Overlooked Health Care Provider

Pharmacy Times

Pharmacists are critically important in care delivery in their ability to influence patient success, patient-reported outcomes, and quality of life while reducing the burden on physicians and their clinical support teams.

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Finding Solutions to the Ongoing US Generic Drug Shortage

Drug Topics

The risk of drug shortages is increasing as the long-term sustainability of generic manufacturing faces challenges, including low return on investment because of lowered prices, drug purchasers becoming more concentrated, and new generics facing slow adoption.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Restricted Eating Shows Similar Improvements in Blood Sugar as Reducing Calories for Type 2 Diabetes

Pharmacy Times

Individuals who restrict their eating to between 12 pm and 8 pm daily lost more weight than those who reduced overall calorie intake for type 2 diabetes.

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Vitamin D Could Provide Benefit to Patients With Psoriasis

Drug Topics

Researchers recommend patients with psoriasis and their dermatologists discuss whether taking a vitamin D supplement is right for them.

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Certain Factors May Increase Long COVID Risk in Children

Drug Topics

Children who tested positive were more likely to report long COVID symptoms at 90 days than children who tested negative.

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Complete Revascularization in Patients with Acute Coronary Syndrome, Multivessel Disease Reduced Risk of Heart Failure

Pharmacy Times

The risk of death from both overall and cardiovascular causes was also reduced in patients who underwent complete revascularization.

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GSK beats Merck to first PD-1 approval in newly diagnosed endometrial cancer

Fierce Pharma

GSK has won the first FDA approval for an immunotherapy to treat certain patients with newly diagnosed endometrial cancer. But the industry-first go-ahead is tempered with a label limitation. | GSK has won the first FDA approval for an immunotherapy to treat certain patients with newly diagnosed endometrial cancer. But the industry-first go-ahead is tempered with a label limitation.

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Merck Announces Positive Results From Phase 3 Pneumococcal Vaccine Trials

Pharmacy Times

If approved, the V116 vaccine would be the first pneumococcal conjugate vaccine specifically designed for adults.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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Signify Health launches in-home testing for chronic kidney disease

Fierce Healthcare

Signify Health is expanding its services with the addition of a new in-home testing option for chronic kidney disease. | Signify Health is expanding its services with the addition of a new in-home testing option for chronic kidney disease.

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A Dab of MAB: Lecanemab, Aducanumab vs Standard of Care Treatment for Alzheimer Disease

Pharmacy Times

Pharmacists play a key role in the management of modern monoclonal antibody treatments for Alzheimer disease.

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National panel will explore requiring free Covid tests

STAT

WASHINGTON — The U.S. Preventive Services Task Force will discuss recommending Covid-19 screening, the first step in requiring insurers to permanently cover the tests at no cost to patients. The national panel of experts will convene and “determine whether and how Covid-19 screening might be considered within the Task Force’s scope,” chair Michael Barry wrote in a letter to Sen.

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Elevance Health to rebrand Amerigroup plans as Wellpoint in 6 states

Fierce Healthcare

Last year, Blues plan giant Anthem unveiled a corporate rebrand as Elevance Health, a move it said better illustrated its ambitions to be more than just a health plan. | The company is updating the branding for its Amerigroup segment to Wellpoint in a bid to better align the government insurance business with its push toward whole health.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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As wildfires burn, scientists race to understand the health dangers of prolonged exposure

STAT

More than 120 million Americans — one-third of the U.S. population — have been living under air quality alerts this summer, with citizens in New York City, Chicago, and Detroit at times experiencing some of the unhealthiest air in the world. The hazy conditions, fed by an unprecedented surge in Canadian wildfires likely fueled by climate change, has grounded planes, canceled outdoor sporting events, and filled emergency rooms with asthma patients.

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Johnson & Johnson's $8.9B talc deal in jeopardy as judge shoots down 2nd bankruptcy attempt

Fierce Pharma

Johnson & Johnson’s attempt to end its talc litigation with a sweeping $8.9 billion settlement didn’t pass muster at the bankruptcy court, which instead dismissed the company's latest bankruptc | U.S. Bankruptcy Judge Michael Kaplan ruled that J&J's LTL Management subsidiary didn't establish immediate financial distress when it applied for bankruptcy protections.

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Opinion: I’m a tick biologist whose body seems to kill off ticks

STAT

Sometimes people call me “the tick guy,” but I’m a mammal guy by training. Although I respect ticks, I don’t fear them, especially after developing an immunity that kills them when they try to bite me. Back in 1991 I joined some colleagues at the Cary Institute in New York on a project devoted to understanding the responses by eastern deciduous forests in the United States to stress and damage.

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Takeda's Exkivity sputters in lung cancer trial, with accelerated approval on the line

Fierce Pharma

An accelerated approval for a potential growth driver for Takeda is in danger. | Takeda's targeted non-small cell lung med Exkivity has failed in a phase 3 trial in newly diagnosed patients, just days after Johnson & Johnson touted a win for its rival EGFR inhibitor.

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Magnetic tentacles represent possible novel approach for less invasive lung cancer treatment

Hospital Pharmacy Europe

The use of magnetic tentacles offer a novel therapeutic and targeted approach for minimally invasive lung cancer treatment, according to researchers from the University of Leeds. The researchers developed a tiny, magnetically operated robot that is capable of travelling deep into the lungs and able to detect and treat the first signs of cancer. Their approach makes use of a 2.4 mm diameter, ultra-soft, patient-specific magnetic catheter – or tentacle – which can be delivered from the end of a st

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Strategies to Boost Your Pharmacy’s Front-of-House Sales

Digital Pharmacist

To boost your pharmacy’s storefront sales, the best place to start is by understanding the importance of pharmacy marketing and making sure you are taking the necessary steps to optimize your front-end sales. With the right strategies, you can increase customer loyalty, drive more sales, and establish yourself as a reliable pharmacy in your community.

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Tenet Healthcare banks $123M profit in Q2 thanks to 'robust' ASC, inpatient volumes

Fierce Healthcare

Tenet Healthcare beat the street in the second quarter, reporting Monday $123 million in net income thanks to higher volumes and revenues across its ambulatory care segment. | The for-profit system beat the street with net operating revenues up 9.5% year over year, prompting an increase to 2023 guidance.

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Can dogs take Zyrtec?

The Checkup by Singlecare

Does your dog constantly scratch its neck or gnaw at its legs? It could be a sign they have an itch caused by an allergic reaction to grass, mold, dust mites, an insect bite, or another source. Giving your dog Zyrtec may help ease your its itchy skin and other symptoms. If you experience seasonal allergies, you know what kind of relief your go-to allergy medication provides.

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STAT+: Gene therapy is in crisis. For nine hours, the field’s leading minds looked for a solution

STAT

WASHINGTON — Jennifer Puck has successfully treated 10 children with a gene therapy for a fatal disorder that decimates their immune system. But she has no idea how to get her drug approved and frankly is running out of ideas. “I wish I had a clue about where to go from here,” said Puck, an immunologist at University of California, San Francisco, from a plush chair above Union Station.

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Attracting Young Talent in Pharma

PharmExec

Rebekah Martin, senior VP of reward, inclusion, and talent acquisition at AstraZeneca, discusses ways to address the need for talent in pharma, how pharma can increase more interest in young talent, and how many roles in pharma will require a degree in the coming years in this Pharmaceutical Executive Podcast video.

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Opinion: New attacks on the drug industry would have made my breakthrough sickle cell treatment impossible

STAT

I was born in Alabama in the Jim Crow South, one of eight siblings in a hard-working Black farming community. Our family doctor, a leading figure in the community, inspired me to follow in his footsteps and help people in need. Years later, while working as a physician in Massachusetts, I was appalled to observe how many medicines failed to benefit society’s most vulnerable, in particular people of color.

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In win for generics industry, Viatris wards off $50M payment in tax battle with IRS

Fierce Pharma

Viatris has successfully held its ground in a pitched battle with the Internal Revenue Service over tens of millions of dollars. | Viatris has successfully held its ground in a pitched battle with the Internal Revenue Service over tens of millions of dollars. The case hinges on charges Viatris accrued in patent litigation tied to its generic drug approvals in the 2010s.

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STAT+: New safety details link Apellis eye drug to rare cases of blindness. Cause still unknown

STAT

Five elderly people have been blinded by a severe side effect after receiving injections of a newly approved treatment for eye disease from Apellis Pharmaceuticals. The frequency of this side effect — a severe type of eye inflammation — is low but its cause remains unknown. The new safety information related to the Apellis drug, called Syfovre, was presented Saturday by a committee of eye disease experts at the annual meeting of the American Society of Retinal Specialists (ASRS).

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Study finds high-dose influenza vaccine candidate safe and effective

Hospital Pharmacy Europe

OVX836 is a universal influenza A vaccine which appears to be safe and has previously shown a preliminary signal of protection against influenza symptoms. Now, in a study published in The Lancet Infectious Diseases , researchers sought to explore the safety and potential efficacy of higher doses of OVX836. This is a recombinant protein-based vaccine which targets the highly conserved influenza nucleoprotein (NP) and therefore potentially confers broad-spectrum protection against influenza.

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Industry Voices—What the healthcare industry can learn from recessions past

Fierce Healthcare

While the past is usually an excellent teacher about the future, the healthcare industry has typically bucked standard conventions of business and even the laws of economics. | If the past is prelude, healthcare organizations across the board can rest easy knowing that demand will remain, even during a recession. But organizations that will be best positioned on the other side of the recession are those that take action now.

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STAT+: Flow Neuroscience shows promising results in trial of brain-stimulation headset for depression

STAT

Flow Neuroscience, a small Swedish company treating depression with brain-stimulating headsets, released early data on Monday showing that its device relieved depressive symptoms in clinical trials.  The company has not yet formally written up the data for a journal. But Flow leaders have included the data in an application for Food and Drug Administration approval and provided STAT with topline data ahead of releasing them publicly.

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A Long Time Coming: DEA Regs Finally Authorize Schedule II Prescription Partial Fills

The FDA Law Blog

By Larry K. Houck — President Barack Obama signed the Comprehensive Addiction and Recovery Act of 2016 (“CARA”) intended to reverse serious prescription drug abuse trend in the United States on July 22, 2016. CARA amended the Controlled Substances Act (“CSA”) to enable physicians or patients to request pharmacists to partially fill prescriptions for schedule II substances including opioids and to allow remaining quantities to be filled up to 30 days after issuance of the prescription (up to 72

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Citius' $40M bid to market a follow-up to Eisai's Ontak hits wall at FDA

Fierce Pharma

Citius Pharmaceuticals’ $40 million bet on a Dr. Reddy’s drug to replace the withdrawn cancer med Ontak has hit a snag in the U.S. | Citius' application for Lymphir (denileukin diftitox) in relapsed or refractory cutaneous T-cell lymphoma (CTCL) has been rejected by the FDA. The regulator is requiring Citius to bolster its application with enhanced product testing and “additional controls agreed to with the FDA during the market application review,” the company said.

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STAT+: Medicare wants to improve Alzheimer’s care, but sidesteps drug prices

STAT

WASHINGTON — Medicare announced Monday a pilot program aimed at improving dementia care and reducing the strain on unpaid caregivers, but it does not deal with controlling the price of new Alzheimer’s drugs. The pilot is voluntary. Physician practices that participate will get a lump-sum payment for each dementia patient in their care.

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Eculizumab gains EU approval for paediatric refractory generalised myasthenia gravis

Hospital Pharmacy Europe

Eculizumab has been approved by the European Commission for use in those aged six to 17 years who have refractory generalised myasthenia gravis (gMG) and who are also anti-acetylcholine receptor (AChR) antibody-positive (Ab+). The use of eculizumab (brand name Soliris) has been extended in the European Union (EU) to include the treatment of refractory gMG in children and adolescents, having already been licensed for the treatment of adults with refractory gMG who are AChR antibody-positive.