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AI-Generated Summary This article by infectious diseases pharmacist Aneeka Chavda outlines five key considerations for pharmacists in the treatment of Mycobacterium tuberculosis (TB), particularly drug-sensitive cases. The piece advocates for therapeutic drug monitoring (TDM) in specific high-risk groups to personalize treatment.
Tarlatamab established a new standard for relapsed SCLC, with improved survival and easier administration, enhancing treatment accessibility. Zanubrutinib demonstrated sustained efficacy in CLL with del(17p), emphasizing the importance of BTK inhibitors in high-risk hematologic malignancies.
Pharmacists should actively promote take-back programs, educate patients on secure disposal methods, and stay informed about regulatory requirements. Safe disposal options include DEA Take Back Days, pharmacy kiosks, law enforcement kiosks, mail-back envelopes, and home disposal methods.
Pharmacists are positioned to personalize HFpEF care through monitoring, patient-centered strategies, and shared decision-making, enhancing treatment adherence and outcomes. Finerenone, a nonsteroidal MRA, shows promise in reducing HF events and atrial fibrillation, offering potential benefits over steroidal MRAs like spironolactone.
Because of their ability to cover a wide array of bacteria, low adverse effect profile, and oral availability, cephalosporins are commonly used in the treatment of outpatient infections. Both agents have high bioavailability, achieve high urinary concentrations, are available as suspensions, and can be used in infants.
Malesker, PharmD, FCCP, FCCM, FASHP, BCPS +1 More Hypertension is widespread and linked to serious health risks, but new treatments for resistant cases target new mechanisms of action. Jansen, PharmD Candidate , Mark A.
SHOW MORE Pharmacists can help oversee the treatment process to ensure patients with transthyretin amyloid cardiomyopathy (ATTR-CM) are adhering to tafamidis. Ongoing research explores tafamidis' long-term efficacy, potential in other heart failure forms, and combination therapies for enhanced outcomes.
Although the use of colony-stimulating factors (CSFs) is well-established in mitigating severe FN, existing literature suggests there is only an approximate 3% difference in FN rates between various CSF agents. Utilizing colony-stimulating factors (CSFs) decreases the incidence of severe FN.
3 Although meloxicam injection delivers a non-opioid alternative for pain control, it is not recommended as a first-line agent when rapid onset of analgesia is needed due to its delayed onset. 2 REFERENCES 1. Meloxicam: Selective COX-2 inhibition in clinical practice. Seminars in Arthritis and Rheumatism. December 21, 2004. Subscribe Now!
Cardiovascular disease risks in HIV patients have evolved with ART, requiring preventive measures like statins and cardiovascular risk scores for effective management. Cardiovascular disease risks in HIV patients have evolved with ART, requiring preventive measures like statins and cardiovascular risk scores for effective management.
The presentation emphasized early intervention and personalized treatment plans in managing type 2 diabetes, shifting from "treating to failure" to "treating to target." It is not indicated for type 1 diabetes and carries a boxed warning for thyroid C-cell tumors, with unknown risk in humans.
Further research is needed on the clinical impact, treatment longevity, and cost implications of biosimilar use in pediatric IBD. 2 Tumor necrosis factor alpha inhibitors (anti-TNFs) have become both first- and second-line therapies for the treatment of pediatric patients with Crohn disease and ulcerative colitis.
Understanding and addressing barriers to medication adherence are crucial for effective treatment of psychiatric disorders and improving patient outcomes. Long-acting injectable antipsychotics may improve adherence in homeless populations, but transportation and clinic visit logistics must be considered.
Gilead’s recently approved drug for HIVprevention, Yeztugo (lenacapavir), has the potential to transform the pre-exposure prophylaxis (PrEP) sector in the US, according to market analysts. Go deeper with GlobalData Reports LOA and PTSR Model - BRII-732 in Human Immunodeficiency Virus (HIV).
She emphasizes that treatment options are mostly supportive, making prevention through good hygiene and vaccination essential. Pharmacists play a crucial role in educating high-risk individuals about RSV risks and encouraging vaccination to reduce severe illness.
The US Food and Drug Administration (FDA) has placed a clinical hold on several of Gilead’s trials evaluating two HIVtreatment candidates, though the rest of the drugmaker’s diverse pipeline remains unaffected. Gilead is considered the leading big pharma in HIVtreatments. Shares in Nasdaq-listed Gilead opened 0.3%
Upon sensing dsRNA, the cell effectively halts protein synthesis, thereby preventing the virus from manufacturing the essential proteins required for its own reproduction. This innovative approach allowed for the high-throughput screening of many compounds, specifically 370,830, to discover potential therapeutic agents.
1,2 “There is an extraordinary unmet need in obesity treatment, which is the ability for patients to stop GLP-1 drugs without regaining weight. 1 “These early Revita data are better than I expected and suggest the potential to prevent the weight regain we see in practice. Fractyl Health. News release. June 23, 2025. Gallagher A.
Please continue reading to learn about some of the most effective treatments for folliculitis. If you have certain health conditions or are taking medications that weaken the immune system, treatment is almost always warranted, as your body cannot clear infections well enough compared to others. What is folliculitis?
It may also be prescribed preventively in patients receiving chemotherapy or radiation or before a bone marrow transplant. They include: The severity of the infection: Systemic infections or very acute ones are slow to show a response to the treatment. What is the standard fluconazole dosage? RELATED: Can men get yeast infections?
18 years Administration Oral Oral Oral PK/PD MOA: Nirmatrelvir – inhibitor of the SARS-CoV-2 main protease Prevents viral replicationRitonavir is a CYP3A inhibitor included to increase nirmatrelvir plasma levelsRitonavir alone has NO activity against SARS-CoV-2 Time to peak: Nirmatrelvir: 3 hrs & Ritonavir: 3.98 Introduction.
1 , 4 A Retrospective Journey In 2015, Vertex’s Orkambi was the first approved drug produced under a CM process for the treatment of cystic fibrosis. This is demonstrated by the rise from $1.05 billion US in 2021 to $1.9 billion US in 2022 for the global market share for prescription drugs produced using CM.
I wish I had had this information when I was losing so much hair, feeling cold, moody, and tired! Today, we’ll be focusing on iron deficiency anemia (for more detailed information on the other two types of anemias, please see my B12 and MTHFR articles). I call it the “digging for the root cause, while chopping down branches” approach.
Nikolai Lazarev defined adaptogens as “an agent that raises the body’s ability to resist stress by countering undesired stressors, whether physical, chemical, emotional, or biological.” See my detailed article on aloe vera for important additional information regarding aloe vera. This can also mean fewer nutrients are absorbed.
Pneumonia is often mild to moderate, requiring only outpatient treatment. Risk factors of pneumonia are age older than 65, chronic obstructive pulmonary disorder ( COPD ), HIV infection , weakened immune system and smoking. Pneumonia usually requires evaluation and treatment. Treatment depends on the cause.
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