Fri.Sep 16, 2022

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New data: The 340B program is driving up costs for patients and our health care system

PhRMA

Guess what? The 340B program grew, yet again, hitting a whopping $43.9 billion in sales at the discounted 340B price in 2021. But there has not been evidence of corresponding growth in care provided to vulnerable patients at 340B covered entities. And making matters worse, fresh data show that 340B may actually be driving up costs for some patients and our health care system as whole.

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STAT+: Intellia says CRISPR treatment safely corrects DNA of six patients with rare disease

STAT

Intellia Therapeutics said Friday the first six patients to receive its CRISPR-based treatment for a genetic swelling disorder have safely had small, corrective changes made to dysfunctional DNA inside their liver cells. Preliminary results from the study — just the second to show that CRISPR-based gene editing can be delivered systemically and performed in vivo, or inside the body — found that the treatment, NTLA-2002, reduced levels of the disease-causing protein, kallikrein, by

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The future of AI drug discovery & development in immunology and GPCR research

pharmaphorum

Alphabet subsidiary and precision health company Verily recently announced a breakthrough in its AI drug discovery GPCR research collaboration with Sosei Heptares. A mere six months ago Verily launched the study with Sosei Heptares – a global leader in GPCR structure-based drug design – with an aim to “prioritise protein targets for therapeutic targeting in immune-mediated disease”.

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Borrowing CAR-T tool from cancer therapy, lupus patients go into remission

STAT

Rheumatology — the study of immune-system-driven diseases of the bones, joints, muscles, and in-betweens — has inherited plenty of hand-me-downs from cancer research. For example, there are ways of squelching an immune system in order to shrink certain kinds of cancerous tumors. And scientists have found that, when retrofitted, those strategies can also alleviate some symptoms of autoimmune conditions.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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Discontinuation Rates for Biosimilars Are High But Similar to Rates for Reference Biologics

Drug Topics

The review focused on Remicade (infliximab) and Enbrel (etanercept). The annualized discontinuation rate was 21% among patients who had undergone nonmedical switching to biosimilars. However, the rates were similar to those found in some separate analyses of patients on reference biologics.

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At a fashion show for people with spinal muscular atrophy, models take back their own stories

STAT

NEW YORK — The scene: a fashion show on Fifth Avenue. The catwalk was not elevated, as it usually would be. People were packed tightly on benches alongside it in the dark. The first person to walk it was a singer/songwriter, James Ian, dressed in a flashy suit with a howling wolf embroidered in beadwork on the back. Ian walked with a slight limp.

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Time to Glycemic Targets by 4-12 Weeks Reduced in Tirzepatide In Comparison to Other Therapies

Drug Topics

New research offers evidence that tirzepatide could help patients achieve glycemic goals.

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Pharmacy Focus Episode 55: Advocating for Support as a Health Systems Pharmacist

Pharmacy Times

Using your voice as a health care professional and supporting each other through burnout are just a few ways to better advocate in the profession.

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BJ’s Wholesale Club to accept online SNAP EBT payments chainwide

Drug Store News

When using its SNAP EBT cards to shop online at BJs.com or on the BJ’s mobile app, members have the option of selecting from multiple delivery methods, including free pickup, shipping and same-day delivery.

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The Impact of Prior Authorization on Patients With Cancer

Pharmacy Times

Prior authorizations have delayed time to treatment for patients and can directly impact clinical outcomes.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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Gilead’s Veklury receives WHO recommendation to treat severe Covid-19

Pharmaceutical Technology

Gilead Sciences has received expanded recommendation under the World Health Organization’s (WHO) Therapeutics and COVID-19: living guideline for the use of Veklury (remdesivir) to treat severe Covid-19 patients. The guideline update comes after the treatment received recommendation from the health agency for treating non-severe Covid-19 in patients at increased risk of hospitalisation.

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Study: Geographical Location May Be Associated With Certain Risk Factors, Cancer Mortality

Pharmacy Times

Researchers found differences in the variable importance of cancer mortality risk factors depending on an individual’s geographical region.

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FDA and NIH partner for neurodegenerative disease treatment development

Pharmaceutical Technology

The US Food and Drug Administration (FDA) and the US National Institutes of Health (NIH) have unveiled a public-private partnership (PPP) to understand and develop treatments for neurodegenerative diseases. Named the Critical Path for Rare Neurodegenerative Diseases (CP-RND), the partnership will be convened by the Critical Path Institute (C-Path). It will focus on developing therapies for amyotrophic lateral sclerosis (ALS) and various other rare neurodegenerative diseases.

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Pharmacy Care Coaches Improve Outcomes in Patients With Diabetes

Pharmacy Times

Care Coach program offers a comprehensive set of pharmacy and counseling services to patients struggling to manage their diabetes.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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Opinion: The White House has a major chance to improve coordination of federal nutrition efforts

STAT

At the end of September, the White House will host a Conference on Hunger, Nutrition and Health , the first such conference in more than 50 years. Its goal is to accelerate progress toward ending hunger, improving nutrition and physical activity, and reducing diet-related disease. Given the ubiquity of contradictory and headline-grabbing information that can lead to confusion about what to eat or drink, progress on improving diets and the science underlying dietary recommendations is needed now

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FDA Approves Daxxify for Temporary Improvement of Moderate to Severe Frown Lines

Pharmacy Times

DaxibotulinumtoxinA-lanm from Revance Therapeutics Inc is the first peptide-formulated neuromodulator with long-lasting results.

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Red Jacket: Fabio Gratton

PharmaVoice

The serial entrepreneur has relied on his gift for storytelling, creativity and a bit of “magic” as he’s launched one successful niche tech company after another.

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Rite Aid kicks off family immunization days

Drug Store News

Routine vaccinations and immunizations are available at select Rite Aid and Bartell Drugs locations on weekdays after work and on the weekends.

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The meth crisis is worse than ever, but new treatments might be around the corner

STAT

When it comes to meth addiction, Thomas Robey has long been at a loss. As an emergency room doctor, he treats a steady stream of patients who show up at Providence Regional Medical Center in Everett, Wash., after experiencing a methamphetamine overdose.

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Opdivo set to take on Keytruda in adjuvant melanoma

pharmaphorum

Bristol-Myers Squibb’s Opdivo has shown efficacy when used as a post-surgery (adjuvant) treatment for patients with melanoma, extending the time before the disease recurrence or patient death in a phase 3 trial. The positive readout from the CheckMate-76K study means that Opdivo (nivolumab) has a chance to draw level again with Merck & Co’s rival cancer immunotherapy Keytruda (pembrolizumab), which was approved for adjuvant treatment of melanoma last December.

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STAT+: Humana appeases Wall Street with big projections of Medicare Advantage growth

STAT

Humana is targeting ambitious growth of its Medicare Advantage plans and primary care clinics over the next three years, which executives said Thursday will significantly propel Humana’s profitability. Humana’s stock price ended the day up 8%, valuing the company at $63 billion. The main purpose of Humana’s messaging was to comfort Wall Street over concerns the company was losing ground in the booming Medicare Advantage market.

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Red Jacket: Jim Lang

PharmaVoice

The CEO of Eversana has made his mark on the life sciences by disrupting the status quo for commercialization — and he’s got more industry-shifting changes in the works.

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Immune Thrombocytopenia Purpura Treatment Options Abound

Pharmacy Times

Corticosteroids are first-line therapy for gaining platelet stability but should only be used short term.

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Red Jacket: Udit Batra

PharmaVoice

A combination of logic and love — that’s how the CEO of Waters Corp. leads and how he inspires those around him to “solve the problems that matter.

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Health Innovators – Matt Dugan

pharmaphorum

Pharmaphorum Editor-in-Chief Jonah Comstock welcomes Matt Dugan, director and head of innovation at Novo Nordisk, to discuss the company’s digital transformation journey. Recently, Novo Nordisk launched a new digital strategy around optimising operations, augmenting offerings, and exploring new treatment modalities, especially around the idea of “sustainable prevention” – particularly relevant given the company’s focus on chronic conditions like diabetes.

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STAT+: Up and down the ladder: The latest comings and goings

STAT

Hired someone new and exciting? Promoted a rising star? Finally solved that hard-to-fill spot? Share the news with us, and we’ll share it with others. That’s right.  Send us your changes, and we’ll find a home for them.  Don’t be shy. Everyone wants to know who is coming and going. And here is our regular feature in which we highlight a different person each week.

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Maternal Vaccination Cut the Risk of COVID-19 hospitalization for Infants

Drug Topics

Infants of fully vaccinated mothers had fewer cases of hospitalization from COVID-19 than those unvaccinated.

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Low Testosterone in Men May be a Risk Factor for Hospitalization from COVID-19

Pharmacy Times

Men with chronically low testosterone levels are more likely to be hospitalized from COVID-19 than those with normal levels, but testosterone therapy could decrease this risk.

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Listen: Pharma’s telehealth gold mine, the return of the biotech IPO, & a merger deferred

STAT

Is online prescribing a good idea? When is $2 billion not a lot of money? And what’s going to happen at J.P. Morgan 2023? We cover all that and more this week on “The Readout LOUD,” STAT’s biotech podcast. Our colleague Katie Palmer joins us to explain a burgeoning trend in pharmaceutical advertising that has health policy experts alarmed.

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Study: Online Communities Can Provide Lifeline for Patients in Remission from Opioid Use Disorder

Pharmacy Times

Online communities can help opioid users in remission maintain long-lasting sobriety, however the research suggests these communities should be non-drug-related.

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Almirall/Lilly lebrikizumab offers potential long-term management of atopic dermatitis

pharmaphorum

Atopic dermatitis (AD) is a highly prevalent chronic dermatological disease, with symptoms which include itching, dry skin, severe pain, and inflammation – all of which create considerable stress in the daily lives of patients and often negatively affect their day-to-day and long-term well-being. Lebrikizumab, a monoclonal antibody that inhibits an interleukin named IL-13, is especially promising in treatment of this disease.

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Onset of Type 2 Diabetes in Adults Aged 40 or Younger Increases Risk of Cardiovascular Disease

Pharmacy Times

Researchers found that patients diagnosed with early-onset type 2 diabetes have a greater risk of premature death than the general population.

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Foreo’s Luna 4 collection cleanses face, body

Drug Store News

The Luna 4 collection consists of face and body cleansing devices that gently massage the skin and temporarily dilate pores to remove impurities.

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Nasal Self-Sampling Rapid Antigen COVID-19 Test Performance May Have Decreased Over Time

Pharmacy Times

While the performance of nasal self-sampling rapid antigen tests for COVID-19 was found to decrease over time, adding oropharyngeal may improve its performance.

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