Mon.Nov 21, 2022

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The 340B program is interfering with the U.S. biosimilars market and impacting patient costs

PhRMA

Research has shown that 340B hospitals are more likely to prescribe more expensive medicines and significantly mark up the price of medicines. For example, 340B hospitals received nearly five times what they paid, on average, to acquire oncology medicines through 340B. These practices have implications for what patients pay out of pocket — and new research adds to the evidence.

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Research Examines Link Between Vitiligo and Systemic Sclerosis

Drug Topics

Israeli researchers find more than fivefold risk of developing systemic sclerosis among people with vitiligo.

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Dental Health Plays Vital Role in Cardiovascular Well-Being

Pharmacy Times

Research also focuses on connection between oral hygiene and other chronic diseases, neurological disorders, pulmonary infections.

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First-in-human gene therapy trial for major cardiac syndrome

European Pharmaceutical Review

The first-in-human gene therapy trial for heart failure patients with preserved ejection fraction (HFpEF) has been approved by the US Food & Drug Administration (FDA). SRD-001, the adenovirus associated virus (AAV)-based gene therapy is delivered to cardiac ventricular muscle cells via an intracoronary infusion system (produced by Sardocor, a clinical-stage gene therapy subsidiary of Medera), to increase the protein expression and functional activity of sarcoplasmic reticulum calcium ATPase

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Multiple SARS-CoV-2 Infections May Elevate Risk of Organ Failure, Death

Pharmacy Times

Individuals with COVID-19 reinfections were twice as likely to die and three times more likely to be hospitalized than those who did not have COVID-19 multiple times.

Hospitals 139
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Provention prices type 1 diabetes drug Tzield at $194,000

pharmaphorum

Provention Bio has priced its new type 1 diabetes (T1D) prevention therapy Tzield at $13,850 per vial – equivalent to almost $194,000 for its 14-day course – a higher level than had been predicted by industry observers. The company argues that the cost is justified as Tzield (teplizumab) is the first drug that can delay the onset of type 1 diabetes, fending off the time when they become highly reliant on insulins and at risk of the serious complications that can accompany advanced T1D.

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More Trending

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How infectious disease experts are responding to Covid nearly three years in

STAT

The world is fast approaching the third anniversary of those days when we got our first inkling that a new disease was spreading in China. In the months that followed, normal life was suspended, then upended. At this point, everyone is well and truly sick of Covid-19 and the accommodations we have had to make to co-exist with it. So sick of it, in fact, that many people appear to have given up trying to avoid the SARS-CoV-2 virus.

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Study: Significant New Onset Morbidity Observed in Children, Adolescents, Adults Following COVID-19 Infection

Pharmacy Times

Although long-term health issues from COVID-19 are a major public health concern, evidence on post-acute COVID-19 syndrome, or post-COVID-19, is still limited, specifically among children and adolescents.

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STAT+: Northwest Bio study of brain cancer vaccine still falls short

STAT

Northwest Biotherapeutics tried again, but its experimental treatment for brain cancer still falls short. Last Thursday in JAMA Oncology, Northwest Biotherapeutics and its scientific collaborators published the results of a large clinical trial showing its personalized cancer vaccine administered to patients with brain tumors reduced the risk of death by 20% compared to a group of patients taken from “external controls.

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Smoking, Insurance Coverage Show Link in Those With Mental Health Disorders, SUD

Pharmacy Times

The objective of the study was to estimate recent trends in cigarette use and health insurance coverage for US adults with and without mental health and SUD.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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mRNA revolutionized the race for a Covid-19 vaccine. Could cancer be next?

STAT

This story has been adapted from the STAT Report “The future of messenger RNA: Covid-19 vaccines are just the beginning.” The unprecedented success of messenger RNA vaccines against the coronavirus is raising hopes that the technology could lead to new and better vaccines against a much older public health scourge: cancer.

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New Tool Developed to Track How Breast Cancer Grows

Pharmacy Times

New system combines computational and experimental techniques to map evolutionary cancer lineages in their natural habitat of human tissue.

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Flash Glucose Monitoring May Prompt Lifestyle Changes in Prediabetes

Drug Topics

New research indicates that glucose monitoring could lead to lifestyle changes during prediabetes.

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Post-COVID-19 Symptoms Not Worse Among Hospitalized Patients Compared to Non-hospitalized Patients

Pharmacy Times

Approximately 2 years after patients were infected with COVID-19, non-hospitalized patients suffered from post-COVID-19 symptoms nearly 8% more than hospitalized patients.

Hospitals 115
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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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Rite Aid opens small-format pharmacy in Virginia

Drug Store News

The retailer opened its first small-format Rite Aid Pharmacy location, in Craigsville, Va., as part of a pilot program to improve access to pharmacy services.

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Compare Medicare Advantage Plans

The Checkup by Singlecare

What are Medicare Advantage Plans? | Enrollment Periods | Types of Medicare Advantage plans | How to compare plans | Best plans | Lowering costs. Medicare Advantage (Part C) plans continue to improve their coverage and become more popular. Medicare Part C plans may have certain advantages over Original Medicare, such as additional services and protections, but there may also be disadvantages.

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IT Infrastructure in the Current Life Science Company Environment

ISPE

IT Infrastructure in the Current Life Science Company Environment. Trudy Patterson. Mon, 11/21/2022 - 10:06. iSpeak Blog. iSpeak. IT Infrastructure in the Current Life Science Company Environment. Christopher J. Reid. Arthur D. Perez, PhD. 21 November 2022. A look through the lens of GAMP 5® Second Edition. IT Infrastructure is a broad term that encompasses both the platforms upon which business applications run, as well as the services that keep these platforms and applications running.

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Watch: This small-town pharmacy may be a model for more affordable drugs

STAT

STAUNTON, Va. — Honest Rx operates like any other pharmacy in the United States — with one big exception. It does not accept health insurance. Pharmacist and owner Matthew Garner opened his business in 2022, after over 20 years of working in and managing other pharmacies. In that time, companies like CVS have become behemoths by merging with pharmacy benefit managers and insurers.

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What is Medigap?

The Checkup by Singlecare

What are Medigap plans? | Medigap vs. Medicare Advantage | Costs | How to enroll | FAQs . If you have recently enrolled in Medicare, you may have heard of Medigap plans and wondered how they work. Medigap policies , also known as Medicare Supplement policies, help cover some out-of- pocket costs associated with Original Medicare. There are multiple types of Medigap policies to choose from that fit your medical and financial needs.

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Merck agrees to acquire Imago for $1.35bn

Pharmaceutical Technology

Merck (MSD outside North America) has signed a definitive agreement for the acquisition of all outstanding shares of Imago BioSciences, through a subsidiary, for $36.00 per each share in cash or for a total equity price of nearly $1.35bn. A clinical-stage biopharmaceutical firm, Imago focuses on the development of new therapies to treat myeloproliferative neoplasms (MPNs) and other bone marrow ailments.

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Opinion: Congress: Confront the superbug crisis and pass PASTEUR

STAT

By 2050, drug-resistant infections caused by “superbugs” could kill 10 million people each year around the world. That’s more than the annual global death toll from cancer. In new research published this year in The Lancet, drug-resistant infections were found to be at least partly responsible for nearly 5 million deaths worldwide in 2019.

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House lawmakers press Biden admin to change latest surprise billing rule

Fierce Healthcare

House lawmakers press Biden admin to change latest surprise billing rule. rking. Mon, 11/21/2022 - 17:18.

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The case for universal oral health coverage, according to a new WHO report

STAT

On Friday, oral health advocates across the globe got an early holiday gift from their longtime wish lists. They had been waiting their whole careers — for some STAT spoke with, up to nearly half a century — for oral health to be folded into conversations calling for health care access for all. The World Health Organization’s new Global Oral Health Status report took that first step.

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Holiday Gift Guides

The Luxe Pharmacist

Happy holidays love! My favorite time of the year is fast approaching and I couldn’t be more excited. Not only do the holidays bring me so much but Sagittarius season is also right around the corner So happy early birthday to all my fellow fiery archers out there! This year I turn 28 which I’m still trying to wrap my mind around, but at least I can age more gracefully with my favorite pharmaceutical toxins on the market and my holy grail skincare products, many of which are listed be

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Sporting night vision goggles, a scientist probes the internal clocks that help parasites infect people

STAT

In the 1700s, French astronomer Jean-Jacques d’Ortous de Mairan noticed that the leaves of the mimosa plant opened towards the sun and closed at dusk. His discovery was in keeping with thousands of years of observations. But de Mairan also found that the plant followed the same rhythm even in the constant darkness of a cupboard, suggesting that some innate metronome kept the plant in sync with the rotation of the earth.

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The race for a new class of antibiotics

European Pharmaceutical Review

A study on the surge of new antimicrobial research has shown that despite almost a quarter of a million research papers (227,808) being published on the 12 bacterial families in the World Health Organization (WHO) global priority pathogen list of antibiotic-resistant bacteria from 2017, no new class of antibiotics has gone to market since 1987. Study data from Elsevier’s abstract and citation database Scopus, identified that 2,450 papers were published in 2021 on the pathogen WHO identified as m

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STAT+: A CEO’s plan to monetize health data rescued from IBM Watson’s wreckage

STAT

A company being built from the ashes of IBM’s Watson Health division is launching new lines of business with a much different message: The real value is in the health data, not the fancy AI engine it might eventually power. The new venture, dubbed Merative, will focus on distributing data through channels designed to maximize its value for health plans, providers, pharmaceutical companies, employers and other businesses.

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Why the biopharma ‘IPO playbook’ changed in 2022

PharmaVoice

Biopharma IPOs have puttered in 2022, particularly compared to the record-breaking previous year, but they might be set to rebound.

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ASH: AbbVie, J&J's Imbruvica under serious threat as BeiGene's Brukinsa delivers head-to-head trial win

Fierce Pharma

ASH: AbbVie, J&J's Imbruvica under serious threat as BeiGene's Brukinsa delivers head-to-head trial win. aliu. Mon, 11/21/2022 - 16:29.

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MegaFood updates packaging on key product lines

Drug Store News

Designed to keep its key visual elements, the new product layout includes enhanced readability of product names and varieties.

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Accelerated Approval to Mirvetuximab Soravtansine-gynx Granted by FDA

Drug Topics

This is the first FDA-approved ADC for platinum-resistant disease, according to ImmunoGen.

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In cancers with very low survival rates, Sellas aims higher

PharmaVoice

The company hopes its drugs can “take over where other available treatments fail” in multiple types of cancer.

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STAT+: Merck to acquire Imago, bolstering pipeline for drugs targeting bone marrow diseases

STAT

Merck said Monday that it is acquiring Imago BioSciences for $1.35 billion, adding experimental drugs that target bone marrow diseases to its research pipeline. The all-cash deal values Imago at $36 per share, or a 107% premium from its closing price on Friday.

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Pfizer's Paxlovid access brought into question as WTO set to discuss patent waiver—again

Fierce Pharma

Pfizer's Paxlovid access brought into question as WTO set to discuss patent waiver—again. aliu. Mon, 11/21/2022 - 11:21.

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