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Catalent CEO drops FY2023 revenue forecast by $450m after “disappointing” quarter

Pharmaceutical Technology

In an investor call on 19 May, Catalent reduced its annual net revenue forecast by approximately 10% compared to its February predictions. Catalent has enough drug stock to meet immediate customer demand, he added. Source: GlobalData Pharmaceutical Intelligence Center (Accessed 24 May 2023). ©GlobalData.

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Five Things To Know About Beta-Lactam Therapeutic Drug Monitoring (TDM)

IDStewardship

In this article 3 clinical pharmacists provide insights, pulling from their advanced experience with beta-lactam therapeutic drug monitoring (TDM). Historically, therapeutic drug monitoring (TDM) has been widely utilized for vancomycin and aminoglycosides given the narrow therapeutic index.

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Investing in biologics excellence

pharmaphorum

In little over three decades, advances in biotechnology have noticeably disrupted the development landscape of small molecule drugs. Now, amid a wave of innovation, investors and drugmakers are putting their weight behind the drug class. As such, companies are rethinking the existing landscape of drug development.

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Shanghai ISPE Pharmaceutical Information Company holds 2022 China Pharmaceutical Supply Chain Summit

ISPE

The pharmaceutical supply chain runs through the entire process of new drugs from innovation to clinical to approval. The capacity of the global supply chain determines whether drug R&D, production, and clinical trials can be carried out smoothly, and determines the speed of new drugs from R&D to market.

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2022 ISPE China Pharmaceutical Supply Chain Summit

ISPE

The pharmaceutical supply chain runs through the entire process of new drugs from innovation to clinical to approval. The capacity of the global supply chain determines whether drug R&D, production, and clinical trials can be carried out smoothly, and determines the speed of new drugs from R&D to market.

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Key developments: mRNA vaccines and therapeutics

European Pharmaceutical Review

A key benefit of mRNA therapeutics is that manufacturing time is fast compared to antibodies or protein-based drugs. The research also identified other challenges for mRNA therapeutics’ delivery , including their high cost, susceptibility to degradation by ribonucleases and limitations with drug delivery systems.

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PROTAC development gains momentum, but clinical performance is poor

Pharmaceutical Technology

According to the GlobalData Pharma Intelligence Center, there are currently 71 PROTACs in development in the oncology pipeline by non-academic developers, mostly clustering in the preclinical and discovery phases, with only 14 agents in clinical stages. Among 44 patients with measurable disease, two had confirmed partial responses.

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