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More big wins for the AstraZeneca-Daiichi Sankyo collaboration

Pharmaceutical Technology

Enhertu has already achieved regulatory approval as a second-line therapy for metastatic or recurrent HER2-positive breast cancer, as well as HER2-positive gastric or gastroesophageal junction adenocarcinoma, with annual sales for these indications alone expected to exceed $1.3bn by 2028.

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Pfizer acquires ADC pioneer Seagen for $43bn

Pharmaceutical Technology

The drug is currently licensed in combination with chemotherapy for patients with classical Hodgkin lymphoma, both as frontline therapy and for those at risk of progressing or having progressed following stem cell transplantation. compound annual growth rate (CAGR) according to Pfizer’s risk-adjusted projection.

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Roche scores phase 3 win for subcutaneous Tecentriq, eyes filings

pharmaphorum

The trial involved cancer immunotherapy-naïve patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) patients who were getting treatment with Tecentriq second-line after earlier platinum-based chemotherapy failed. Results from a trial in first-line NSCLC are due in early 2023.

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High risk, high reward – the future of CAR-T therapy in CLL

Pharmaceutical Technology

According to GlobalData’s analyst consensus forecast, Yescarta is expected to reach peak sales of $1.8bn in 2028, and Kymriah is expected to reach sales of $686m in the same year. Autologous CAR-T agents are now becoming the standard of care for patients in the third line and later settings, providing lucrative returns for these agents.

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Future of Bispecific Antibody: Exploring the Rise in Approvals

Roots Analysis

One area of interest is in oncology , where bispecific antibodies can be used to target two different antigens at the same time, leading to improved efficacy and reduced toxicity compared to traditional chemotherapy.

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A history of blood cancer treatment

pharmaphorum

While they may not have known it at the time, through their work Ehrlich and Metschnikow formed the cornerstone of modern immunology, including chemoreceptor and chemotherapy concepts that revolutionised blood cancer treatment over the following century. 1942 – Chemotherapy moves from trenches to treatment .

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MSD secures full approval for Keytruda’s use in MSI-high solid tumours

Pharmaceutical Technology

On March 27, MSD announced that the combined use of Keytruda with chemotherapy significantly improved progression-free survival versus the chemotherapy alone, as a first-line therapy for advanced or recurrent endometrial carcinoma. billion in 2028. This announcement is not the only recent development for Keytruda.