Wed.Nov 08, 2023

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Gene Therapy Advances in Hemophilia A Treatment

Pharmacy Times

Atta Chowdhry, RPh, and Robert Sidonio Jr, MD, MSc, discuss the emergence of gene therapy as an exciting option for patients with hemophilia A and highlight benefits, limitations, and ongoing research in the field.

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Breaking: FDA Approves Tirzepatide Injection for Chronic Weight Management in Obesity, Overweight

Drug Topics

The drug, Zepbound, will be available in the United States by the end of 2023.

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FDA Approves Tirzepatide for Chronic Weight Management

Pharmacy Times

Tirzepatide is already approved under the brand name Mounjaro (Lilly) to be used along with diet and exercise to improve blood sugar in adults with type 2 diabetes.

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HPV vaccines are so effective that new screening policies may be in order, suggests study

STAT

Vaccines work well to prevent cancers caused by the human papillomavirus (HPV). So well, in fact, that it may be time to review HPV screening protocols, according to the somewhat provocative conclusion of a new study examining the occurrence of genital HPV types eight years after immunization, published today in Cell Host & Microbe. The randomized control study included more than 60,000 women from 33 Finnish communities born in 1992, 1993, and 1994.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Pharmacist-Led Intervention for Blood Pressure Control Could Help Patients, Economy

Drug Topics

A study found that a pharmacist-prescribing intervention for high blood pressure could save the health care system $1.137 trillion over a 30-year period.

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Eli Lilly gets FDA approval to sell Mounjaro as obesity drug called Zepbound

STAT

Eli Lilly’s blockbuster drug tirzepatide, sold as Mounjaro for type 2 diabetes, has been cleared to treat obesity, making it the second in a highly effective class of weight loss medications to enter the market. The Food and Drug Administration’s long-awaited approval of the drug, which will be marketed under the name Zepbound for obesity, is a major milestone for Lilly.

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STAT+: In the fight against cancer, it’s boom times for radiopharmaceuticals

STAT

When Ken Song was getting ready to leave his job as the CEO of a small biotech in 2020, he wasn’t sure what was next. But he knew one thing. “I deliberately said I’m not going to do oncology. Oncology is so crowded. Everybody thinks they have the solution, but the reality is, it’s all noise,” he said. That was until late March 2020, when he received two phone calls from two different investors, both pondering about the same thing: Was it possible to make more e

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Senate votes to reform PBMs again, stop $16 billion in hospital cuts

Fierce Healthcare

Legislative spotlight was put back on pharmacy benefit manager reform and mental health in a comprehensive draft packaged presented by the Senate Finance Committee, which was passed Wednesday 26-0. | A comprehensive healthcare package garnered near unanimous approval on Wednesday, which could lead to big changes for PBMs down the road.

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Opinion: Many Americans receive too much health care. That may finally be changing

STAT

The opioid crisis rocked America, bringing addiction and overdose into the spotlight. But it also highlighted the overtreatment of pain: Medical and dental providers alike overprescribed opioids after procedures and for chronic conditions. Out of that overtreatment came an epidemic. In American health care, overtreatment is common. Recently though, there has been a subtle shift in the opposite direction.

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With FDA approval, Eli Lilly's weight-loss drug Zepbound arrives to challenge Novo Nordisk

Fierce Pharma

In the Big Pharma battle to treat obesity, Novo Nordisk sprinted to an early lead, but Eli Lilly is catching up quickly. | In the Big Pharma battle to treat obesity, Novo Nordisk sprinted to an early lead, but Eli Lilly is catching up quickly. Wednesday's FDA approval of Lilly's Zepbound to treat obesity closes the gap further. In addition, Lilly said it will charge 20% less than Novo for its obesity med in an attempt to provide increased access.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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Why preventative care is such a tough sell in the U.S., according to chronic disease experts

STAT

WASHINGTON — With the prevalence of some chronic diseases trending up, the U.S. needs to revamp its approaches to preventative care and disease management, experts said at the Milken Future of Health Summit on Tuesday. Already, 6 in 10 Americans live with a chronic condition , and 4 in 10 live with at least two. Factors such as the U.S.’s aging population, delayed care during Covid-19, and the rising prevalence of obesity are only exacerbating the problem, said Karen Hacker, the Ce

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Men Who Develop Asthma Later in Life Are More Likely to Have Harmful T Cells in Their Lungs

Pharmacy Times

CD4+ tissue-resident memory T cells may trigger severe, and potentially fatal, asthma attacks in men aged 40 years and older.

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STAT+: Sanofi CEO defends company’s move to abandon profit guidance and boost research

STAT

LONDON — Sanofi CEO Paul Hudson on Wednesday defended his company’s recent moves to abandon future profit guidance and up its investment in its own research programs, arguing that the dramatically negative market response didn’t reflect the potential rewards that could stem from the plan. “Would I have liked the stock market reaction to be more generous?

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Mass General Brigham taps Best Buy Health to scale up its at-home care services

Fierce Healthcare

Mass General Brigham tapped retailer Best Buy Health to scale up its Healthcare at Home services to meet growing demand for home-based care and address workforce shortages. | Mass General Brigham tapped retailer Best Buy Health to scale up its Healthcare at Home services to transition more medical care to patients' homes while also addressing workforce shortages.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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Why do some CAR-T cancer patients have severe complications? Data points to latent virus

STAT

The therapy, an infusion of CAR-T cells designed to kill the lymphoma, was going well. Nearly a month after the treatment, the engineered cells had crushed the cancer, and the patient, a 49-year-old woman in the Netherlands, appeared to be cancer-free. But two weeks later, something was wrong. The patient couldn’t remember having been in the hospital or, indeed, ever being treated for lymphoma.

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Bayer CEO Anderson says 'radical realignment' is underway

Fierce Pharma

In three years as the pharma chief at Roche, Bill Anderson executed a massive overhaul of the division, lopping off layers of management and recharting its course. | In three years as the pharma chief at Roche, Bill Anderson executed a massive overhaul of the division, lopping off layers of management and recharting its course. Now in his fifth month as CEO at struggling conglomerate Bayer, Anderson is focused on an even larger renovation, saying the company is on its way to a “radical realignme

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STAT+: Biotech incubator Curie.Bio graduates its first startup

STAT

Curie.Bio, the new biotech investment firm and incubator launched earlier this year by a group of industry veterans including Alexis Borisy and Zach Weinberg, has graduated its first startup. The startup, Forward Therapeutics, is coming out of the incubator with three drug candidates for chronic inflammatory disorders. It also just closed its first major financing round: a $50 million Series A round led by BVF Partners, with participation from RA Capital Management and OrbiMed.

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Majority of Eligible People Are Not Receiving Hepatitis A Vaccines

Drug Topics

In a recent Morbidity and Mortality Weekly Report (MMWR), the results of a study showed 63% of those who died from HAV had at least 1 documented preexisting indication for vaccination.

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STAT+: Senate panel clears PBM reforms, safety-net hospital payments

STAT

WASHINGTON — A prominent Senate panel on Wednesday passed a new package of health policy reforms that would rein in certain pharmacy middlemen practices and ensure Medicare patients aren’t paying more than insurers do for medications. The package passed the committee 26-0 with no amendments added. Sen. Ron Johnson (R-Wis.) didn’t vote.

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Studies Show Association Between Regular Cannabis Use, Heart Failure

Pharmacy Times

Regular usage of cannabis may increase the risk of heart failure, stroke, or heart attack, even after adjusting for other cardiovascular disease risk factors.

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STAT+: FDA’s Califf wants to get the public as excited about life expectancy as cures

STAT

WASHINGTON — It’s easy to get people worked up about cures, but they don’t seem to be bothered by falling life expectancy, and Food and Drug Administration Commissioner Robert Califf would like to figure out how to connect the two. The United States has one of the lowest life expectancy rates among wealthy nations. Post-pandemic, the average American life span is down to 76.4 years.

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As Biogen's sales flatline, CEO Chris Viehbacher touts progress on Leqembi, Skyclarys and other launches

Fierce Pharma

While Biogen CEO Chris Viehbacher seems satisfied with the company's third-quarter financial metrics, the main question at the drugmaker isn’t so much how the company’s doing now, but what its plan | While Biogen CEO Chris Viehbacher seems satisfied with the company's third-quarter financial metrics, the main question at the drugmaker isn’t so much how the company’s doing now, but what its plans are for future growth, he said on a call with investors.

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Opinion: Listen: Putting an end to a racist ‘diagnosis’

STAT

The term “excited delirium” has been used for years by law enforcement and other first responders, including health care workers, to describe people who exhibit behavior that is considered “out of control.” This diagnosis has been applied again and again, even posthumously, as a justification for extreme, and sometimes deadly, interventions by law enforcement.

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A tiny container making a large impact

Drug Store News

Patrick Morrow, founder of Tini Naturals, has a goal to prevent no less than 100 tons of plastic from negatively impacting the environment in their first year of production alone.

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STAT+: FDA approves high blood pressure device from Recor Medical

STAT

The Food and Drug Administration approved a surgical system used to reduce blood pressure from Recor Medical, the company announced Wednesday. The treatment, called renal denervation, is controversial in the cardiology community due to its unclear efficacy. Renal denervation is a treatment for patients who cannot manage standard doses of blood pressure medication — whether because the drugs aren’t effective enough for them, create overwhelming side effects, or become too cumbersome

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Amazon intros new healthcare benefit for Prime members

Drug Store News

The new benefit includes care from One Medical, including 24/7 on-demand virtual care nationwide and easy to schedule office visits at any of One Medical’s hundreds of locations across the United States.

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Nonprofit hospital sector to stabilize in 2024 amid rising reimbursement, volumes, Moody's predicts

Fierce Healthcare

Moody’s Investor Services is forecasting stronger financials across the nonprofit hospital sector in 2024 thanks to upticks in reimbursement rates and volumes that will outpace continued labor expe | The ratings agency said it anticipates a 10% to 20% increase in nonprofit providers' median operating cash flow during the coming year. Median operating revenue is projected to grow between 4% and 6% while median operating costs are forecasted between 3% to 5%.

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Survey: 2.8 Million Middle, High School Students Use Tobacco Products, Usage Declining

Pharmacy Times

More individuals who used e-cigarettes have reported pulmonary diseases compared with those who never smoked, including asthma.

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Burt’s Bees latest findings showcase benefits of nature-based skin care routines

Drug Store News

Clinical studies from the Integrative Dermatology Symposium showcase how ingredients from nature support the lip and skin microbiome, in addition to improving the appearance of age spots and hyperpigmentation.

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BioMarin’s new CEO inherits a profitable company, a pioneering gene therapy, and a brewing activist challenge

STAT

Want to stay on top of the science and politics driving biotech today?  Sign up  to get our biotech newsletter in your inbox. Hello, everyone. Damian here with a close look at an en-vogue idea in oncology, an awkward welcome for a new CEO, and a twist on the classic drug pricing backlash.

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FDA Approves Zepbound for Chronic Weight Management

PharmExec

Tirzepatide (Zepbound; Eli Lilly and Company) is expected to be available in the United States by the end of 2023 with a list price of $1,059.87.

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Walmart makes sensory-friendly shopping hours a permanent addition

Drug Store News

The retail giant said it is enacting sensory-friendly hours at all of its locations after a successful test program during the recent back-to-school shopping season.

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Amazon offers healthcare services through One Medical as a Prime membership add-on

Fierce Healthcare

Amazon's push into healthcare has focused on making medical services more affordable and convenient. | Building on its One Medical deal, Amazon is now offering a One Medical for Prime membership, including 24/7 virtual care, for $9 per month, or $99 a year.

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Researchers Assess Innate Immune System Changes Following Severe COVID-19

Pharmacy Times

Changes in gene expression could ultimately boost the production of inflammatory cytokines.