Wed.Jun 05, 2024

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Researchers Find Shared Multiomic Molecular Dysregulations in Brains With PTSD and MDD

Pharmacy Times

The investigators are optimistic that the data can establish stress-related pathways while revealing potential therapeutic options for patients with major depressive disorder and post-traumatic stress disorder.

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Finland to offer bird flu vaccine to select groups of people, a possible global first

STAT

LONDON — Finland is preparing to offer vaccines to people at risk of exposure to an avian influenza strain spreading among farmed and wild animals, health officials there said, potentially becoming the first country to take such a step as concerns about the threat the virus poses to people intensify. The vaccine campaign will be limited, with doses set to be available to groups including poultry farmers, veterinarians, scientists who study the virus, and people who work on fur farms housi

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Study: Tezepelumab Reduces Annual Rates of Exacerbations Related to COPD

Pharmacy Times

For patients with a blood eosinophil count of 150 cells/µL or greater, tezepelumab had a significant reduction of approximately 37% in the rate of moderate or severe exacerbations.

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Opinion: 100,000 models show that not much was learned about stopping the Covid-19 pandemic

STAT

In the midst of the Covid-19 pandemic, scientists and public health institutions made bold claims about the effectiveness of various policy responses such as closing schools and banning public gatherings. These claims shaped government responses and had enormous effects on the lives of billions of people around the world. Are those claims supported by data?

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Increased Social Vulnerability Accounted for Decrease in Diabetes Control

Drug Topics

In an abstract presented at the Endocrine Society’s ENDO 2024 annual meeting in Boston, Massachusetts, researchers addressed the association between social vulnerability and glycemic control in patients with diabetes.

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These are the bird flu questions that influenza and animal scientists desperately want answered

STAT

Ten weeks after government scientists discovered that H5N1 bird flu was sickening dairy cattle in the United States, many of the mysteries surrounding what is happening on affected farms remain just that. Widespread reluctance on the part of farmers to allow scientists — government or otherwise — onto their premises to study spread of the virus among infected cows has created a frustrating lack of understanding of the dynamics of this outbreak.

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STAT+: Student group that ranked med schools over industry conflicts votes to accept pharma funding

STAT

An organization devoted to educating future doctors about conflicts of interest will now accept industry funding due to financial stress, prompting outrage from former members who argue the decision will undermine its mission. In a little-noticed move, the American Medical Student Association board recently approved an emergency resolution to accept money from drug and device makers, as well as health insurers, so long as funding does not exceed 25% of its operating budget.

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Examining Excessive Weight Gain, Impact of High Insulin Levels in Breast Cancer

Drug Topics

Posters presented at ENDO 2024 investigated excessive weight gain in breast cancer survivors and how high insulin levels impact outcomes for Black women with an aggressive form of the disease.

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STAT+: Gilead to pay $40 million to settle claims it delayed newer HIV treatment to boost profits

STAT

Gilead Sciences agreed in principle to pay $40 million to more than 2,600 AIDS patients who claimed the company boosted profits by marketing an HIV drug without disclosing harmful side effects while delaying development of a safer alternative treatment. The agreement caps a dispute that cast a harsh spotlight on a strategy that Gilead allegedly used to maximize revenues and extend the lifespan of a best-selling product, but at the expense of patients.

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Bristol Myers puts more than 860 jobs on chopping block in NJ as $1.5B savings campaign rolls ahead

Fierce Pharma

The scope of Bristol Myers Squibb’s $1.5 billion savings drive is beginning to come into focus. | Starting this month, BMS will begin the process of laying off around 863 employees in Lawrenceville, New Jersey, according to a Worker Adjustment and Retraining Notification (WARN) alert from the state. The move forms part of BMS’ campaign to shave off $1.5 billion in costs by the end of 2025, a company spokesperson said over email.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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STAT+: Eli Lilly’s obesity drug Zepbound improved liver scarring in mid-stage MASH study

STAT

Eli Lilly’s blockbuster diabetes and obesity drug improved living scarring in a mid-stage study of the liver disease MASH, adding to positive data announced earlier this year. The study tested three doses of tirzepatide, sold commercially as Mounjaro or Zepbound. The percentage of patients who experienced a greater than one-stage improvement in scarring, or fibrosis, without worsening of their disease was ​​54.9%, 51.3%, and 51.0% from the lowest to highest doses.

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Coverage pathways for psychedelic therapies

Fierce Healthcare

This week on "Podnosis," we explore therapeutic psychedelics. | This week on "Podnosis," we explore therapeutic psychedelics. Noah Tong from Fierce Healthcare sat down with Kim Chew, Senior Counsel at Husch Blackwell, to discuss the accessibility challenges in this promising but complex space.

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First rare disease therapies chosen for FDA START programme

pharmaphorum

An initiative set up by the FDA to accelerate the development of therapies for rare disease in the same way that Operation Warp Speed delivered COVID-19 vaccine has chosen its first pilot programme candidates.

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Withdrawal symptoms hit one in six patients stopping antidepressants, review finds

STAT

The moment when a person stops taking their antidepressant is fraught. Not only can patients see their psychiatric symptoms return, but they can experience a wide variety of new symptoms in the days and weeks immediately following the medication change. Symptoms like nausea and headache can be manageable, and typically begin and end within days of ending the medication.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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Judge denies FTC's preliminary bid to block Novant, CHS' $320M hospital deal

Fierce Healthcare

Novant Health and Community Health Systems (CHS) will be permitted to consummate their contested $320 million hospital deal, though the pair still face some regulatory uncertainty following the dea | U.S. District Judge Kenneth Bell wrote that the two-hospital transaction has "at least as much likelihood of competitive benefits as it does competitive harm.

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Poor Cardiovascular Health in Women Linked to Cognitive Decline in Midlife

Pharmacy Times

Data show women with poor cardiovascular health may have an increased risk of early signs of cognitive decline in midlife.

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Appeals court revives $411M antitrust class action against Sutter Health

Fierce Healthcare

An appellate court panel has resuscitated a nine-figure antitrust class-action lawsuit against Sutter Health, ruling Tuesday that a 2022 jury was given improper instructions and that a new trial mu | The decadelong case had been unanimously ruled in the nonprofit system's favor back in 2022. A 2-1 panel has now reversed the judgment and remanded for a new trial.

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ASCO: KRAS upstarts set their sights on NSCLC market

pharmaphorum

KRAS inhibitors from Eli Lilly, Genfleet, and InxMed make their case for use in NSCLC at ASCO, as they case down Amgen and Bristol-Myers Squibb's market drugs

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Regenerative cell therapy biotech uses IPO to blast into human trials

PharmaVoice

Bucking conventional fundraising, FibroBiologics’ CEO Pete O’Heeron explains why the biotech company bet on themselves in the public market.

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Gilead, Ipsen build the case for their PBC drugs at EASL

pharmaphorum

Gilead Sciences is just a few weeks away from an FDA decision on seladelpar for rare liver disease primary biliary cholangitis (PBC) and will be buoyed by new data pointing to its long-term efficacy and safety.

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When is the best time to take milk thistle?

The Checkup by Singlecare

Milk thistle ( Silybum marianum ) is a tall plant with purple flowers that belongs to the daisy family. Originally native to Europe, milk thistle can now be found all over the world. The plant’s main active ingredient, an antioxidant called silymarin , is responsible for many of the health benefits of milk thistle. Because of this, milk thistle and silymarin are often used interchangeably to refer to the same plant.

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Discover how Phastar is making a vast contribution the life sciences community at DIA 2024

Outsourcing Pharma

At the DIA 2024 Global Annual Meeting, Phastar iwill be proud to join a diverse group of stakeholders from industry, regulatory bodies, academia, and patient communities.

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Study: Prevalence of Diabetes Expected to Increase by 59.7% in 2025

Pharmacy Times

Body mass index is the main driver of type 2 diabetes globally, accounting for 52.2% of disability-adjusted life years.

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STAT+: As Washington mulls new AI rules, startup leaders want a seat at the table

STAT

WASHINGTON — In San Francisco, Y Combinator’s firebrand chief executive Garry Tan is one of the startup economy’s most recognizable figures. Well before he became the leader of the coveted startup accelerator that bred global brands like Airbnb, Stripe and OpenAI, Tan was a self-made founder who sold his own company to Twitter. But here in the nation’s political capital, Tan is far less known.

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Cyberattack disrupts patient care at London hospitals

pharmaphorum

NHS hospitals in London have declared a critical incident caused by a ransomware attack on a pathology services provider, leading to cancelled procedures and patients having to be transferred to different care providers. The attack on Synnovis has had an impact on patient care at Guy’s and St Thomas’ and King’s College Hospital NHS Foundation Trusts, as well as GP services in southeast London, according to an NHS England statement.

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Don't miss out: Qinesca's creative innovations revealed at DIA

Outsourcing Pharma

As the anticipation for the 60th DIA annual meeting reaches a fever pitch, eyes should be on Qinesca, the latest breakthrough in clinical research technology.

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STAT+: FTC loses its bid to block Novant’s hospital merger in North Carolina

STAT

A federal judge ordered Wednesday that Novant Health can move forward with its plan to buy two North Carolina hospitals, denying the Federal Trade Commission’s request for an injunction. The FTC sued to block the deal in January, arguing that it would give Novant control of more than 65% of the region’s inpatient market. The case, one seeking to block nearby hospitals from merging and creating an even more powerful dominant player, is the FTC’s bread and butter.

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AI at DIA 2024: GiftHealth unveils game-changing patient support innovations

Outsourcing Pharma

Get ready for a big reveal at the DIA conference in San Diego as GiftHealth introduces its latest AI-enabled features designed to revolutionize patient care.

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STAT+: Appeals court overturns Sutter Health’s victory in $400 million antitrust case

STAT

When Sutter Health was on trial for anticompetitive conduct in 2022, the San Francisco jury missed out on some crucial details. They didn’t hear, for example, how its former finance chief said the system would make an extra $200 million per year by making insurers contract with all of its hospitals instead of just a few. Or how its former CEO said, “Related to the health plans, we force them to pay us more.

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Secrets to trial success: CluePoints reveals how its tech is transforming research

Outsourcing Pharma

As the DIA conference in San Diego approaches, Outsourcing Pharma secured an exclusive preview with FranÃois Torche, chief product & technology officer and co-founder of CluePoints

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Migraine and Headache Awareness Month: Resources Roundup

Drug Topics

Check out this list of resources to share with patients who are managing a migraine or other headache diagnosis.

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Stella Vnook on founding biotech companies and solid advice for women entering the field

Outsourcing Pharma

Stella Vnook has founded several biotech companies, including Oral BioLife, a biotechnology firm specializing in pioneering therapies for dental diseases.

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PHTI backs virtual therapies for musculoskeletal disorders

pharmaphorum

PHTI's latest report finds that digital therapies for musculoskeletal conditions like low back pain can deliver clinically meaningful benefits

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From one juggernaut to another: Lilly CFO Anat Ashkenazi takes same role at tech giant Alphabet

Fierce Pharma

After 23 years at Eli Lilly, including the last three as its CFO, Anat Ashkenazi is leaving to take the same role at Google's parent company Alphabet.

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