Remove tag protein-protein-interactions
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New purification method could enhance protein drug manufacturing

European Pharmaceutical Review

In a recent study, Massachusetts Institute of Technology (MIT) researchers developed a new purification method to cut the costs of manufacturing protein drugs. The engineers used bioconjugate-functionalised nanoparticles to quickly and inexpensively isolate proteins from a bioreactor. It separates proteins based on their size.

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Almirall and IRB Barcelona team up to tackle skin disease

pharmaphorum

The use of monovalent degraders, which enable the targeted degradation of disease-relevant proteins, offers a new avenue to reach tissue that cannot be targeted with conventional therapeutic agents. Researchers at Almirall have identified several proteins whose abnormal function is associated with inflammatory immune skin diseases.

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Actualising the power of antibody-drug conjugates as cancer therapeutics

European Pharmaceutical Review

The antibody is chosen based on its high selectivity and affinity for the tumour-associated antigen and its ability to facilitate internalisation or endocytosis, wherein molecules such as proteins are engulfed by the cell membrane and drawn into the cell. Functional Protein? Tubulis’ second technology platform is called Tub?tag

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Upcoming sickle cell gene therapies cost effective at $2 million, says ICER

Pharmaceutical Technology

Although the findings in the report are only preliminary, they shed light at the considerations behind the high price tags of gene therapies. Sickle cell disease is an inherited blood disorder that is caused by mutations in the HBB gene, which codes for the oxygen-carrying protein haemoglobin in red blood cells.

FDA 59
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Mounjaro (tirzepatide) alternatives: What can I take instead of Mounjaro?

The Checkup by Singlecare

Other GLP-1 receptor agonists (with indication for diabetes) If the price of Mounjaro or insurance coverage is not sustainable, the first move might be to find a GLP-1 drug with a lower price tag or better coverage on an insurance plan. High protein diets have also been linked to higher production of GLP-1.

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Donepezil alternatives: What can I take instead of donepezil?

The Checkup by Singlecare

Aduhelm is a monoclonal antibody that targets amyloid beta, the protein which piles up in the brain and seems to be at the root of the disease. Aduhelm carries a hefty price tag, and it is not appropriate for any other form of dementia, such as dementia with Lewy bodies and vascular dementia. Compare donepezil alternatives.

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Conjugation and Labeling of Molecules: A Burgeoning Approach in Therapeutics Development and Molecular Imaging

Roots Analysis

Conjugation is the process of formation of a single, stable hybrid, wherein one of the entities is a molecule, such as protein, antibody, peptide and small molecule. Bioconjugation is a subset of conjugation where one of the entity is a biomolecule, such as protein or an antibody.