Thu.Sep 15, 2022

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Opinion: 6 tactics to make artificial intelligence work on the frontlines

STAT

Artificial intelligence is a transformative tool in the workplace — except when it isn’t. For top managers, state-of-the art AI tools are a no-brainer: in theory, they increase revenues, decrease costs, and improve the quality of products and services. But in the wild, it’s often just the opposite for frontline employees who actually need to integrate these tools into their daily work.

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Cabozantinib, Nivolumab, Ipilimumab Combination Does Not Reach PFS

Pharmacy Times

Triplet combination demonstrates a reduction in the risk of disease progression or death in individuals with previously untreated advanced intermediate- or poor-risk renal cell carcinoma.

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Top biopharmaceutical Covid-19 vaccine companies boosted with over 80% revenue growth

Pharmaceutical Technology

Last year was a positive year for biopharmaceutical companies, particularly those with Covid-19 vaccines. The top 13 players reported more than 10% revenue growth, with BioNTech (3,834.4%), Moderna (2,199.1%), Pfizer (95.2%) and Regeneron Pharmaceuticals (89.1%) reporting a more than 80% year-on-year (YoY) revenue growth from 2020 to 2021, according to GlobalData’s Pharma Intelligence Centre Companies Database.

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Anti-Malaria Drug Hydroquinine May Effectively Treat Drug-Resistant Bacteria

Pharmacy Times

Researchers have identified hydroquinine as a potential treatment against drug-resistant bacteria, which can cause infections with a 70% mortality rate.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Novartis probed by Swiss authorities over ‘unlawful’ patent use

pharmaphorum

The competition authorities in Switzerland said this morning they have carried out a raid on a pharma company – now confirmed to be Novartis – as part of an investigation into a “possible unlawful use of a patent to reduce competitive pressure.” The Swiss Competition Commission (COMCO) arrived unexpectedly at Novartis at dawn on Tuesday morning, to gather information on an unidentified dermatology drug, as part of a wider investigation into the drugmaker by the European Commission.

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Long-Term Data Show Efficacy of Deucravacitinib Maintained Up to 2 Years in Moderate-to-Severe Plaque Psoriasis

Pharmacy Times

Deucravacitinib is a selective, allosteric tyrosine kinase 2 (TYK2) inhibitor, which is a member of the Janus kinase (JAK) family.

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More Trending

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Opinion: Congress needs to preserve seniors’ access to pharmacist care

STAT

Covid-19 demonstrated how quickly the United States can mobilize to produce and distribute new tests, vaccines, and treatments for a previously unknown virus. The pandemic also highlighted significant inequalities and gaps in its health care system, with many rural and underserved urban areas lacking sufficient access to care. Amid those two realities, pharmacists played a central role in providing access to testing, vaccination, and treatment, especially for older and socioeconomically vulnerab

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COVID-19 and RSV: A roundup of news on pediatric vaccines for these viruses

Drug Topics

William J. Muller, MD, PhD, discusses COVID-19 vaccinations for children of all ages and describes what is on the horizon for RSV.

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‘How do we support each other?’: A physician and ethicist on the difficult decisions doctors now face in abortion care

STAT

As new abortion bans are enacted around the country, physicians working with pregnant patients are facing potential ethical and legal dilemmas. Even if a law allows for an exception when the life of the mother is at risk, there are no clear answers for doctors trying to decide if and when they can act. Matthew Wynia is a physician who has spent decades focused on medical ethics, including roles at the helm of the ​​Ethics Institute at the American Medical Association and the Ethics

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Help Patients Prevent and Treat Dry Eye

Pharmacy Times

Pharmacists should ascertain whether self-treatment is appropriate and suggest medical care if it isn’t.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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Medicare provides insufficient access to opioid addiction treatment, report finds

STAT

Medicare is vastly underserving older Americans with opioid use disorder, with only 18% of enrollees with the diagnosis receiving recommended medication treatment, according to a new federal oversight report. The report, from the U.S. health department’s Office of Inspector General, also found that more than 50,000 Part D beneficiaries overdosed on opioids in 2021, whether painkillers or illicit drugs.

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It’s time to tackle the gender health gap with technology

pharmaphorum

The potential for technology to transform the way we deliver healthcare is nothing new. We’ve been discussing it for some years now and are starting to see more widespread adoption, particularly post-pandemic. But the area where I believe technology can have the greatest impact – and where there is still plenty of work to do – is women’s health. Today, women spend around a quarter of their lives in poor health or disability, compared with one fifth for men.

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STAT+: Swiss authorities raid Novartis offices seeking info on patents used to block rivals

STAT

The Swiss Competition Commission has begun an investigation into Novartis over the possible unlawful use of a patent to block competitors for some of its medicines, the latest instance in which European authorities have probed drug companies for antitrust infractions. Earlier this week, the Swiss agency conducted a dawn raid on Novartis headquarters in Basel, Switzerland, seeking information about efforts the company allegedly made to protect a drug for an unspecified skin treatment.

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Annex 1 Implementation Strategies

ISPE

Annex 1 Implementation Strategies. Trudy Patterson. Thu, 09/15/2022 - 13:50. iSpeak Blog. iSpeak. Annex 1 Implementation Strategies. Thomas Zimmer, PhD. 15 September 2022. Annex 1 of the EC GMP Guide " Manufacture of Sterile Medicinal Products " has a long history. First published in 1989, there have been a total of 5 adaptations in 1996, 2003, 2005, 2007 and 2009, but no complete revision.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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These 3 startups are trying to improve diversity in clinical trials, a challenge experts say will take more than just tech

STAT

A host of health tech startups and companies are advertising their apps and platforms as key solutions to improving diversity in clinical trials, promising to help researchers improve their outreach, enrollment, and retention — what one researcher calls a “modern-day gold rush.” The Power platform focuses on breaking down medical jargon and helping users connect with trial sponsors nearby.

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Rising prices push consumers to purchase store-brand products

Drug Store News

According to a survey by Reach 3 Insights, 80% of Americans say that rising prices have driven them to purchase more store-brand products.

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STAT+: Brazil dismisses antitrust complaint against Gilead over pricing for a hepatitis C drug

STAT

In a victory for Gilead Sciences, Brazilian antitrust authorities dismissed a complaint filed by several advocacy groups that alleged the company charged “abusive” prices for a hepatitis C treatment. In their filing , which was made in 2019, the groups argued that “unlawful conduct” carried out by Gilead had hurt the public interest, because its prices led the government to ration the Sovaldi medication.

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Skin care goes back to basics

Drug Store News

The beauty category, most notably the skin care space, has seen a massive resurgence in the demand for environmentally friendly, clean, vegan and cruelty-free products.

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Pharma leans into telehealth, Flo’s anonymous mode arrives, and clever digital deals

STAT

You’re reading the web edition of STAT Health Tech, our guide to how tech is transforming the life sciences.  Sign up to get this newsletter  delivered in your inbox every Tuesday and Thursday.

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Dr. Scholl’s debuts Instant Cool Athlete’s Foot solutions

Drug Store News

Dr. Scholl’s is working with former head football coach and analyst Rex Ryan and surgeon Brad Schaeffer of TLC’s “My Feet Are Killing Me” on the launch of its Instant Cool Athlete’s Foot solutions.

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STAT+: Pharmalittle: Swiss authorities probe Novartis over patent used to block rivals; Medicare underserves older Americans with opioid use disorder

STAT

Rise and shine, everyone, another busy day is on the way. This morning is getting off to a fabulous start, though, as a delightfully cool breeze and warm sun are enveloping the subdued Pharmalot campus, where the official mascot is snoozing nearby. As always, we are quaffing some cups of stimulation — chocolate raspberry is our choice du jour — and assembling some tidbits for your pleasure.

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AN APPROACH TO THE HAIR FALL & HAIR GROWTH MANAGEMENT

Pharma Tutor

AN APPROACH TO THE HAIR FALL & HAIR GROWTH MANAGEMENT. About Authors Avdesh Thassu. MPharm (Nat. Chem.); MBA(Mkt.). Associate Vice President. Global Regulatory Affairs, Emami Limited, 7044455199. athassu@hotmail.com. Chandra Mohan Nandi. MSc. (Organic Chem.). Deputy Manager, Global Regulatory Affairs, Emami Limited, 9051706947 chandramohannandi@yahoo.in. admin.

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Mallinckrodt’s long haul with terlipressin in US ends in approval

pharmaphorum

Mallinckrodt has finally claimed FDA approval for terlipressin as a treatment for hepatorenal syndrome (HRS), after manufacturing problems scuppered an earlier attempt. Terlipressin – now given the brand name Terlivaz – has become the first and only FDA-approved treatment for adults with HRS who are experiencing a rapid reduction in kidney function, a life threatening condition, getting the green light well ahead of the FDA’s deadline date of 9 December.

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FDA Accepts New Drug Application for Ritlecitinib for Patients 12 Years of Age and Older With Alopecia Areata

Pharmacy Times

Alopecia areata is an autoimmune disease with an underlying immuno-inflammatory pathogenesis.

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Methadone at home? Emerging tech provides new tool in the fight against opioid addiction

PharmaVoice

Sonara Health’s inexpensive, specially engineered label and web app allow for at-home, digitally supervised dosing of high-cost or high-risks drugs.

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Albertsons, WinnCompanies bring essential services to affordable housing communities

Drug Store News

Albertsons is working with WinnCompanies to provide grocery, prescription and vaccination resources to seniors and families.

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Takeda to invest €300 million in plasma-derived therapy production

European Pharmaceutical Review

Investing close to €300 million, Takeda plans to construct a new state-of-the-art production facility for plasma-derived therapies and a net-zero carbon emissions warehouse in Lessines, Belgium – the largest investment Takeda has ever made in the country. The investment is part of the company’s global effort to implement the most innovative technologies and most sustainable processes at its manufacturing sites.

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Amazon intros free email marketing capabilities for sellers

Drug Store News

Utilizing Amazon Customer Engagement’s Tailored Audiences, sellers can now increase their email marketing reach and build brand loyalty, the company said.

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Novartis’ Kisqali® provides “unparalleled survival benefit” in breast cancer

European Pharmaceutical Review

According to Novartis, Kisqali ® (ribociclib) plus endocrine therapy in the first-line setting added nearly a year of additional overall survival (OS) benefit in a subgroup of patients with aggressive forms of hormone receptor-positive, human epidermal growth factor receptor-2 negative (HR+/HER2-) advanced breast cancer (aBC). The pooled exploratory analysis from the MONALEESA Phase III programme revealed that patients with visceral metastases, including liver metastases and multiple metastatic

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NEJM Publishes Positive Phase 2 Results for Biogen’s Litifilimab Lupus Treatment

Pharmacy Times

Part A results from the 2-part LILAC study show that the therapy significantly reduced disease activity based on active joint count in individuals compared with the placebo.

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AbbVie’s Skyrizi® shows long-term efficacy in psoriatic arthritis

European Pharmaceutical Review

Long-term data from the KEEPsAKE trials shows more than half of adult psoriatic arthritis patients receiving Skyrizi ® (risankizumab, 150mg) achieving a 90 percent reduction in the Psoriasis Area and Severity Index (PASI 90) and an American College of Rheumatology 20 (ACR20) response at 100 weeks. The long-term data analyses of the Phase III KEEPsAKE 1 and 2 trials also revealed no new observed safety signals through 100 weeks.

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Pharmacy Focus: Public Health Matters- Connecting to the Community Through Migrant Health

Pharmacy Times

Services such as managing/updating patient programs and working with non-profits can go a long way in healthcare education for patients.

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Limits on paracetamol purchases could reduce injury and death from overdoses, expert panel says

The Guardian - Pharmaceutical Industry

TGA report recommends reduced packet sizes and restricting over-the-counter sales of the drug to people 18 and over Follow our Australia news live blog for the latest updates Get our free news app , morning email briefing or daily news podcast The size of paracetamol packets sold in supermarkets could be reduced and limits introduced on the number of boxes that can be bought, in a bid to reduce injury and death from intentional overdoses.

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Australian CRO Avance buys C3 Research to support sponsors as programs advance

Outsourcing Pharma

Australian CRO Avance Clinical has expanded in North America by acquiring C3 Research Associates, positioning it to continue supporting sponsors as they move into later-phase studies that need US sites.

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