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STAT+: ‘It’s like Groundhog Day’: The cancer drug shortage isn’t new — and neither are the solutions

STAT

” Methotrexate isn’t the only essential chemotherapy clinicians are having a hard time getting their hands on right now. Two other key chemotherapies, cisplatin and carboplatin, which are also generic injectable drugs, have been in shortage for the last few months. “It’s just so, so maddening.”

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Sciensus’s licence partly suspended after death of cancer patient

The Guardian - Pharmaceutical Industry

Regulator acts after firm paid millions by NHS for healthcare gave patients wrong chemotherapy dose Britain’s health regulator has partly suspended the manufacturing licence of Sciensus, a private company paid millions by the NHS to provide vital medicines, after the death of a cancer patient who was given the wrong dose of chemotherapy.

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EC approves first-line ovarian cancer treatment

European Pharmaceutical Review

The small molecule treatment is indicated as a first-line maintenance treatment for individuals with advanced ovarian cancer regardless of their BRCA mutation status, who have responded to first-line platinum-based chemotherapy. ” The EC based its approval the Phase III ATHENA-MONO study results.

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Sugemalimab plus chemo boosts lung cancer survival, trial reveals

pharmaphorum

EQRx’s GEMSTONE-302 study evaluated the efficacy and safety of the investigational anti-PD-L1 antibody, sugemalimab, in combination with chemotherapy as a first-line treatment for patients with stage four non-small cell lung cancer (NSCLC), versus using chemotherapy alone. But prevalence still increased by 10% between 2008 and 2012.

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Daiichi Sankyo grabs first approval for blood cancer drug Ezharmia

pharmaphorum

It is usually treated with chemotherapy, but has a high rate of relapse and a low five-year survival rate of between 12% and 14%. ATL is a rare and highly aggressive form of non-Hodgkin lymphoma (NHL), generally associated with infection by the HTLV-1 retrovirus, that can manifest as either a lymphoma or a leukaemia.

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Ethnopharmacology: traditional medicine and modern drug discovery

Pharmaceutical Technology

For example, a widely referenced study from 2012 reported that up to 50% of approved drugs between 1981 and 2010 were directly or indirectly from natural products, while according to the WHO, 11% of drugs considered basic or essential originated from flowering plants.

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J&J’s Darzalex Faspro is first US therapy for rare blood disorder

pharmaphorum

Until now people with AL amyloidosis have had to rely on chemotherapy, with its accompanying side effects, and other drugs to tackle organ failure once damage gets severe. Amyloid plaques can then form in multiple organs such as the heart, kidneys and liver, damaging them and in some cases leading to organ failure.