Fri.Mar 15, 2024

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Blood-Based Test Demonstrates High Sensitivity for Colorectal Cancer

Drug Topics

A blood-based cell-free DNA (cfDNA) test was able to find patients at increased risk of colorectal cancer (CRC), advanced neoplasia, and advanced precancerous lesions.

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With Pfizer struggling in 2023, CEO Bourla hit with 35% pay cut to $21.6M

Fierce Pharma

Pfizer knew 2023 was going to be a challenging year of transition. But even the drugmaker was surprised by the plummeting demand for its COVID-19 products, missing badly on its 2023 guidance. | After a difficult year for Pfizer, in which its share price fell by 44%, CEO Albert Bourla’s compensation fell by 35% from $33 million in 2022 to $21.6 million in 2023.

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HIMSS24: Oracle Health builds out generative AI tools in its quest to 'eliminate clicks' for clinicians

Fierce Healthcare

ORLANDO, Florida — Software giant Oracle continues to build out generative AI tools in its healthcare solutions as it debuted a new service for care management this week and plans to roll out | Oracle is integrating generative AI and ambient listening technologies into its EHR to streamline medical notetaking for clinicians. "We're not trying to go from 10 clicks to seven clicks.

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Study: Only 40% of Adults With Childhood Asthma Experience Remission

Pharmacy Times

The study showed no clinical differences for remission or asthma at age 28 years based on lung function, body mass index, daily smoking, exposure to parental tobacco smoke, or house dampness.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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AHA: 94% of hospitals financially impacted by Change Healthcare's cyberattack

Fierce Healthcare

Nearly every hospital is feeling the consequences of Change Healthcare’s cyberattack on their finances, patient care delivery, or both, according to reports from almost 1,000 hospitals compiled by | Almost 60% of surveyed hospitals reported at least $1 million of impacted revenues per day, and 74% said that the incident has had "direct" implications on patient care within their facilities.

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What the brains of song birds can teach us about human stuttering

STAT

A symphony of synapses fires every time a songbird sings. For Erich Jarvis, a neurobiologist at Rockefeller University, the neural pathways he finds particularly interesting inside a birds’ brain are those that enable the bird to make new sounds from listening to their environment. This is an ability known as vocal learning, and is perhaps most notably exhibited when a parrot mimics a person’s speech (or profanity).

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STAT+: FDA advisers back CAR-T therapies in blood cancer, despite safety concerns

STAT

A panel of expert advisers to the Food and Drug Administration on Friday voted in favor of expanding the use of CAR-T therapy in blood cancer, despite concerns about the powerful treatment’s side effects. The group voted 11-0 that the benefits of Carvykti, a CAR-T medicine from Johnson & Johnson and Legend Biotech, outweighed its risk for patients with multiple myeloma whose disease has persisted despite initial treatment.

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Despite early death concerns, FDA advisers back J&J and Legend's Carvykti for earlier myeloma

Fierce Pharma

Even though the BCMA CAR-T therapy Carvykti showed a potential problem of early patient deaths in a trial, experts on the FDA’s Oncologic Drugs Advisory Committee (ODAC) still believe that the drug | Even though the BCMA CAR-T therapy Carvykti showed a potential problem of early patient deaths in a trial, experts on the FDA’s Oncologic Drugs Advisory Committee still believe that the drug’s long-term benefits outweigh its risks.

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Opinion: Lessons for scientists from the All of Us Research Program backlash

STAT

Scientists are taught early in our training that criticism is a fundamental part of the job. What we are not usually trained to navigate, however, is public backlash, which is exactly what followed the publication of the comprehensive genomic sequencing results from the All of Us Research Program. The study aims to add the genomic information of 1 million volunteers from normally underrepresented genetic backgrounds to datasets that have been mostly constituted by people of European descent.

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KFF: A look at healthcare spending trends in Medicare households

Fierce Healthcare

Medicare households are spending far more on healthcare than other households, according to a new KFF analysis. | Medicare households are spending far more on healthcare than other households, according to a new KFF analysis.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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Novartis lays out $256M for antibody plant expansion in Singapore, plots 100 hires

Fierce Pharma

Over the years, Singapore has attracted a suite of biopharma majors, and Novartis is no exception. | Novartis broke ground on a $256 million expansion of its biopharmaceutical production facility in Singapore. The project will introduce digitalization and automation at the site in a bid to boost manufacturing productivity and to help upskill the company’s workforce.

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Practice Better adds new tools, billing integration for mental health practitioners

Fierce Healthcare

Practice Better, a practice management software vendor, is expanding its platform to better support the needs of mental health practitioners. | The practice management platform is adding range of mental health screening forms, client progress tracking tools and mental health templates with more specialized features to its platform. It has also teamed up with clearinghouse Claim.MD to add insurance billing integration to its platform.

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Navigating digital transformation in pharma: The rise of mobile messaging

pharmaphorum

Popular mobile messaging apps that offer end-to-end encryption for their users' communications means that the content of messages is only accessible to the sender and the recipient. However, like any software, they still have potential cybersecurity risks and compliance concerns that users should be aware of - especially in pharma.

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Senate Finance Committee grills Becerra on HHS' delayed relief in Change Healthcare cyberattack

Fierce Healthcare

Leading senators want Department of Health and Human Services, insurers and hospitals alike to know they’re keeping a close eye on the fallout from Change Healthcare’s cyberattack. | Influential senators held HHS Secretary Xavier Becerra's feet to the fire on Thursday, urging him and his department to deliver prompt support and maintain pressure on the industry to invest in cybersecurity.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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Changing Faces: Digital and supplier hires from February 2024

pharmaphorum

Explore the latest digital and supplier hires in the pharmaceutical industry, including Campbell, EMS Healthcare, PhRMA, and Exscientia in February 2024. Stay updated on the changing faces in industry.

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STAT+: Bayer exec: U.S. is key in reviving beleaguered pharma’s drug pipeline

STAT

German pharmaceutical company Bayer is expanding its U.S. pharma business significantly, despite corporate turmoil and pricing pressures that have led many in the drug industry to bemoan the potential end of the American biotech innovation boom. Bayer’s C-suite has been on a soul-searching mission for the last year, spurred by new leadership and the realization that the company is, as new CEO Bill Anderson said earlier this month, “ badly broken.

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LSD D-Tartrate Receives Breakthrough Therapy Designation From FDA for Generalized Anxiety Disorder

Pharmacy Times

LSD d-tartrate (MM-120) showed rapid improvements in patients with generalized anxiety disorder by day 2 of the study.

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Telehealth-Based OUD Treatment May Lead to Better Health, Obstetric Outcomes Among Pregnant Patients

Drug Topics

Telehealth mitigates barriers like stigma, fear, and legal concerns associated with receiving opioid use disorder (OUD) care by offering a convenient and discreet treatment option.

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Healthee heads latest crop of digital health financings

pharmaphorum

Our latest round-up of funding rounds in the digital health category features updates from Healthee, Aktiia, Moxe Health, Eleanor Health, Tava Health, BrainCheck, and Redi Health.

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The Case for Domestic Sourcing to Establish Reliable Pharmaceutical Supply Chains in the United States

Pharmaceutical Commerce

Reliance on foreign imports means that disruptions in the supply chain can profoundly impact the ability of individuals in the United States to get access to the medications they need.

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8 Ways to Cope with a Disappointing Residency Match 

Board Vitals - Pharmacist

You’ve worked tirelessly through years of medical school, and the culmination of your efforts has finally arrived: the residency match. While you may be excited to have matched, it can be disappointing to realize you matched into a program lower on your preference list, especially as watch your classmates celebrate their own successes. It’s okay to feel disappointed, and it’s natural to have envisioned a different outcome after investing so much time and effort into your medica

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FDA approves first treatment for liver scarring due to fatty liver disease

Pharmafile

The US Food and Drug Administration (FDA) has announced that it has approved Rezdiffra (resmetirom) for the treatment of adult patients with noncirrhotic non-alcoholic steatohepatitis (NASH) with moderate to advanced liver scarring (fibrosis), for use alongside diet and exercise. This approval follows an analysis of the safety and efficacy of the drug based on a […] The post FDA approves first treatment for liver scarring due to fatty liver disease appeared first on Pharmafile.

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FDA Approves Lisocabtagene Maraleucel For Treatment of Relapsed or Refractory CLL, SLL

Drug Topics

The approval was based on data from the phase 1/2 TRANSCEND CLL 004 study, in which the CAR T cell therapy demonstrated statistically significant complete response rates.

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Future medicine makers will get VR training at new UK centre

pharmaphorum

Consortium led by Birmingham University unveils a centre of excellence for medicines manufacturing training using VR, to answer a UK skills shortage.

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BioDesign: Accelerating the Momentum of Bioconjugate Therapeutics

Fierce Pharma

Over the last several decades, mounting interest has positioned bioconjugate therapeutics as one of the most promising biopharmaceutical modalities. | Antibody-drug conjugates are a promising biopharma modality but specialized expertise is instrumental for successfully bringing drugs to the clinic.

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After Amylyx drug failure, what’s next for ALS?

PharmaVoice

The company’s combo treatment Relyvrio was approved in 2022, but after failing a phase 3 trial, may be pulled from the market.

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FDA Grants Breakthrough Device Designation for Neuroimmune Modulation Platform To Treat MS

Pharmacy Times

The platform is a first-of-its-kind therapeutic approach to promote remyelination among individuals with relapsing/remitting multiple sclerosis.

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What happens when an approved drug doesn’t work?

STAT

Want to stay on top of the science and politics driving biotech today?  Sign up  to get our biotech newsletter in your inbox. Hey there. Today, we see the first approval of a drug to treat MASH, a Gilead medication shows huge promise in Ebola, and more.

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Community Health Workers Can Promote Diversity in Clinical Trial Enrollment

Pharmacy Times

Their expansive scope of services can ultimately help to elevate the work of the entire community pharmacy.

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STAT+: Up and down the ladder: The latest comings and goings

STAT

Hired someone new and exciting? Promoted a rising star? Finally solved that hard-to-fill spot? Share the news with us, and we’ll share it with others.  That’s right. Send us your changes, and we’ll find a home for them.  Don’t be shy. Everyone wants to know who is coming and going. And here is our regular feature in which we highlight a different person each week.

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Fierce Pharma Asia—BIO-WuXi break-off; Takeda's site closure; FDA's concern over Carvykti

Fierce Pharma

WuXi AppTec left the Biotechnology Industry Organization amid increasing pressure on the trade group stemming from a draft U.S. bill targeting certain Chinese biotechs. | WuXi AppTec left BIO amid alleged biosecurity concerns and as U.S. lawmakers target certain Chinese biotechs. Takeda will shut down a gene therapy manufacturing and R&D facility in Austria.

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ALS body takes digital approach to clinical trials access

pharmaphorum

The ALS Association is partnering with myTomorrows to connect patients and physicians with clinical trials using a digital platform.

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Mycoplasma testing market expected to value nearly $2 million by 2031

European Pharmaceutical Review

According to research published by Coherent Market Insights, the global mycoplasma testing market is anticipated to reach $1,907.6 million by 2031. The market is set to witness a compound annual growth rate (CAGR) of 9.7 percent during the forecast period, the report predicted. What is driving and limiting growth in the market? Specifically, technology innovations such as sequencing technology, supported by “strong government funding for biomedical research” in the US has driven rapid developmen

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Madrigal Pharma is first over the MASH finish line

pharmaphorum

Madrigal Pharma is first pharma company to get FDA approval for a drug to treat metabolic dysfunction-associated steatohepatitis (MASH)

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