article thumbnail

Mesoblast pummelled as Novartis exits COVID deal

pharmaphorum

In COVID-19, the drug was being tested in patients with acute respiratory distress (ARDS), which like GvHD is caused by over-stimulation of inflammatory cytokines, which causes the immune system to attack the patient’s own body. It has made cumulative loses of almost $650 million since being founded in 2004.

article thumbnail

Reconfiguring COVID and influenza vaccines for long-term effectiveness

pharmaphorum

When exposed to a virus, one’s immune system develops antibodies in response to foreign antigens, with or without a vaccine. However, a vaccine trains the immune system to recognise that familiar virus and kill it more rapidly. Osivax’s technology, oligoDOM, trains the T-cell immune response to recognise the nucleoprotein.

Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Trending Sources

article thumbnail

Sugemalimab plus chemo boosts lung cancer survival, trial reveals

pharmaphorum

Some cancer cells contain large amounts of PD-L1, which helps them to evade the body’s immune system. Lung cancer prevalence rates have risen by 23% since 2004, notes the BLF: “The earlier part of this trend may have been affected by changes in the way data were collated and incentivised.

article thumbnail

Intracellular Drug Delivery – A Potential Treatment for Lethal Orphan Diseases

Roots Analysis

Efficiency of this system is less than viral systems in gene transduction, but their cost-effectiveness, availability, and more importantly less induction of immune system and no limitation in size of transgenic DNA compared with viral system have made them more effective for gene delivery than viral delivery systems.

article thumbnail

Can you use metronidazole for cats?

The Checkup by Singlecare

A 2004 study found that administering 25 mg/kg of metronidazole twice a day for seven days was effective and safe for stopping the shedding of giardia cysts in cats. White blood cells play a vital role in fighting infections, so a lowered count can potentially reduce the immune system’s ability to ward off diseases.

Dosage 109
article thumbnail

The future of targeted alpha therapy development and manufacture

European Pharmaceutical Review

Firstly, alpha particles exhibit greater biological effectiveness by inducing irreparable DNA double-strand breaks, minimising the risk of resistance or immune escape in tumour cells. He then worked at BCG from 2004 to 2011, where he developed expertise in the energy, engineering, and high-tech sectors.

article thumbnail

Acetaminophen interactions to avoid

The Checkup by Singlecare

Acetaminophen may also blunt the effects of other medications that impact the immune system, including some medicines used to manage cancer diagnoses and even the immune response following vaccinations. If alternatives to acetaminophen can be employed, they should be recommended. Paracetamol disposition in normal subjects and.