Tue.Apr 01, 2025

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How long does olanzapine take to work for anxiety?

The Checkup by Singlecare

Olanzapine (brand names Zyprexa or Zyprexa Zydis) is a second-generation antipsychotic medication that’s FDA approved to treat mental health conditions like schizophrenia and bipolar disorder, including mixed or manic episodes. It’s also approved for treatment-resistant depression or depression with bipolar I disorder in combination with fluoxetine.

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HHS starts layoffs of thousands of workers across its agencies

STAT

Layoff notices began arriving early Tuesday for thousands of employees of the sprawling Department of Health and Human Services and its subsidiary agencies, with as many 10,000 workers potentially expected to be hit by the cuts. “I regret to inform you that you have been affected by a reduction in force (RIF) action,” an email to affected employees said.

FDA
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AI toolkit for pharmacy practice launched by FIP

Hospital Pharmacy Europe

A new toolkit to support pharmacists when integrating artificial intelligence (AI) into daily practice has been launched by the International Pharmaceutical Federation (FIP). The toolkit for hospital, industry and community settings offers structured guidance on AI adoption. It covers ethical considerations, implementation strategies, regulatory compliance and real-world applications to help pharmacists optimise patient care, stimulate multidisciplinary interaction and enhance operational effici

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Potential impact of Pharma Tariffs on Marketing

Pharma Marketing Network

Introduction How might your pharmaceutical marketing strategy change if your core products suddenly became more expensive to import or export? Pharma tariffs have quickly emerged as a critical consideration for pharma marketing executives, reshaping how brands strategize, position, and market their products globally. As the landscape evolves, marketers need clarity on navigating this complex terrain effectively.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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STAT+: FDA Commissioner Marty Makary gets off to a bruising start as agency is wracked by layoffs

STAT

WASHINGTON — Marty Makary’s first official day as commissioner of the Food and Drug Administration began with employees in tears, learning from security guards that they were losing their jobs. The news release announcing the start of his tenure points readers to a press office that, after large-scale layoffs, basically no longer exists.

FDA
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More Uncertainty and Less Advice from FDA Means Companies will Need to Even More Carefully Chart their own Course to Achieve their Goals

The FDA Law Blog

By Dr. Naomi Lowy, Principal Drug Regulatory Expert Trade and national press have reported that recent changes in FDA staffing levels have already led to slower responses to calls and emails. According to reports, which were published before the most recent reports of HHS staff level reductions and tumultuous changes in leadership, FDA staff were missing minor deadlines.

FDA

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Victor Alves Presenting at ASCA 2025 Conference & Expo in Denver

OctariusRx

OctariusRx President and Consultant Pharmacist Victor Alves is presenting Pharmacy Documentation: Tips for Patient Safety and Survey Success at the ASCA 2025 Conference & Expo, April 30May 3, in Denver Colorado. He will discuss the essential elements of patient safety through complete pharmacy documentation. Additionally, he will address the most common survey issues and provide practical tips for improving patient safety and survey success.

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Trump administration sued over decision to rescind billions in health funding

STAT

A coalition of state attorneys general sued the Trump administration on Tuesday over its decision to  cut $11 billion in federal funds that go toward Covid-19  initiatives and  various public health projects  across the country. Attorneys general from 23 states filed the suit  in federal court in Rhode Island. They include New York Attorney General Letitia James, Colorado Attorney General Phil Weiser, Kentucky Gov.

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Innovative framework could enhance process efficiency in manufacturing quality control

European Pharmaceutical Review

Researchers have demonstrated a novel framework that supports the advancement of quality control in manufacturing. Current quality control strategies are often inefficient for large process uncertainties, as they often do not provide the flexibility necessary, due to a reliance on set-point control, Kay et al. explained. This therefore raises a clear need for more advanced and robust optimal control strategies to maintain product quality.

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Opinion: Former CDC Director Tom Frieden: Cuts to the agency will cost American lives and dollars

STAT

The CDC cuts announced Tuesday threaten America’s health, safety, and economy. Despite claims of efficiency, these cuts target proven programs that prevent disease and save lives — and as a result, Americans will be sicker and face increased health care costs. The government’s goal should not be to hit an arbitrary number of jobs eliminated, but to focus on the number of illnesses and premature deaths prevented.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Rybelsus found to reduce major adverse cardiovascular events in Novo Nordisk trial

Pharmafile

Novo Nordisk announced results from its SOUL cardiovascular outcomes trial. Rybelsus (oral semaglutide) significantly reduced the risk of major adverse cardiovascular events (MACE) in adults with type 2 diabetes and cardiovascular disease (CVD) and/or chronic kidney disease (CKD). The new phase 3b data was presented at the American College of Cardiologys (ACC) Annual Scientific Session […] The post Rybelsus found to reduce major adverse cardiovascular events in Novo Nordisk trial appeared

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Opinion: Reduce drug spending by drastically simplifying monopolies on drugs

STAT

In 2024, total U.S. spending on prescription drugs was almost $800 billion. Although low-cost generic drugs filled 91% of all prescriptions, the 9% of prescriptions filled with a branded medicine accounted for 84% of drug spending. The monopolies on new drugs last so long, launch prices are so high, and price increases are so steep that they more than wipe out the savings Congress hoped to achieve by encouraging robust generic competition.

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Corcept’s relacorilant trial in patients with platinum-resistant ovarian cancer meets primary endpoint

Pharmafile

Corcept Therapeutics announced that relacorilant plus nab-paclitaxel met its primary endpoint of improved progression-free survival in ROSELLA, the companys phase 3 trial of the therapy. The ROSELLA trial enrolled 381 patients with platinum-resistant ovarian cancer across sites internationally. Patients were randomised 1:1 to receive either relacorilant plus nab-paclitaxel or nab-paclitaxel alone.

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Prosecutors directed to seek death penalty against UnitedHealthcare killing suspect Luigi Mangione

STAT

NEW YORK — U.S. Attorney General Pam Bondi said Tuesday she has directed federal prosecutors to seek the death penalty against Luigi Mangione, the man accused of gunning down  UnitedHealthcare CEO  Brian Thompson outside a New York City hotel on Dec. 4. Mangione, 26, faces separate federal and state murder charges for the killing, which rattled the business community while also galvanizing health insurance critics.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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Secarna Pharmaceuticals to announce positive new data at cancer research conference

Pharmafile

Secarna Pharmaceuticals will present new preclinical data with its lead programme SECN-15 at the American Association for Cancer Research (AACR) taking place 25 to 30 April 2025 in Chicago, Illinois, US. Data will showcase SECN-15s potential to significantly improve the efficacy of immune checkpoint inhibitors (ICIs). Secarna is a biopharma company which develops and redefines […] The post Secarna Pharmaceuticals to announce positive new data at cancer research conference appeared first on

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At CDC, Trump administration’s job cuts wipe out wide array of specialists

STAT

Workers across the Centers for Disease Control and Prevention were summarily fired on Tuesday, triggering what will be an unprecedented and chaotic withdrawal of the agency from many areas of disease prevention on which it has long worked. In all, the CDC is expected to lose roughly 2,400 employees, or about 18% of its staff, as part of the broader cuts playing out across the Department of Health and Human Services.

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COVID-19 Five Years Later

Drug Topics

Community pharmacies have a clear role in public health, as they manage ongoing services and take on a more significant role as immunizers.

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STAT+: Trump’s proposed tariffs may cause shortages of Canadian-made drugs in the U.S., analysis finds

STAT

The tariffs being proposed by the Trump administration on pharmaceuticals may cause shortages and raise prices for numerous medicines that are made in Canada and sold in the U.S., a new analysis suggested. An estimated $3 billion in pharmaceuticals sold in the U.S. each year are produced, at least in part, in Canadian manufacturing facilities, and if President Trump proceeds with reported plans to impose 25% tariffs, this would lead to another $750 million in costs for Americans, according to th

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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Mailing Campaign Feasible, Effective in Improving Pneumococcal Vaccine Rates

Drug Topics

Researchers explored the efficacy of a targeted mailing campaign for improving pneumococcal vaccination coverage among adults 65 and over.

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Medical record fallout from Trump’s executive orders

STAT

Y ou’re reading the web edition of STAT’s Health Tech newsletter, our guide to how technology is transforming the life sciences.  Sign up to get it  delivered in your inbox every Tuesday and Thursday. In March, an office at the federal health department announced it would not enforce requirements that electronic health records have fields to record and exchange patients’ sexual orientation and gender identity.

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Procedure Helps Prevent Weight Regain After Discontinuation of GLP-1 Medication

Drug Topics

The outpatient endoscopic procedure modifies duodenal dysfunction and restores metabolic health.

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STAT+: ‘We are all terrified’: Mass General Brigham to lose millions in medical research grants under Trump cuts

STAT

This story originally appeared in STAT’s sister publication, The Boston Globe. The deepening  Trump administration budget cuts  have hit Mass General Brigham, the nation’s largest hospital recipient of research grants, and other Massachusetts universities and hospitals, canceling tens of millions in funding and shutting down medical research programs in areas such as primary care, reproductive health, and pandemic preparedness.

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Dispensing Leadership: Philosophies for Teamwork

Drug Topics

In this episode of the podcast, Shawn and Jesse outline 3 key principles about teamwork that can drive success in the pharmacy.

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Study: Vitamin B12 Levels Within "Normal" Range Linked to Cognitive Decline in Older Adults

Pharmacy Times

Current recommended levels of vitamin B12 might not be sufficient to protect against neurological decline.

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FDA Approves Freeze-Dried Formulation of Smallpox, Mpox Vaccine

Drug Topics

The approval expands the flexibility of storing the vaccine to protect against smallpox events or mpox outbreaks.

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With government health info in limbo, drugmakers lose credible sources

PharmaVoice

The lack of clear communication from the government could spark wide-ranging issues in pharma — from sowing confusion about clinical trial design to further eroding public trust.

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Why Different Prescription Drugs Require Targeted Advertising

Drug Topics

Jenny Markell, BA, joined us to discuss the nuances of drug promotion in the US and how specific medications are targeted to various patient populations.

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Former Pfizer CSO Mikael Dolsten on writing his next chapter, embracing AI and asking the ‘big questions’

PharmaVoice

Dr. Mikael Dolsten, Pfizer’s former chief scientific officer, is embarking on a journey of curiosity and interconnectedness in his post-Big Pharma career.

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Q&A: Pharmacists Can Overcome Vaccine Hesitancy Through Trust and Communication | APhA 2025

Drug Topics

In an era of persistent medical misinformation, addressing vaccine hesitancy has become a critical challenge for health care professionals.

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As the Measles Outbreak Continues to Spread, Texas Hospitals Report Cases of Vitamin A Toxicity

Pharmacy Times

The CDC reports 483 total cases across 20 states as of March 28, 2025.

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RIF job losses are underway at HHS agencies; reports

pharmaphorum

Reduction in force (RIF) job losses have started in earnest at US federal agencies, including the FDA and CDC, according to media reports

FDA
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Intravenous Immunoglobulin Plus Rituximab Effective Alternative Option for Refractory Autoimmune Disease Treatment

Pharmacy Times

Given rituximabs tendency to cause infections in patients being treated for autoimmune diseases, the addition of intravenous immunoglobulin works to reduce that risk and induce clinical improvements.

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EVERSANA joins with Veeva in push to 'pharmatise AI'

pharmaphorum

EVERSANA has joined the growing roster of companies partnering with Veeva on the development of GenAI applications for the life sciences industry