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Handling HPAPIs safely – what does it take?

European Pharmaceutical Review

” Highly potent APIs are pharmacologically and biologically active compounds at low doses. The compounds require special handling due to their cytotoxicity in the NCEs and investigational new drug applications (INDs). Based on the latest report and data, HPAPI market size is expected to reach $32 billion by 2028.

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PROTAC development gains momentum, but clinical performance is poor

Pharmaceutical Technology

This makes early R&D less risky, as many lead compounds are discontinued due to inadequate pharmacokinetic profiles and require excessively high dosages to be pharmaceutically active. GlobalData’s analyst consensus forecast database estimates peak annual sales for ARV-110 of $325 million in 2028.

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