Remove tag immune-oncology-therapeutics
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PharmaShots Weekly Snapshots (May 08 - 12, 2023)

PharmaShots

Sanofi Reports P-IIIb Trial (HARMONIE) Results of Nirsevimab for the Prevention of Hospitalizations due to RSV-Related LRTD Date: May 12, 2023 | Tags: Sanofi, Nirsevimab, RSV-Related LRTD, Clinical Trial, P-IIIb, HARMONIE Trial G1 Therapeutics Presents Preliminary Results from P-II Trial of Trilaciclib for Triple-Negative Breast Cancer at ESMO 2023 (..)

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A broad range of unmet needs remains in the immuno-oncology space

Pharmaceutical Technology

Immuno-oncology (IO) agents have transformed the cancer therapeutics landscape, driving long-term remissions in a subset of patients who historically had limited options. IO agents include the classes of immune checkpoint modulators, cell therapies, bispecific antibodies, oncolytic viruses, therapeutic vaccines, and cytokines.

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Protein Precision: “Harnessing Targeted Protein Degradation”

Roots Analysis

Specific inhibitors, which bind to disease-associated proteins and prevent them from functioning abnormally, have demonstrated remarkable therapeutic potential in such diseases. The promise of induced protein degradation as a novel therapeutic modality has attracted considerable attention in the pharmaceutical industry.

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Developing point-of-care CAR T manufacturing

European Pharmaceutical Review

This is especially important due to the two unique toxicities of CAR T cells, namely CRS and the neurology toxicities that subsequently received the term immune effector cell- associated neurotoxicity syndrome (ICANS). This is in addition to its considerable price tag. Journal of Hematology & Oncology. Annals of Oncology.