Sat.Oct 08, 2022 - Fri.Oct 14, 2022

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Protecting against influenza: A conversation with David Ross, Vice President, Commercial Operations, North America, CSL Seqirus

PhRMA

Our industry is at the forefront of fighting the annual influenza virus. I recently had the chance to connect with David Ross, Vice President, Commercial Operations, North America, CSL Seqirus about how the industry is working to fight the annual flu and what lessons learned during COVID-19 are allowing us to better respond to influenza.

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Five Achievements You Need To Unlock To Become An Antibiotic Ninja

IDStewardship

In this article a pharmacist with specialized training in infectious diseases discusses five key areas of study to master in the field of antimicrobial pharmacotherapy, to become an antibiotic ninja. Authored By: Timothy P. Gauthier, Pharm.D., BCPS, BCIDP. Article posted 11 October 2022. It is commonplace for learners such as students and residents to struggle with infectious diseases pharmacotherapy.

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Trending Sources

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PTSD Therapies on the Fast Track

Drug Topics

Several drugs with novel mechanisms of action have been put on the pathway for speedier approval decisions by the FDA. Phase 2 and 3 trials are underway.

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Pharmacists Can Affirm Transgender, Non-Binary Patients

Pharmacy Times

A presentation at the AMCP Nexus conference focuses on the health care disparities and pharmacotherapy options for gender affirmation.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Opinion: Maternity care in the U.S. is in crisis. It’s time to call the midwife

STAT

After pushing for several hours, my patient looks exhausted but happy, clutching her seconds-old newborn to her chest. As I help her put her baby to breast for the first time, she isn’t thinking about anything other than the tiny human blinking up at her. As well she shouldn’t.

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Robotic capsule could replace injected biologics

European Pharmaceutical Review

Scientists at MIT have demonstrated that a novel robotic capsule could potentially replace conventional biologic injection methods by tunnelling through the intestinal mucus barrier to deliver insulin. The research, published in the journal Science Robotics described how the new drug delivery system can transport large protein and small-molecule drugs, like vancomycin, an antibiotic peptide.

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Unmet Needs in Management of C. Difficile Infection (CDI)

Pharmacy Times

Bincy Abraham, MD, MS; Thomas Lodise, PharmD, PhD; Teena Chopra, MD, MPH; and Paul Feuerstadt, MD, share unmet needs, including access to therapies, in treatment of C. difficile infection (CDI).

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Human neurons implanted in a rodent’s brain lead a rat to water — and make it drink

STAT

The scientist flicked on a laser, filling the rat’s brain with blue light. The rodent, true to its past two weeks of training, scampered across its glass box to a tiny spout, where it was duly rewarded with a drink of water. From the outside, this would appear to be a pretty run-of-the-mill neuroscience experiment, except for the fact that the neurons directing the rat to its thirst-quenching reward didn’t contain any rat DNA.

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Novel cancer therapeutic synthesised by Stanford researchers

European Pharmaceutical Review

Research published in the journal Nature Chemistry , shows how researchers from Stanford University in the US uncovered a promising new method to synthetically manufacture the compound tigilanol tiglate, named EBC-46, which could offer targeted medicine for cancer and other diseases. Natural sources of the compound can only be found in a small section of the Northeastern Australia rainforest, in fruit seeds from the blushwood tree ( Fontainea picrosperma ).

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Industry Trends: What to Watch For

Drug Topics

From biosimilars to artificial intelligence, these are the trends poised to take community pharmacy by storm.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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Clinical Results Support Greater Use of Oncology Biosimilars

Pharmacy Times

Presenters at the AMCP Nexus conference explore outcomes data and whether these medications should be substituted for reference products more frequently.

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Which diet and health habits are backed by science? Now there’s a tool for that

STAT

Does eating red meat increase one’s risk of heart disease? Would eating more vegetables help? Is leaving high blood pressure untreated really a death wish? The answers might vary, depending on who a person asks, which friend or TikTok nurse, and when. Researchers at the University of Washington want to make it easier to find current, evidence-based health advice.

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Janssen leads effort to cut waste in digital health devices

pharmaphorum

A consortium of industry and academic groups – led by Johnson & Johnson’s pharma division Janssen – has been set up to tackle the environmental impact of digital health products, specifically aimed at minimising waste that could end up in landfill. The Digital Health in a Circular Economy (DiCE) group was formed earlier this year with the aim of developing ways to “design, collect, directly reuse, refurbish, remanufacture, and recycle digital health devices.” The programme

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What CBD Brings to the Table for Dermatologic Concerns

Drug Topics

Drug Topics® is joined by Dr. Alex Capano, Chief Science Officer at Ananda professional to discuss what CBD is used for in dermatology.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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How Cancer Vaccines Can Educate an Immune Response in Advanced Cancer Patients

Pharmacy Times

Jeremy Graff, chief scientific officer at IMV, discusses why the development of viable cancer vaccines is a bit more slow-going in comparison to the fast-paced development of COVID-19 vaccines during the pandemic.

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‘It still prevented cancers’: Experts discuss furor over colonoscopy study and dissect the nuances

STAT

On Sunday, the New England Journal of Medicine published the interim results of a landmark trial examining the effect of inviting people to colonoscopy screening. The paper, which STAT covered , exploded across medical media and ignited debate over the trial’s results, how to interpret those results, and the popular coverage of the study. The frenzy resulted over the trial’s main finding — which is that offering colonoscopies to people did not reduce cancer deaths within a 1

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Merck and Moderna partner to develop and sell cancer vaccine

Pharmaceutical Technology

German pharmaceutical firm Merck has extended its partnership with Moderna to jointly develop and sell mRNA-4157/V940, an investigational personalised cancer vaccine (PCV). In 2016, the companies entered a strategic partnership to develop novel messenger RNA (mRNA) based PCVs. They subsequently expanded the collaboration to include the development of antigen mRNA cancer vaccines in 2018.

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Mental, Behavioral Health Issues Call for Creative Solutions

Drug Topics

In an ideal world, pharmacists would be able to spot patients in mental health crisis and provide appropriate solutions.

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COVID-19 Infection Increases Risk of Diabetes Diagnosis in Pediatric Patients

Pharmacy Times

At month 6 post-COVID-19 infection, 123 patients received a diagnosis of type 1 diabetes (T1D) and only 72 were diagnosed with T1D at 6 months post-non-COVID-19 respiratory infection.

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Faster brain imaging technique seems to overcome limitations of current MRI scans

STAT

Research often proceeds in a logical progression, new studies building upon a detailed understanding of the underlying processes revealed by earlier work. But a new brain imaging technique that can directly track the activity of neurons emerged from one of academics’ favorite questions: “What would happen if we tried doing it this way?

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AstraZeneca’s intranasal COVID vaccine fails first clinical test

pharmaphorum

An intranasal formulation of AstraZeneca’s widely-used COVID-19 vaccine Vaxzevria has failed at the first hurdle, after results from a phase 1 trial found it was unable to stimulate a strong immune response to the virus. The 30-subject study – funded by AZ and published in the Lancet journal eBioMedicine – tested two strengths of the current formulation of the vaccine administered as a nasal spray, with half the group receiving a second intranasal dose 28 days later, and half getting a reg

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Closing the Historic Routine-Vaccination Gap

Drug Topics

Pharmacists can play a key role in helping to improve backsliding vaccination rates.

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Mentoring, Supporting Others Can Help Advance Women Pharmacists

Pharmacy Times

Nakia Eldridge, PharmD, MBA, discussed her career, the impacts of COVID-19 on women in pharmacy, and how mentorship can pave the way for more women pharmacists.

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Maternity care ‘deserts’ on the rise across the U.S., report finds

STAT

The home birth had been going well, with the baby having been delivered safely, when midwife Lauren Genter noticed that the mother was losing more blood than normal. The family was Amish and didn’t have a phone in the house, so Genter took her cellphone to the one window where she had spotty service to call for an ambulance. She was able to keep the mother stable while they waited.

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RemeGen receives ODD for myasthenia gravis treatment

European Pharmaceutical Review

RemeGen has announced that the US Food and Drug Administration (FDA) has granted Orphan Drug Designation (ODD) for its proprietary novel fusion protein Telitacicept (RC18) for the treatment of myasthenia gravis (MG). Telitacicept is a proprietary novel fusion protein from RemeGen to treat autoimmune diseases. It is constructed with the extracellular domain of the human transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) receptor and the fragment crystallisable

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Managing Metabolic Syndrome in Diabetes

Drug Topics

Patients with metabolic syndrome and diabetes may be experiencing challenges outside medication management.

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Trends in Behavioral and Mental Health Treatment Since the Start of the Pandemic

Pharmacy Times

New research finds that mental health has replaced COVID-19 as the top health concern among Americans, but deeper analysis needs to be done into whether depression and anxiety are truly becoming more widespread.

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In gold-standard trial, colonoscopy fails to reduce rate of cancer deaths

STAT

For decades, gastroenterologists put colonoscopies on a pedestal. If everyone would get the screening just once a decade, clinicians believed it could practically make colorectal cancer “extinct,” said Michael Bretthauer, a gastroenterologist and researcher in Norway. But new results from a clinical trial that he led throw confidence in colonoscopy’s dominance into doubt.

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How retail pharmacies go beyond the basics to impact communities

Drug Store News

In his latest column, DSN editor-in-chief Nigel Maynard asks readers to share personalized stories of individuals or stores that went above and beyond.

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Atopic Dermatitis Patients Treated with Tralokinumab See No Greater COVID-19 Risk

Drug Topics

A new study shows the AD drug does not interfere with vaccinations or increase severity.

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Changing Treatment Landscape for Chronic Migraine Shows Promise Over 5 Years

Pharmacy Times

New treatments for chronic migraine have been increasing, with robust evidence for eptinezumab, erenumab, fremanezumab, galcanezumab, and onabotulinumtoxin A.

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STAT+: Documents detail how pharmacy giants Walgreens, CVS, and Walmart failed patients in the opioid epidemic

STAT

In 2011, Walgreens executives were under pressure. Amid a growing addiction crisis, and with the country already awash in prescription painkillers, the federal government was demanding accountability from the pharmacy giant for filling thousands of opioid prescriptions written by doctors in suspiciously large quantities.   Scrambling for a solution, the company’s leadership traded ideas for new ways of ensuring its pharmacies would stop filling medically illegitimate prescriptions.

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How the food allergy sector is benefitting from health tech’s recent boom

pharmaphorum

For the 32 million individuals in the US with food allergies, more research into symptoms, causes, and treatments has been long sought after, but historically underfunded. The National Institutes of Health (NIH), which oversees disease research, has a total annual budget equivalent to $120 per person, with only $0.19 per person being spent on food allergy research.

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October 2022: In This Issue

Drug Topics

A look at what’s to come in the October issue of Drug Topics®.

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