Tue.May 07, 2024

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Fentanyl Education, Prevention Key to Ending Crisis in US

Drug Topics

For National Fentanyl Awareness Day, Drug Topics talked with Scott H. Silverman about how public health leaders can address the fentanyl crisis and the best ways to educate the public on the dangers of fentanyl use.

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Elevating Pharmacists, Empowering Pharmacy Technicians: A Symbiotic Journey in Health Care Excellence

Pharmacy Times

As pharmacy practice continues to evolve, it is imperative to recognize the vital contributions of all members of the pharmacy team, including pharmacy technicians.

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Trending Sources

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Slideshow: The Gut-Skin Connection

Drug Topics

Recent research exploring the gut-skin connection shows that dietary modifications and probiotic supplements may help skin conditions like acne, atopic dermatitis, and rosacea.

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Opinion: Measles is coming back. My sister Marcie isn’t

STAT

At the end of February 1960, my healthy, precocious sister Marcie was halfway through the fourth grade when she contracted measles from a classmate who lived down the street. Their cases were among the nearly 500,000 that year , before the measles vaccination program began in the U.S. in 1963. For every 1,000 people who get measles, one develops measles encephalitis , which can cause permanent brain damage.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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FCRL5-Directed CAR T-Cell Therapy: A Novel Therapeutic Approach for Multiple Myeloma

Pharmacy Times

CAR T-cells specifically targeting FCRL5, when integrated with IL-15, may improve cytotoxicity, thereby enhancing the therapeutic potency of these cells.

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STAT+: Young boy dies in trial for Pfizer Duchenne gene therapy

STAT

A young boy died in a trial for Pfizer’s experimental gene therapy for Duchenne muscular dystrophy, the company told patient advocates Tuesday. The boy was enrolled in Daylight, a trial studying the treatment in boys aged 2 or 3. The boy had received the therapy early last year, Pfizer told the advocates in a note posted online by Parent Project Muscular Dystrophy.

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WHO’s top scientist learned a hard lesson about H5N1 two decades ago: Stopping it takes more than biology

STAT

Jeremy Farrar, now the World Health Organization’s chief scientist, was working in Vietnam 20 years ago when the H5N1 virus started to spread across Asia — at that point in poultry. He recalls there was a reluctance among farmers to cull their chickens because they weren’t being compensated for them. Movement of infected birds to evade culling only served to disseminate the virus, which in the years since has spread to all continents except Australia.

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Acalabrutinib Demonstrates Improvements in PFS in Patients With Previously Untreated MCL

Pharmacy Times

Compared with placebo, acalabrutinib plus standard of care chemoimmunotherapy demonstrated better progression-free survival in patients with mantle cell lymphoma.

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Opinion: As livestock move around the country, so does H5N1. The U.S. needs real-time tracking of livestock movements

STAT

The presence of H5N1 avian influenza virus, better known as bird flu, among dairy cows in Texas — the second largest producer of dairy cattle — was first confirmed in late March. By then, H5N1 had likely been circulating among dairy cows for months. Six weeks later, the nine states responsible for more than one-quarter of U.S. dairy production, which accounts for 3.5% of the U.S.

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Navigating the Long, Bumpy Road to Rare Disease Diagnosis and Treatment

Pharmacy Times

A patient details his experience juggling the roles of caregiver of his wife with cancer and patient struggling to receive a diagnosis for a rare disease.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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STAT+: Assistants, not replacements: How AI can accelerate research and health care

STAT

When patients are dealing with a sexually transmitted infection, they don’t always get advice on whether they should come into the clinic in a timely fashion. So patient interface company Healthvana created a conversational AI chatbot to quickly answer some of their questions. It had two options: standard AI persona or a drag queen. As it turned out, the rainbow-colored drag queen helped engage more patients.

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Exxua: A Lengthy Approval Under a Regulatory Lens

Pharmacy Times

The story of gepirone may spark new conversations for industry standards on drug development to facilitate future innovations.

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Life sciences in Ireland: Nurturing talent, innovating excellence

pharmaphorum

The life sciences sector in Ireland is booming thanks to nurturing talent and fostering innovation. Companies like Eli Lilly and Regeneron have major operations driving excellence.

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Kenvue maps out hundreds of layoffs as service pact with J&J winds down

Fierce Pharma

Even after consumer outfit Kenvue split from Johnson & Johnson one year ago, the company has been performing certain services for the pharma and medtech giant as part of a transition process. | Kenvue’s board of directors on Monday approved a plan to cut 4% of the company’s global workforce. The J&J spinoff employed about 23,000 staffers at the end of last year, so the layoff initiative could affect some 920 workers.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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STAT+: House panel eyes PBM reform to pay for telehealth extensions

STAT

A new bill set to be considered on Wednesday by the House Ways & Means Committee would extend for two years telehealth flexibilities for Medicare enrollees that were adopted during the Covid-19 pandemic, and look to reform drug industry middlemen to pay for it. At the end of the official public health emergency, Congress extended flexibilities that changed where and what kinds of care people could receive over telehealth, but those rules are set to expire at the end of the year.

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FDA Advisory Committee Will Soon Meet to Discuss MDMA-Assisted Therapy for PTSD

Drug Topics

The Psychopharmacologic Drugs Advisory Committee will meet June 4 to review a new drug application from Lykos Therapeutics.

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Overcoming veteran healthcare hurdles

Fierce Healthcare

More than 18 million veterans live in the U.S., making up about 7% of the adult population. | In this week’s episode of “Podnosis,” Fierce Healthcare Senior Writer Anastassia Gliadkovskaya sits down with two experts to discuss how stakeholders can help overcome the issues plaguing the veteran healthcare system.

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Asembia: Pharmacists Have a Role in Health Care System Sustainability

Drug Topics

As medication experts, pharmacists can advocate to organizational decision makers around the benefits of biosimilars.

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Sorcero genAI conjures plain language from scientific papers

pharmaphorum

Understanding complex scientific studies is often a challenge for patients as well as healthcare professionals, but one that may become easier thanks to artificial intelligence.

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Oscar Health records first quarterly net profit, exceeds EPS expectations

Fierce Healthcare

Insurtech Oscar Health is standing by its full-year outlook after surpassing market expectations and beating year-over-year measures. | Oscar Health is in the green for the first time in company history, with nearly all financial metrics exceeding market expectations during the company's first quarter earnings call.

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AstraZeneca withdraws Covid-19 vaccine worldwide, citing surplus of newer vaccines

The Guardian - Pharmaceutical Industry

Pharmaceutical company says newer shots led to decline in demand for AstraZeneca vaccine, which is no longer being manufactured or supplied AstraZeneca has begun the worldwide withdrawal of its Covid-19 vaccine due to a “surplus of available updated vaccines” that target new variants of the virus. The announcement follows the pharmaceutical company in March voluntarily withdrawing its European Union marketing authorisation , which is the approval to market a medicine in member states.

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New bill aims to establish provider incentive program to combat drug shortages

Fierce Healthcare

A new draft bill from the Senate Finance Committee aims to establish a new provider incentive program to address drug shortages. | A new draft bill from the Senate Finance Committee aims to establish a new provider incentive program to address drug shortages.

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Asthma and Allergy Awareness Month: Resources Roundup

Drug Topics

Check out this list of resources to share with patients who are managing an allergy or asthma diagnosis.

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Lung Cancer Action Week: How Individuals Can Aid the Fight Against Lung Cancer

Pharmacy Times

Pharmacists can raise awareness for lung cancer during and after Lung Cancer Action Week.

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Sandoz delivers 6% sales growth with Humira biosimilar leading the charge

Fierce Pharma

In its opening months, after spinning off as a separate business from Novartis, Sandoz is riding the wave of a strong launch of its biosimilar version of AbbVie’s Humira (adalimumab). | After spinning off as a separate business from Novartis, Sandoz is riding the wave of a strong launch of its biosimilar version of AbbVie’s Humira (adalimumab). With Hyrimoz leading the way, sales of the company’s biosimilars reached $623 million in the first three months of this year.

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When is the best time to take MiraLAX?

The Checkup by Singlecare

MiraLAX ( polyethylene glycol 3350 ) is a brand-name laxative used to treat occasional constipation. It is an osmotic stool-softening medication, which means it works by drawing water into the colon to soften stool and ease bowel movement naturally. It acts differently from stimulant laxatives like Senokot (senna) and Dulcolax (bisacodyl) , which act on the inner lining of the intestinal tract , causing contractions that help push out stool.

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Pfizer pauses DMD gene therapy trial after boy’s death

pharmaphorum

Pfizer has paused dosing in a study of its Duchenne muscular dystrophy gene therapy after a sudden patient death in another trial

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STAT’s Casey Ross and Bob Herman named 2024 Pulitzer Prize finalists

STAT

Dear Readers, We are enormously proud that STAT reporters Casey Ross and Bob Herman have been named finalists for the Pulitzer Prize in the investigative reporting category “for exposing how UnitedHealth Group, the nation’s largest health insurer, used an unregulated algorithm to override clinicians’ judgments and deny care, highlighting the dangers of AI use in medicine.

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Vertex's Casgevy launch progresses as CF business posts impressive growth

Fierce Pharma

While cystic fibrosis has long been Vertex Pharmaceuticals’ bread and butter, the company has been eager to diversify its revenue base in recent years. | As of mid-April, Vertex said it had collected 5 patients' cells for eventual treatment with sickle cell disease therapy Casgevy. That puts Vertex ahead of its gene therapy rival bluebird bio, which recently said it had collected just one patient's cells for its own SCD treatment Lyfgenia.

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Vertex starts gene therapy Casgevy in five patients 

STAT

Want to stay on top of the science and politics driving biotech today?  Sign up  to get our biotech newsletter in your inbox. Good morning, incredibly exciting news from the STAT newsroom — two of our reporters, Casey Ross and Bob Herman (or as we call them,  Bob Ross ), were  named Pulitzer finalists  in investigative reporting!

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House Ways & Means committee unveils two-year telehealth extension bill, and tacks on PBM reforms

Fierce Healthcare

The House Committee on Ways & Means Monday night unveiled a first-of-its-kind piece of telehealth extension legislation to preserve Medicare telehealth flexibilities for two years. | Pandemic-era Medicare telehealth flexibilities which removed restrictions on how a Medicare beneficiary could access telehealth are set to expire at the end of 2024.

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STAT+: Life science leaders on how to make drug development less expensive, slow, and risky

STAT

Drug development is essentially a long, expensive bet: 90% of drugs fail during clinical trials, goes one of the life science industry’s most oft-quoted statistics. But new ways of identifying and testing therapies, a more precise understanding of disease, and a renewed sense of urgency to address longstanding public health issues could change that dynamic, life science leaders argued this week.

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In This Issue: Drug Topics May 2024

Drug Topics

See what's trending in pharmacy with a preview the Drug Topics May issue.

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STAT+: Endo Health ordered to pay more than $1.5 billion in opioid criminal case

STAT

In the second-largest fine ever levied on a pharmaceutical company, Endo Health Solutions was ordered to pay nearly $1.1 billion in criminal penalties and another $450 million in criminal forfeiture for illegally marketing its Opana ER prescription opioid. The company, which last month pleaded guilty to a misdemeanor, admitted that, from April 2012 through May 2013, some of its sales representatives marketed its medicine, also known as oxymorphone, to doctors by touting the drug as abuse deterre