Tue.Oct 10, 2023

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JAK Inhibitors May Increase Risk of Shingles in Patients With Immune-Mediated Inflammatory Diseases

Drug Topics

Patients with rheumatoid arthritis had a higher risk of shingles when treated once a day with 4 mg of baricitinib, 100 mg of peficitinib, or 30 mg of upadacitinib.

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Pharmacists Raise the Alarm About Staffing, Workload

Pharmacy Times

With walkouts across the country and other efforts to raise public awareness, pharmacists are working to find solutions to understaffing and workload challenges.

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Malaria Vaccine Recommended by WHO Could Help Fix Supply Issues

Drug Topics

Based on data from an ongoing clinical trial and other studies, the R21 vaccine has been shown to have a high degree of efficacy when administered just before the high transmission season, with data showing a 75% reduction in cases of malaria in the 12 months following the 3-dose series.

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The ‘model-eat-model world’ of clinical AI: How predictive power becomes a pitfall

STAT

A growing number of AI tools are being used to predict everything from sepsis to strokes, with the hope of accelerating the delivery of life-saving care. But over time, new research suggests, these predictive models can become a victim of their own success — sending their performance into a nosedive and generating inaccurate, potentially harmful results.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Preventing Severe Respiratory Infections in Children

Drug Topics

A refresher on best interventions for common respiratory disorders in children.

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To protect chickens from bird flu, researchers try to CRISPR in immunity

STAT

LONDON — In this case, it was neither the chicken nor the egg that came first. Rather, it started with some specially engineered cells in a lab. The chicken cells had had their genomes edited, not to correct a faulty mutation, but in an effort to blunt the bird flu virus. The chickens that were bred from those cells were designed to be resistant to the infection.

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STAT+: Bernie Sanders bashes nonprofit hospitals over their tax breaks

STAT

WASHINGTON — Hospitals get tax breaks that are worth far more than the value of the charity care they provide in return for their tax-exempt status, according to a report by Senate health committee Chair Bernie Sanders (I-Vt.). The American Hospital Association called the report “just plain wrong.” The federal government requires that tax-exempt nonprofit hospitals operate for the benefit of the public.

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Supply chain, email attacks against healthcare groups frequently threatening patient care, report finds

Fierce Healthcare

Supply chain and business email compromise (BEC) attacks against healthcare organizations are among the leading threats to patients’ care and outcomes, according to a new survey report from cyberse | A newly published industry survey also found that IT executives were less concerned about ransomware vulnerability despite an uptick in organizations experiencing such an attack within the past year.

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STAT+: Dana-Farber CEO on Mass General split: Boston needed a dedicated cancer hospital

STAT

One of the first items on Laurie Glimcher’s agenda after becoming CEO of the renowned Dana-Farber Cancer Institute was to build a freestanding cancer hospital in Boston. The most obvious partner would be Mass General Brigham, the large, not-for-profit system that operates the Boston hospital where Dana-Farber’s doctors currently treat cancer patients.

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The Community Pharmacy Can Leverage Trust To Improve Health Equity Outcomes

Pharmacy Times

Community pharmacies are ideal locations to identify and recruit underrepresented patients for clinical trials.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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HLTH23: Walmart takes virtual primary care nationwide for its employees

Fierce Healthcare

LAS VEGAS — The team at retail giant Walmart didn't realize how fortuitous a virtual primary care pilot would prove to be when it launched in January of 2020. | LAS VEGAS — The team at retail giant Walmart didn't realize how fortuitous a virtual primary care pilot would prove to be when it launched in January of 2020.

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Merck's Keytruda hits overall survival goal in early lung cancer as FDA decision nears

Fierce Pharma

What doctors described as a “messy” treatment landscape in early-stage non-small cell lung cancer (NSCLC) could get clearer thanks to a first-in-class overall survival win from Merck & Co.’s Ke | What doctors described as a “messy” treatment landscape in early-stage non-small cell lung cancer could get clearer thanks to a first-in-class overall survival win from Merck & Co.’s Keytruda.

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STAT+: ‘Like playing the lottery’: A mixed picture for laid-off life sciences workers in Massachusetts

STAT

Gina Calvanese got laid off from Jounce Therapeutics, a struggling Cambridge biotech, in April but landed a higher-paying, six-figure administrative job at a Boston drugmaker within days. Dwight Morrow   was let go by Rubius Therapeutics   five months before it shut down in February. But the veteran scientist quickly moved to a small startup and then got a high-ranking job at Moderna, one of the state’s biggest biotechs, all without leaving Cambridge.

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Bayer christens $250M cell therapy 'launch facility' in Berkeley

Fierce Pharma

Despite the promise of cell therapies, manufacturing the personalized medicines at scale has been a limiting factor for many companies. | Despite the promise of cell therapies, manufacturing the personalized medicines at scale has been a limiting factor for many companies. Now, as BlueRock Therapeutics advances its lead prospect, its parent company Bayer is ready to kick production into high gear.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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HLTH23: In the era of AI in healthcare, Microsoft unveils end-to-end data, analytics platform

Fierce Healthcare

In May, Microsoft rolled out Microsoft Fabric, an end-to-end, unified analytics p | Microsoft unveiled industry-specific healthcare solutions in Fabric that will enable organizations to combine data from previously siloed sources and integrate structured and unstructured clinical information along with imaging and medical device data.

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Study: Pre-Exposure Prophylaxis Significantly Under-Prescribed to Prevent HIV in Eligible Patients

Pharmacy Times

Primary care physicians, particularly in family medicine, offer PrEP at a significantly low rate, despite US Preventive Services Task Force recommendations.

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HLTH23: Walgreens to roll out direct-to-consumer virtual health services in 9 states

Fierce Healthcare

LAS VEGAS—Pharmacy retail giant Walgreens plans to roll out virtual healthcare services later this month for common health needs like urgent care, birth control and seasonal allergies. | Walgreens' goal is to be the "most convenient health and wellness destination" whether consumers are physically in the retailers' stores or virtually in its stores, chief operating officer Tracey D.

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STAT+: Sana to lay off nearly a third of staff, de-prioritize a key program

STAT

Sana Biotechnology, a startup that just a couple of years ago raised over $1 billion off a grand plan to create a portfolio of powerful medicines, said Tuesday it would lay off nearly a third of its employees and de-prioritize one of its most ambitious programs as it looks to save money. The layoffs are Sana’s second round of cuts in less than a year.

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HLTH23: Sutter Health unveils SF-based innovation center, calls for startup, VC collaborators

Fierce Healthcare

Sutter Health announced Tuesday plans to build a dedicated innovation center in San Francisco that the system will use for the development of novel healthcare technologies and services. | Alongside internal innovation efforts, the California system said the center will be a door for early-stage partners to co-develop and scale their digital health products in real-world clinical environments.

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Navigating Data Integrity for Generic Drug Approvals

Pharmacy Times

Continuous innovation is required in various technological aspects to effectively manage the challenges of vast clinical data.

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With a rare immunodeficiency disease, a performer and patient advocate learned lessons the hard way

STAT

When asked where he’s from, Casey Warford often waffles. He was born in San Antonio, but raised in Georgia, and then moved back to Texas for college. It’s a little complicated because all that time Warford was dealing with a complex medical condition.  The oldest of three children and a couple of close cousins, Warford was a quiet, sleepy baby.

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HLTH23: Headspace, Oura partner to bring a high-tech approach to tackling stress, mental wellness

Fierce Healthcare

LAS VEGAS—Wearable company Oura, the maker of the "smart ring," has tapped Headspace to integrate physical health with stress management and meditation and mindfulness services. | Wearable company Oura, the maker of the "smart ring," has tapped Headspace to integrate physical health with stress management and meditation and mindfulness services.

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STAT+: Akero’s treatment for NASH falls short in cirrhosis study

STAT

Akero Therapeutics said Tuesday that an experimental medicine failed to show a significant benefit for patients with cirrhosis caused by NASH, the most advanced and life-threatening stage of the fatty liver disease. While the study’s primary goal of improving liver fibrosis, or scarring, was not achieved, the Akero drug, called efruxifermin, outperformed placebo by 10 percentage points.

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Inositol Safe, Effective Against Polycystic Ovary Syndrome

Drug Topics

PCOS is reported in 5% to 20% of reproductive aged women, making it the most common endocrine disorder and one of the most common causes of infertility in women.

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Opinion: Connecticut’s comptroller explains his thinking about GLP-1s for state employees

STAT

This article is part of a partnership between First Opinion and Tradeoffs, a podcast exploring our confusing, costly, and often counterintuitive health care system. To learn more about how the high price of this new wave of weight loss drugs is causing employers to confront their attitudes about obesity, listen to a deeper dive from Tradeoffs, and  subscribe  to never miss an episode.

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Walmart expands virtual healthcare benefits

Drug Store News

As part of this expansion, virtual care options for digestive health and physical therapy also will be available, including some basic at-home lab work early next year.

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STAT+: A fraught question for the children of Alzheimer’s: Is it coming for us?

STAT

My sister has a fantasy about our old age: She imagines that the seven siblings in our family will be living together again, in a house somewhere. Five will be wandering around in bathrobes, lost to dementia. The other two, their minds intact, will look after the lost ones. In this whimsical scenario, for some reason I am one of the two who stay lucid and do the caretaking.

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Does coffee dehydrate you

The Checkup by Singlecare

If you’ve ever guzzled one too many cups of coffee, you may be worried about the caffeinated elixir dehydrating you. After all, it does have diuretic properties. But really, the relationship between caffeine and hydration is more complicated. Dehydration happens when you don’t have enough water in your body. When dehydrated, you may experience fatigue, cramping, dizziness and confusion—symptoms no one wants when they need an afternoon pick-me-up.

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Study: More than half of consumers have a negative outlook on the economy

Drug Store News

Some 58% of consumers have a negative outlook on the economy, while 71% of marketers say that they are most concerned with inflation, supply chain and labor shortages.

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On World Mental Health Day, URAC unveils accreditation for mental health programs

Fierce Healthcare

It’s World Mental Health Day, and, to help commemorate that, URAC unveiled an accreditation standard it hopes will improve mental healthcare.

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Life Sciences Innovation Day – Accelerating Digital Transformation Ambition

European Pharmaceutical Review

Schneider Electric, a leader in digital transformation, energy management and automation, has announced the speaker lineup for its exclusive event, Life Sciences Innovation Day – Accelerating Digital Transformation Ambition. Set at the world-renowned Silverstone F1 Racetrack on 18 October 2023, it promises to be a day of immersive insights and top rate networking.

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Instacart, Mount Sinai Solutions launch grocery benefit to support patients after hospital

Drug Store News

​​​​​​​The Instacart Health Fresh Funds benefit is available to recovering post-operative and post-partum patients who are insured by a Mount Sinai Solutions customer's health plan.

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Point of Care Personalization: A Conversation with Veradigm

Fierce Pharma

Personalization—we’re all talking about it, and we’re all trying to do it better. So what sets Veradigm apart? | Veradigm has insights as to how personalized and targeted messaging can drive awareness and engagement, ultimately improving the patient experience.

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Robert F. Kennedy is pitching centrism on health care, even on abortion

STAT

You’re reading the web edition of D.C. Diagnosis.  Sign up here  to receive this newsletter in your inbox on Tuesdays and Thursdays. What RFK’s new lane means Robert F. Kennedy is officially running for president as an independent. In a Monday afternoon Philadelphia rally, the Kennedy family scion harkened back to the Declaration of Independence and “the one other president who did not have a political party” (George Washington), promising to take on D.C. in