Sat.Sep 03, 2022 - Fri.Sep 09, 2022

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2022-2023 Flu Season Vaccination Recommendations for Children and Adolescents

Drug Topics

Keep your pharmacy vaccine-ready for your youngest patients with the most current influenza vaccination information from the American Academy of Pediatrics.

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Study: Programs to Limit Prescription Opioids May Spur Illegal Drug Use

Pharmacy Times

Prescription drug monitoring programs have decreased prescription opioids in the United States but resulted in unintended spikes of illegal drug use and heroin-related deaths.

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Rejecting ICER’s bad advice

PhRMA

America leads the world in biomedical innovation today because our system rewards investment in research and discovery of new treatments. Now, with the passage of the Inflation Reduction Act , Dr. Steven Pearson, president of the Institute for Clinical and Economic Review (ICER), coolly admits we will see fewer new cures and treatments and suggests that trade-off is one we need to make.

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STAT+: In reversal, FDA advisers vote to support approval of Amylyx’s drug for ALS

STAT

At the end of an unusual and dramatic meeting on Wednesday, an independent panel of advisers to the Food and Drug Administration recommended the approval of a new drug to treat people with ALS developed by Amylyx Pharmaceuticals. The vote was 7-2, a substantial margin of support for the Amylyx drug called AMX0035 and a reversal of the same group’s vote against the drug last March.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Waste Problem Shows COVID-19 Vaccines Aren’t Just a Dime a Dozen

Drug Topics

When it comes to the COVID-19 vaccine, independent pharmacies are being set up to fail by federal health partners.

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Study: Fertility Preservation Measures Do Not Increase Risk of Breast Cancer Recurrence

Pharmacy Times

Analysis shows that over 5 years, the percentage of women without relapse was 89% for those who had hormonal stimulation of the ovaries and 83% for those with ovarian tissue freezing.

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Pfizer isn’t sharing Covid vaccines with researchers for next-gen studies

STAT

WASHINGTON — Researchers studying next-generation vaccines to fight an evolving Covid-19 threat are running into problems getting existing vaccines to use in their research. Because Pfizer and Moderna hold the patents for the current vaccines, researchers would likely have to get the companies’ permission to use them for research into products like nasal or pan-coronavirus vaccines.

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How Pharmacists Can Address Vaccine Hesitancy for the Flu and Beyond

Drug Topics

Address vaccine hesitancy at your pharmacy to encourage patients and their families to get vaccinated against COVID-19, flu, and more.

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Migraine, Chronic Migraine Associated with Lower Vitamin B12 Levels

Pharmacy Times

Patients with chronic migraines and higher frequencies of pain experienced the lowest vitamin B12 levels compared with patients with less frequent or no headache symptoms.

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Bridge Bio will use Brainomix AI in lung fibrosis trial

pharmaphorum

Brainomix has reeled in another pharma partner for its artificial intelligence-powered biomarker software, used to track the performance of therapeutic interventions in clinical trials. South Korea’s Bridge Biotherapeutics has signed up to use the UK medtech firm’s e-ILD software package in a phase 2 trial of BBT-877, its experimental therapy for serious lung disease idiopathic pulmonary fibrosis (IPF).

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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STAT+: Gilead drug prolongs survival of women with common form of breast cancer

STAT

Gilead Sciences said Wednesday that its cancer drug Trodelvy prolonged the survival of women with the most common form of breast cancer by just under 30% — a clinical trial result that could lead to a better treatment option for patients with advanced disease and strengthen the drug’s commercial outlook. In the study, called TROPICS-02, Trodelvy showed a median overall survival of 14.4 months compared to 11.2 months for comparator chemotherapy.

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Cannabis Treatment for Sleep Disorders Warrants Further Investigation

Drug Topics

Encouraging outcomes in recent studies have researchers calling for more analysis of the effect of cannabinoids on sleep disorders.

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CDC Updates ACIP Guidance, Recommending Specific Flu Vaccines for Patients 65 and Older

Pharmacy Times

Flublok Quadrivalent and Fluzone High-Dose Quadrivalent are both proven to prevent more cases in older adults compared with a standard-dose vaccine in randomized controlled trials.

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The 2022 PharmaVoice 100

PharmaVoice

From standout executives to R&D pioneers — this year’s class of honorees is defining the next era of leadership.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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STAT+: Relay Therapeutics drug shows promise in early trial

STAT

A daily dose of Relay Therapeutics’ experimental drug for cholangiocarcinoma, a rare cancer of the bile ducts, led to tumor shrinkage of a third or more in 15 of 17 patients with metastatic disease, the company said Wednesday. The results were released in an abstract at the annual meeting of the European Society of Molecular Oncology, where they will be presented in full on Sunday.

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Improving Glycemic Markers in Children with Type 1 Diabetes Using Technology

Drug Topics

Software updates in closed-loop systems may lead to better time in range numbers for children with type 1 diabetes.

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Addressing Certain Risk Factors May Decrease Likelihood of a Patient With a Liver Transplant Returning to Operating Room

Pharmacy Times

Obesity, heavy alcohol consumption, and coagulopathy were some of the greatest risk factors associated with patients returning to the operating room within 48 hours of a surgery.

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AstraZeneca on the hunt for new acquisitions

Pharmaceutical Technology

Following AstraZeneca’s success in vaccine development during the Covid-19 pandemic , the pharmaceutical giant is now looking to expand its scope through acquisitions across a range of indications, says CEO Pascal Soriot. “We want to be a sustainably growing company. Until 2025, we have strong growth ahead of us, but we also believe we can continue to grow very strongly post-2025 and it’s all about innovation in the pipeline.”.

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Fentanyl test strips could help save lives. In many states, they’re still illegal

STAT

Nothing has made the nation’s addiction epidemic more deadly than fentanyl’s infiltration of the drug supply. Yet in more than a dozen states, tools used to detect the ultra-potent synthetic opioid are still classified as drug paraphernalia — making it a crime to possess or distribute them. The practice of “drug-checking” — essentially, testing illicit drugs to see if they contain unknown toxins — has remained controversial even as the crisis of f

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Glycemic Control in Teenagers with Type 1 Diabetes Could Be Key to Stave Off Neurological Damage

Drug Topics

Improved glycemic control could reduce the risk of diabetes-related brain damage among teens and adolescents with type 1 diabetes.

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Study: Better Blood Sugar Control in Teens Limits Diabetes-Related Brain Damage

Pharmacy Times

Cognitive harm appears reversible, results of analysis by Nemours Children’s Health Jacksonville and Stanford University shows.

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NICE says no to Lynparza in prostate cancer, creating UK access divide

pharmaphorum

NICE has said it is unable to recommend NHS use of AstraZeneca’s Lynparza for some patients with prostate cancer, after failing to reach an agreement on price with the drugmaker. The health technology assessment (HTA) authority said that the PARP inhibitor “is not cost-effective at its current price” as a treatment for BRCA-positive prostate cancer that has spread to other parts of the body and relapsed after prior hormonal therapy.

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Opinion: Dying of a disease I never knew existed

STAT

By this time next year, if the medical forecasts are correct, I will probably be dead, another casualty of a fatal illness that most people have never heard of: idiopathic pulmonary fibrosis (IPF). This condition has been described by Michael J. Stephen in his 2021 book “Breath Taking” as the “most frustrating and disheartening of all the diseases in pulmonary medicine.

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Drug Testing Challenges Emerge With CBD Product Use

Drug Topics

Even “THC-free” cannabidiol products may contain trace amounts of THC.

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New Data Show Farxiga Lowers Risk of Cardiovascular Death in Patients With Heart Failure

Pharmacy Times

Pre-specified pooled analysis from phase 3 trials demonstrates 14% reduction in CV mortality and from any cause by 10% in individuals with HF, irrespective of ejection fraction.

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Roche to acquire biopharma firm Good Therapeutics for $250m

Pharmaceutical Technology

Roche has signed a definitive merger agreement for the acquisition of US-based biopharmaceutical company Good Therapeutics for an upfront payment of $250m in cash. Good Therapeutics focuses on the development of PD-1-regulated IL-2 drugs that are based on innovative conditionally active drug technology. With the takeover, Roche will attain rights to a conditionally active, PD-1-regulated IL-2 programme of Good Therapeutics.

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STAT+: Why Illumina has a merger mess of its own making

STAT

For Illumina, the leading maker of DNA sequencing equipment, there was bad news and worse news Tuesday. The bad news: The European Commission said it was blocking Illumina’s $8 billion acquisition of Grail, a firm focused on the early detection of cancer. The worse news? In its press release on the ruling, Illumina acknowledged that, although it will appeal, that may not prevent the European Commission from forcing it to divest Grail, which it purchased before regulatory approvals were in

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Impact of Laws on Pediatric Opioid Prescriptions

Drug Topics

Are prescription cap laws for opioids effective for children and teenagers?

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NSAIDs Linked to Thousands of Heart Failure Hospitalizations Among Patients With Type 2 Diabetes

Pharmacy Times

A recent study suggests that infrequently taking non-steroidal anti-inflammatory drugs, especially ibuprofen, with type 2 diabetes can increase the risk of first-time heart failure and hospitalization.

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Ypsomed brings Sidekick on board to fight self-injection anxiety

pharmaphorum

Asking patients with chronic conditions to regularly inject themselves can be challenging, causing needle anxiety and worry that they may not carry out the procedure correctly, which can reduce compliance. Now, a partnership between Ypsomed and Sidekick Heath aims to tackle that problem. Ypsomed is a top developer of injection and infusion systems, so knows a lot about the difficulties that patients can face when getting to grips with these medical devices, particularly when they are just starti

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Push to double up on Covid booster and flu shot may have a downside, experts caution

STAT

“I really believe this is why God gave us two arms — one for the flu shot and the other one for the Covid shot.” — Ashish Jha, White House Covid coordinator, Sept. 6, 2022. As the promotional push to get people vaccinated with one of the updated, bivalent Covid vaccines heats up, federal health authorities are urging Americans to consider getting their Covid shot and their flu shot at the same time.

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Counseling Pearls for CBD

Drug Topics

Addressing patient concerns about cannabidiol can be the key to patient satisfaction.

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Study: Dolutegravir-based Antiretroviral Therapies for HIV-1 Effective in Pregnancy

Pharmacy Times

Dolutegravir is a more recently approved ART that is a part of a once-a-day regimen found to be more effective, easier to tolerate, and less likely to create new drug resistance in people with HIV-1 compared with other antiretroviral drugs.

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Bayer agrees to pay $40m to resolve claims on three drugs

Pharmaceutical Technology

Bayer has agreed to make a payment of $40m for settling claims over the alleged violations of the False Claims Act linked to three drugs, Trasylol, Avelox and Baycol, the US Department of Justice said in a press statement. The settlement comes after a former Bayer employee, Laurie Simpson, filed two 'whistleblower' lawsuits against the company. These litigations were filed under the qui tam or whistleblower provisions of the False Claims Act, which facilitate private citizens to file lawsuits ag

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