Fri.Oct 13, 2023

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Assessing, Implementing Geriatric Oncology Model of Care for Lung Cancer Patients

Drug Topics

Geriatric screening and assessment have not been widely used, despite international society recommendations for screening older patients with cancer.

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Opinion: Yes, everyone should get an updated Covid-19 vaccine

STAT

Last month, the Centers for Disease Control and Prevention recommended that everyone in the U.S. 6 months and older receive an updated Covid vaccine targeting the XBB.1.5 variant. Since then, some notable voices, including Paul Offit , have publicly questioned whether the updated vaccine is needed for those who are not in a high-risk group. He recently wrote, “At this point in the pandemic, it is hard to make a case for vaccinating everyone.

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Trending Sources

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Uptake, Acceptability of HIV Pre-Exposure Prophylaxis Treatment Influenced by Knowledge, Perception of Risk in MSM

Pharmacy Times

Although increased knowledge and understanding could increase uptake and acceptability of pre-exposure prophylaxis for HIV, action is needed to remove barriers and improve accessibility.

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STAT+: Like a vampire, some cancer cells can suck the energy source from immune cells

STAT

As elite hunters of the immune system, T cells are constantly prowling our bodies for diseased cells to attack. But when they encounter a tumor, something unexpected can happen. New research shows that some cancer cells can fire a long nanotube projection into the T cell that, like a vampire’s fang, sucks energy-creating mitochondria from the immune cell, turning the predator into prey.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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UnitedHealth posts $5.8B in profit, $92.4B in revenue on Q3 beat

Fierce Healthcare

UnitedHealth Group kicked off another round of quarterly earnings calls Friday morning, when it reported $5.8 billion in profit for the third quarter. | UnitedHealth Group kicked off another round of quarterly earnings calls on Friday morning, where it reported $5.8 billion in profit for the third quarter.

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He was named a MacArthur ‘genius’ fellow for research on gene regulation, but still has imposter syndrome

STAT

The youngest of this year’s class of MacArthur “genius grant” fellows, 35-year-old Jason Buenrostro was just a graduate student when he pioneered a technique that’s become a mainstay for studying how cells regulate gene expression. While doing his doctoral work at Stanford University, with geneticists William Greenleaf and Howard Chang, he developed the assay for transposase-accessible chromatin, or ATAC-seq, a highly sensitive and accurate method for identifying regi

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More Trending

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Accessibility of OTC Short-Acting Beta-2 Agonists Contributes to Overuse for Asthma

Pharmacy Times

Many patients would like more education about managing their asthma, which can help to reduce the overuse of short-acting beta-2 agonists.

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Amylyx's ALS drug Albrioza rebuffed by EU regulator—again

Fierce Pharma

Even as Amylyx’s ALS drug gains steam in the U.S. after a long-awaited FDA approval, the company is struggling with regulatory hurdles overseas. | Europe's drug regulator wasn't swayed by Amylyx's phase 2 data. The European Commission will make the final call on the drug's approval in the bloc by the end of the year.

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STAT+: Amgen reports first clinical data on new targeted cancer therapy

STAT

It’s been a busy week for a cancer drug target called PRMT5 that may play a role in treating a variety of solid tumors. Amgen on Friday presented preliminary results from its first study of an experimental pill that selectively blocks the enzyme in cancer cells, showing five partial responses from 31 evaluable patients. The Amgen reveal followed the announcement on Sunday that a rival PRMT5 inhibitor being developed by Mirati Therapeutics factored into Bristol Myers Squibb’s decisi

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CMS is removing PET scan restrictions for Alzheimer’s patients

Fierce Healthcare

The Centers for Medicare & Medicaid Services has decided to remove the national coverage determination (NCD) that limits patients’ ability to qualify for new drugs, giving people with Alzheimer | After CMS floated the idea in July, the agency decided to remove restrictions for brain scans that could help patients receive access to drugs like Leqembi.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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High-flying Novo Nordisk again dials up its 2023 sales and profit expectations

Fierce Pharma

The popular diabetes med Ozempic and its sister weight-loss drug Wegovy are boosting Novo Nordisk to new highs again and again. | The popular diabetes med Ozempic and its sister weight-loss drug Wegovy are boosting Novo Nordisk to new highs again and again.

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Patient Perceptions of Benefits, Barriers in Diabetes Technologies

Drug Topics

Patients with type 1 diabetes who use technologies for glycemic management may perceive these devices as important for glucose monitoring and emotion well-being, but affordability remains a significant barrier.

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Kaiser Permanente reaches tentative agreement with workers

STAT

After a historic strike, healthcare giant Kaiser Permanente and the Coalition of Kaiser Permanente Unions announced early Friday that they have reached a tentative union contract agreement. More details will be disclosed soon, they said. The agreement was reached with the help of acting U.S. Labor Secretary Julie Su, who was also on hand for the failed last-minute set of negotiation talks before the unions went on strike last week.

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Pharmacies Can Help Expand HIV PrEP Awareness, Accessibility to Cut New Infections

Drug Topics

Considering recent legal challenges to gender affirming and reproductive healthcare, pharmacists play an essential part to help marginalized populations have access to HIV prevention.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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STAT+: European regulators once again recommend Amylyx’s ALS drug be rejected

STAT

LONDON — European regulators on Friday reiterated their view that an ALS treatment from Amylyx Pharmaceuticals should not be approved, likely dooming the drug’s chances for now.   A European Medicines Agency committee had initially recommended against approving the drug , known as Albrioza, in June. Friday’s confirmation of that position came after the company appealed the decision.

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An Evolving ‘Opinion’ Landscape: New Paths—and Synergies—for Pharma KOLs & DOLs

PharmExec

Industry experts discuss the relationship between digital and traditional (key) opinion leaders and how companies are adjusting their strategies to harness the unique brand engagement benefits each role can provide in driving better patient outcomes.

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STAT+: Medicare to cover more brain scans related to Alzheimer’s drugs

STAT

Medicare has officially expanded its coverage policy for brain scans that detect a brain plaque associated with Alzheimer’s disease, the agency announced on Friday. Amyloid PET scans are important tools to help determine whether patients with mild cognitive impairment are good candidates for new Alzheimer’s drugs, including Eisai and Biogen’s drug Leqembi , which means there will likely be an increase in demand for the scans as uptake increases.

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Eying Incyte's Opzelura, Leo Pharma shares data for JAK cream in hand eczema

Fierce Pharma

Back in February, Leo Pharma revealed that its JAK-inhibitor cream delgocitinib met its primary and secondary endpoints in a phase 3 trial in chronic hand eczema, putting pressure on Incyte’s appro | Back in February, Leo Pharma revealed that its JAK-inhibitor cream delgocitinib met its primary and secondary endpoints in a phase 3 trial in chronic hand eczema, putting pressure on Incyte’s approved topical Opzelura.

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Study Finds Mental Health-Related Emergency Department Visits Dropped in 2020, Began Increasing in Mid-2021

Pharmacy Times

Adolescents with mental health conditions must be monitored as they are at a higher demand for the need of mental health care.

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Pfizer takes aim at BMS' first-in-class Zeposia with FDA nod for ulcerative colitis drug Velsipity

Fierce Pharma

Bristol Myers Squibb’s Zeposia is no longer the only S1P receptor modulator on the market for ulcerative colitis, thanks to an FDA approval for what appears to be a more effective drug from Pfizer. | Bristol Myers Squibb’s Zeposia is no longer the only S1P receptor modulator on the market for ulcerative colitis, thanks to an FDA approval for what appears to be a more effective drug from Pfizer.

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Deep Sleep With Pink Noise Increases Benefits to Cardiovascular System

Pharmacy Times

A study shows a significant increase in left ventricular ejection fraction when using pink noise stimulation with deep sleep.

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Children 5 and younger may be particularly vulnerable to flu and should be vaccinated: CDC study

Fierce Healthcare

Youngsters 5 to 17 years old need to get vaccinated against influenza as soon as possible. | Children and adolescents should receive the seasonal influenza vaccination by the end of October, according to the Centers for Disease Control and Prevention.

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Removal of Phenylephrine From Nasal Decongestants Could Reshape OTC Cold Remedies

Pharmacy Times

Intranasal decongestants are preferred alternatives to oral phenylephrine for relief of nasal congestion.

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STAT+: Eye docs urge Medicare to lower insurance hurdles amid shortage of repackaged Avastin

STAT

Due to a shortage of a widely used compounded medicine for serious eye diseases, two leading ophthalmologic groups want Medicare contractors to halt practices that limit coverage of other — albeit costlier — treatments over concerns about patient access. At issue is Avastin, an older cancer medicine that is often used by physicians to treat age-related macular degeneration and macular edema, among other ailments.

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Todd Vasos returns as CEO of Dollar General

Drug Store News

Vasos, who previously served as Dollar General’s CEO from June 2015 to November 2022, is returning as CEO, succeeding Jeff Owen, whose separation from the company and resignation from its board is effective today.

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Biopharma Stock Check: Market Review and Outlook

PharmExec

Exploring the pharma and biotech financing, M&A, and stock market pictures through the first half of 2023—and implications for the future, as market challenges continue to weigh heavily in senior management decision-making.

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Brooklinen continues to evolve the DTC model

Drug Store News

DSN spoke to Kelly Hallinan, senior vice president of emerging channels at Brooklinen, about how Marlow’s partnership with Walmart came about and future expansion plans.

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Follicular lymphoma BTK inhibitor recommended by CHMP

European Pharmaceutical Review

The Committee for Medicinal Products for Human Use (CHMP) has recommended approval of BRUKINSA ® (zanubrutinib), a Bruton’s tyrosine kinase inhibitor (BTKi), in combination with obinutuzumab. BeiGene’s anti-cancer treatment is indicated for adults with relapsed or refractory (R/R) follicular lymphoma (FL) who have received at least two prior lines of systemic therapy.

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STAT+: UnitedHealth’s profit jumps as medical costs come in lower than expected

STAT

UnitedHealth Group has made it clear that more people, especially older adults, are seeing their doctors and getting more medical care this year. But that is certainly not dragging down the company’s profits. In the third quarter of this year, UnitedHealth’s net profit increased by more than 11%, to more than $5.8 billion, the company reported Friday.

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Study reports rapid method for microbial contaminant detection

European Pharmaceutical Review

A paper published in Pharmaceuticals has reported the first demonstration of the possibility of using fluorescent optical respirometry (FOR) to detect aerobic bacteria in selected sterile pharmaceutical products. Rapid , real-time measurement of living aerobic microorganism cells was achieved using the fluorescent sensor tris-[(4,7-diphenyl-1,10 phenanthroline)ruthenium(II)] dichloride (Ru(DPP) 3 Cl 2 ).

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Vampiric cancer cells, a brain atlas, & alleged misconduct at Cassava

STAT

Want to stay on top of the science and politics driving biotech today?  Sign up  to get our biotech newsletter in your inbox. Hello! Today, we learn about energy-sucking cancer cells, explore a map of the human brain, and update you on the downfall of Cassava Sciences. Have a good weekend.

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FDA lifts clinical hold on PepGen’s myotonic dystrophy type 1 candidate

Pharmaceutical Technology

The dose-selection Phase I trials for evaluating PepGen’s peptide-conjugated antisense oligonucleotide have been cleared to begin in the US.

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A Blueprint for Balance

PharmExec

Stephen Rivera, vice president, global technical accounting advisory services and policy, Johnson & Johnson, capitalizes on his lively personality—and a courageous career journey—to bring people together to shape the future of biopharma.

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EMA Recommends Multiple Myeloma Treatment

BioPharm

The agency recommended conditional marketing authorization for Elrexfio (elranatamab) as a monotherapy for adult patients with relapsed and refractory multiple myeloma.

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