Sat.Jan 28, 2023 - Fri.Feb 03, 2023

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Novartis announces cut to multiple drug research programmes in 2022 full-year report

Pharmafile

Novartis, a Swiss pharmaceutical company, has announced in its 2022 full-year report that it is cutting several of their programmes, including their Huntington’s disease trial.

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Novo's Rybelsus comes into its own as Wegovy shakes off supply constraints

Fierce Pharma

Novo's Rybelsus comes into its own as Wegovy shakes off supply constraints fkansteiner Thu, 02/02/2023 - 08:57

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Trending Sources

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Racial Discrepancies Among US Residential Areas Might Have Implications for Health Effects

Drug Topics

Geographical data could potentially yield insight on racial and ethnic health disparities in the United States. An analysis of the large dataset could help identify any potential causes for observed inequities.

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Recognizing National Glaucoma Awareness Month

PhRMA

January was National Glaucoma Awareness Month and provided us an opportunity to spread the word and honor the millions of patients around the world who are impacted by this debilitating disease. Glaucoma refers to a group of eye diseases that can cause vision loss or blindness due to damage of the optic nerve. It is one of the leading causes of irreversible blindness in the United States.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Opinion: Disruptive science is leaping forward, not limping along

STAT

A recent study and accompanying news story in the preeminent journal Nature provocatively concludes that disruptive innovation in science has dramatically and mysteriously declined 90% since 1945. The study has prompted a wave of news coverage and tweets decrying the apparent languishing of modern science. We feel that the authors make interesting observations on publishing trends, but their conclusions seem to be quite disconnected from the valuable and transformative innovations that benefit h

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J&J's pharma group quietly works through global overhaul, with layoffs expected to reach multiple countries

Fierce Pharma

J&J's pharma group quietly works through global overhaul, with layoffs expected to reach multiple countries mbayer Fri, 02/03/2023 - 09:29

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U.S. must address IP and market access barriers abroad to protect American innovation

PhRMA

PhRMA recently submitted comments to the Office of the U.S. Trade Representative (USTR)’s 2023 Special 301 Report. The comments highlight foreign government actions and policies that undermine American innovation, biopharmaceutical leadership and more than 4.4 million American jobs.

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STAT+: Medicare Advantage insurers to repay billions under final federal audit rule

STAT

The federal government will audit Medicare Advantage insurers aggressively under a rule finalized Monday, which is expected to result in billions of dollars in overpayments going back toward Medicare’s trust fund and patients over the next decade. However, federal officials watered down one of the auditing policies by giving insurers seven years of immunity from having the samples of their diagnosis coding errors extrapolated to their broader Medicare Advantage membership.

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HIV vaccines suffer setbacks but new approaches could turn the tide

Pharmaceutical Technology

Only a few weeks into the new year, the prospect of getting a successful advanced HIV vaccine shrank after the discontinuation of yet another late-stage trial. On January 18, Janssen, a Johnson & Johnson (J&J) subsidiary, stated that its vaccine was not effective in preventing HIV infections. This marks the second time one of Janssen’s HIV vaccines failed after another showed disappointing results in the Phase IIb Imbokodo trial in August 2021.

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States Move to Ban Accumulators

Drug Topics

Sixteen states have banned a pharmacy benefit management practice that involves not counting the value of drug copay assistance from manufacturers toward patient deductibles.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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Minnesota lawmakers are letting PBMs off the hook, and threatening patients’ access to medicines

PhRMA

Middlemen don’t want patients to know how they are stacking the deck against them.

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These blood-clot catching devices have been controversial for years. Why are doctors still relying on them?

STAT

Inferior vena cava filters are supposed to save lives. The spider-like devices catch blood clots before they can travel up to the lung and cause deadly pulmonary embolisms. But for over a decade, these devices have been dogged by questions about how well they work and the serious complications they can cause for patients. The latest data make clear they’re still causing problems: Researchers examined a Food and Drug Administration database and found that adverse event reports related to t

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8 supplements that can lower cholesterol

The Checkup by Singlecare

High cholesterol is a known risk factor for cardiovascular diseases. It contributes to the formation of fatty deposits in your blood vessels—which is linked to many problems such as coronary artery disease, stroke, aortic aneurysm (a balloon-like bulge in your major blood vessel), heart attack, and even death. A growing body of research has shown that some dietary supplements may play a role in lowering cholesterol levels; however, the evidence is far from conclusive.

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FDA Approves Orserdu for Metastatic Breast Cancer

Drug Topics

Elacestrant, now with the brand name Orserdu, is an oral selective estrogen receptor degrader (SERD), which works by blocking the effects of estrogen on hormone receptor-positive breast cancer cells.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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US FDA approves GSK’s Jesduvroq to treat anaemia of CKD

Pharmaceutical Technology

The US Food and Drug Administration (FDA) has approved GlaxoSmithKline ’s (GSK) Jesduvroq (daprodustat) to treat anaemia caused by chronic kidney disease (CKD) in adults who have been on dialysis for at least four months. Jesduvroq is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI). It is claimed to be the only HIF-PHI approved in the country that offers a new oral treatment option for adult patients on dialysis with anaemia of CKD.

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Survey: A majority of Americans support banning all tobacco products

STAT

WASHINGTON — A majority of Americans support banning all tobacco products, according to a new poll published by researchers at the Centers for Disease Control and Prevention. The survey , which was published Thursday in the peer-reviewed journal Preventing Chronic Disease, asked 6,455 people nationwide: “To what extent would you support a policy to prohibit the sale of all tobacco products?

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MedAvail sells SpotRx pharmacy assets to CVS Pharmacy

Drug Store News

MedAvail has agreed to sell to CVS certain assets related to its SpotRx pharmacies located in Arizona, California, Michigan and Florida.

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COVID-19 National Emergencies to End in May

Drug Topics

The public health emergency, which was set to end April 11, and the national emergency, which was set to end March 1, will be ended on May 11 by the Biden administration.

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Pfizer reports 30% operational growth in full-year 2022 revenues

Pharmaceutical Technology

Pfizer has reported a 30% operational growth in revenues to $100.3bn in full-year 2022 compared with $81.2bn reported last year. The revenues grew 2% operationally excluding Paxlovid and Comirnaty’s contributions. In the fourth quarter (Q4) of 2022, they increased 13% operationally to $24.3bn compared to $23.8bn in the same quarter last year. On an operational basis, the revenues rose by 5%, omitting contributions from Paxlovid and Comirnaty.

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MRI scans reveal disparate impact of poverty and other ‘toxic stress’ on brains of Black children

STAT

Stressful experiences during early childhood — particularly economic strife — appear to act as a toxic stressor that can alter regions of the brain tied to the processing of stress and trauma, according to a new study published Wednesday. The researchers found that Black children were impacted more than white children, largely because of the higher amounts of poverty and adversity they face.

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In the coming years more retail pharmacy brands will adopt technology to gain a competitive edge

Drug Store News

Investments in pharmacy technology and innovation will be a key differentiator for U.S. drug stores wishing to gain an edge over the competition.

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It's Unlikely that Humira Biosimilars Will Drive Down Drug Costs

Drug Topics

As a dozen Humira Biosimilars are set to enter the market this year, it seems to be unlikely that they will drive down drug costs in the future.

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2024 DIR Fee Changes

DiversifyRx

What is the DIR Fee Apocalypse? Everything You Need To Know. DIR Fees are the bane of any pharmacy owner. Make sure you are ready for the changes coming in 2024. If you’re a pharmacy owner, you know DIR fees and how they can negatively impact the cash flow of your pharmacy. What many pharmacy owners are not aware of yet, is the DIR changes coming in January 2024.

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STAT+: Biden administration floats major 2024 pay cut for Medicare Advantage plans

STAT

Medicare Advantage insurers could face an average 2.3% cut to baseline payments in 2024, the Biden administration said Wednesday. If the proposal stands, it would be a net cut of more than $3 billion to the industry. The major reason behind the proposed pay cut: Medicare officials want to update data and coding systems that are used to explain the health conditions of an insurance company’s enrollees.

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Can you drink alcohol while taking amlodipine?

The Checkup by Singlecare

While taking a high blood pressure medication like amlodipine, you might be apprehensive about whether you can drink alcohol. After all, too much alcohol can raise your blood pressure. The fact of the matter is that there are some potential risks to be aware of before combining alcohol and amlodipine—such as an increased risk of side effects. Continue reading to learn more about mixing the two, the possible drug interaction, and the potential side effects you might experience.

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FDA Approves Tezepelumab for Self-Administration With New Pre-Filled Pen

Drug Topics

After being FDA approved in 2021, tezepelumab (Tezspire) has been approved again for self-administration.

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Magazine: CRISPR gene therapies cut through in 2023

Pharmaceutical Technology

If things go as per plan, in a few months, the US Food and Drug Administration (FDA) will deliberate on the first-of-its-kind CRISPR-based gene therapy for sickle cell disease (SCD) and transfusion-dependent beta thalassemia. Having made significant advances in a relatively short period of time, CRISPR research is now edging closer to reaching the clinic , and this month’s cover story takes a look at the major players in this field and the big events that could break through this year.

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Opinion: Promises — and pitfalls — of ChatGPT-assisted medicine

STAT

Not long after the artificial intelligence company OpenAI released its ChatGPT chatbot, the application went viral. Five days after its release, it had garnered 1 million users. Since then, it has been called world-changing , a tipping point for artificial intelligence, and the beginning of a new technological revolution. Like others, we began exploring potential medical applications for ChatGPT, which was trained on more than 570 gigabytes of online textual data, extracted from sources like boo

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What are manufacturer copay cards?

The Checkup by Singlecare

Inflation is driving up the cost of living in the United States, and prescription prices are no exception. Perhaps more than ever, affordability is an important factor for physicians to consider when prescribing medications to their patients. When available, generic medications can help to reduce the cost of medications for many health conditions. But what if no generic exists, and you have to use an expensive brand-name drug to manage your condition?

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2023 Technology Trends: Examining the Impact on Independent Pharmacy

Drug Topics

A new report unpacks some of the challenges that independent pharmacists may face in the years ahead.

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Giant Eagle to modernize in-store product management across 5 states

Drug Store News

Giant Eagle aims to use strategic category management technology to improve the customer experience at 216 supermarkets and 274 GetGo convenience stores throughout Pennsylvania, Ohio, West Virginia, Maryland and Indiana.

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Eye drops linked to U.S. drug-resistant bacteria outbreak

STAT

NEW YORK — U.S. health officials are advising people to stop using over-the-counter eye drops that have been linked to an outbreak of drug-resistant infections. The Centers for Disease Control and Prevention on Wednesday night sent a health alert to physicians, saying the outbreak includes at least 55 people in 12 states. One died.

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Study reveals how cancer cells shrink or super size to enable survival

Hospital Pharmacy Europe

A study has revealed how cancer cells either shrink or super size during drug therapy or other environmental challenges to enable survival In a study published in Science Advances , researchers from the institute of Cancer research in London, showed that melanoma cancer cells will either shrink or become super sized as a survival mechanism in the face of either drug treatment or any other challenges that might occur within their environment.

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COVID-19 Variant, Omicron, Connected to Worse Maternal Outcome in Pregnant Women

Drug Topics

“Vaccination coverage among pregnant women remains a priority,” the researchers wrote.

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