Pharmaceutical Technology

FEBRUARY 21, 2024

Denosumab biosimilar is under clinical development by Lupin and currently in Phase III for Post Menopausal Osteoporosis.

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pharmaphorum

OCTOBER 20, 2021

The digital health tool, known as BoneBot, applies machine learning to X-rays to detect ‘silent’ or asymptomatic fractures in the vertebrae of the spine, a feature of the bone-wasting disease osteoporosis that can remain undiagnosed in more than two-thirds of cases.

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Pharmaceutical Technology

FEBRUARY 7, 2023

Denosumab will be used to treat several conditions, including osteoporosis in postmenopausal women and in men with high fractures risk, treatment-induced bone loss. The BLA submission is supported by a comprehensive analytical and clinical data package, including the Phase I/III ROSALIA trial data.

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Pharmaceutical Technology

MAY 26, 2023

The MAAs include all indications covered by the Xgeva (denosumab) and Prolia (denosumab) reference medicines to treat conditions such as osteoporosis in postmenopausal women. The European Medicines Agency (EMA) has accepted two marketing authorisation applications (MAA) from Sandoz for the proposed biosimilar denosumab.

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Packaging 52

pharmaphorum

APRIL 1, 2022

NICE has reversed its stance on UCB and Amgen’s severe osteoporosis therapy Evenity, saying out can be prescribed on the NHS for women with the disease in England and Wales who are at high risk of fractures. ” “Osteoporosis is one of the most urgent challenges to people living well in later life,” he added.

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PharmaShots

MAY 25, 2023

osteoporosis in postmenopausal women, men with high fractures risk & treatment-induced bone loss The application was based on comprehensive analytical & clinical data incl. Shots: The EMA has accepted the MAA for the proposed biosimilar denosumab (Prolia & Xgeva) indicated for treating multiple indications incl.

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pharmaphorum

SEPTEMBER 20, 2022

Novartis’ soon-to-be-divested Sandoz unit has positive clinical trial data in hand for a biosimilar of Amgen’s blockbuster osteoporosis therapy Prolia (denosumab), clearing the way for regulatory filings. The biotech is, however, facing one of the steepest patent cliffs in the biopharma industry, with $4.35

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Pharmafile

FEBRUARY 22, 2023

Published date: 22/02/2023 Summary: · Edith Hessel, experienced R&D and biopharma executive, named as Chief Scientific Officer · Osteoporosis announced as first indication, driven by Relation’s proprietary engine for indication selection SelectomaticTM London, February 22, 2023 – Relation Therapeutics, a leader in the use of high-resolution biology, (..)

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The People's Pharmacy

APRIL 27, 2023

There are a number of drugs that are used to combat osteoporosis, which is certainly a benefit. A recent study reports that smokers may not benefit as much from Reclast as nonsmokers ( Clinical Epigenetics , March 13, 2023 ). My doctor is recommending Reclast to treat osteoporosis. These all belong to the same class as Reclast.

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Med Ed 101

DECEMBER 12, 2021

Bisphosphonates are frequently used in the management of osteoporosis. Below we provide a bisphosphonate comparison table and I also wanted to highlight some of the most important clinical pearls that we should teach our patients and colleagues. They are often the go-to agent for this condition.

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PharmaShots

MAY 9, 2023

Shots: TScan to receive $30M up front and is eligible to receive ~$500M in success-based preclinical, clinical, regulatory, and commercial milestones along with royalty. UC Ref: PRNewswire | Image: Amgen Related News:- Amgen Reports Real-World Study Results of Prolia (denosumab) for Osteoporosis Associated with High Fracture Risk

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Pharmaceutical Technology

FEBRUARY 27, 2023

Givinostat is under clinical development by Italfarmaco and currently in Phase II for Myelofibrosis. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

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Pharmaceutical Technology

FEBRUARY 27, 2023

Givinostat is under clinical development by Italfarmaco and currently in Phase II for Post-Essential Thrombocythemia Myelofibrosis (Post-ET MF). Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

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Pharmaceutical Technology

FEBRUARY 27, 2023

Givinostat is under clinical development by Italfarmaco and currently in Phase II for Myelofibrosis. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

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The Checkup by Singlecare

SEPTEMBER 7, 2023

There’s no technical definition for a superfood, per the Cleveland Clinic. Help prevent osteoporosis Women have a higher risk of osteoporosis than men, though bone health is vital for everyone. Chia seeds, which come from the plant known as salvia hispanica, have gained a lot of praise as a superfood.

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The Checkup by Singlecare

APRIL 15, 2024

MS, RDN, a clinical associate professor of nutritional sciences at the University of Georgia. Higher potassium intake from fruits and veggies is linked to better bone density, which could slow the onset of osteoporosis. Bananas are also rich in a nutrient called provitamin A, also known as alpha-carotene and beta-carotene.

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The Checkup by Singlecare

DECEMBER 20, 2023

a clinical pharmacologist with St. Most healthcare providers agree that using prednisone for extended periods can be dangerous, and can lead to high blood pressure, eye problems, osteoporosis, and other problems. This is so important that the prescribing information recommends a taper.

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Pharmaceutical Technology

MAY 30, 2023

The company developed and launched Binosto (alendronate sodium) as the first and only buffered solution for osteoporosis. Separate from drug development, the Italian company also offers contract manufacturing and clinical supply services. Alkindi is one of EffRx’s three marketed drugs.

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The Checkup by Singlecare

OCTOBER 20, 2023

The study indicates that by decreasing bone turnover, shilajit may reduce bone loss and the risk of bone fractures and osteoporosis—particularly in high-risk populations. An accelerated bone turnover increases the risk of osteoporosis.

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Hospital Pharmacy Europe

DECEMBER 18, 2023

Here, Chloé Herledan PharmD PhD, pharmacist, Clinical Oncology Pharmacy Unit, Hospices Civils de Lyon and Université Claude Bernard Lyon 1, Lyon, France, shares an overview. Furthermore, falls can have severe consequences for older patients with cancer with osteoporosis or at risk of bleeding.

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Hospital Pharmacy Europe

NOVEMBER 14, 2022

B and therefore may possess therapeutic potential for use in the prevention and treatment of osteoporosis. Daily Low-Dose Aspirin and Risk of Serious Falls and Fractures in Healthy Older People: A Substudy of the ASPREE Randomized Clinical Trial. Citation Barker AL et al. JAMA Intern Med 2022.

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PharmaShots

MAY 12, 2023

Difficile Infection at DDW 2023 Date: May 08, 2023 | Tags: Seres Therapeutics, Nestlé Health Science, Vowst, Recurrence of C.

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The Checkup by Singlecare

DECEMBER 6, 2023

The healthcare clinic monitoring the warfarin dose must be aware of new medication changes. Certain Osteoporosis Medications Alendronate ( Fosamax ) and risedronate ( Actonel ), are bisphosphonate derivatives used to treat and prevent osteoporosis.

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The Checkup by Singlecare

FEBRUARY 14, 2024

Taking magnesium citrate may promote adequate magnesium levels in the body and prevent health conditions like osteoporosis.” A clinical trial published in 2014 linked higher doses of magnesium to lower fasting blood glucose and insulin resistance. “People with low calcium possibly have low magnesium,” Galej says.

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Hospital Pharmacy Europe

JANUARY 20, 2023

Interestingly, a recent meta-analysis of 12 studies with over 12,000 patients found that HDL cholesterol levels were higher among those with osteoporosis. Fractures are a common problem with one study estimating that one in 3 women and one in 5 men would be expected to have a minimal trauma fracture after the age of 50.

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The Checkup by Singlecare

NOVEMBER 16, 2023

A lack of vitamin D can result in thin, brittle, or misshapen bones, increasing the risk of fractures and conditions like osteoporosis and rickets in children. Boosts bone health: Vitamin D may help in the prevention of osteoporosis and fractures, as it supports calcium absorption and healthy bone density.

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Hospital Pharmacy Europe

NOVEMBER 23, 2023

The aim of the funding is to accelerate work on clinical trials and manufacturing, and assist health technology assessment agencies. Under the agreement, which comes into force in 2024, the pharmaceutical industry will also invest £400m over five years through the Life Sciences Investment Programme.

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PharmaShots

MAY 26, 2023

Takeda and HUTCHMED's Fruquintinib Receives Priority Review from the US FDA to Treat Metastatic Colorectal Cancer Date: May 26, 2023 | Tags: Takeda, HUTCHMED, Fruquintinib, Metastatic Colorectal Cancer, Regulatory, Priority Review, US, FDA Gilead Receives EMA’s CHMP Positive Opinion to Extend the Use of Veklury (remdesivir) for COVID-19 Date: (..)

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Pharmacy Friday Pearls

JUNE 9, 2022

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial. Effect of Dexamethasone on Days Alive and Ventilator-Free in Patients With Moderate or Severe Acute Respiratory Distress Syndrome and COVID-19: The CoDEX Randomized Clinical Trial.

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The Checkup by Singlecare

MAY 11, 2023

Medication management : Through dispensing and clinical monitoring, pharmacists play a vital role in ensuring women receive appropriate medications and dosages. They can also advise women on the proper use of medications as well as how to manage side effects.

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The Checkup by Singlecare

JANUARY 9, 2024

Clinic trials are desperately needed to confirm or refute these theories. This hopeful contention needs clinical trials to back it up. This association has proponents hoping that sea moss can also be taken to help prevent the onset or worsening of osteoporosis. Anti-inflammatory properties may aid joint health.

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The Checkup by Singlecare

SEPTEMBER 7, 2023

Examples of common medications that may require step therapy include alendronate or ibandronate for osteoporosis treatment and various medications for high blood pressure , arthritis , and asthma.

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pharmaphorum

NOVEMBER 10, 2020

Clinical trials have shown show that Veltassa may allow patients to stay on RAAS inhibitors for longer or at a higher dose. UCB/Amgen’s Evenity (romosozumab) for the treatment of severe osteoporosis in postmenopausal women.

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The Checkup by Singlecare

JANUARY 31, 2024

a clinical pharmacist who specializes in prednisone side effects. Osteoporosis Osteoporosis is a condition that makes your bones become weak and brittle. Women, in particular, are prone to osteoporosis as they get older. One of the most serious side effects of long-term prednisone use is osteoporosis.

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The People's Pharmacy

JUNE 19, 2023

However, carefully conducted multicenter clinical trials are needed to determine the benefits and safety of PDE5 inhibitors in patients with AD. For example, can these drugs fight osteoporosis ? Like all medications, there are pros and cons to PDE 5is drugs.

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The Checkup by Singlecare

DECEMBER 1, 2023

If left untreated, this deficiency can cause deterioration in bones and muscles that can eventually develop into osteoporosis. Cleveland Clinic (2023) Advice about eating fish , U.S. Mayo Clinic (2022) The new and improved nutrition facts label – Key changes , U.S. Food and Drug Administration (2022) What is vitamin D toxicity?

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The Checkup by Singlecare

JANUARY 9, 2024

Celery also provides nutrients with blood pressure-lowering effects, such as fiber, magnesium, and potassium, according to the Cleveland Clinic. Limiting foods high in saturated fat and increasing high-fiber foods can help maintain healthy cholesterol levels, notes the Mayo Clinic.

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