Mon.Jan 29, 2024

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COVID-19 Perceived as Less Serious Than Other Respiratory Illness Despite Global Spotlight

Drug Topics

Study findings that identified non-COVID respiratory illness as the most serious health issue among members of low- and middle-income countries provide policymakers with a valuable lens through which to understand and address public health concerns.

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Scientists document first-ever transmitted Alzheimer’s cases, tied to no-longer-used medical procedure

STAT

LONDON — There was something odd about these Alzheimer’s cases. Part of it was the patients’ presentations: Some didn’t have the classic symptoms of the condition. But it was also that the patients were in their 40s and 50s, even their 30s, far younger than people who normally develop the disease. They didn’t even have the known genetic mutations that can set people on the course for such early-onset Alzheimer’s.

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Trending Sources

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Slideshow: The Role of CGM in Diabetes Management During Pregnancy

Drug Topics

Three posters being presented at the Society for Maternal-Fetal Medicine 44th Annual Pregnancy Meeting examined the impact of continuous glucose monitoring on pregnancy outcomes.

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Opinion: I’m an anesthesiologist. Kenneth Smith’s execution by nitrogen gas was far from ‘textbook’

STAT

On Thursday evening, the state of Alabama executed Kenneth Eugene Smith by nitrogen gas. Now, there are dueling narratives about what happened. Alabama claims it went perfectly, proving that nitrogen is a humane, effective alternative to lethal injection (which it previously tried, unsuccessfully, to use on Smith). It says that based on this experience, other states should follow its example.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Pfizer's layoff campaign ramps back up with dozens of SF-area cuts expected next month

Fierce Pharma

The start of the new year doesn’t seem to have dulled the zeal of Pfizer’s global cost-cutting campaign, which has already left hundreds of jobs in its wake. | Come mid-February, Pfizer will lay off some 52 employees at a facility in South San Francisco, according to a recent Worker Adjustment and Retraining Notification Act alert. The site is the former headquarters of Global Blood Therapeutics.

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Opinion: Which country has the best health care? That’s the wrong question

STAT

I’ve spent my career studying how different health care systems work. People love to ask me which country has the best care — and are often disappointed when I don’t have an easy answer for them. Every health care model involves people doing their best to balance competing priorities in the face of limited resources. In other words, every system involves tradeoffs.

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Pricey sickle cell treatments raise daunting new challenges for Medicaid programs

STAT

Living with sickle cell disease has not been easy on Kourtney Cunningham. The genetic blood disorder typically causes her to experience three episodes of extreme pain each month and she can end up in the hospital at least twice a year due to these crises. Then there are blood transfusions every four weeks.

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Merck is on the lookout for more opportunities within immunology

Pharmaceutical Technology

At the JP Morgan Healthcare conference, Merck (MSD) indicated its eagerness to continue to establish its place in the immunological space.

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Can the government ask social media sites to take down Covid misinformation? SCOTUS will weigh in

STAT

WASHINGTON — The Supreme Court will this March hear arguments centered on the government’s role in communicating — and sometimes censoring — pertinent public health information in the midst of a pandemic. At the core of the lawsuit is whether the federal government’s requests for social media and search giants like Google, Facebook, Twitter, and YouTube to moderate Covid-19 misinformation violated users’ First Amendment rights.

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First impressions matter: Why getting your onboarding right is key for digital engagement

pharmaphorum

Creating a positive onboarding experience is crucial for engaging healthcare professionals (HCPs) in digital platforms and utilising data effectively. Discover why first impressions matter and how to get your onboarding process right for optimal digital engagement.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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STAT+: Cognito raises $35 million for Alzheimer’s treatment device, touts benefits compared to drugs

STAT

Just as a new wave of approved drugs for Alzheimer’s disease reaches patients, medical device company Cognito Therapeutics has raised a fresh $35 million to advance its alternative treatment for the neurodegenerative disease. With the new Series B extension funding, the Cambridge, Mass.-based company has now raised $128 million to develop its headset that uses gamma frequency light and sound stimulation to combat the cognitive decline that’s the hallmark of Alzheimer’s.

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Paxlovid EUA Revision Narrows Emergency Use to Pediatric Patients

Drug Topics

The FDA states the revision to the emergency use authorization (EUA) is the next phase in the transition from the use of EUA-labeled nirmatrelvir and ritonavir to the use of NDA-labeled nirmatrelvir and ritonavir.

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Supreme Court slates abortion pill case for March

STAT

WASHINGTON — The Supreme Court will hear arguments about access to the abortion medication mifepristone on March 26. The lawsuit is the first major test of abortion limits to go before the highest court since the same panel overturned federal abortion rights in June 2022. It also could have massive ramifications for the Food and Drug Administration’s authority.

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Expanding Your Pharmacy Business Through Pharmacy Home Infusion Services

Pharmacy Times

Partnering with a franchisor can provide a support system and resources for pharmacies looking to diversify revenue

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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Steward Health Care's dire finances have government leaders worried about shutdowns

Fierce Healthcare

Financial troubles and a flurry of planned hospital divestitures have landed for-profit Steward Health Care squarely in the public and lawmakers’ crosshairs. | Millions in unpaid rent and other signs of financial distress have led the for-profit to explore divestitures and other potential strategies in Massachusetts and Texas. Leaders in the former have raised alarms that potential closures could overwhelm other providers.

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STAT+: European regulators tout their accomplishments against pharma’s anticompetitive practices

STAT

European antitrust regulators want you to know that fighting crime in the pharmaceutical industry pays. Between 2018 and 2022, the European Commission and antitrust regulators in numerous European countries adopted 26 decisions concerning anti-competitive practices by drug companies by imposing more than $845 million in fines or accepting legally binding commitments by manufacturers to alter their corporate behaviors.

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MACPAC suggests changes to Medicaid appeals process

Fierce Healthcare

The Medicaid and Chip Payment and Access Commission (MACPAC) voted in favor of seven recommendations during a meeting Jan. 26 that would reshape how beneficiaries are able to appeal for care. | Medicaid advisers want to overhaul the denials and appeals process, partly by implementing a clinician-led independent review.

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Staying Up-to-Date Is Important for Medication Therapy Management

Pharmacy Times

Continuing education and networking can help pharmacists stay current with the profession

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Moody's: Why Medicare Advantage's profitability may be on the decline

Fierce Healthcare

Medicare Advantage (MA) continues to grow, but there are signs that its profitability is on the decline, according to a new report from Moody's Investors Service. | Medicare Advantage continues to grow, but there are signs that its profitability is on the decline, according to a new report from Moody's Investors Service.

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Grifols sues Gotham City over fraud allegations

pharmaphorum

Spanish drugmaker Grifols has hit back at hedge fund Gotham City Research, which claimed it had fraudulently manipulated its financial reporting, with a lawsuit filed in New York. The complaint has been brought against Gotham City and co-founders Daniel Yu and Cyrus de Weck, along with other defendants, and accuses them of being “predatory short sellers…who illicitly profit from their rigged short-and-distort schemes.

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Will there be new baselines for nonprofit hospitals’ financial metrics? Fitch weighs in

Fierce Healthcare

Several nonprofit hospitals have found their operations and balance sheets settling into new ranges following a tough couple years, though that doesn’t necessarily mean that credit ratings will div | Whether or not nonprofit hospitals' operating margins will "reset" from 3%+ to 1%-2% due to sustained cost pressures is "the biggest question long term for ratings agencies," Fitch analysts write in a new outlook report.

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BMS subcutaneous Opdivo clears first phase 3 trial

pharmaphorum

Bristol-Myers Squibb is getting closer to offering a subcutaneous version of its cancer immunotherapy Opdivo to patients after it matched the current intravenous formulation in a head-to-head trial in kidney cancer.

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ACOs to receive $20M in advance investment payments

Fierce Healthcare

In 2024, 50 accountable care organizations are new to the Medicare Shared Savings Program and 71 ACOs renewed participation, according to new numbers released by Centers for Medicare & Medicaid | CMS released new data Monday showing ACO participation in the Medicare Shared Savings Program, with 19 ACOs set to participate in a new payment option,

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Kroger lays out goals advancing supply chain sustainability

Drug Store News

Over the next several years, Kroger will require its fresh produce suppliers to use Integrated Pest Management practices for all products supplied to the grocery based on their size.

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Ron Lanton, Partner, Lanton Law PLLC, Discusses New Drug Plus Pricing Models

Pharmaceutical Commerce

In an interview with Pharma Commerce Associate Editor Don Tracy, Ron Lanton, Partner, Lanton Law PLLC, discusses recent moves by CVS and Express Scripts to follow Mark Cuban's drug plus model.

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23andMe breach targeted Chinese, Jewish populations

STAT

Want to stay on top of the science and politics driving biotech today?  Sign up  to get our biotech newsletter in your inbox. Hey there. Today, we discuss how Medicaid might pay for the costly but potentially curative sickle cell gene therapies, as well as the shocking lawsuit that outlines a data breach at 23andMe that targets Chinese and Jewish customers.

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Grifols files lawsuit against hedge fund for making 'false and misleading statements'

Fierce Pharma

Grifols has filed a lawsuit against Gotham City that accuses the hedge fund of manipulating "the value of Grifols’ stock for their own monetary gain.

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MultiCare allegedly allowed neurosurgeon to perform, bill for unnecessary surgeries despite warnings

Fierce Healthcare

MultiCare has been hit with a False Claims Act complaint by federal law enforcement and its home state of Washington over allegations that it is “knowingly endangering patients” by allowing a neuro | A complaint filed Friday by federal and state officials alleged that the 12-hospital nonprofit set aside "serious concerns" to receive "millions of dollars in revenue, while unknowing patients were endangered and harmed.

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NRF: Valentine’s Day spending hits new record

Drug Store News

NRF’s 2024 Valentine’s Day report found that 53% of consumers plan to celebrate, and overall, consumers plan to spend a total of $25.8 billion to celebrate the holiday.

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FDA starts swift review of tumour-agnostic use of Enhertu

pharmaphorum

AstraZeneca and Daiichi Sankyo’s Enhertu could become the first therapy approved by the FDA for use in any HER2-positive cancer, regardless of its location in the body. The US regulator has started a priority review of the HER2-targeting antibody-drug conjugate (ADC) for the treatment of adults with unresectable or metastatic HER2-positive solid tumours who have been treated previously or have limited treatment options.

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STAT+: Pharmalittle: We’re reading about Medicaid and sickle cell, pharma CEOs, and more

STAT

Good morning, everyone, and welcome to another working week. We hope the weekend respite was relaxing and invigorating, because that oh-so familiar routine of online meetings, phone calls, and deadlines has returned. But you knew this would happen, yes? After all, the world, such as it is, continues to spin. So time to nudge it in a better direction with a cup or two of delicious stimulation.

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Moderna leads the development of mRNA vaccines in infectious diseases

Pharmaceutical Technology

The rapid sequencing of the SARS-CoV-2 and the subsequent development of mRNA vaccines led to the authorisation of the first of these vaccines in late 2020.

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FDA Experts Review Data, Regulatory Insights for New Metastatic Breast Cancer Therapies

Pharmacy Times

Trastuzumab deruxtecan and elacestrant represent important new treatment options.

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Pharmaceutical industry: 2023 in retrospect

European Pharmaceutical Review

N-Nitrosamines By far the biggest issue bedevilling industry during 2023 was the continuing N-nitrosamine contamination saga, which was covered in the third issue of EPR 2023. 1 Some five years after the initial NDMA (N-nitrosodimethylamine) contamination issue 2 initially affecting valsartan drug substance, then other active pharmaceutical ingredients (APIs), eg, sartans, ranitidine, metformin, etc; the toxic short alkyl chain N-nitrosamine issue appears, if not resolved, then well on the way t

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