Thu.Dec 22, 2022

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Phase 3 Trial Shows Benefit of Empagliflozin for Pediatric Type 2 Diabetes

Drug Topics

Eli Lilly and Company and Boehringer Ingelheim announced their SGLT2 inhibitor, empagliflozin, was associated with statistically significant reductions in HbA1c relative to placebo therapy among a population of pediatric patients with type 2 diabetes in the DINAMO trial.

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Opinion: Lessons learned from the deadly combination of sepsis and Covid-19

STAT

Sepsis, a deadly overreaction of the immune system to infection, has befuddled clinicians and researchers for decades. Covid-19 made things worse. The early signs and symptoms of sepsis mimic those of both Covid-19 and influenza: fever, chills, dry cough, shortness of breath, fatigue, muscle or body aches, sore throat, nasal congestion, runny nose, and more.

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Study Finds Half of CBD-Related Tweets Market Therapeutic Claims

Drug Topics

CBD is a hot topic on the internet and social media, but large percentages of posts are making therapeutic claims that are not FDA approved or backed by enough research.

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Study: Intermittent Fasting Shows Link to Diabetes Remission

Pharmacy Times

TD2 remission is defined as a hemoglobin A1C level of less than 6.5% at least 1 year after stopping medication, investigators say.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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CBD May Help Mitigate Opioid Withdrawal Symptoms

Drug Topics

In the midst of an opioid epidemic, CBD may help patients experiencing opioid withdrawal symptoms find relief.

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Public Health Matters - Loving the Pharmacy Profession, Helping Patients

Pharmacy Times

Alex Barker founded The Happy PharmD to provide career coaching and career development classes, and since 2017, the company has helped over 1,500 pharmacists.

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Experts Discuss Specialty Pharmacy Accreditation, Re-Accreditation

Pharmacy Times

Stephen Davis, PharmD, senior director of Health System Strategy at Shields, and Erica Diamantides, PharmD, specialty pharmacy manager at UW Medicine, discuss the current guidance and best practice for specialty pharmacy accreditations.

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Moderna finalises plans for UK mRNA vaccine manufacturing centre

European Pharmaceutical Review

Moderna, Inc. has finalised a strategic partnership with the UK government to establish a state-of-the-art mRNA vaccine research, development, and manufacturing facility in the UK. This milestone follows the agreement in principle between Moderna and the UK Government, announced in June 2022. The Moderna Innovation and Technology Centre (MITC) is intended to provide access to a UK-made supply of COVID-19 jabs.

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FDA Approves Tocilizumab as First Monoclonal Antibody Treatment of COVID-19

Pharmacy Times

Intravenous tocilizumab (Actemra; Genentech) has been approved for the treatment of COVID-19 in individuals who are hospitalized and receiving systemic corticosteroids and supplemental oxygen.

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UK, Moderna formalise 10-year vaccines alliance

pharmaphorum

Construction will start early next year of a new manufacturing centre in the UK with the capacity to produce 250 million vaccine doses per year, the centrepiece of a 10-year alliance between the government and US biotech Moderna. The government said today it has finalised the partnership – agreed in principle earlier this year and estimated to be worth in the region of $1.2 billion – although it is not revealing the financial details, as these are “commercially sensitive.” The overar

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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U.S. life expectancy falls for second straight year as drug overdose and Covid deaths take toll

STAT

Life expectancy for Americans fell for the second straight year in 2021, largely driven by increases in deaths from Covid-19 and drug overdoses, according to new data from the Centers for Disease Control and Prevention. A baby born in the U.S. in 2021 has a life expectancy of 76.4 years, down from 77 years in 2020 and the lowest level the CDC has recorded since 1996.

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Pfizer, Sanofi settle first California Zantac case slated for trial: report

Fierce Pharma

Pfizer, Sanofi settle first California Zantac case slated for trial: report. zbecker. Thu, 12/22/2022 - 12:38.

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Under new rules, methadone clinics can offer more take-home doses. Will they?

STAT

Danielle Russell is, as she says, a “poster child” for methadone. For more than a decade, the medication — one of the most effective treatments for opioid addiction — has helped her move past the heroin she used to use. She finished a series of degrees, and is now a Ph.D. student in justice studies at Arizona State University.

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Fentanyl: a horrifyingly disruptive drug

Pharmaceutical Technology

Fentanyl is a powerful opioid (a narcotic analgesic that is at least partly synthetic) that is being trafficked in increasing quantities from Mexico to the US by cartels. The Drug Enforcement Administration (DEA) recently announced that it had seized 10,000 pounds of illicit fentanyl in 2022 and pointed out that this volume represented enough fentanyl to kill every American.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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mRNA therapeutics: a limitless revolution in medicine

European Pharmaceutical Review

The success of mRNA vaccines against SARS-CoV-2 has quickly catapulted mRNA therapeutics as a disruptive, expanding drug category” The term ‘mRNA’ has become commonplace globally. mRNA technologies have emerged as an innovative and effective approach to developing new drugs that can potentially transform existing therapies or target difficult‑to‑treat indications including respiratory, cardiac, metabolic and autoimmune diseases, as well as cancer.

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Japanese drugmakers make greener packaging pledge

pharmaphorum

Four Japanese drugmakers – Astellas, Eisai, Daiichi Sankyo, and Takeda – have joined forces in a partnership intended to reduce the environmental impact of pharmaceutical packaging. The companies say they will promote the use of greener packaging for their products by sharing knowledge on technologies that can reduce their environmental impact , including blister packs made of biomass- rather than petroleum-derived plastics and more compact packaging, as well as recycled and recyclable materials

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From chemistry to canvas: What the pharma world can learn from art

PharmaVoice

Art and science are often viewed as diametric opposites, but these industry insiders say their passion for painting blends into their pharma work.

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Top 2022 Pharmacy Blog Posts For Non-PBM Revenue

DiversifyRx

Dive into our top 2022 suggestions for increasing your non-PBM revenue to grow and stabilize your pharmacy profits. Last week we shared our Top 2022 Blog Resources To Increase Cash-Based Revenue , which covers our first Pharmacy Profit Pillar Cash-Based Revenue. This week we will recap the most popular blogs from 2022 that focus on non-PBM revenue. We like to differentiate non-PBM revenue from cash-based revenue.

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How Pfizer Delivered the COVID-19 Vaccine in Record Time

PharmExec

Michael Ku, VP of global clinical supply at Pfizer, shares insights for the c-suite as well as reveals behind-the-scenes insight into Pfizer’s ability to deliver a COVID-19 vaccine swiftly.

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2023 Pharmacy Trends to Look For

Digital Pharmacist

The role of the community pharmacy has increased tremendously especially during the COVID pandemic. For pharmacies, it is important to understand the needs of the patients, and the services that patients are looking for so patient expectations can not only be met but exceeded. . In this blog, we will discuss pharmacy trends to look out for in 2023 so your business can be as prepared as possible in the New Year.

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What causes employees to quit and how can it be prevented it?

Drug Store News

Employee well-being experts Loopin has highlighted six of the major factors in the workplace that could lead to a high staff turnover.

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STAT+: Backed by a longtime mental health leader, a new startup aims to build support for serious mental illness

STAT

The number of startups focused on mental health has surged in the wake of the pandemic and a growing mental health crisis. They want to help people to meditate on their phones, or prescribe drugs that can be delivered right to their doors. But few focus on the most vulnerable patients, people with serious mental illness, in the real world. This month, a for-profit startup co-founded by former National Institute of Mental Health leader Thomas Insel quietly launched with $29 million in funding to

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Generic, Biosimilar Drugs Generate Record Savings of $373 Billion in 2021

Pharmacy Times

But many patients pay more than necessary because of PBMs, patent abuses, IQVIA data shows.

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STAT+: Apple Watch hit with import ban, but ruling remains suspended as AliveCor patent battle plays out

STAT

In the latest twist in a battle between Apple and medical device company AliveCor, the U.S. International Trade Commission issued a ban preventing Apple from importing all watches that use the hotly contested heart monitoring technology, but said the enforcement of that order will be suspended until appeals over the patents in question have played out.

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Economist Impact: World Cancer Series – pharmaphorum in attendance, day one (part iv)

pharmaphorum

To conclude pharmaphorum’s look back at day one of The Economist’s 8th Annual World Cancer Series congress in Brussels, Belgium, in November – where the foci were “innovation, equity, and excellence” – after the panel, ‘The future of European cancer control in a time of crisis’, came The Economist’s health policy editor Natasha Loder’s interview with Dame Kate Bingham, managing partner at SV Health Investors and former chair of the UK Government’s Vaccine Taskforce during the pandemic.

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STAT+: Pharmalittle: Merck pays Chinese biotech $175 million for cancer drugs; who will make a gene therapy for very sick kids?

STAT

Good morning everyone! Matthew Herper is here, filling in for Pharmalot, who is taking a well-deserved break, which means that today there’s English Breakfast tea instead of flavored coffee and two cozy cats instead of the usual mascot. What doesn’t change is that we’ve got the usual roundup of pharma news for you to read. We hope your holiday preparations are going swimmingly and that your work is starting to wrap up.

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Neoadjuvant, Adjuvant Therapy for Resectable NSCLC Progresses With Immunotherapy, Targeted Therapy

Pharmacy Times

Significant advancements have changed the treatment landscape and clinical practice procedures.

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Eisai and Biogen’s latest Alzheimer’s drug needs to be cheaper than the last one, analysts say

STAT

The latest Alzheimer’s disease treatment from Eisai and Biogen needs to be cheaper than $20,000 a year to be cost-effective, according to a draft analysis from an influential nonprofit organization published Thursday. The Institute for Clinical and Economic Review, or ICER, dug into the evidence for lecanemab and concluded that the drug’s demonstrated benefits, a modest but statistically significant delay in the advance of Alzheimer’s, are worth between $8,500 and $20,600 pe

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GNC looks to the new year with health and wellness trend predictions

Drug Store News

DSN spoke with Rachel Kreider, senior director of technical product and content design at GNC, about the biggest health and wellness trends for 2023.

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Focusing on the evolution of biotechnology and R&D – the pharmaphorum podcast

pharmaphorum

Following an invite to fly into Parma, Italy to witness first-hand the press launch of the considerable structure that is the Chiesi Group’s new €85 million Biotech Centre of Excellence, pharmaphorum web editor Nicole Raleigh spoke with Chiesi’s head of global manufacturing, Antonio Magnelli. In brief, the European plan for Chiesi is in-house drug development of biologicals and rare disease targeting.

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2022 in review, CEO indictments, & the year ahead

STAT

When does optimism become criminal? Why can’t biotech find its way back? And what’s going to happen in 2023? We cover all that and more this week on “The Readout LOUD,” STAT’s biotech podcast. We look back on the biggest biotech stories of 2022 and how, despite some meaningful advances in Alzheimer’s disease and gene therapy, the industry seems stuck in a sentiment rut.

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Joint Commission cuts 14% of accreditation requirements for 2023, freezes fees

Fierce Healthcare

Joint Commission cuts 14% of accreditation requirements for 2023, freezes fees. dmuoio. Thu, 12/22/2022 - 12:21.

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Giant Food pharmacies offering flu, strep throat testing

Drug Store News

Flu and strep testing are administered by Giant Food's certified in-store pharmacists or certified technicians, with results received within 10 minutes.

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Curavit’s crystal ball – how will 2023 drive meaningful changes in clinical research

pharmaphorum

The life sciences industry is flexing towards innovation in new areas, faster than ever before, and increasing patient care in astonishing ways. Decentralised oncology trials, for example, have shown actual predictive outcome value. We can now measure patient activity, steps, and movement continuously and in real time, which serves as a new potential indicator of treatment effectiveness. 1 And, digital therapeutics have emerged as an effective treatment for chronic diseases, including mental ill