Allogene to pursue new strategy for development of off-the-shelf cell therapy in blood cancer

Allogene Therapeutics is making unexpected changes to development plans for its off-the-shelf cell therapy for a type of blood cancer — a concession that competition from personalized CAR-T treatments, already entrenched in the market, has become more challenging.

In a strategic pivot, two clinical trials involving patients with later-stage lymphoma are being shut down. The studies, open for more than a year, were intended to collect data and support the approval of Allogene’s therapy, called ALLO-501A.

Instead, Allogene plans to conduct an entirely new study of ALLO-501A in patients with newly diagnosed lymphoma at higher risk of relapse.

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