Diphenhydramine interactions to avoid
The Checkup by Singlecare
NOVEMBER 14, 2023
Diphenhydramine and other CNS drugs Diphenhydramine can have a compounding effect when used with other drugs that have activity within the central nervous system. Antidepressants and anxiety medications can cause some level of CNS depression, and this effect can be compounded with diphenhydramine.
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