Wed.Oct 25, 2023

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Temporal Characterization of Radiation Therapy-Associated Acute Pain in Oral, Oropharyngeal Cancer

Drug Topics

Accurate characterization and differentiation of acute pain during radiation therapy may help facilitate symptom management for patients with oral cavity and oropharyngeal cancers.

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‘We’re absolutely making it too hard’: The complexity of adult immunization delivery hinders vaccine uptake

STAT

Alison Buttenheim was floored by a sign she saw in her doctor’s office when she went to get the first jab of the two-dose shingles vaccine to protect her against painful flare-ups of varicella zoster. “Medicare patients cannot receive Tdap or zoster vaccines here. They need to obtain [them] at their pharmacy. If they receive it here, they need to pay out of pocket,” the notice read.

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Lenacapvir Demonstrates Small Margin of Resistance for Those Heavily Treated With HIV

Pharmacy Times

Patients with HIV who were resistant to treatment with lenacapavir (Sunlenca; Gilead Sciences Inc) were found to have inadequate adherence to optimized background regimen or did not have a fully active antiretroviral.

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Giant sloths and woolly mammoths: Mining past creatures’ DNA for future antibiotics

STAT

PHILADELPHIA — Cesar de la Fuente believes the next breakthrough antibiotic might come from animals that have been dead for thousands of years. Since 2021, his lab here at the University of Pennsylvania has built algorithms to trawl genetic databases for protein fragments, called peptides, with microbe-squashing properties. They started with human DNA.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Maternal mRNA COVID-19 Vaccination May Protect Against Adverse Newborn Outcomes

Drug Topics

Infants of vaccinated mothers had a lower risk of severe neonatal morbidity, neonatal death, and admission to neonatal intensive care units, according to a new study published in JAMA Pediatrics.

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STAT+: Biogen’s tau-lowering drug slows cognitive decline in early study of Alzheimer’s disease

STAT

An experimental treatment for Alzheimer’s disease that removes a toxic protein called tau from brain cells showed “favorable trends” across several measures of cognition and function in a small study — results that offer some hope for an emerging drug class that has failed to deliver benefits in the past. The drug, called BIIB080, is being developed by Biogen.

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STAT+: Oncologists more likely to provide low-value care after receiving pharma money, study finds

STAT

Oncologists were more likely to provide low-value cancer care after receiving money from pharmaceutical companies, and the findings raise questions about the extent to which industry influence may have led to patient harm, according to a new study. The study looked at two scenarios: medications that were not recommended for treating a particular cancer, such as denosumab, which is administered for prostate cancer, and GCSF medications that are used to stimulate the bone marrow to make blood cell

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Ayble Health unveils mind-gut program with behavioral therapy techniques to ease GI symptoms

Fierce Healthcare

Ayble Health, a digital health platform focused on chronic gastrointestinal conditions, has unveiled a mind-gut program. | The program integrates with Ayble’s baseline nutrition program and offers evidence-based brain-gut behavioral therapy techniques including cognitive behavioral therapy, acceptance and commitment therapy and gut-directed hypnosis.

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Cancer disparities persisted even among clinical trial participants, study finds

STAT

Participation in a clinical trial is often considered something of an equalizer in medicine. Researchers have pushed for better access to trials for historically disadvantaged populations, hoping that increasing diversity in trials will both advance medicine and also help close health disparities by providing more equitable access to high-quality care.

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Patient groups have become a powerhouse in R&D. Here’s a look at their impact.

PharmaVoice

“They have the money,” and they’re using it to influence drug development, according to the executive director of the IQVIA Institute for Human Data Science.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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STAT+: Under-the-skin injection of Eisai’s Leqembi is as effective as IV infusion, new Alzheimer’s data show

STAT

A version of the Alzheimer’s disease drug Leqembi that can be given with a simpler, under-the-skin injection is equally effective as the currently approved intravenous infusion, according to study results presented Wednesday by its maker, Eisai. But hopes that the subcutaneous injection would also cause lower rates of brain swelling and bleeding — the drug’s most worrisome side effects — were not borne out in the study.

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States accelerated bills focused on health equity from 2020 to 2023, Chartis analysis finds

Fierce Healthcare

States have accelerated legislation intended to promote health equity in the last few years, with a special focus on several key areas like bias training and maternal health,

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WHO considers adding ‘noma,’ a rare childhood disease, to its list of neglected conditions

STAT

It’s a disease of children living in extreme poverty. Its cause is uncertain. So is the number of children it affects. But soon, the devastating condition known as noma may be a bit less neglected.

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Walmart expands doula services benefit nationwide following pilot in 4 states

Fierce Healthcare

Walmart is expanding doula services for its employees nationwide. | The decision is a reflection of Walmart’s desire to support maternity care and family building services, the company said in its announcement.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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Why is maternity leave for doctors such a complete mess?

STAT

I was sitting in my car around 4 p.m. on a Friday, waiting in the parking lot to be called in for my pre-delivery Covid test. I was equally exhausted from the physical demands of my second pregnancy and the emotional labor of typing up my loose ends at work with hundreds of patients. That’s when I received an email from an administrator at the hospital where I worked.

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Over twice as many healthcare workers report harassment in 2022 than 2018, CDC finds

Fierce Healthcare

New survey data from the Centers for Disease Control and Prevention (CDC) is reinforcing doctors’ warnings that the medical field is crumbling under a largely unaddressed mental health crisis and a | Survey data outlining healthcare workers' worsening mental health and workplace difficulties comes alongside new calls for action from the CDC and AMA.

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The cardiologist building digital tools to help colleagues stay on top of new research

STAT

Visit the website of cardiologist Ruey Hu, and you can scroll through his prolific scientific articles neatly arranged into 11 sections by study type, peruse a folder of medical education resources, and browse links to a couple of hand-coded tools. More curiously, there’s also a tab labeled, “Composing.” There live three sheets of music for works titled “Gauntlet,” “Topsody,” and “Renewal.

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Universal Health Services beats estimates with $167M profit in Q3 2023

Fierce Healthcare

Universal Health Services (UHS) came out slightly ahead of analyst estimates with a $167 million profit ($2.55 per diluted share) for the third quarter. | Acute and behavioral care chain Universal Health Services has enjoyed sequential quarters of rising volumes across both of its business segments.

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STAT+: Europe takes steps to head off drug shortages, even as U.S. proposals stall

STAT

European drug regulators are updating regulations to stem drug shortages. Are there lessons for Americans? Drug shortages are not solely an American problem. Last winter, European supplies of common antibiotics were critically low, especially for children, due to the surge of respiratory infections that followed two years of laying low to avoid Covid-19.

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UnitedHealth invests in Enable Ventures to drive improvements for people with disabilities

Fierce Healthcare

UnitedHealth Group is making a $5 million investment in Enable Ventures, a fund that aims to improve the lives of people with disabilities. | UnitedHealth Group is making a $5 million investment in Enable Ventures, a fund that aims to improve the lives of people with disabilities.

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Phase 3 Study Results Show Tebentafusp Provides Long-Term Survival Benefit in Patients With Metastatic Uveal Melanoma

Pharmacy Times

Patients with previously untreated HLA-A*02:01+ mUM saw improvements in OS, PFS, and ctDNA clearance.

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'Podnosis': Cultivating cultural competency in the healthcare workforce

Fierce Healthcare

In this week's episode of “Podnosis,” we look at the major health disparities facing Native Americans and explore what can be done to make meaningful improvements. | In this week's episode of “Podnosis,” we look at the major health disparities facing Native Americans and explore what can be done to make meaningful improvements.

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STAT+: Novartis claims Takeda is stonewalling efforts to review trade secrets taken by a former employee

STAT

Novartis has gone to court to gain access to Takeda Pharmaceutical documents over concerns that a former employee took trade secrets with him to his new job at the rival drugmaker. In a complaint filed in Massachusetts Superior Court, Novartis claimed that Khaled Shams Eldin transferred approximately 10,000 company files to his personal e-mail before leaving his job last May in Cairo, where he most recently worked in technical operations handling site divestments and relationships with suppliers

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Endometrial Cancer Treatment Linked to Long-Term Bowel Dysfunction in Older Women

Drug Topics

Older women who had a hysterectomy without chemotherapy and/or radiation had less chance of gastrointestinal issues than women who had those treatments.

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Gwyneth Paltrow’s goop launches affordable beauty, wellness line

Drug Store News

Good.clean.goop consists of clean skin care, hair care, body care and wellness essentials that are made with a trio of ingredients that work together to deliver results, the company said.

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After FDA found misconduct at trial site, BioXcel touts result from third-party audit and eyes filing

Fierce Pharma

After misconduct at a key trial site raised questions of | The FDA previously uncovered evidence of forged emails and trial misconduct in the company's phase 3 Alzheimer's disease agitation study. Now, with a third-party audit in hand, BioXcel looks to push forward with the drug.

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Walgreens to add 5 Hartford HealthCare clinics in Connecticut

Drug Store News

Five clinics operated by Hartford HealthCare medical providers will be added to Walgreens locations, offering 7-day-a-week availability of healthcare providers.

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On heels of FDA approval, trial results set up GSK's RSV vaccine for label expansion

Fierce Pharma

Five months after becoming the first company to secure FDA approval for a respiratory syncytial virus (RSV) vaccine, GSK is taking steps toward expanding its label for Arexvy. | Five months after becoming the first company to secure FDA approval for a respiratory syncytial virus (RSV) vaccine, GSK is taking steps toward expanding its label for Arexvy.

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STAT+: Boston Scientific’s drug-coated balloon may reduce risk of heart attack

STAT

A drug-coated balloon made by Boston Scientific reduced the risk of heart attack in patients with complications from stents, researchers reported on Wednesday. Boston Scientific hopes to use this data to win approval from the Food and Drug Administration. The company has not yet published its full slate of data in a journal. Outside experts told STAT they needed more data before assessing the device’s full potential.

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Walmart expands doula services for associates nationwide

Drug Store News

Walmart, which introduced doula services for its associates as part of a pilot program in Georgia, Louisiana, Indiana and Illinois, is now offering the services to associates nationwide.

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Is meloxicam safe to take every day?

The Checkup by Singlecare

Meloxicam reduces pain, tenderness, swelling, and stiffness caused by conditions like rheumatoid arthritis , osteoarthritis , ankylosing spondylitis , and juvenile rheumatoid arthritis. It works by inhibiting the production of the enzyme cyclooxygenase (COX), which triggers an inflammatory response. Many of these conditions are painful and chronic. So you may be wondering, is meloxicam safe to take every day?

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Roche, Biogen quickly settle patent lawsuit over biosimilar of arthritis med Actemra

Fierce Pharma

That didn’t take long. Roche has already settled a patent infringement lawsuit that it filed against Biogen in July. | Roche has already settled a patent infringement lawsuit that it filed against Biogen in July. The case surrounded Biogen’s biosimilar version of Roche’s blockbuster rheumatoid arthritis therapy Actemra.

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CPHI selects 2023 Pharma Award winners

European Pharmaceutical Review

CPHI Barcelona has announced the winners of 2023 CPHI Pharma Awards. These recognise outstanding achievements and contributions from the global pharmaceutical industry and supply chain across 12 broad categories. Winners of the 2023 CPHI Pharma Award – highlights For spearheading Procos’ growth, the company’s CEO Enrico Zodio, won CEO of the Year award for enabling the contract development and manufacturing organisation (CDMO) to achieve a current turnover in excess of €200 million.

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STAT+: Medtronic CEO talks latest bets on diabetes, high blood pressure technology

STAT

As one of the largest and oldest medical device companies in the world, Medtronic has a foot in almost every clinical area. The device maker with a market valuation of nearly $100 billion sells pacemakers, spinal cord stimulators, stents, monitors. Name a device, and they probably make it. The behemoth is ubiquitous in health care, but its size can make innovation sluggish.

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