Fri.May 12, 2023

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RPHCast, Episode One: Statins, Bloood Pressure, and Curves Galore

Drug Topics

Listen to the first episode of RPHCast, where Kevin and Donna educate you on all things statins, blood pressure, cholesterol, and as many curves as you can imagine.

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5 Tips For Incoming PGY2 Pharmacy Residents

IDStewardship

In this article five tips for incoming PGY2 pharmacy residents is provided. Authored by: Timothy P. Gauthier, Pharm.D., BCPS, BCIDP Article posted: 12 May 2023 The ASHP pharmacy residency match phases 1 and 2 have come to a close. Pharmacy residents are headed for their second year of training and are now lined up to land at the (likely) final destination in their training journey.

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Trending Sources

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How Health Care Systems Are Working to Improve DEI Efforts

Drug Topics

Research shows that patient experiences and sometimes outcomes are improved when they are treated by health care professions from similar communities.

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Novel Treatment Achieves Up to 14.9% Weight Loss After 46 Weeks

Pharmacy Times

BI 456906 activates the GLP-1 and glucagon receptors that help to control metabolic function, and could potentially offer clinically relevant benefits for those living with obesity or overweight without type 2 diabetes.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Creating and Leveraging Community Partnerships That Last

Drug Topics

Sometimes, paid advertising isn’t the best way to get the word out.

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Parents More Likely to Vaccinate Children Against COVID-19 After Talking to Trusted Parent

Pharmacy Times

Investigators found that providing parents with a hypothetical scenario outlining why they should immunize their children against COVID-19 was effective in improving vaccination rates.

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More Trending

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Multidisciplinary Teams in Medically Integrated Pharmacies Can Improve Personalized Care

Pharmacy Times

With a growing expectation for individualized and personalized care, medically integrated pharmacies have a great opportunity to support patients and the care team.

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In Order to Maintain the Industry, the Status Quo for Biosimilars Needs to Change

Drug Topics

Juliana Reed, executive director of the Biosimilars Forum, discussed the impact of market dynamics and changing pricing structures during a presentation at the 2023 Asembia Specialty Pharmacy Summit.

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FDA Ends Ban on Blood Donations From Gay, Bisexual Men

Pharmacy Times

A new FDA policy would assess blood donor eligibility using a set of individual risk-based questions to reduce the risk of transfusion-transmitted HIV.

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AI Tracking Can Increase Drug Delivery Efficiency for Specialty Pharmacies

Drug Topics

Parcel tracking technology that used predictive analytics can help with real-time package delivery monitoring and ensure on-time delivery.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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FDA Approves Brexpiprazole for Agitation Associated With Dementia Related to Alzheimer Disease

Pharmacy Times

Brexpiprazole was associated with a statistically and clinically meaningful improvement in agitative behaviors caused by dementia compared to placebo.

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Tracking the FDA advisory panel on Sarepta’s gene therapy for Duchenne muscular dystrophy

STAT

The Food and Drug Administration is convening a meeting of outside experts on Friday to review clinical data on an experimental gene therapy for Duchenne muscular dystrophy from Sarepta Therapeutics. The stakes for this all-day meeting are high and deliberations could be contentious. The advisory panel meeting is one of the most pivotal moments in recent memory for Duchenne patients and their families, many of whom view Sarepta’s gene therapy as the best hope for slowing the fatal muscle-

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NACDS honors pharmacists, pharmacy team members in TV ad

Drug Store News

Timed with the formal end of the COVID-19 public health emergency on May 11, an NACDS ad is punctuating the occasion with a “thank you” to pharmacists and pharmacy teams.

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An ultrasound device may unlock brain cancer treatment, early study shows

STAT

Brain cancer patients are left with few options when tumor cells spread, as most potent chemotherapies are unable to cross the blood-brain barrier. But a study published last week in the Lancet offers some hope: an ultrasound device implanted in 17 patients’ skulls successfully increased the concentration of drugs in their brains.  It’s the first, in-human trial of the novel device, which is manufactured by French device maker Carthera.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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Addressing Current Challenges Women Face in the Health Care System

Drug Topics

Discussions around women’s health should extend beyond talking about menstruation and pregnancy to include all aspects of health.

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$1.7b acquisition to develop rare haematology therapy

European Pharmaceutical Review

Swedish Orphan Biovitrum AB (Sobi ® ) has agreed to acquire CTI BioPharma for $1.7 billion, with the intention to advance an oral kinase inhibitor treatment for the rare disease myelofibrosis. Innovative therapies for rare diseases The acquisition will help to drive the growth of CTI’s lead product, kinase inhibitor VONJO ® (pacritinib) “in treating myeloproliferative disease,” stated Dr Adam Craig, President, Chief Executive Officer and Interim Chief Medical Officer of CTI BioPharma

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STAT+: Up and down the ladder: The latest comings and goings

STAT

Hired someone new and exciting? Promoted a rising star? Finally solved that hard-to-fill spot? Share the news with us, and we’ll share it with others.  That’s right. Send us your changes, and we’ll find a home for them.  Don’t be shy. Everyone wants to know who is coming and going. And here is our regular feature in which we highlight a different person each week.

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Help Patients Choose Appropriate Treatments to Survive Allergy Season

Pharmacy Times

Nonprescription products manage mild to moderate symptoms, but more severe cases need further medical evaluation.

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A physician’s Mother’s Day gift: reclaimed time with my children — and for myself

STAT

As a child, I fondly remember running through the kids’ aisle at Video World with my younger brother. We were excited to pick out VHS tapes for our family to watch over the weekend. I don’t recall whether this was every weekend or once a month, but movie nights were frequent enough that they made up for my parents’ repeated absences in those years.

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Researchers develop CRISPR-based drug candidate for microbiome targeting

Pharmaceutical Technology

The Technical University of Denmark (DTU) has announced that an international scientific team has developed a CRISPR-based drug candidate that targets E coli directly and leaves the microbiome intact. Blood cancer patients with E coli infection are at risk of bacteria infecting the bloodstream. An E coli infection can be fatal in these cases, with a 15-20% mortality rate.

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STAT+: FDA advisory panel narrowly recommends approval for Sarepta’s gene therapy for Duchenne

STAT

For an archived version of a live blog about Friday’s FDA advisory panel hearing, click here. A panel of independent advisers to the Food and Drug Administration narrowly voted 8-6 to recommend accelerated approval for Sarepta’s gene therapy for Duchenne muscular dystrophy , ruling that the potential benefit to patients outweighs a long list of concerns from the agency’s reviewers.

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Takeda reports 12.8% rise in FY2022 revenue

Pharmaceutical Technology

Takeda has reported a 12.8% increase in its reported revenue to $29.96bn (Y4,027bn) during the fiscal year 2022 (FY2022) compared to that reported in FY2021. At a constant exchange rate (CER), the company’s core revenue grew by 3.5% compared to the previous year. In the FY2022 ending 31 March 2023, the company also reported a 6.4% rise in its operating profit to $3.65bn (Y490.5bn) compared to 2021.

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Opinion: Proposed rules to protect health data in an era of abortion bans fall short

STAT

When the Supreme Court overturned Roe v. Wade , it effectively rescinded national protections of reproductive health care. The decision was very quickly followed by abortion bans in 14 states with more pending such as the highly restrictive 12-week abortion ban recently passed by North Carolina. The tragic results are already too numerous to name here.

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Editas continues to trend efficacy signals with sickle cell disease gene therapy

Pharmaceutical Technology

Editas Medicine will release new efficacy and safety results of its gene therapy EDIT-301 in severe sickle disease as part of an oral presentation at the European Hematology Association’s (EHA) Hybrid Congress. The EHA Hybrid Congress will take place on June 8-11 in Frankfurt, Germany. Last month, the US Food and Drug Administration (FDA) granted the treatment an orphan drug designation for sickle cell disease.

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Atogepant Significantly Reduced Migraine Days in Patients With Prior Treatment Failure

Pharmacy Times

Atogepant reduced mean monthly migraine days by more than 2 days compared to placebo in the ELEVATE trial.

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STAT+: Pharmalittle: U.S. Senate committee passes PBM bills; Pfizer CEO predicts pharma will sue over Medicare price negotiations

STAT

And so, another working week will soon draw to a close. Not a moment too soon, yes? This is, you may recall, our treasured signal to daydream about weekend plans. Our agenda will focus largely on Mrs. Pharmalot as she turns another page on the calendar and also on fostering a potential mascot — wish us luck. And of course, we hope to squeeze in another listening party.

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Pharma 2023: Vaccines Journey to the Consumer

PharmExec

Stefan Merlo, Vice President, Commercial Development, CSL Seqirus discusses how COVID-19 has evolved the discussion of vaccines and the long-term concerns stemming from flu vaccine fatigue.

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FDA Approves Fezolinetant, A Novel Therapy for Vasomotor Symptoms in Menopause

Drug Topics

Vasomotor symptoms include hot flashes and night sweats, which can negatively impact a woman's quality of life.

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As pharma fights IRA, Senate moves forward basket of bills aimed at lower drug prices

Fierce Pharma

As pharma fights IRA, Senate moves forward basket of bills aimed at lower drug prices aliu Fri, 05/12/2023 - 10:48

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Could personalised mRNA vaccine be first for cancer?

European Pharmaceutical Review

A BioNTech-led Phase I trial demonstrated preliminary evidence that adjuvant autogene cevumeran, a personalised mRNA neoantigen vaccine, in combination with atezolizumab (Genentech) and mFOLFIRINOX can induce substantial T cell activity in pancreatic ductal adenocarcinoma (PDAC). In a paper published in Nature , researchers hypothesised it may correlate with delayed recurrence and elimination of micrometastases in PDAC.

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Colon cancer increasing in younger adults, new research warns

Drug Store News

Patients may have symptoms for a long time before seeking medical attention or receiving a colon cancer diagnosis, which is treatable if discovered early.

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Million-dollar claims on the rise in self-insured employer plans: report

Fierce Healthcare

Million-dollar claims on the rise in self-insured employer plans: report fdiamond Fri, 05/12/2023 - 15:45

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Payers More Likely to Prefer Multiple Biosimilars for the Same Reference Product, Survey Finds

Drug Topics

88% of surveyed payers said interchangeability will have the biggest impact on adoption.

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Ocean Spray, Hershey offer chocolate dipped cranberry snacks

Drug Store News

New launches include milk chocolate dipped cranberry bites and dark chocolate dipped cherry-infused cranberry bites.

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