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Understanding Recent Changes to 505(b)(2) Drugs and Reimbursement

Pharmacy Times

“This act…allowed a pathway for manufacturers to create a ‘copy’ of a licensed patent product to make it cheaper and more discounted,” Soefje, director of pharmacy cancer care services and associate professor of pharmacy at Mayo Clinic in Rochester, Minnesota, said at the HOPA conference.

FDA 65
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CoQ10 side effects and how to avoid them

The Checkup by Singlecare

People with cancer : There is little information about the interactions between CoQ10 and cancer chemotherapy, so healthcare professionals may advise against its use during cancer treatment. CoQ10 comes in dosage strengths of 30 mg to 600 mg. Women who are pregnant or breastfeeding are cautioned to avoid CoQ10 supplementation.

FDA 52
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Ondansetron interactions to avoid

The Checkup by Singlecare

Some dosage forms of ondansetron contain sodium benzoate, a metabolite of benzyl alcohol. Sources Monoamine oxidase inhibitors (MAOIs) , Mayo Clinic (2019). The effect of rifampin on the pharmacokinetics of oral and intravenous ondansetron , Clinical pharmacology and therapeutics (1999). Mayo Clinic (2022).

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Olanzapine interactions to avoid

The Checkup by Singlecare

While it can be used to manage many mental health conditions, including bipolar disorder and schizophrenia , it also plays a role in the prevention and treatment of chemotherapy-induced nausea and vomiting. If deemed necessary to combine, the dosages and durations of the contributing medications should be reduced and kept to a minimum.