Thu.Jun 15, 2023

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ASCO 2023: Protecting our progress in the fight against cancer

PhRMA

I always look forward to the American Society of Clinical Oncology’s Annual Meeting, which took place in Chicago earlier this month. It’s an opportunity for the world’s leading cancer experts to celebrate the latest innovations that are changing the treatment paradigm for patients with this disease.

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Generative AI Framework Could Help Create Better Medicine Faster

Drug Topics

G2Retro, developed by investigators from Ohio State University, can produce hundreds of new reaction predictions in just a few minutes.

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Trending Sources

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Reject efforts to undermine America’s R&D ecosystem

PhRMA

America’s biopharmaceutical research companies are central to the research and development (R&D) of innovative medicines in the United States. Unfortunately, a new report by Sen. Sanders mischaracterizes the role the National Institutes of Health plays in the research and development (R&D) process and risks stifling the innovative biopharmaceutical ecosystem vital to advancing medicines for patients.

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Pharmacists Applaud New Bionic Pancreas for Type 1 Diabetes

Drug Topics

The iLet Bionic Pancreas combines data from the Dexcom G6 CGM with different algorithms to deliver insulin throughout the day.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Pharmacists are Untapped Resource for Reducing Health Disparities

Pharmacy Times

Pharmacists can address the needs of health care consumers earlier in the care journey by building interpersonal relationships and community trust, as well as by leading institutional and public policy reform.

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Meeting Preview: McKesson ideaShare 2023

Drug Topics

Meet this year’s Pharmacy of the Year nominees and preview some of the sessions available at this year’s meeting.

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More Trending

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Pharmacy Compounders Defend Semaglutide Compounding Amid Continued Shortages

Drug Topics

Novo Nordisk is the only company with FDA-approved products containing semaglutide.

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Walgreens inks another deal for clinical trials business as CVS exits research recruitment

Fierce Healthcare

Retail pharmacy giant Walgreens inked another partnership to recruit participants for research as it continues to build out its clinical trials business. | Retail pharmacy giant Walgreens inked another partnership to recruit participants for research as it continues to build out its clinical trials business.

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The Changing Landscape of Digital Health

Drug Topics

What does the future of digital health look like?

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Romiplostim Biosimilar Found Non-Inferior to Reference Drug, May Be Effective for Chronic Immune Thrombocytopenia

Pharmacy Times

Despite having a lower cost of development than the innovator, romiplostim biosimilar has comparable efficacy and safety in patients with chronic immune thrombocytopenia.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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FDA advisers endorse updating Covid vaccines to target latest Omicron strain

STAT

The Covid-19 vaccines are on track for a big recipe change this fall. Today’s vaccines still contain the original coronavirus strain, the one that started the pandemic — even though that was long ago supplanted by mutated versions as the virus rapidly evolves.

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Ensuring Access to Vaccinations Among Older Adults and Underserved Populations

Pharmacy Times

A broader understanding of vaccine hesitancy and barriers has helped to enhance acceptance of vaccination services through educational outreach.

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'Heads, brains, skin, bones and other human remains' stolen and sold by Harvard morgue manager, DOJ says

Fierce Healthcare

The former manager of a morgue at Harvard Medical School is up against federal charges for allegedly stealing, selling and shipping human body parts, federal prosecutors said Wednesday. | The former manager of a morgue at Harvard Medical School is up against federal charges for allegedly stealing, selling and shipping human body parts, federal prosecutors said on Wednesday.

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Summer Skin Protection: Pharmacist's Guide to Sunscreen and Aftercare

Pharmacy Times

Pharmacists can empower their community with essential knowledge for summer skin protection to protect against skin cancer.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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Opinion: What happens when patients beat their doctors to their test results

STAT

Not so long ago, a father broke down in tears with me over Zoom — tears of relief. When this father had received test results for his child, some of the values in the report appeared in red. That font color made him terrified for his child’s health. It was only when we hopped on Zoom to go over the results that I was able to reassure him: They were in red because the system was comparing them with adult range values.

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Continuous Glucose Monitors Useful for Predicting Pre-Diabetes

Drug Topics

When employed as a prescreening tool, care must be taken to avoid overdiagnosis of healthy individuals without diabetes.

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STAT+: Instead of credible data, PDS Biotech delivers ‘results might get better, later’ promises

STAT

Tumor response rate is a common way to assess the efficacy of a cancer drug. It’s not a perfect measure, for sure, but it’s easy to calculate and understand — or it should be. PDS Biotech is a small developer of cancer drugs that is zealously seeking investor eyeballs, yet it can’t seem to grasp the tumor-response concept.

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Continuous Glucose Monitors Useful to Predict Pre-Diabetes

Drug Topics

When employed as a prescreening tool, care must be taken to avoid overdiagnosis of healthy individuals without diabetes.

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Eloxx repackages ELX-02 data in cystic fibrosis as it eyes pivotal trial

Pharmaceutical Technology

Eloxx has revealed its lead candidate ELX-02 improved predicted forced expiratory volume (ppFEV1) in patients with Class 1 cystic fibrosis (CF) in a new analysis of a Phase II trial that missed its efficacy endpoints. Following underwhelming topline results from the Phase II trial (NCT04135495) announced in late 2022, Eloxx recalculated the results using the change in ppFEV1 (a secondary outcome) from day 1 instead of from baseline.

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Mandy Cohen, seen as next CDC director, would bring political chops to an agency lacking them

STAT

The Centers for Disease Control and Prevention may be about to undergo a paradigm shift with the anticipated appointment of former North Carolina health secretary Mandy Cohen as the agency’s next director. The Atlanta-based CDC has always prided itself at being at a remove from Washington, and the politics that engulf it. With 634 miles separating the U.S.

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FDA committee set to discuss strain selection for next round of COVID-19 boosters

Fierce Pharma

While demand for COVID-19 vaccines has plummeted throughout 2023, healthcare officials remain focused on ensuring that the most effective shots are available for those who need them. | While demand for COVID-19 vaccines has plummeted throughout 2023, healthcare officials remain focused on ensuring that the most effective shots are available for those who need them.

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White House ‘naloxone summit’ omitting prominent advocates for lower costs

STAT

The invite list for the White House’s upcoming “summit” on naloxone pricing and accessibility has some noteworthy omissions. Two of the most prominent organizations focused on providing cheaper overdose-reversal medications will be conspicuously absent from Tuesday’s event : Harm Reduction Therapeutics, a nonprofit drug manufacturer currently seeking approval for a naloxone nasal spray, and Remedy Alliance, a group that distributes cheap naloxone to harm-reduction gro

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Progression-free survival improved in IDH–mutant grade 2 gliomas through vorasidenib use

Hospital Pharmacy Europe

Vorasidenib improves progression-free survival in patients with residual or recurrent grade 2 glioma, according to a recent double-blind, placebo-controlled trial. Diffuse gliomas represent 75% of all primary malignant brain tumours in adults and are both locally aggressive and currently incurable. Moreover, mutations in the isocitrate dehydrogenases (IDHs) encoded by IDH1 and IDH2 are present in the majority of malignant gliomas.

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Black former NFL players more burdened by chronic pain than white counterparts, study finds

STAT

It’s to be expected, says two-time Pro Bowler Julius Thomas, that “colliding into other people for a living” might result in some long-term injuries. But among former NFL players, Black athletes report worse and more disruptive chronic pain than white players, according to a new study Thomas co-authored with researchers at Harvard and Brigham & Women’s Hospital.

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Oseltamivir does not reduce risk of hospitalisation for influenza, review suggests

Hospital Pharmacy Europe

Oseltamivir use does not lower the risk of hospitalisation among older and high-risk patients with influzena, according to the findings of a recent systematic review and meta-analysis. Published in JAMA Internal Medicine , researchers examined whether oseltamivir use in adult and adolescent outpatients with influenza reduced the risk of hospitalisation.

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Manufacturing Execution Systems & Electronic Production Records Management: A Building Block for Pharma 4.0™ & Your Organisation’s Digitlization Journey

ISPE

Manufacturing Execution Systems & Electronic Production Records Management: A Building Block for Pharma 4.0™ & Your Organisation’s Digitlization Journey Trudy Patterson Thu, 06/15/2023 - 09:27 iSpeak Blog iSpeak Manufacturing Execution Systems & Electronic Production Records Management: A Building Block for Pharma 4.0™ & Your Organisation’s Digitlization Journey Paul J.

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Sandoz reveals plan to boost global biosim uptake, starting in the Americas

Fierce Pharma

As biosimilars gradually gain steam in the U.S. market, one of the biggest manufacturers of the copycat biologics has unveiled a plan to boost uptake across the globe. | Sandoz' Act4Biosimilars action plan includes a detailed report of challenges preventing wider biosimilar access in each region, starting with the Americas. The initiative's steering group will work with stakeholders across the region to implement steps to boost uptake.

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Walgreens, Freenome partner to increase diversity in early detection cancer research

Drug Store News

Walgreens will combine its national footprint, patient insights, compliant recruitment technology and local infrastructure to engage diverse patient populations in Freenome’s multi-cancer research program.

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Suicides and homicides among young Americans jumped early in the pandemic, study says

STAT

The homicide rate for older U.S. teenagers rose to its highest point in nearly 25 years during the COVID-19 pandemic, and the suicide rate for adults in their early 20s was the worst in more than 50 years, government researchers said Thursday. The Centers for Disease Control and Prevention report examined the homicide and suicide rates among 10- to 24-year-olds from 2001 to 2021.

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Coherus breached Humira patent settlement by striking deal with Mark Cuban's drug firm, AbbVie contends

Fierce Pharma

An announcement early this month by Mark Cuban’s deep discount drug company that it would sell Coherus Biosciences’ biosimilar version of AbbVie’s Humira has the Illinois drugmaker calling foul.

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Opinion: STAT+: How I’m helping companies think through whether they should cover GLP-1s like Ozempic for employees

STAT

We have a knack in the U.S. for blurring behavior and medicine. Look at weight. For a long time, we’ve treated obesity as a moral failing, a lack of willpower. That was wrong. Now we’re treating weight as a medical issue that can be cured by pill or injection. Is this any better? Up to 130 million Americans could qualify for Ozempic or other GLP-1s (glucagon-like peptides), which cost nearly $1,000 per month.

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Show 1344: Managing Meat Allergy and Other Tick-Borne Diseases

The People's Pharmacy

If you are like us, you welcome the first warm days of the season with joy. And then you start to fret. How can you keep the ticks from biting? Many people recognize Lyme disease as a serious health threat from deer tick bites. Fewer are aware that a bite from a completely different tick, the lone star tick, can lead to a mysterious meat allergy that may disrupt their lives.

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STAT+: USDA to push food producers to substantiate claims that animals are raised without antibiotics

STAT

The U.S. Department of Agriculture is launching a program to ensure food producers substantiate claims that their animals are not raised on antibiotics, a move that reflects ongoing concerns that unnecessary use of these medicines causes resistance among humans. The agency will conduct a sampling project to assess antibiotic residues in cattle destined for the so-called raised without antibiotics market.

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Fierce Pharma Asia—Astellas CEO's 'aggressive' strategy; Leqembi's adcomm win; BeiGene's legal hurdle

Fierce Pharma

Astellas' new CEO Naoki Okamura talked to Fierce Pharma about the company's business plans. | Astellas' new CEO Naoki Okamura discussed the company's business plans. Eisai and Biogen's Leqembi won backing from the FDA's external advisers. AbbVie has brought a BTK patent infringement lawsuit against BeiGene. And more.

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