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Sanofi backs out of $500m cancer alliance with Revolution

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The deal – which included a $50 million upfront payment and up to $450 million in follow-up payments – had advanced the RMC-4630 drug candidate from preclinical testing to a phase 2 trial in combination with Amgen’s first-to-market KRAS inhibitor Lumakras (sotorasib) as a treatment for KRASG12C mutated non-small cell lung cancer (NSCLC).

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Top 20 Biopharma Deal Terminations of 2022 Based on Total Deal Value

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Sanofi Terminated its Clinical Development and Commercialization Agreement with Revolution Medicines In Jul 2018, Sanofi and Revolution Medicines entered an exclusive global partnership to co-develop and commercialize SHP2 inhibitors including RMC-4630 for the treatment of patients with cancers carrying certain mutations including NSLC.