Thu.Feb 08, 2024

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Opinion: Moving from crisis response to crisis prevention in U.S. mental health systems

STAT

Despite widespread promises of reform after the murder of George Floyd in 2020, in 2023, police killed at least 1,246 people — the most in more than a decade. This police violence is intertwined with a parallel public policy disaster: America’s abysmal mental health systems that force police officers to function as de facto mental health workers.

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Women With High-Risk HPV at Increased Risk of Death From Cardiovascular Disease

Drug Topics

The link between high-risk human papillomavirus infection and atherosclerotic cardiovascular disease mortality was strongest in women with obesity.

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STAT+: More than half the slots on a key vaccine advisory panel are vacant. Where’s HHS?

STAT

A critical government advisory committee charged with charting U.S. vaccination policy appears to be atrophying, jeopardizing timely decision-making on how vaccines should be used in this country. The Advisory Committee on Immunization Practices, which has in recent years been a 15-person panel, has eight vacancies — one of which dates back more than a year.

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Heparanase Inhibitors May Reduce Risk of Diabetic Kidney Disease, Diabetic Retinopathy in Patients with Diabetes

Pharmacy Times

This agent can prevent the depletion of heparan sulphate in the endothelial glycocalyx layer of endothelial cells, ultimately protecting against vision loss and renal failure caused by diabetes.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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STAT+: A junior scientist. A prominent oncologist. Now, a clash at MD Anderson over who gets research credit

STAT

Three years ago, Jamie Lin, an early-career nephrologist at MD Anderson Cancer Center, made findings that could potentially help both save the kidneys of cancer patients and propel her career as a physician-scientist hoping to one day run her own lab. It was a promising start, but that’s when Lin says one of the Texas institute’s most powerful researchers interfered.

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Combination Therapy Reduces Blood Pressure for Those Taking Ibrutinib

Pharmacy Times

Ibrutinib and other Bruton tyrosine kinase inhibitors can cause the development of or worsen pre-existing hypertension.

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More Trending

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Study Finds High Antimicrobial Resistance Against Pneumococcal Diseases, Despite Vaccination

Pharmacy Times

Investigators found high incidences of non-susceptibility with penicillin and increasing resistance to macrolides for pneumococcal diseases.

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Higher naloxone doses have no impact on overdose survival, study shows

STAT

People receiving a double dose of naloxone are no more likely to survive an opioid overdose than people receiving a standard, 4-milligram nasal spray, according to a new study. The new paper , published Thursday in the Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report, showed no significant difference in survival rates between people who were revived using 4- and 8-milligram sprays of naloxone, commonly known by the brand name Narcan.

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Inside the NCVR evolution in the UK

pharmaphorum

Explore the commercial research landscape in the UK and the evolution of the National Institute for Health Research (NIHR) through an informative webinar.

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STAT+: Senate Democrats push for stronger rules around AI in Medicare Advantage

STAT

Senate Democrats on Thursday said Medicare should take more urgent and aggressive action to prevent health insurance companies from using artificial intelligence to unlawfully deny medical services. The Biden administration’s latest efforts to increase transparency into AI tools don’t go far enough to protect patients, the lawmakers said at a Senate Finance Committee hearing.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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PBMs take bulk of blame as senators question BMS, J&J and Merck CEOs on high drug prices in US

Fierce Pharma

Thursday, when senators questioned three Big Pharma CEOs about the high price of drugs in the U.S., Health, Education, Labor and Pensions (HELP) committee chairman Bernie Sanders, I-Vermont, put th | CEOs from Bristol Myers Squibb, Johnson & Johnson and Merck faced tough questions from senators on why prices for drugs in the U.S. exceed those in other countries.

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Could testosterone be a useful treatment for menopause?

STAT

The world may be getting over the idea that men are from Mars and women from Venus , but public perception still holds that testosterone is the male hormone , and estrogen, the female. That can make the following fact a little puzzling: There is more testosterone than estrogen in a premenopausal woman’s body. Testosterone levels decrease with time and reach especially low values after menopause, which can lead to loss of bone density, lower energy, and depression.

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Oscar Health execs weigh in on future of ACA subsidies, signal 2024 profitability

Fierce Healthcare

Enrollment in individual market plans continues to grow, with a record high of 21.3 million people signing up for plans during the most recent open enrollment period. | CEO Mark Bertolini told investors that Oscar “closed out 2023 with another strong quarter, driving financial performance for the full year.

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STAT+: As Medicare drug pricing negotiations begin, AstraZeneca stays mum on government’s offer

STAT

LONDON — Medicare’s first-ever drug pricing negotiations are officially underway. But neither government officials nor drugmakers are wanting to show their cards, at least publicly. Last week, Medicare made its first offers to the makers of the 10 products subject to negotiation, though it said it would be up to the companies to discuss the proposals.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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Gilead drops CD47 drug magrolimab for blood cancers

pharmaphorum

Gilead Sciences has said it will no longer develop its CD47-targeting antibody magrolimab in blood cancers after data suggested that patients taking the drug in clinical trials were more likely to die than those in control groups.

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STAT+: A looming cancer vaccine test for Gritstone Bio, and pushback about Novartis-MorphoSys

STAT

This week, I address pushback I received on my Novartis-MorphoSys column. But first, a preview of the expected readout from Gritstone Bio’s neoantigen cancer vaccine study. A looming test for neoantigen cancer vaccines Before the end of the quarter, Gritstone Bio will release preliminary results from a randomized, Phase 2 clinical trial investigating a personalized therapeutic cancer vaccine in microsatellite-stable colon cancer, a type of “immunologically cold” tumor that i

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Immune-Related Mechanisms Associated with Functional Connectivity in Patients With Anxious Depression

Pharmacy Times

The study authors noted that further research with larger populations should be conducted to boost the reliability and generalizability of the results.

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In a showy hearing, Bernie Sanders gets few answers about lower drug prices

STAT

WASHINGTON — Call it Sen. Bernie Sanders’ prescription drug pricing theater. The hearing, featuring Merck CEO Robert Davis, Johnson and Johnson CEO Joaquin Duato, and Bristol Myers Squibb CEO Chris Boerner, was designed to draw public interest, and in that respect, it worked. The wood-paneled hearing room in a Senate office building was standing room only, with an overflow room prepared.

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This week in clinical trials: 22nd to 26th January 2024

pharmaphorum

Stay up to date with the latest updates in the world of clinical trials. This week's highlights include Bayer's new study on aflibercept, BioNTech's groundbreaking research, and the exciting developments from Duality Bio. Get all the important information here.

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Listen: AI in medicine, detangling hype, and Icelandic DNA

STAT

Has AI really solved biology? What can machines teach us about medicine? And what’s a digital twin? We cover all that and more this week on “The Readout LOUD,” STAT’s biotech podcast. It’s our all-AI episode. First, STAT’s Casey Ross joins us to explain his reporting on how researchers and pharmaceutical firms are using the technology to find new drug targets, design therapies, and improve clinical trials.

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The hospital pharmacy landscape in 2024

Hospital Pharmacy Europe

Tiene Bauters, PharmD PhD, Pharmacy Department , Ghent University Hospital in Belgium, offers her take on what’s hot on the horizon for hospital pharmacy in 2024. We have just stepped into a new year, and it is already clear that the pharmacy landscape is set to experience significant innovations and challenges over the coming weeks and months. These will undoubtedly present great opportunities for hospital pharmacists and their teams.

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STAT+: Key House Republican on health care plans exit from Congress

STAT

WASHINGTON — Rep. Cathy McMorris Rodgers, the chair of a crucial House committee that handles health care issues, plans to leave Congress at the end of the year, she announced Thursday. It will be a major shakeup for a panel already ravaged by Republican retirements. Reps. Michael Burgess (R-Texas), Larry Bucshon (R-Ind.), Jeff Duncan (R-S.C.), Debbie Lesko (R-Ariz.), Greg Pence (R-Ind.) and Kelly Armstrong (R-N.D.) are all leaving at the end of this Congress, too.

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Roche gets first world okay for PNH drug crovalimab

pharmaphorum

China has become the first country in the world to approve Roche’s anti-complement C5 antibody crovalimab, the only treatment for the rare disorder paroxysmal nocturnal haemoglobinuria (PNH) that can be given by subcutaneous injection.

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STAT+: Lasers, cardiology, clinical trials: 2023’s top private equity targets

STAT

By some measures, private equity investment lagged in 2023, a year marked by growing distress and high-profile downfalls among private equity-backed health care companies. Even so, three sectors still managed to see strong deal flow and prices: med spa, cardiology, and clinical trial sites, according to a new PitchBook report analyzing private equity investments in health care services in 2023.

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AstraZeneca hit CEO Pascal Soriot's $45B revenue goal after all. But is Enhertu approaching a plateau?

Fierce Pharma

With $45.8 billion in 2023 revenues, AstraZeneca has met the $45 billion-by-2023 goal CEO Pascal Soriot established in 2014 when he was fending off a takeover bid from Pfizer. | AstraZeneca has met the $45 billion-by-2023 revenue goal that CEO Pascal Soriot established in 2014. But questions have emerged for one of the company's key growth drivers.

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American Academy of Dermatology survey notes lack of sun protection during winter

Drug Store News

One in five adults are unaware of the possibility of being sunburnt during the winter months, according to a new study by the American Academy of Dermatology.

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New pharma CEOs in the hot seat

STAT

You’re reading the web edition of D.C. Diagnosis, STAT’s twice-weekly newsletter about the politics and policy of health and medicine.  Sign up here  to receive it in your inbox on Tuesdays and Thursdays. A road test for fresh pharma CEOs A lot can change in five years — including the leadership of the three major pharmaceutical companies that will be testifying before Sen.

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Astellas adds digital to its top management team

pharmaphorum

Astellas appoints Nick Eshkenazi as chief digital and transformation officer (CTDO), the first time the pharma has included a digital role in its top management team

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Gilead sours on the ‘don’t eat me’ business

STAT

Want to stay on top of the science and politics driving biotech today?  Sign up  to get our biotech newsletter in your inbox. Good morning, everyone. Damian here with the latest Senate harangue for the drug industry, green shoots in biotech sentiment, and the potential of a gene therapy eye drop.

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BioNTech adds CAR-T manufacturing with $250m Autolus deal

pharmaphorum

BioNTech has taken a $200 million stake in Autolus in a private placement that will allow it to tap into the UK company’s manufacturing capacity for CAR-T therapies

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OmniSYS, XiFin webinar focuses on how to take your pharmacy to the next level

Drug Store News

The webinar highlighted how you can transform your pharmacy into a higher performing business that improves patient health and generates more revenue.

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Charac's funding from Traditum to help pharmacies digitalize in preparation for government's new edict

Outsourcing Pharma

With independent pharmacies now facing significant challenges, healthcare SaaS provider Charac was pleased to announce more investment so it can accelerate a digitization drive.

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FDA: PDUFA Date Assigned for Arexvy as RSV Prevention in Age 50 to 59

Drug Topics

June 7, 2024 is the target PDUFA date for the additional indication of GSK's respiratory syncytial virus vaccine Arexvy.

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Movers and shakers: New appointments in pharma industry - Transgene, CN Bio and more

Outsourcing Pharma

Outsourcing Pharma and BioPharma Reporter breaks down the key people on the move in the pharma industry. Enhanc3D Genomics, Cytomos and Cellular Origins are among the companies welcoming new faces to top jobs.

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