Wed.Jul 19, 2023

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Monthly Buprenorphine Initiation Rates Remain Flat, Despite Policy Changes

Drug Topics

Only 1 in 5 patients who initiated buprenorphine were retained in therapy for at least 180 days.

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As biologics boom, here’s how manufacturers are keeping up

PharmaVoice

Stevanato’s focus on biologic-related vials and delivery devices has put it in a unique position amid a quickly growing market.

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Investigating Gastrointestinal Involvement in Post-Acute COVID-19 Syndrome

Drug Topics

Investigators found significant associations between GI-PACS and multi-system concomitant symptoms.

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AI’s great expectations

PharmaVoice

With AI expectations riding high, here’s a look at some areas where the technology could be most useful in drug development.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Smartphone-based Interventions Alone Do Not Increase Smoking Cessation Rates

Drug Topics

Smartphone app-based interventions were found to be more effective when combined with pharmacotherapy.

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Double-Blind Trial Shows Low-Cost Subcutaneous Version of Ketamine Is Effective Over Placebo in Treating Treatment-Resistant Depression

Pharmacy Times

Generic ketamine could cost as little as $5, which is significantly lower than the $800 per dose for the currently available S-ketamine nasal spray.

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Recommended Flu Vaccines for Older Adults

Pharmacy Times

An expert panel examines the distinctions among the 3 primary recommended flu vaccines for individuals aged 65 and above, assessing their efficacy compared with standard-dose flu vaccines.

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Total Pharmacy Solutions Summit: Expanding Your Pharmacy’s Clinical Capabilities

Drug Topics

What are pharmacies capable of, and how do we work to reach those possibilities?

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Increasing Social Support for Young Adults With HIV Could Improve Viral Suppression

Pharmacy Times

Patients with perinatally-acquired HIV reported low emotional, instrumental, and friendship support at 37%, 32%, and 36%, respectively.

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The kidney, in all its complexity, is captured in an atlas that could aid disease research

STAT

The kidneys are some of the most architecturally complex organs in the human body — intricate in a way that becomes frustrating when, for millions of people each year, they lose function.  It’s only in recent decades that scientists have been able to leverage new techniques, like the ever-growing list of “-omics,” to peer deep inside human cells.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Correlation Between Vaccines and Flu Transmissions

Pharmacy Times

Adam C. Welch, PharmD, MBA, FAPhA, evaluates the impact of yearly flu vaccinations on curtailing the spread of influenza among communities and populations.

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Stanford president to resign after investigation finds he failed to ‘decisively and forthrightly’ correct research

STAT

In an abrupt turn, Stanford president and renowned neuroscientist Marc Tessier-Lavigne announced Wednesday that he will step down as the university’s leader. His resignation came after he learned the results of an extensive investigation into his past research, which confirmed data-manipulation in scientific papers that he co-authored and found that he took insufficient steps to correct them.

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Specialty Pharmacists Can Help Identify, Alleviate 5 SDOH Categories

Pharmacy Times

Specialty pharmacists can have more contact with patients than providers.

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These proteins could predict dementia risk decades before symptoms, new study suggests

STAT

Can we predict the risk of dementia decades before onset? In a study published in Science Translational Medicine on Wednesday, neuroscientists reported a startling clue. The neuroscience researchers, who are from the National Institute on Aging and Johns Hopkins University School of Medicine, decided to peer into more than 4,000 proteins found in plasma, which is blood with the blood cells removed.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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Avoid Errors by Checking Patients’ Medications Lists

Pharmacy Times

Inaccurate information, miscommunication during transition points can have dire consequences.

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Key lawmaker blasts Congress’ efforts on addiction: ‘Shame on us’

STAT

A Democratic congressman on Wednesday blasted a bipartisan set of proposals focused on addiction, arguing that current congressional efforts will barely scratch the surface of the U.S. drug crisis. The criticism from Rep. Paul Tonko (D-N.Y.) came during a subcommittee hearing at which lawmakers advanced several bills focused on the substance use and overdose epidemic.

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Confirmatory PAPILLON Study Supports Amivantamab-vmjw For Patients with Severe Lung Cancer Mutation

Pharmacy Times

The 5-year survival rate for patients with exon 20 insertion EFGR mutation is 8% in the frontline setting, worse than the survival rate of the 2 most common types of EGFR mutations in patients with advanced or metastatic non-small cell lung cancer.

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Pharma 4.0™ Is Gaining Momentum and Driving Innovation

ISPE

Pharma 4.0™ Is Gaining Momentum and Driving Innovation Trudy Patterson Wed, 07/19/2023 - 08:17 Online Exclusives July / August 2023 Pharma 4.0™ Is Gaining Momentum and Driving Innovation Thomas ZIMMER, PhD 19 July 2023 The fifth Pharma 4.0™ conference was held December 2022 in Vienna, Austria, in combination with the Aseptic Processing conference. Nearly 500 participants attended either in person or online to learn about the latest developments.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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Supporting the Evolving Retail Pharmacy Landscape While Improving Medication Adherence

Pharmacy Times

Mobile apps can help consumers acquire medications, but few help with adherence beyond automatic refills or medication synchronization.

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Cancer drug shortages deliver ‘gut punch’ to patients unsure if their survival odds will be undercut

STAT

Mairéad McInerney will never know if changes in her treatment plan have undercut her odds of surviving stage 3 triple-negative breast cancer. Critical shortages in cancer drugs have forced her to change course not once, but twice. The first time, her physicians flipped the order of her drug regimen because Taxol (paclitaxel), one of two drugs she was supposed to take, was not available, said McInerney, who was diagnosed in December 2022.

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Targeting Folate Receptor ? Is Ideal for Ovarian Cancer Treatment

Pharmacy Times

FRα expression is limited on normal cells, but upregulated in ovarian cancer cells.

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TikTok cracks down on users posting about popular weight loss drugs

STAT

As the demand for GLP-1 based drugs grows, content about the new class of weight loss drugs on TikTok has fueled the flames of its popularity. Now, the social media platform has taken action against many of the users who post frequently about the medications. Dozens of accounts were suspended from TikTok in early July, many belonging to content creators who talk about their weight loss and monetize the platform via partnerships with telehealth companies that prescribe GLP-1s and other weight los

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Rollout of Long-Acting Cabotegravir Without Delay Can Have Greatest Impact on HIV PrEP

Pharmacy Times

Investigators said pre-exposure prophylaxis rollout is efficient in settings with high HIV incidence, but not in settings with low HIV incidence.

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STAT+: Stanford president’s departure begs the question: Who takes the credit — or blame — in team science?

STAT

The resignation of Marc Tessier-Lavigne as president of Stanford University following an investigation into irregularities in his past research marks more than just the startling downfall of the leader of one of the nation’s top research powerhouses. The case is likely to have broader repercussions, signaling a tipping point in an ongoing and often contentious debate about how to assign blame and credit in the increasingly collaborative world of research.

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Event-Free Survival Improved by Radiotherapy for B-Cell Lymphoma in Younger Patients

Pharmacy Times

Due to the assessment of computerized tomography with criteria from 1999, the role of radiotherapy in patients with diffuse large B-cell lymphoma with bulky or extranodal disease remains undefined.

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STAT+: To get better heart data from wearables, researchers train AI to separate the signal from the noise

STAT

As wearable health devices grow more popular in the U.S., there’s a growing opportunity to track the broader adult population’s heart health. But it’s much harder for an Apple Watch to accurately detect the heart’s electrical signals and rhythm than a set of hospital-grade electrodes. Its readings are messier, often because of poor contact with the skin.

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Twist and Cancer Research Horizons sign antibody library platform deal

Pharmaceutical Technology

Twist Bioscience and CRUK innovation arm Cancer Research Horizons have signed an agreement for licensing a library of libraries.

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STAT+: App developer Twill hunts for pharma partner to market its digital depression treatment

STAT

In another sign of the business headwinds facing prescription mental health apps, developer Twill will shop around for a pharmaceutical company to market Aspiro, its cognitive behavioral therapy treatment for both generalized anxiety and major depression. Twill executives told STAT the company hopes that a drugmaker developing or currently marketing a product for generalized anxiety, or GAD, and major depressive disorder, or MDD, will be interested in adding a digital therapeutic to boost the ef

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Efficacy of novel drug proven in MDD study

European Pharmaceutical Review

Phase II study results for navacaprant (NMRA-140), a novel kappa opioid receptor (KOR) antagonist for major depressive disorder (MDD) demonstrated significant and clinically meaningful improvement in depression for participants. The data “are compelling, particularly the significant improvements observed in both depressive and anhedonic symptoms,” stated Dr Roger S McIntyre, FRCPC, Professor of psychiatry and pharmacology, University of Toronto and Executive Director of the Brain and Cogni

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STAT+: House committee probes FDA inspections of pharma plants in China and India

STAT

A congressional committee is demanding the U.S. Food and Drug Administration provide detailed information about pharmaceutical plant inspections in China and India, two countries whose significant production of generic drugs and active pharmaceutical ingredients has caused concern about an overreliance on foreign manufacturers. Chinese and Indian manufacturers receive the largest number of warning letters about quality control issues from the FDA, including carcinogens in medicines, destroyed or

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Mechanism responsible for antimicrobial resistance identified as mixed strain pathogens

Hospital Pharmacy Europe

The assumption that pathogen populations within a host are clonal and therefore antimicrobial resistance (AMR) will occur through the emergence of de novo variants has been challenged by a new study offering insight into the mechanism through which AMR is generated. Published in the journal Nature Communications , the study showed how mixed strain infections within the host play a key role in shaping the emergence of resistance in response to treatment.

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Opinion: Listen: Dance helped this nurse heal from trauma. Now she’s bringing it to others

STAT

“Y ou can’t pour from an empty cup” is what registered nurse Tara Rynders learned the hard way after two decades of work and one heartbreaking, life-threatening experience of being a critical care patient herself. Before that experience, she’d always found found that dance, play, and other types of movement helped her express and heal from the trauma she encountered and held in her body every day.

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New HTA body pledges to ‘cut the hype’ in digital health

pharmaphorum

New HTA body pledges to ‘cut the hype’ in digital health Phil.

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