European Pharmaceutical Review

JANUARY 29, 2024

The guideline states that compounds “at or above the AET must be reported for toxicological risk assessment.” The researchers evaluated DHS extraction performance and compared it to traditional SHS and SBSE GC–MS methods. The paper highlighted that SHS analysis is currently a supplementary technique for volatile analysis.

Compounding 83

Compounding FDA 83

European Pharmaceutical Review

OCTOBER 9, 2022

Research published in the journal Nature Chemistry , shows how researchers from Stanford University in the US uncovered a promising new method to synthetically manufacture the compound tigilanol tiglate, named EBC-46, which could offer targeted medicine for cancer and other diseases.

Compounding 132

Compounding FDA 132

The Checkup by Singlecare

DECEMBER 18, 2023

Coffee itself doesn’t contain any cholesterol, but its natural oils contain kahweol and cafestol , two chemical compounds that have the potential to raise cholesterol levels. In other words, yes, the chemical compounds in coffee can raise cholesterol, but the effect coffee has on your cholesterol depends on individual factors.

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Compounding 105

Pharmaceutical Technology

NOVEMBER 29, 2022

This takeover will bolster the pipeline of Full-Life, offer a second peptide-based discovery platform and utilise the Radio Technology manufacturing and logistics platforms of Focus-X to progress compounds into clinics. The company’s pipeline currently has two lead compounds, which are set to enter clinical trials.

Compounding 59

Compounding 59

pharmaphorum

MARCH 7, 2022

The Princeton, New Jersey-based startup will use the funding to develop its artificial intelligence and imaging based drug discovery platform, used to identify compounds with new and under-exploited mechanisms of action.

Compounding 135

Compounding 135

European Pharmaceutical Review

APRIL 8, 2024

stated that when conventional small-molecule compounds were the norm within the industry, closed innovation was standard practise and pharmaceutical companies did R&D in-house. noted that based on this analysis, approximately 20 percent of the total number of mAbs launched in 2020. Yoshiura et al. Yoshiura et al. Yoshiura et al.

Pharmaceutical Companies 52

Pharmaceutical Companies Pharmaceutical Companies Compounding 52

The Checkup by Singlecare

APRIL 19, 2023

Garlic is loaded with organic sulfur compounds that make it particularly beneficial; these compounds fight inflammation, bacteria, fungi, and viruses, and have protective effects on the heart and kidneys. The garlic bulb (as part of the onion family alongside shallots , leeks , and chives) deserves a spot on this list—and your plate.

Compounding 98

Compounding Immunization 98

pharmaphorum

MARCH 24, 2022

GlaxoSmithKline has thrown its financial and drug development weight behind LifeMine Therapeutics, a US startup that aims to find new therapeutics from fungi – widely regarded as an underexplored resource of biologically-active compounds. Image by jggrz from Pixabay .

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Compounding Immunization 98

Pharmaceutical Technology

FEBRUARY 6, 2023

In March 2020, the findings from the trial were published in the New England Journal of Medicine. We look forward to advancing this new compound as part of combination regimens that could yield a short, simple, safe, and highly effective cure for all forms of TB.”

Compounding 59

Compounding FDA 59

Pharmaceutical Technology

NOVEMBER 25, 2022

Additionally, the platform could produce preclinical tumour vaccine candidate compounds with strong immune activity by incorporating algorithmic feedback to streamline activity and efficacy. In September 2020, the company raised funds worth $318.8m Automated experiments will be used to monitor and validate the tumour vaccines.

Vaccines 98

Vaccines Process Improvement Immunization Compounding 98

Pharmaceutical Technology

JULY 13, 2022

The initial agreement was signed in February 2020 for discovering, developing and marketing new immuno-oncology therapies based on Bicycle’s bicyclic peptide technology. The agreement is exclusive of the compounds in the oncology pipeline of Bicycle, including its immuno-oncology candidates.

Compounding 59

Compounding 59

Pharmaceutical Technology

MAY 5, 2023

Since 2020, TFF Pharmaceuticals has entered into multiple CRADAs with various US government agencies that cover a broad range of applications, and today’s announcement with NIEHS is further recognition of thin film freezing’s potential.”

Compounding 64

Compounding 64

pharmaphorum

MARCH 2, 2022

The term ‘psychedelic treatments’ incorporates a broad spectrum of different compounds, from LSD, psilocybin and DMT, to MDMA, ibogaine and ketamine. The latter compound has already been approved for treatment-resistance depression as the product Spravato (esketamine), after being developed by Janssen. Paving the way to patients.

Compounding 101

Compounding FDA 101

Omnicell

SEPTEMBER 5, 2022

Mark Neuenschwander Founding Director, THRIVCoalition.org Seminal research from 1997 on IV compounding discovered that 9 percent of manually compounded sterile preparations had incorrect ingredients and/or volumes. Worst yet, 74% of all respondents were aware of at least one pharmacy compounding error in the last 12 months.

Compounding 52

Compounding Sterile Compounds Compounding Pharmacies Documentation 52

pharmaphorum

JUNE 30, 2022

AI-designed drug candidates are starting to reach the human testing stage, headed by Exscientia’s DSP-1181 candidate for obsessive-compulsive disorder partnered with Sumitomo Dainippon Pharma, which started a clinical trial in 2020.

Research Laboratories 115

Research Laboratories Compounding 115

European Pharmaceutical Review

AUGUST 19, 2022

The market was valued at approximately $100 billion in 2020. percent compound annual growth rate (CAGR) of the market include the increasing commercialisation of generics and emerging technologies and small biotechs with limited or no production capabilities driving development in the biopharmaceutical sector. billion by 2026.

Packaging 91

Packaging Compounding 91

European Pharmaceutical Review

OCTOBER 7, 2022

billion by 2030, displaying a compound annual growth rate (CAGR) of 6.0 In the years 2015 and 2020, clinical-stage cancer programmes increased by a considerable 77 percent (1,642 to 2,911), resulting in a quarter of drugs currently in development worldwide being highly potent.

Dosage 85

Dosage Compounding Pharmaceutical Companies Pharmaceutical Companies 85

The People's Pharmacy

MAY 10, 2023

25, 2020 ). Researchers report benefit in conditions as varied as Barrett’s esophagus, multiple myeloma and prostate cancer ( Scientific Reports , March 17, 2020 ; American Journal of Hematology , March 6, 2020 ; Cancer Medicine , Feb. Many people take statin drugs to control their cholesterol.

Chemotherapy 66

Chemotherapy Compounding Insurance 66

pharmaphorum

JANUARY 11, 2023

The industry now hopes that feeding the same limited experiential data to AI may help tweak existing drug-like compounds slightly faster than before. Bucking the compound library trend, and the future. The drug candidates we find are vastly different from the compound libraries used by the rest of our industry.”.

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Compounding 119

Pharmafile

JANUARY 5, 2023

Summary: • TMP-301 (formerly HTL0014242) is a potent, selective, and orally available mGluR5 negative allosteric modulator (NAM) candidate discovered by Sosei Heptares and out-licensed to Tempero Bio • Phase 1 study in healthy volunteers expected to begin in Q1 2023 with support from a US$5.3M

FDA 40

FDA Compounding 40

Hospital Pharmacy Europe

APRIL 5, 2023

Multiple sclerosis (MS) is the most common cause of neurological disability in young adults worldwide and a 2020 study estimated that, globally, some 2.8 million people are living with the condition. Although the underlying cause remains uncertain, there is evidence that certain dietary factors may have an effect.

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Compounding Hospitals 98

pharmaphorum

JUNE 7, 2022

The Hong Kong-based startup – one of an emerging crop of companies which are using artificial intelligence platforms to discover and design new therapeutic compounds – took its first drug into clinical trials in February.

Compounding 52

Compounding 52

pharmaphorum

JULY 13, 2022

Genentech has been looking at the platform since 2020 under the terms of a deal worth up to $1.7 Genentech has been looking at the platform since 2020 under the terms of a deal worth up to $1.7 The time the peptides stay in the body can also be fine-tuned, allowing for precise control of drug exposure, according to the biotech.

Immunization 100

Immunization Compounding 100

pharmaphorum

NOVEMBER 15, 2022

Their earlier partnership , signed in 2020, covered small molecule drugs directed at SLC transporters, a class of more than 450 human membrane proteins that are gatekeepers for controlling the movement of metabolites in and out of cells and organs.

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Immunization Compounding 103

pharmaphorum

NOVEMBER 3, 2021

The report refers to data collected across 350+ global pharma companies between November 2020 through January 2021, and notes a 70% compound average growth rate in the volume of content managed in Veeva Vault PromoMats since 2018.

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Compounding Pharmaceutical Companies Pharmaceutical Companies Communication 93

pharmaphorum

OCTOBER 31, 2022

. “We are proud to be not just one of the few AI-driven biotech companies to have made it to the clinical stage, but also one of the first to bring forward a novel clinical compound against a novel target, that was entirely discovered and developed internally on our platform,” said Zhang, who acts as Verge’s chief executive.

Compounding 133

Compounding 133

pharmaphorum

JUNE 7, 2022

In a deal signed in 2020, the biotech bought a licence to co-develop and co-market inhibitors of LRRK2 – another target linked to lysosome function – from Denali Therapeutics. It’s not the first time that Biogen has licensed rights to a drug targeting lysosomal function in Parkinson’s disease.

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Compounding 71

pharmaphorum

JANUARY 23, 2023

Morphic said it had received notice that Janssen had decided to pull out of the agreement, which initially focused on two targets but was revised at the end of 2020 to with the additional programme covering “antibody activators for an undisclosed integrin target.” In a filing with the Securities and Exchange Commission (SEC).

Compounding 52

Compounding FDA 52

pharmaphorum

MAY 12, 2022

These small drug compounds destabilise proteins by bringing them into proximity with enzymes called E3 ubiquitin ligases that cause them to be broken down. Compounds that modulate the activity of these enzymes have potential in oncology, for example, in blood cancers like multiple myeloma. billion partnership last week.

Compounding 52

Compounding 52

The Checkup by Singlecare

OCTOBER 26, 2023

Scientific studies have confirmed that thymoquinone, a compound found in black seed oil, is packed with antioxidants , along with antimicrobial, anti-inflammatory, and anti-cancer activity. However, thymoquinone , the active compound in the black cumin seed, has been shown to reduce the growth of certain cancer cells.

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Compounding Dosage Immunization 98

pharmaphorum

FEBRUARY 10, 2022

But the goals of maintaining that momentum and reaping the rewards of 21 st century processes rely on the sector attracting and retaining the staff – a proposition that’s becoming increasingly difficult thanks to a stubborn digital skills gap that is being compounded by the COVID brain drain. Digital skills gap. COVID brain drain.

Compounding 101

Compounding 101

pharmaphorum

JUNE 27, 2022

Tazverik is a first-in-class EZH2a inhibitor that was cleared by the FDA in 2020 as a third-line or later treatment for adults with relapsed or refractory follicular lymphoma (FL) whose tumours have an EZH2 mutation. ” Epizyme’s shares are currently trading at around $0.95, well short of the stock’s 52-week high of $9.86.

Compounding 101

Compounding FDA 101

The People's Pharmacy

MARCH 27, 2023

Drip-filtered, instant and percolator coffee do not ( New England Journal of Medicine , July 23, 2020 ). Compounds from coffee can raise total cholesterol, triglycerides and bad LDL cholesterol ( European Journal of Clinical Nutrition , Aug., This can make an important difference.

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Compounding 63

pharmaphorum

FEBRUARY 2, 2022

ViiV claimed the latter compound infringes its patents for dolutegravir and other compounds based on the drug’s chemical scaffold. Gilead acquired the drug as part of its $21 billion takeover of Immunomedics in 2020. Gilead now expects product sales in 2022 will be between $23.8 billion and $24.3

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Compounding FDA 70

The FDA Law Blog

AUGUST 21, 2023

Attorney’s Office for the Western District of Texas announced that People’s Rx, a local chain operating five retail pharmacies and a compounding laboratory in the Austin area, agreed to pay $200,000 to settle allegations that it violated the Controlled Substances Act (“CSA”). We note that in December 2020, the same U.S. By Larry K.

Controlled Substances 52

Controlled Substances General Merchandise Stores Grocery Stores Compounding 52

European Pharmaceutical Review

SEPTEMBER 25, 2023

NMR relaxation methods distinguish between components (phases or compounds) that have different molecular mobilities For monoclonal antibodies, identification methodologies can employ chromatography, spectroscopy, isoelectric focusing, capillary electrophoresis and peptide mapping techniques. 2020; 10(1). Anal Bioanal Chem.

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Compounding Pharmaceutical Companies Pharmaceutical Companies FDA 96

pharmaphorum

JANUARY 9, 2023

“Stalicla stratifies patient subgroups and identifies compounds that may provide medical benefit in neurodevelopmental indications with clear unmet need,” said its founder and chief executive, Lynn Durham. The market potential of the CUD and NDD indications alone could top 2 billion euros ($2.12 Lynn Durham.

Compounding 57

Compounding 57