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Doxepin and CYP2D6

Med Ed 101

We blogged about doxepin a few weeks ago now and I had a colleague bring this article to my attention. The relationship between doxepin and CYP2D6 is a very important one and I wanted to discuss it further with some potential drug interactions that may come up in practice. Here’s the abstract from the article. […].

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Meclizine interactions to avoid

The Checkup by Singlecare

Drug interactions | Food interactions | Other interactions | Avoiding interactions | When to see a doctor Meclizine is an antihistamine prescribed to treat or prevent nausea, vomiting, and dizziness caused by motion sickness. It may also be prescribed for treating vertigo related to inner ear problems.

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Atomoxetine interactions to avoid

The Checkup by Singlecare

Drugs with QT-prolonging potential include the following medicines: Zithromax (azithromycin) Clarithromycin Levofloxacin Moxifloxacin Seroquel (quetiapine) Risperdal (risperidone) Abilify (aripiprazole) Zyprexa (olanzapine) Remeron (mirtazapine) Silenor (doxepin) The entire list of medications that can prolong the QT interval is much longer.

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Sertraline interactions to avoid

The Checkup by Singlecare

Sertraline, otherwise known under its brand name, Zoloft, is an antidepressant medication in the selective serotonin reuptake inhibitor (SSRI) class. Mental health conditions are very common, with 1 in every 6 adults experiencing depression at some time in their life.