Wed.Dec 06, 2023

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New gene therapies confront many sickle cell patients with an impossible choice: a cure or fertility

STAT

As a teenager, Marie Tornyenu was always having to explain herself. If it wasn’t the chronic absences that had her doing homework from a hospital bed, it was the quilted blanket she carried with her on the days she could attend class. “It was a running joke that I was like 80 years old,” she said. “I would usually just laugh it off because the alternative was too depressing.

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FDA Approves Iptacopan for the Treatment of Paroxysmal Nocturnal Hemoglobinuria in Adult Patients

Pharmacy Times

During clinical trials, individuals treated with iptacopan had increased hemoglobin levels and did not need to receive blood transfusions.

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‘Last roll of the dice’ for a near-term HIV vaccine fails

STAT

A study billed as the last chance to develop an HIV vaccine this decade has been shut down, investigators announced Wednesday at a conference in Harare, Zimbabwe. The trial, known as PrEPVacc, was testing two different vaccine regimens on about 1,500 volunteers in East and Southern Africa. After multiple other high-profile trials failed , a PrEPVacc investigator described the study this summer as “ the last roll of the dice ” for an HIV vaccine until the 2030s.

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Generative AI expected to take off in 2024, but concerns linger over cost, reliability and security

Fierce Healthcare

Only 25% of healthcare organizations have deployed generative AI solutions. | Only 25% of healthcare organizations have deployed generative AI solutions but that is expected to more than double next year as executives see opportunities to automate clinical documentation and improve patient communication.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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New England Journal of Medicine reckons with its racist past and complicity in slavery

STAT

The New England Journal of Medicine, the world’s oldest continually published medical journal, publicly reckoned with its history and complicity surrounding slavery and racism Wednesday, publishing the first of a series of essays by independent historians on the role the prestigious publication has played in perpetuating racist thinking in medicine that continues to this day.

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UnitedHealth report: Chronic conditions like depression, diabetes are on the rise

Fierce Healthcare

Chronic conditions, including mental health needs, are on the rise, according to a new report. | The United Health Foundation, the philanthropic arm of industry giant UnitedHealth Group, released its annual America's Health Rankings report.

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A tough 2024 is on the horizon. Here's how Deloitte says healthcare leaders should prepare

Fierce Healthcare

Many of the past year’s buzziest topics and omnipresent struggles will likely rear their heads as major talking points across 2024, per the year-ahead predictions of Deloitte’s healthcare industry | Generative AI, outsourcing and skilled labor retention are among the focal points provider and payer executives will need to keep in their crosshairs.

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Virtual Education Program Feasible in Improving Vaccination Knowledge, Trust Among Black Older Adults

Drug Topics

Study results outlined in a poster at ASHP Midyear 2023 revealed that virtual delivery education programs could contribute to a more inclusive and accessible health care information landscape for Black older adults.

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Hims & Hers rolls out weight loss program with future plans to include GLP-1 drugs

Fierce Healthcare

Digital health company Hims & Hers launched its much-anticipated weight loss program this week that includes digital tracking tools, educational content and access to medications. | Digital health company Hims & Hers launched its much-anticipated weight loss program this week that includes digital tracking tools, educational content and access to medications.

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Evaluating a Pharmacist-Led Medication Refill Management Service

Drug Topics

A study presented at ASHP Midyear 2023 found that primary care physicians said a refill management service helped reduce burnout and improved the quality of patient care.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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Advocacy and Precision in Hemophilia Pharmacy Care: Insights and Best Practices

Pharmacy Times

Experts discuss the critical role of specialty pharmacists in advocating for patients during challenging moments in their hemophilia treatment journey and explore precision dosing considerations and the importance of adherence to dosing guidelines.

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Cardiovascular disease is a major concern for women. Here's what employers can do

Fierce Healthcare

Cardiovascular disease is a key health concern for women, and a new guide seeks to arm employers with the tools and information need | Cardiovascular disease is a key health concern for women, and a new guide seeks to arm employers with the tools and information needed to help workers manage these needs.

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Enhancing Hemophilia Care: The Role of Specialty Pharmacies and Coordinated Efforts

Pharmacy Times

Atta Chowdhry, RPh, and Lisa Schrade, PharmD, discuss best practices in coordinating specialty pharmacy services between payers and prescribers to ensure timely access to critical hemophilia treatments.

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Getting the lead out of the water supply: How one health expert crunched the numbers and prodded the EPA

STAT

It’s known that lead in the water supply has severe health effects, including brain damage in children and heart and liver issues in adults. Now the Environmental Protection Agency has released an ambitious and expensive proposal to replace 100% of the lead pipes in water system service lines across the country over the next 10 years. Ronnie Levin, a former EPA scientist and an environmental health instructor at the Harvard Chan School of Public Health, deems it “ a good move in th

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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Expert Discusses A Health System Specialty Pharmacy Initiative: Abemaciclib Linkage to Care

Pharmacy Times

Carly Giavatto, PharmD, discusses the CPS conducted study that highlights a first of its kind linkage to care initiative performed by health systems specialty pharmacists.

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STAT+: Using AI, scientists create blood test that measures organ aging and predicts disease risk

STAT

In today’s mostly plague- and famine-free world, if you can avoid more modern scourges like gun and car violence , you can expect your death to arrive not with a bang but a whimper; when one of your organs sput-sput-sputters out. And it is usually just one organ or organ system. For some, it’s a calcium-clogged heart. For others, kidneys that no longer filter.

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HIV/AIDS Awareness Month Highlights Opportunities for Pharmacy

Pharmacy Times

As HIV has become a manageable chronic condition, and even curable in some cases, the role of pharmacists cannot be understated.

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STAT+: AbbVie purchases neuroscience developer Cerevel for $8.7 billion

STAT

Abbvie announced Wednesday that it will purchase Cerevel Therapeutics and its pipeline of experimental neurological and psychiatric medications for $8.7 billion. The deal marks the second billion-dollar acquisition by AbbVie in under a week. Facing the prospect of declining sales from two of its best-selling drugs, the company also acquired Immunogen and its ovarian cancer treatment for $10 billion last Thursday.

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Experts Say More Research Is Needed to Understand Obesity-Cancer Link

Pharmacy Times

Evidence has shown that reversing pro-cancer effects requires significant weight loss as well as substantial metabolic reprogramming.

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STAT+: Using Pap smears for earlier ovarian cancer detection shows promise in small new study

STAT

Ovarian cancer owes its often-dismal prognosis to the late stage at which it’s typically discovered. If a tumor is found when it’s small and cancer cells haven’t spread, treatment works well for 90% of patients. But most women are diagnosed at stage 3 or later in their disease, when only 30% reach the five-year survival benchmark.

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FDA endorses Novartis' 'pipeline in a pill,' granting first nod for potential blockbuster Fabhalta

Fierce Pharma

With an FDA approval in PNH, Novartis has gained its first nod for iptacopan, dubbed two months ago “a pipeline in pill," by analysts at ODDO BHF.

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STAT+: Stephen Hemsley, UnitedHealth Group board chair, sells nearly $113 million in stock

STAT

Stephen Hemsley, the board chair and former CEO of UnitedHealth Group, has sold nearly $113 million worth of company stock since the middle of October, new filings show. Hemsley most recently sold $36.4 million worth of stock on Tuesday, according to the documents filed with the Securities and Exchange Commission. The other $76.5 million of UnitedHealth stock was sold in October and November.

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Are You Ready for DSCSA?

Drug Topics

Ready or not, DSCSA goes into full effect in November 2024. Not everyone in the supply chain is ready for the new requirements, but advance planning can help you protect patients, inventories, and your business. It's also an opportunity for you to build a competitive edge!

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Daiichi Sankyo scores $182M from Novartis settlement in long-running patent case

Fierce Pharma

After years of back and forth with Daiichi Sankyo over cancer drug patent claims, Novartis has thrown in the towel with a $182 million settlement. | In 2017, Daiichi's former subsidiary Plexxikon alleged that Novartis stepped on its Zelboraf patents with its GSK-acquired medicine Tafinlar. Many years later, Novartis is settling the case.

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CalOptima launches campaign delivering free naloxone, a first-of-its-kind accomplishment for a public health plan

Fierce Healthcare

Attempting to reduce the number of drug overdose deaths in Orange County, California, CalOptima Health is beginning a $15 million campaign to distribute free naloxone to members. | CalOptima became the first public health plan to distribute free naloxone to members, the company recently announced.

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STAT+: U.S. judge orders Minnesota to pause its drug pricing transparency law over constitutional issues

STAT

In a victory for the pharmaceutical industry, a U.S. judge ruled that Minnesota must temporarily halt a controversial law that is designed to provide transparency into prescription drug pricing over concerns that it is unconstitutional. The order was issued in response to a lawsuit filed last July by the Association for Accessible Medicine, which argued the law gives Minnesota the power to regulate interstate commerce and apply the law to prices charged in other states.

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Artificial Intelligence Changing the Landscape for Healthcare Social Media Marketing

PharmExec

Experts from Hootsuite noted that the primary social media ROI concern for healthcare companies is the time and money it takes to maintain a multi-platform presence.

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Most drugmakers have so far ignored looming FTC deadline to withdraw or amend wayward patents

STAT

With 10 days to go, only one company has responded to a demand by the U.S. Federal Trade Commission for several brand-name drugmakers to delist dozens of patents that were improperly or inaccurately listed in a government registry, according to a source familiar with the matter. As a result, the agency is readying plans to file lawsuits against the other companies, some of which are among the biggest drugmakers in the world, such as AbbVie, AstraZeneca, and GSK.

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Seattle Children’s Hospital launches BrainChild Bio for CNS therapies

Pharmaceutical Technology

Seattle Children's launched BrainChild Bio to focus on expediting the development of CAR T-cell therapies in central nervous system tumours.

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Opinion: STAT+: A bold approach to pay for weight loss drugs for everyone who needs them

STAT

The news about anti-obesity drugs keeps getting better. In November, data presented at the American Heart Association meeting added cardiovascular benefit to value in combating obesity and diabetes. This comes on the heels of news that Novo Nordisk halted a clinical trial to test Wegovy’s impact on renal function early because the results they were seeing were so strong.

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SABCS: Handing Novartis a win, Lilly's Verzenio barely misses overall survival goal in first-line breast cancer

Fierce Pharma

Novartis’ Kisqali is getting a leg up in the CDK4/6 breast cancer realm as another rival failed to significantly extend patients’ lives in a pivotal trial. | Novartis’ Kisqali is getting a leg up in the CDK4/6 breast cancer realm as another rival failed to significantly extend patients’ lives in a pivotal trial.

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Sanofi expands genAI drug discovery pact with Aqemia

pharmaphorum

Sanofi has deepened an existing collaboration with artificial intelligence specialist Aqemia in the latest among a flurry of collaborations between pharma companies and generative AI (genAI) companies. The French pharma group has signed a multi-year agreement with Paris-based Aqemia, focused on the discovery of small-molecule drug candidates across multiple therapeutic categories, through the application of genAI and deep physics algorithms that can model molecular interactions.

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How to relieve sinus pressure

The Checkup by Singlecare

A pounding, throbbing feeling in your cheeks and forehead, an inability to breathe clearly, and a head that feels like an overfilled balloon are all signs that you’re experiencing some severe sinus pressure or inflammation in your nasal passages. Worse, sinus pressure isn’t just uncomfortable; it can also be hard to relieve. According to Christine Franzese, MD , an allergist and immunologist at MU Health Care , sinus pressure is a symptom, not a disease or condition itself, so that it can be cau

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Inhaler Storage and Beyond Use Dates Table: Free Downloadable PDF

Med Ed 101

Patients who live with asthma or COPD often require the use of inhaler(s) to help manage symptoms of their disease. As healthcare professionals we must ensure that the medications these patients are receiving actually work. In this article, we provide a table on inhaler storage and beyond use dates. You’ll find this free inahler storage […] The post Inhaler Storage and Beyond Use Dates Table: Free Downloadable PDF appeared first on Med Ed 101.

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