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FDA looks at pulling speedy approvals for three cancer drugs

pharmaphorum

On Wednesday (28 April), the focus will shift to Keytruda and Tecentriq as first-line treatments for UC patients unable to be treated with cisplatin-containing chemotherapy – which got the go-ahead in 2017 and 2018, respectively.

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BMS lawsuit claims AZ’s Imjudo infringes Yervoy patents

pharmaphorum

BMS’ lawsuit claims that Imjudo (tremelimumab) infringes two patents covering its own CTLA4 drug Yervoy (ipilimumab), which has been on the market since 2011 and is a key component of combination therapies for cancer with BMS’ PD-1 inhibitor Opdivo (nivolumab).

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EU okays BMS’ azacitidine pill for first-line maintenance of AML

pharmaphorum

The EMA has cleared Onureg (formerly CC-486) as the first-ever orally-active drug that can be used for frontline maintenance treatment of AML who are in remission after initial chemotherapy but are not eligible for potentially curative therapies like a stem cell transplant. months from 14.8 months in a placebo-treated group.

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ESMO 2022: neoadjuvant or adjuvant immunotherapy for locally advanced cancers?

Pharmaceutical Technology

Since the approval of the first ICI – Bristol-Myers Squibb's (BMS) Yervoy (ipilimumab) in 2011 for unresectable metastatic melanoma – multiple checkpoint inhibitors have been approved in this disease setting. month progression-free survival (PFS) benefit over SOC chemotherapy. MSI-H/dMMR CRC accounts for 10-15% of all CRC.

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Is amoxicillin good for a UTI?

The Checkup by Singlecare

Sources Community-acquired urinary tract Infection by Escherichia coli in the era of antibiotic resistance , BioMed Research International (2018) Urinary tract infection , Centers for Disease Control and Prevention (2021) Amoxicillin , StatPearls (2022) Uncomplicated urinary tract infections , StatPearls (2023) Beta-lactam antibiotics , StatPearls (..)

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7 Best DRY MOUTH lozenges for saliva production

Druggist

Treatment, for example, chemotherapy and radiotherapy. Zinc is incorporated in many oral products to control the plaque and possibly to reduce enamel demineralisation and modify remineralisation (Lynch, 2011). 2011 Aug;61 Suppl 3:46-54. One of the most common reasons for dry mouth is dehydration. Published 2019 Jun 29.

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AZ, HutchMed’s savolitinib gets 1st approval in China for NSCLC

pharmaphorum

Savolitinib will be sold as Orpathys for the treatment of NSCLC patients whose tumours have MET exon 14 skipping mutations who have previously had systemic treatment or are unable to receive chemotherapy. Savolitinib was discovered by HutchMed (formerly Hutchison China Meditech) and has been partnered by AZ since 2011.