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For biosimilar, generic, and branded medications, Cencora researchers conducted a report detailing growth in formulary exclusions among the 3 largest pharmacy benefit managers in the US.
Since 2014, the three largest pharmacy benefit managers (PBMs) have excluded 1,584% more medicines from commercial formularies, according to a new report from Cencora. Formularies are the lists of medicines covered in commercial health plans, often organized into tiers.
Indeed, since 2014, DPD facilitatedthe publication of 42 quarterly batches and dozens of stand-alone PSGs, plus three one-off batches of PSGs updated to align with recommendations in general guidance documents ( g. , Publishing virtually every GDUFA guidance and MAPP since 2014 to fulfill FDAs GDUFA commitments.
Guideline On Similar Biological Medicinal Products, CHMP/437/04 Rev 1. European Medicines Agency. Guideline On Similar Biological Medicinal Products Containing Biotechnology-Derived Proteins As Active Substance: Non-Clinical and Clinical Issues, EMEA/CHMP/BMWP/42832/2005 Rev1. Guillen E, Ekman N, Barry S, et al.
Steven Smoke, Pharm.D., BCIDP, BCPT Five Things To Know: How To Use Artificial Intelligence To Be A Better Clinical Pharmacist Katarzyna Wojcik, PMP, PhD,Andrea Prinzi, PhD, MPH, CPH, SM(ASCP),Amanda Suchanek, Ph.D., Jessica Blavignac Microbiology Laboratory Strategies to Advance Antimicrobial Stewardship Timothy Gauthier, Pharm.D.,
of NIHR Doctoral Fellowship applications between 2014 and 2021 came from pharmacy professionals. According to Professor Debi Bhattacharya, professor of behavioural medicines at the University of Leicesters School of Allied Health Professions, who is leading the Incubator project, only 2.7%
In the generic filers view, the regulatory review period should have started in January 2014 when the patent was reissued rather than in April 2004, when the IND was opened, because the reissued patent did not exist in April 2004. The plain text of 35 U.S.C.
Between 2014 and 2019, the average monthly insulin price rose from $318 to $493. Diabetes Care , 2020) Between 2014 and 2019, the monthly out-of-pocket cost for insulin users with insurance coverage rose from $49 to $58. Melamed says. There are recent price cuts due to public and legal pressure, but the prices are still remaining high.”
History and evolution of the Advisory Committee on Immunization Practices — United States, 1964-2014. Pharmacists should continue to monitor policy changes, political conjecture, and a new lawsuit brought by physician groups to be prepared to dialogue with patients. 2 REFERENCES Smith JC, Hinman AR, Pickering LK. Morb Mortal Wkly Rep MMWR.
In 2014, the US FDA approved this regimen, and it features in the latest WHO guidelines for LTBI treatment. Thorax 2014 20. The PREVENT TB trial showed that a weekly regimen of isoniazid and rifapentine for 3 months was non-inferior to daily isoniazid for 9 months 21. The rifapentine group had higher treatment completion rates (82.1%
Guideline on Similar Biological Medicinal Products Containing Biotechnology-derived Proteins as Active Substances: Quality Issues (revision 1) (May 22, 2014). Development of Therapeutic Protein Biosimilars: Comparative Analytical Assessment and Other Quality-Related Considerations, Draft Guidance for Industry (CDER, CBER, 2019). Easton, R.L.
Recent Videos Advertisement Related Content Q&A: How Pharmacists Find Themselves in Non-Traditional Roles Brian Nowosielski ; Ashley Kay Pendrick, PharmD August 12th 2025 Article Community Pharmacy’s Pivotal Role in Boosting Immunization Rates Brian Nowosielski ; Hashim Zaibak, PharmD August 12th 2025 Podcast Top 3 PBMs Contribute to Over 1500% (..)
Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the Infectious Diseases Society of America. 2014 Jul 15;59(2):e10-52. [link] Stevens DL, Bisno AL, Chambers HF, et al; Infectious Diseases Society of America. Clin Infect Dis. doi:10.1093/cid/ciu444.
The drug also isn’t new and was first approved in 2014 before being acquired by Currax in 2019. But Currax has seen more uptake in the last few years thanks to the rising profile of obesity meds, especially among patients who might not be a fit for GLP-1s.
2 The National Review of Asthma Deaths (NRAD) Why asthma still kills report from 2014 was a landmark publication. One in 11 children and young people in the UK has asthma and it is the most common long-term medical condition in children in the UK. State of Child Health Insight into the state of child health in the UK. Why asthma still kills.
Recent Videos Related Content Top 3 PBMs Contribute to Over 1500% Increase in Formulary Exclusions Since 2014 Brian Nowosielski August 3rd 2025 Article For biosimilar, generic, and branded medications, Cencora researchers conducted a report detailing growth in formulary exclusions among the 3 largest pharmacy benefit managers in the US.
FDA, USP Salt Policy (December 2014). 1, 2014 (accessed April 29, 2025). USP, USP General Chapter , “Nomenclature,” USP35–NF30 (Rockville, MD, 2011). FDA, Guidance for Industry, Naming of Drug Products Containing Salt Drug Substances (CDER, June 2015). YouTube.com , Dec.
Addiction Science & Clinical Practice , 2014) Preventing opioid misuse Preventing opioid misuse is a collective effort from individuals, healthcare systems, and government policy.
. | image credit: Edugrafo / stock.adobe.com READ MORE: Q&A: How Advancements in GLP-1s, CGM Impact Insulin Management Since the approval of liraglutide (Saxenda) for weight-loss in 2014, 2 the demand for GLP-1s among patients with either diabetes or obesity has skyrocketed.
The lawsuit contested that prices for a two-pack of EpiPens rose from around $100 in 2008 to $600 during the class period between March 2014 and February 2025. In January 2025, Mylan reached a $73.5m GlobalData Strategic Intelligence US Tariffs are shifting - will you react or anticipate? Don’t let policy changes catch you off guard.
A study by Xcenda found that only about 40 diabetes, weight loss, endocrine, and metabolic drugs had been excluded from at least one pharmacy benefit manager (PBM) formulary in 2014. By 2022, that number had jumped to 179. Contact your insurance company.
Founded in 2014, Sydnexis is a US-based company and has recently concluded the three-year primary endpoint of its Phase III trial of the low-dose atropine formulation.
Zoetis and Elanco have previously been the target of CVM complaints about their promotion: Of 10 ULs issued by CVM re advertising since 2014, Zoetis received 4 one in 2025, 2023, 2018 and 2016 and Elanco received 2 ULs 1 in 2018 and another in 2015.
In 2014, I suffered a sudden flare-up of my Hashimotos after starting to use a new lipstick. Published 2014 Jan 3. While the reasons behind the disproportionate rate of Hashimotos in women (seven women for every one man) are complex, the heavy use of endocrine-disrupting chemicals may be a contributing factor. Springerplus.
In fact, a 2019 study demonstrated that this combination therapy is more effective than glimepiride alone, while a study from 2014 showed that its more effective than metformin uptitration (the gradual increase of dosage). Morkos , Pharm.D. of Marshall B. Ketchum University.
between 2013 and 2014. (WHO, 2025) For both men and women, obesity is most common among adults ages 40–59. ( CDC , 2024) The percentage of people with severe obesity, defined as a BMI of 40 or higher, is slowly growing: It was 9.7% between 2021 and 2023, up from 7.7% CDC, 2024) How many people use Mounjaro for Type 2 diabetes?
According to a November 2024 GlobalData report, per-trial costs have risen steadily since 2014, with single country trials increasing by 2.9% The rising cost of clinical trials Clinical trials have always been expensive, but costs are reaching new heights. per year and multinational studies rising by 4.9% per year over this decade.
doi:10.1155/2014/531969 [27] Alexander EK, Pearce EN, Brent GA, et al. doi:10.1182/blood-2014-12-614446 [36] Wang JW, Liao XX, Li T. doi: 10.1155/2014/602894. Epub 2014 Aug 31. Published 2014 Oct 30. doi:10.1136/bmjopen-2014-006571; Forster DA, Moorhead AM, Jacobs SE, et al. 2020;34(4):101438. J Thyroid Res.
A 2014 study reported that statin-intolerant people were more likely to have a history of hypothyroidism than statin-tolerant people. However, a study from 2021 also found that statins can improve thyroid function independently of their effects on cholesterol levels.
While Wegovy is a once-weekly injection, Saxenda is a once-daily injection and has been available since 2014. It belongs to a class of medications called glucagon-like peptide-1 (GLP-1) receptor agonists , which also includes Wegovy (semaglutide). Insurance coverage for weight loss medication can be difficult to navigate.
The arm of the agency that handles submissions for medicines began requiring fees in September 2014, while the other unit overseeing cancer drugs took that step in April 2015.
Back in 2014, it was reported that vitamin D testing for Medicare patients was the fifth most common lab test ordered ( American Family Physician , 2018). NIH , 2024) For those taking the supplements, vitamin D intakes were ten times higher when compared to diet alone. What We Eat in America , 2019).
Soriot, who fended off a takeover from the US predator Pfizer in 2014 , has grown AstraZeneca into Britain’s most valuable company, thanks to an astute eye for promising medicines and developing one of the first Covid vaccines. Continue reading.
This loss came after losing her 17-year-old son, Graham, in 2014 shortly after leaving rehab. The other, Teresa, lives with the permanent, aching void left by the loss of her beloved son Spencer at age 24 to a preventable overdose. Losing both of her children to this epidemic has left an irreplaceable emptiness. Read the rest…
The US Food and Drug Administration (FDA) approved Amgen’s Blincyto (blinatumomab), the first bispecific T-cell engager (BiTE), in 2014 for adults with Ph- R/R B-ALL, with its label expanded in 2017 to include Ph+ and paediatric cases.
For documents published in 2014 this number was just six; in 2024 it was 157 ( Figure 2 ). 2014-2024 (Credit: Elsevier BV – Scopus) Figure 2 : Documents by year. 2014-2024 (Credit: Elsevier BV – Scopus) Regionally, the US is dominating rare disease research. 1 Figure 1 : Documents by year.
A whistleblower lawsuit that originated in 2014 and filed by an executive at Aetna — now a CVS Health unit — alleged CVS Caremark inflated Medicare Part D drug prices to offset higher costs in other lines of business.
Insmed CEO Will Lewis keeps a newspaper story from 2014 framed on the wall of his office. This is the online version of Adam’s Biotech Scorecard, a subscriber-only newsletter. STAT+ subscribers can sign up here to get it delivered to their inbox. The headline reads, “Insmed joins the biotech trash heap.”
Access to care for Medicaid fee-for-service beneficiaries with substance use disorder has improved from 2014 until 2021, but much more can be done to improve it further, researchers say. There have been substantial improvements in coverage for substance use disorder and opioid use disorder since 2014, according to a study in JAMA Network.
A former WHO epidemiologist is applying lessons learned during the Ebola epidemic to her work leading a company at the forefront of women’s health: the reproductive microbiome.
The approval was based on the results of a phase 3 trial that found an improvement in progression-free survival among individuals treated with pembrolizumab.
Strategies to Prevent Ventilator-Associated Pneumonia in Acute Care Hospitals: 2014 Update. Infect Contr Hosp Epidemiol 2014; 35(8): 915–36. Clin Infect Dis 2016; 63 (5):e61–e111. . Klompas, M., Branson, R., Eichenwald, E. Tamma, Samuel L. Aitken, Robert A. Bonomo, et al.
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