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Since their debut, these novel agents have formed an important armamentarium in the management of T2DM,” authors of a review published in Diabetes, Metabolic Syndrome, and Obesity said. GLP-1/GIPs have shown favorable outcomes in diabetes, significantly improving hemoglobin A 1c , which varies by therapeutic agent.
The recent approval of brentuximab vedotin (BV, Adcetris; Seagen Inc) in combination with lenalidomide (Len, Revlimid; Bristol Myers Squibb) and a rituximab (R; BV-R2) product is a pivotal moment in cancer therapeutics and provides an alternative treatment for adult patients with relapsed or refractory diffuse large B-cell lymphoma (R/R DLBCL).
Tarlatamab established a new standard for relapsed SCLC, with improved survival and easier administration, enhancing treatment accessibility. Zanubrutinib demonstrated sustained efficacy in CLL with del(17p), emphasizing the importance of BTK inhibitors in high-risk hematologic malignancies.
Because of their ability to cover a wide array of bacteria, low adverse effect profile, and oral availability, cephalosporins are commonly used in the treatment of outpatient infections. Both agents have high bioavailability, achieve high urinary concentrations, are available as suspensions, and can be used in infants.
GLP-1 receptor agonists should be considered as second-line agents for older adults with DKD, but potential gastrointestinal side effects must be monitored. SHOW MORE Pharmacists should consider GLP-1 receptor agonists as second-line agents in older adults with DKD when additional glycemic control is needed.
Pharmacists are key in advising on self-care, prevention, and OTC product selection for mild to moderate contact dermatitis. Pharmacists are key in advising on self-care, prevention, and OTC product selection for mild to moderate contact dermatitis. SHOW MORE Prompt identification and appropriate clinical intervention are critical.
Image credit: OM | stock.adobe.com Why Proper Disposal Matters Disposing of medications appropriately helps prevent environmental contamination of water and soil. Safe disposal options include DEA Take Back Days, pharmacy kiosks, law enforcement kiosks, mail-back envelopes, and home disposal methods.
Pharmacists are positioned to personalize HFpEF care through monitoring, patient-centered strategies, and shared decision-making, enhancing treatment adherence and outcomes. Finerenone, a nonsteroidal MRA, shows promise in reducing HF events and atrial fibrillation, offering potential benefits over steroidal MRAs like spironolactone.
SHOW MORE Intranasal insulin shows promise in targeting memory regions of the brain, offering new hope for Alzheimer disease treatment in older adults. Insulin absorption varies between cognitively normal individuals and those with mild cognitive impairment, with higher uptake in the former.
Malesker, PharmD, FCCP, FCCM, FASHP, BCPS +1 More Hypertension is widespread and linked to serious health risks, but new treatments for resistant cases target new mechanisms of action. Jansen, PharmD Candidate , Mark A.
These technologies prevent the risk of both hypo- and hyperglycemic episodes, facilitating safer fasting. The guidance is updated every 5 years, with the most recent update published in May 2025. Monitoring technology is valuable to assess glycemic control and enable timely interventions in T1D patients.
SHOW MORE Pharmacists can help oversee the treatment process to ensure patients with transthyretin amyloid cardiomyopathy (ATTR-CM) are adhering to tafamidis. Ongoing research explores tafamidis' long-term efficacy, potential in other heart failure forms, and combination therapies for enhanced outcomes.
Pharmacists are essential in managing OIC, advising on treatment, monitoring effectiveness, and identifying contraindications and potential complications. Pharmacological support often starts with OTC agents, like water-holding laxatives (e.g., polyethylene glycol and lactulose) and stimulant laxatives (e.g., bisacodyl and senna).
Although the use of colony-stimulating factors (CSFs) is well-established in mitigating severe FN, existing literature suggests there is only an approximate 3% difference in FN rates between various CSF agents. Utilizing colony-stimulating factors (CSFs) decreases the incidence of severe FN.
3 Although meloxicam injection delivers a non-opioid alternative for pain control, it is not recommended as a first-line agent when rapid onset of analgesia is needed due to its delayed onset. 2 REFERENCES 1. Meloxicam: Selective COX-2 inhibition in clinical practice. Seminars in Arthritis and Rheumatism. December 21, 2004. Subscribe Now!
Cardiovascular disease risks in HIV patients have evolved with ART, requiring preventive measures like statins and cardiovascular risk scores for effective management.
The presentation emphasized early intervention and personalized treatment plans in managing type 2 diabetes, shifting from "treating to failure" to "treating to target." It is not indicated for type 1 diabetes and carries a boxed warning for thyroid C-cell tumors, with unknown risk in humans.
Prescription cascades refer to a medication being prescribed to prevent or treat an adverse drug reaction to another medication. Further, it would be potentially inappropriate if there are more suitable treatment alternatives available, such as switching the drug causing the adverse drug reaction.
Further research is needed on the clinical impact, treatment longevity, and cost implications of biosimilar use in pediatric IBD. 2 Tumor necrosis factor alpha inhibitors (anti-TNFs) have become both first- and second-line therapies for the treatment of pediatric patients with Crohn disease and ulcerative colitis.
Understanding and addressing barriers to medication adherence are crucial for effective treatment of psychiatric disorders and improving patient outcomes. Long-acting injectable antipsychotics may improve adherence in homeless populations, but transportation and clinic visit logistics must be considered.
The FDA's fast track designation highlights birelentinib's potential to meet unmet needs in CLL/SLL treatment. A cornerstone of treatment for these patients is BTK and BCL-2 inhibitors, but many patients progress or relapse on these therapies.
She emphasizes that treatment options are mostly supportive, making prevention through good hygiene and vaccination essential. Pharmacists play a crucial role in educating high-risk individuals about RSV risks and encouraging vaccination to reduce severe illness.
The compounds activate the integrated stress response (ISR) pathway, halting viral protein synthesis and enhancing the cell's ability to shut down viral replication. The compounds activate the integrated stress response (ISR) pathway, halting viral protein synthesis and enhancing the cell's ability to shut down viral replication.
Even in full-term, healthy pregnancies, maternal health conditions including hypothyroidism, hormonal imbalances and PCOS (especially if they occurred during puberty), and many others can prevent or delay the production of breast milk. A practitioner will help assess individual patients to determine if or when breastfeeding is advised. [11]
1,2 “There is an extraordinary unmet need in obesity treatment, which is the ability for patients to stop GLP-1 drugs without regaining weight. 1 “These early Revita data are better than I expected and suggest the potential to prevent the weight regain we see in practice. Fractyl Health. News release. June 23, 2025. Gallagher A.
Certain foods can increase sweating or lead to a change in body odor because of the compounds they contain. Some medicines have a strong smell themselves or produce compounds that can cause body odor. However, there is no evidence of a lasting improvement in excessive sweating with these treatments.
And as we’ve seen, even with supplementation, you need to address your root causes to prevent iron supply and demand challenges. Viruses that have been associated with anemia include Epstein-Barr Virus , hepatitis A and C, human herpes virus 6 (HHV-6), cytomegalovirus, parvovirus B19, and HIV. [45] However, when they added 1.5
Nikolai Lazarev defined adaptogens as “an agent that raises the body’s ability to resist stress by countering undesired stressors, whether physical, chemical, emotional, or biological.” Would you like to know if adaptogenic herbs might be of benefit to you? This can also mean fewer nutrients are absorbed.
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