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First CAR T-cell therapy recommended on NHS

European Pharmaceutical Review

CAR T-cell therapy engineers a patient’s own immune cells (T-cells) to detect, target and destroy cancer cells. Of those who receive a transplant, about 50 percent will ultimately relapse, stated research from 2017, published in the journal Blood. Could CAR T therapies be manufactured in one day?

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NK cell immunotherapy: what’s next in clinical development?

European Pharmaceutical Review

He discusses why NK cell therapy’s ability to generate ‘synthetic immunity’ in the body means this modality holds potential as an anti-cancer treatment. We specialise in the development of new cutting-edge immunotherapies , based on the use of therapeutic antibodies capable of activating the immune system to fight cancer.

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Transforming oncology with antibody therapeutics

European Pharmaceutical Review

Amivantamab was the first bispecific monoclonal antibody (BsMAb) approved in the EU to treat advanced NSCLC with EGFR exon 20 insertion mutations post chemotherapy. Overall, the mechanisms of action for amivantamab include ligand blocking, receptor degradation, and immune cell-mediated activity. 2017; 8(43): 75712–26.

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Merck pulls Keytruda’s FDA nod for third-line stomach cancer

pharmaphorum

Merck’s drug has been approved for this use since 2017, but failed to show a statistically significant improvement over third-line chemotherapy in either of two confirmatory trials – KEYNOTE-061 and KEYNOTE-062. The data means that immunotherapy has now moved earlier in the treatment pathway.

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The top 5 pharma M&A deals of 2020

pharmaphorum

California-based Gilead announced its strong intentions in oncology in 2017 with its $11.9 months in patients treated with chemotherapy. Sanofi’s acquisition builds on a partnership to develop central nervous system drugs that began in late 2017. billion (see below). months, compared with 6.7 Johnson and Johnson & Momenta.

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Governments and pharma relationships and implications for antimicrobial resistance

Pharmaceutical Technology

AMR occurs when disease-causing bacteria become resistant or immune to the antibiotics used to treat them. If left unchecked, it may soon not be possible to use antibiotics as prophylaxis for immunocompromised patients during chemotherapy or organ transplants. AMR is already the third leading cause of death worldwide, causing around 1.27

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Unconvinced by NHS test run, NICE rejects BMS’ Opdivo in head and neck cancer

pharmaphorum

But there was too much uncertainty around the results and one of the comparators, the chemotherapy docetaxel, is already used as a standard treatment on the NHS. Opdivo is currently available to NHS patients in England on the Cancer Drugs Fund after NICE agreed to fund it through the CDF in October 2017.