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Tarlatamab established a new standard for relapsed SCLC, with improved survival and easier administration, enhancing treatment accessibility. Zanubrutinib demonstrated sustained efficacy in CLL with del(17p), emphasizing the importance of BTK inhibitors in high-risk hematologic malignancies.
Because of their ability to cover a wide array of bacteria, low adverse effect profile, and oral availability, cephalosporins are commonly used in the treatment of outpatient infections. Of note, only first-, second-, and third-generation cephalosporins are available as oral formulations.
GLP-1 receptor agonists should be considered as second-line agents for older adults with DKD, but potential gastrointestinal side effects must be monitored. SHOW MORE Pharmacists should consider GLP-1 receptor agonists as second-line agents in older adults with DKD when additional glycemic control is needed.
Pharmacists are positioned to personalize HFpEF care through monitoring, patient-centered strategies, and shared decision-making, enhancing treatment adherence and outcomes. Finerenone, a nonsteroidal MRA, shows promise in reducing HF events and atrial fibrillation, offering potential benefits over steroidal MRAs like spironolactone.
Image credit: OM | stock.adobe.com Why Proper Disposal Matters Disposing of medications appropriately helps prevent environmental contamination of water and soil. Pharmacists should recommend proper disposal guidance and explain the possible consequences of improper disposal.
SHOW MORE Intranasal insulin shows promise in targeting memory regions of the brain, offering new hope for Alzheimer disease treatment in older adults. Insulin absorption varies between cognitively normal individuals and those with mild cognitive impairment, with higher uptake in the former.
These technologies prevent the risk of both hypo- and hyperglycemic episodes, facilitating safer fasting. Nieto, BS, PharmD Candidate Amy C. Nieto explains essential guidelines for managing diabetes during Ramadan, ensuring safe fasting practices and optimal health for patients.
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Pharmacists are essential in managing OIC, advising on treatment, monitoring effectiveness, and identifying contraindications and potential complications. PAMORAs, such as methylnaltrexone, naloxegol, and naldemedine, target the underlying mechanism of OIC by blocking μ-opioid receptors in the gut.
Although the use of colony-stimulating factors (CSFs) is well-established in mitigating severe FN, existing literature suggests there is only an approximate 3% difference in FN rates between various CSF agents.
3 Although meloxicam injection delivers a non-opioid alternative for pain control, it is not recommended as a first-line agent when rapid onset of analgesia is needed due to its delayed onset. 2 REFERENCES 1.
The presentation emphasized early intervention and personalized treatment plans in managing type 2 diabetes, shifting from "treating to failure" to "treating to target." It is not indicated for type 1 diabetes and carries a boxed warning for thyroid C-cell tumors, with unknown risk in humans.
Cardiovascular disease risks in HIV patients have evolved with ART, requiring preventive measures like statins and cardiovascular risk scores for effective management.
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Understanding and addressing barriers to medication adherence are crucial for effective treatment of psychiatric disorders and improving patient outcomes. Long-acting injectable antipsychotics may improve adherence in homeless populations, but transportation and clinic visit logistics must be considered.
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Upon sensing dsRNA, the cell effectively halts protein synthesis, thereby preventing the virus from manufacturing the essential proteins required for its own reproduction. 1,2 The researchers believe that compounds that boost the ISR pathway could be effective candidates for antiviral drugs.
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