Biosplice’s bid to transform the treatment of everything from arthritis to cancer ran into a snag this week, with the San Diego biotech announcing that its experimental osteoarthritis drug failed to benefit patients in a pair of Phase 3 clinical trials.
The results, presented at the American College of Rheumatology conference in Philadelphia, show that the small-molecule drug lorecivivint failed to significantly soothe the pain of osteoarthritis patients. Both trials were randomized, placebo-controlled studies conducted across multiple medical research centers — the gold standard of scientific evidence.
The company is already preparing to launch a new Phase 3 trial, convinced that treating patients with milder disease will prove more effective. Biosplice made those plans after meeting with the Food and Drug Administration during the third quarter of this year.
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