Therapeutics Education Collaboration

MARCH 27, 2024

In episode 569, James and Mike continue to go over what statistics really show – we focus on what inferential statistics can and cannot do, what a p value means and more importantly what it doesn’t mean. And yes we try to keep all this stat stuff on a realistic and practical level – easier said than done.

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Therapeutics Education Collaboration

MARCH 21, 2024

In episode 568, James and Mike go over what statistics really show – and importantly what they don’t show. We go over the terms and nuances and hopefully put them all into a simple context. Statistics are not just in medicine – they are in much of what you do every day – so you really do need to understand them.

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Therapeutics Education Collaboration

FEBRUARY 28, 2024

In episode 566, Mike and James invite Émélie back yet again to the podcast and the topic is the balance of benefits to harms of using corticosteroids in adults or children for atopic dermatitis. We come to the realization, as always, that how to use topical corticosteroids is based on knowing the best available evidence […]

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Therapeutics Education Collaboration

FEBRUARY 22, 2024

In episode 565, Mike and James invite Émélie Braschi back to the podcast to talk about do-it-yourself hearing aids. You really need to listen to this podcast – your patients will thank you. You really need to listen to this podcast – your patients will thank you. Show notes […]

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Therapeutics Education Collaboration

FEBRUARY 7, 2024

In episode 564, Mike and James invite Samantha Moe back to the podcast to talk about the benefits and harms of non-hormonal medications for vasomotor symptoms in menopause. Episode 564: Can non-hormonal drugs improve vasomotor symptoms in menopause?

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Therapeutics Education Collaboration

DECEMBER 18, 2022

In episode 528, James and Mike go through the logic and math around CVD risk estimates with regard to repeat cholesterol measurements. We discuss the impact remeasuring cholesterol has on CVD risk estimates and show that re-measuring every 5-10 years provides minimal if any value when it comes to making treatment decisions.

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Therapeutics Education Collaboration

JANUARY 30, 2024

In episode 563, Mike and James go over all the RCT evidence for the Respiratory Syncytial Virus (RSV) vaccine in older adults. You need to know the vaccine works, but you really need to know the baseline risk of RSV before anyone can really make an informed decision about this vaccine. We’ll do our best to give you all the numbers.

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Vaccines 52

Therapeutics Education Collaboration

JANUARY 18, 2024

In episode 562, Mike and James continue to discuss our recently revised 2023 simplified lipid guidelines with Adrienne and Mike. We talk about all the medications used for cardiovascular risk reduction. We go over all the evidence and all the numbers for the benefits (and sometimes lack of benefit) and the harms.

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Therapeutics Education Collaboration

JANUARY 8, 2024

In episode 561, Mike and James invite Adrienne Lindblad and Mike Kolber to discuss our recently revised 2023 simplified lipid guidelines. We talk about the guideline process, the best available evidence, and discuss some of the rationale we used to recommend the simpler approaches outlined in our guideline.

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Therapeutics Education Collaboration

DECEMBER 29, 2023

In episode 560, Mike and James finish their discussion around the use of hallucinogens/psychedelics by going over the psilocybin evidence. As with ketamine we cover the many limitations of the evidence around psilocybin and also talk about the side effects, costs and inconvenience. So now you know all we know for what that is worth.

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Therapeutics Education Collaboration

DECEMBER 21, 2023

Show notes HANDOUT Psychodelics Podcast From Hallucinations to Healing? Show notes HANDOUT Psychodelics Podcast From Hallucinations to Healing? In episode 559, Mike and James continue to discuss the best available evidence around ketamine and severe depression.

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Therapeutics Education Collaboration

DECEMBER 15, 2023

Show notes HANDOUT Psychodelics Podcast From Hallucinations to Healing? Mike talks about what the media says about ketamine and then he delves into what the guidelines say. Then as always, we discuss the best available evidence. Have a listen so that you can be in the know about ketamine.

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Therapeutics Education Collaboration

DECEMBER 4, 2023

Episode 557: Fancy Creams for Scaly Skin: Topical calcineurin inhibitors for atopic dermatitis In episode 557, Mike and James invite Emelie Braschi back to the podcast to talk about how effective topical calcineurin inhibitors are for atopic dermatitis. We’ll give you all the numbers so have a listen and learn what they are.

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Therapeutics Education Collaboration

NOVEMBER 17, 2023

In episode 556, Mike and James have Betsy Thomas back to podcast to talk about how effective are artificial tears for people with dry eyes. Both of us cry halfway through the podcast because of the craziness and inconsistency of the evidence. Have a listen and see what we found. Have a listen and see what we found.

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Therapeutics Education Collaboration

NOVEMBER 9, 2023

In episode 555, James and Mike invite Jamie Falk back to the podcast to talk about the best available evidence for acetylsalicylic acid and its potential impact on reducing the risk of complications in women at risk of preeclampsia. The evidence is pretty clear and we are able to give decent estimates of the benefits and harms.

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Therapeutics Education Collaboration

NOVEMBER 6, 2023

In episode 554, James and Mike go over a topic we have never covered in 553 previous podcasts. We invited Samantha Moe back to the podcast to talk about how effective are pelvic floor exercises or pessaries for stress urinary incontinence. In episode 554, James and Mike go over a topic we have never covered in 553 previous podcasts.

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Therapeutics Education Collaboration

OCTOBER 31, 2023

In episode 553, James and Mike get Jen Potter back to talk about the last option we have for heavy menstrual bleeding – tranexamic acid. We talk about how it compares to placebo, NSAIDs, progestins and levonorgestrel intrauterine devices and go over all the numbers for benefits and harms. And then as always, we put everything into clinical context.

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Therapeutics Education Collaboration

SEPTEMBER 7, 2023

In episode 551, James and Mike invite Danielle Perry back to the podcast to talk about the best available evidence for the use of statins in people 65 and over. As you’ll hear, we have lots of evidence so all you need to know is what it says. Then, you can have an evidence-based discussion with all your people in this age category.

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Therapeutics Education Collaboration

OCTOBER 4, 2022

In episode 522, James and Mike quickly go over 3 new COVID trials that give useful PREMIUM information. BUT then we quickly go SUPER PREMIUM with evidence around the shelf life of medications and we discuss why the expiry dates on medications in almost no circumstances represent the date when medications should no longer be used.

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Labelling 75

Therapeutics Education Collaboration

AUGUST 22, 2023

In episode 550, James and Mike talk in a PREMIUM way about a new cholesterol lowering agent. Bempedoic acid is nothing tremendously exciting but what was very interesting was a subsequent publication that looked at a primary subset analysis, yet completely left out the secondary subset data. Have a listen and find out why.

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Therapeutics Education Collaboration

AUGUST 20, 2023

In episode 549, James and Mike invite Blair MacDonald to the podcast for the first time and we talk about a topic that we haven’t really covered to-date. Have a listen as the results may surprise you somewhat. Have a listen as the results may surprise you somewhat. Show Notes Tools for Practice Triglyce-Ride that High?

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Therapeutics Education Collaboration

JULY 21, 2023

In episode 547, James and Mike invite Jessica and Scott back again to talk about whether or not COPD patients seen in primary care are like the people studied in the large COPD trials. We talk about how to focus care on the people who are most likely to benefit from therapy. There are lots of important primary care tips in this one. Have a listen.

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Hospitals 52

Therapeutics Education Collaboration

JUNE 30, 2023

In episode 545, James and Mike invite Samantha Moe back again to the podcast to talk about whether or not statins increase the risk of dementia or worsening of cognitive scores. I forgot the answer so you will have to listen to the podcast. I forgot the answer so you will have to listen to the podcast. Statins and the […]

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Therapeutics Education Collaboration

JUNE 16, 2023

In episode 544, James and Mike invite Samantha Moe to the podcast to talk about whether or not PPIs improve crying, fussiness, irritability, or regurgitation attributed to feeds. If you’ve ever used PPIs for this condition, you may be surprised by the results. Show Notes 1) Tools for Practice Crying babies: Can proton pump inhibitors help?

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Therapeutics Education Collaboration

JUNE 7, 2023

In episode 543, James and Mike invite Tina Korowynk and Jennifer Young to discuss their recent paper where they talk about the evidence around comprehensive primary care that is led by a family physician.

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Hospitals 52

Therapeutics Education Collaboration

MAY 31, 2023

In episode 542, James and Mike finish their discussion around placebo. We then talk about tips and tricks for how to best use the knowledge about the placebo group effect when it comes to day-to-day decisions of choosing, stopping and starting medications/treatments.

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Therapeutics Education Collaboration

MAY 26, 2023

In episode 541, James and Mike get into a powerful discussion of placebo. We talk about the evidence around placebo, the placebo effect, the placebo group effect/response and we try to put it all into the context of clinical practice.

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Therapeutics Education Collaboration

MAY 6, 2023

In episode 540, James and Mike invite Jennifer Young to go over all the evidence we have for what antibiotics to choose for bladder infections. The evidence clearly shows that the antibiotics we have been using for decades are still the drugs of choice. Tune in and find out which one you should choose and also what dose and duration.

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Therapeutics Education Collaboration

APRIL 11, 2023

In episode 539, James and Mike focus in a PREMIUM way on the latest prostate cancer intervention trial. Patients with prostate cancer were randomized to active monitoring, surgery, or radiotherapy and followed for 15 years to see which was the best option. Have a listen and hear what was found.

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Therapeutics Education Collaboration

APRIL 5, 2023

In episode 538, James and Mike discuss the great (but pretty much silly) egg controversy. We go over the best available evidence for eggs which is at best not great. We talk about the cohorts, the effect of eggs on cholesterol and much more.

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Therapeutics Education Collaboration

MARCH 27, 2023

In episode 537, Mike and James invite Ricky Turgeon back to the podcast to talk about the impact of the influenza vaccination on cardiovascular events in both primary and secondary prevention. The best evidence is in secondary prevention. Tune-in to hear the numbers. The best evidence is in secondary prevention.

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Vaccines 52

Therapeutics Education Collaboration

MARCH 17, 2023

In episode 536, Mike and James talk about 4 questions – Is any bacteriuria associated with altered mental state? – Does treating ASB improve/prevent clinical outcomes? – Does treating ASB improve altered mental state? – Do antibiotic reduction interventions for ASB affect patient outcomes? Tune in to find out the answers.

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Therapeutics Education Collaboration

NOVEMBER 16, 2022

In episode 525 – part two of our series on weight – James and Mike talk about how best to measure “weight” – and waste circumference, and hip -to-weight ratio and so on. We show that there is very little reason to measure much else other than actual weight. We also look at the evidence around whether intentional weight loss improves outcomes.

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Therapeutics Education Collaboration

MARCH 10, 2023

In episode 535, Mike and James work through all the evidence and come up with the definitive (in our minds) answer as to whether or not statins cause muscle symptoms. They likely do in 1% of people, but if you have muscle symptoms when you are on a statin it is very unlikely it is because of the statin.

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pharmaphorum

MARCH 15, 2021

This price represents a premium of approximately 43% to GenMark’s unaffected closing share price on 10 February 2021, the last trading day before a media report was published speculating about a potential sale process. Listen to our recent podcast interview with Roche Diagnostics’ Dr Ashton Harper here.

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Hospitals 57

Therapeutics Education Collaboration

FEBRUARY 20, 2023

In episode 534, Mike and James bring Jamie Falk to go through all the evidence for continuous glucose monitors that use subcutaneous sensors. There certainly seems to be evidence of benefit for T1DM but when it comes to T2DM the evidence for a benefit is not clear at all. Have a listen to get all the details.

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Therapeutics Education Collaboration

JANUARY 25, 2023

In episode 532, Mike and James bring Mike Kolber in to chat about potential treatments for anal fissures. We discuss the evidence for topical nitroglycerin, topical calcium channel blockers and topical Vitamin E. At the end we provide guidance that will blow your head off – or maybe we were all using too high a dose of topical nitroglycerin.

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