Tue.Dec 13, 2022

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Suggestions for Saving: Help Patients Navigate Diabetes Management Costs

Drug Topics

By offering resources such as free samples and generic alternatives, pharmacists can help patients lower costs.

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STAT+: Moderna says cancer vaccine reduces melanoma’s return by 44%

STAT

An experimental cancer vaccine being developed by the biotechnology firm Moderna and the drug giant Merck reduced the risk that melanoma would return after surgery or that patients would die by 44%, the company said. The data, made public in a press release, represent the first evidence of an effective individualized cancer vaccine based on mRNA, the technology used in the Covid shots.

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Relyvrio: A New FDA-Approved Treatment for Patients With ALS

Drug Topics

Relyvrio is intended to slow the disease progression of amyotrophic lateral sclerosis.

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FDA Grants Accelerated Approval to Adagrasib for KRAS-G12C-Mutated NSCLC

Pharmacy Times

Adagrasib (Krazati; Mirati Therapeutics, Inc) approved for adults with KRAS-G12C-mutated locally advanced or metastatic non-small cell lung cancer as determined by an FDA-approved test.

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Position Your Pharmacy for Expansion

Speaker: Chris Antypas and Josh Halladay

Access to limited distribution drugs and payer contracts are key to pharmacy expansion. But how do you prepare your operations to take the next step? Meaningful data: Collect and share clinical data regarding outcomes, utilization, and more Reporting: Limited distribution models require efficient tracking and reporting systems Workflows: Align workflows with specific pharma and payer contractual requirements For in-depth, expert insights on pharmacy expansion, watch this webinar from Inovalon.

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‘Out of control’: Dozens of telehealth startups sent sensitive health information to big tech companies

STAT

Open the website of Workit Health, and the path to treatment starts with a simple intake form: Are you in danger of harming yourself or others? If not, what’s your current opioid and alcohol use? How much methadone do you use? Within minutes, patients looking for online treatment for opioid use and other addictions can complete the assessment and book a video visit with a provider licensed to prescribe suboxone and other drugs.

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Patient-Controlled Analgesia: Pharmacy Haven or Nursing Nightmare?

Pharmacy Times

Patient-controlled analgesia typically consists of opioids or local anesthetics, but it may also include non-opioid analgesics or other medications.

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Not just small adults…

Hospital Pharmacy Europe

Paediatrics is a unique and fulfilling area of pharmacy practice but challenges in overcoming the gaps in pharmaceutical care for these patients remain. A well-worn adage used in paediatrics is: “children are not just small adults”. Having paediatric-specific diseases (for example, neuroblastoma, congenital heart diseases and juvenile onset diabetes) and often requiring specific testing and special techniques or individualised frameworks for many procedures, we cannot deny that children are a ve

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Leveraging Artificial Intelligence and Human Know-How to Accelerate Drug Discovery

BioPharm

Through the integration of human expertise, artificial intelligence, and automation robotics, bio/pharma companies can more efficiently target drug discovery efforts with bigger payoff.

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Death certificate records of long Covid are a ‘floor of an estimate,’ experts say

STAT

Long Covid has begun appearing on death certificates for a small percentage of people who have died during the pandemic, but that tiny fraction of records only hints at the whole story, two experts told STAT, while another has doubts about drawing any conclusions from it at all. Death certificates listing long Covid as a cause of death numbered 3,544, representing 0.3% of the 1,021,487 Covid deaths in the United States from January 2020 through June 2022, according to an analysis issued Wednesda

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Study to Evaluate Efficacy of Device That Closes Patent Foramen Ovale in Treating Migraine

Pharmacy Times

Prior research indicates a platelet-based connection between migraine and the patent foramen ovale.

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What the FDA's New Dosage Guidance Means for the Future of Clinical Research

Speaker: Dr. Ben Locwin - Biopharmaceutical Executive & Healthcare Futurist

What will the future hold for clinical research? A recent draft from the FDA provides valuable insight. In "Optimizing the Dosage of Human Prescription Drugs and Biological Products for the Treatment of Oncologic Diseases," the FDA notes that "targeted therapies demonstrate different dose-response relationships compared to cytotoxic chemotherapy, such that doses below the Maximum Tolerated Dose (MTD) may have similar efficacy to the MTD but with fewer toxicities.

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Opinion: Lessons from Ecuador on responding to the mental health crisis in the U.S. and around the world

STAT

In his assessment of governments’ work to provide sufficient mental health resources to their citizens, Tedros Adhanom Ghebreyesus, the director-general of the World Health Organization, warned that “good intentions are not being met with investment.” Though many countries have implemented policies, plans, and laws to improve mental health care, they haven’t offered enough leadership and governance for community-based mental health resources and sufficient promotion a

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Rare Disease Moonshot launched at European Health Summit

pharmaphorum

A new initiative to boost research and development into rare and paediatric diseases launched last week, on Thursday 8 th December, at the European Health Summit. The Rare Disease Moonshot is a collaborative commitment between seven organisations, seeking to break down barriers to finding new treatments and cures for some of the world’s rarest and most severe conditions.

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Study offers a genetic explanation for why some drugs trigger a deadly brain disease

STAT

Medicines that reshape or tamp down immune responses may be life-changing for patients with cancer and autoimmune disorders, but in some cases they can awaken a dormant virus and unleash a deadly brain disease. A new study suggests that the root of the problem is buried in our genetic code. Researchers uncovered four gene variants connected with the immune system that significantly increase a person’s risk of developing the disease, known as progressive multifocal leukoencephalopathy or P

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Cancer center leaders lay bare CAR-T makers' struggles—and an unexpected laggard

Fierce Pharma

Cancer center leaders lay bare CAR-T makers' struggles—and an unexpected laggard. aliu. Tue, 12/13/2022 - 20:12.

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5 Reasons to Upgrade Your Pharmacy Management Software

Are you still using workarounds to manage your daily operations? To achieve peak performance, it's time to explore other options for specialty and infusion pharmacy software. Streamline pharmacy operations and improve clinical performance with automated processing, real-time data exchange, and electronic decision support. Download this helpful infographic to: Drive efficiency and patient adherence from referral receipt to delivery and ongoing care – all with our Pharmacy Cloud.

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WHO names Jeremy Farrar, director of the Wellcome Trust, as chief scientist

STAT

Jeremy Farrar , director of the Wellcome Trust, the world’s second largest private funder of biomedical research, has been named the new chief scientist of the World Health Organization. The appointment was announced Tuesday by the global health agency, which also revealed the appointment of Amelia Latu Afuhaamango Tuipulotu as WHO’s chief nursing officer.

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How to write a health insurance appeal letter

The Checkup by Singlecare

Imagine you need to get an MRI. You’ve had unexplained headaches with no discernable trigger, and your provider wants additional tests to rule out anything serious. So, you get a referral from your healthcare provider, make an appointment, and then wait until the scheduled day. Meanwhile, the radiologist’s office contacts your insurance to get the service approved.

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‘Make People Better’: The CRISPR babies story you probably don’t know, and how it was filmed in real-time

STAT

In May of 2017, Samira Kiani found herself in a San Diego hotel ballroom surrounded by some of the CRISPR field’s brightest shining stars. Jennifer Doudna , George Church , and others were all there at the behest of the Defense Advanced Research Projects Agency to talk about gene drives — a CRISPR-enabled technology that forces a genetic trait through a population at evolutionary warp speed — and what they as scientists could do to build guardrails around them.

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Canadian and US developers to trial psychedelic medicines in UK

European Pharmaceutical Review

North American psychedelic drug developers Mindset, PharmAla, Mydecine and Psyence have signed with clinical research organisation (CRO) Clerkenwell Health to trial therapies for mental health conditions, in London, UK, to benefit from the country’s swift drug regulatory process. The mental health conditions that the companies aim to treat include social anxiety, Autism Spectrum Disorder (ASD), nicotine addiction, major depressive disorder (MDD), and Adjustment Disorder in those facing a termina

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Huge U.S. study starts sharing gene findings with volunteers

STAT

More than 155,000 Americans who shared their DNA for science are about to learn something in return: Do they have some particularly worrisome genes? It’s part of a  massive project to unravel how people’s genetics, environments, and habits interact to determine their overall health. The National Institutes of Health said Tuesday it’s now starting to notify participants about some early findings — if they carry variants that can cause any of 59 inherited diseases

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Regular Exercise Improves Outcomes in Patients With Colorectal Cancer

Pharmacy Times

Regular physical activity helps to facilitate a healthy gut microbiome and lowers inflammation, which were observed in patients independent of body mass index.

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Opinion: Primary care physicians try to give their all — until they can’t. It’s time to flip the archetype to teamwork

STAT

My colleague, Skip, was the kind of primary care doctor I always wanted to be. He could riff on the evaluation of a patient with new joint or liver inflammation like an improvising jazz musician. He could discern a familiar rash in the most puzzling plumes of hot, angry bumps. When I had lab results that flummoxed me, I’d go see Skip. He’d tip back in his chair, swivel a bit in thought, and make sense of the findings.

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Commonwealth Fund: COVID-19 vaccine prevented more than 18M hospitalizations, 3M deaths

Fierce Healthcare

Commonwealth Fund: COVID-19 vaccine prevented more than 18M hospitalizations, 3M deaths. rking. Tue, 12/13/2022 - 15:04.

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Addiction treatment got easier during Covid. A new proposal would keep it that way

STAT

Addiction treatment got easier during the Covid-19 pandemic — and the Biden administration wants to keep it that way. Federal regulators on Tuesday announced a proposal to take the emergency policies enacted in 2020, in response to the emerging pandemic, and make them permanent. In particular, the changes would preserve patients’ expanded access to two key medications used to treat opioid addiction: methadone and buprenorphine.

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UK pharmacists report sharp rise in prices for strep A antibiotics

The Guardian - Pharmaceutical Industry

Concerns raised over pharmacists’ losses as market prices outpace NHS reimbursement tariffs The cost of antibiotics used to treat infections including strep A have risen more than tenfold in the UK in recent weeks, pharmacists have said, with many facing continued difficulties in sourcing supplies. Cases of scarlet fever and strep A have increased earlier in the season than usual: last Thursday the UK Health Security Agency said that since mid-September there had been 60 deaths from invasive str

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STAT+: New Biden changes to Obamacare coverage for generics splits the industry

STAT

WASHINGTON — The Biden administration signaled Monday that it will require health plans on federal exchanges to cover more of the costs of generic drugs, a small tweak that nevertheless has industry groups divided on how best to manage drug costs. The proposal, laid out in a Monday regulation , would direct plans offered through the Affordable Care Act marketplace to put all generic drugs in their lowest cost-sharing tier, which typically translates to little to no out-of-pocket spending

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Perfecting the Present, Shaping the Future: The Pharmacy at Wellington

PioneerRx

Opening an independent pharmacy is making a statement. It’s a call to take the pharmacy industry and turn it into an even better place. It’s a way of saying.

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STAT+: Lawmakers tell Pfizer CEO to ‘back off’ on planned price hike for Covid-19 vaccine

STAT

A pair of U.S. lawmakers wrote Pfizer chief executive officer Albert Bourla that he should “back off” from plans to charge Americans up to $130 for the company’s Covid-19 vaccine, a move they described as “pure and deadly greed.” In their letter, U.S. Sen. Elizabeth Warren (D-Mass.) and Sen. Peter Welch (D-Vt.) argued the planned price tag is nearly four times the current $30 price paid by the U.S. government and also represents a 10,000% markup over what some

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At the heart of hematology breakthroughs, a community of researchers and patients comes together

PharmaVoice

As new and advanced therapies are revealed at the annual meeting of the American Society of Hematology this week, the patients are always at the center.

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STAT+: Pharmalittle: Moderna and Merck vaccine lowers risk of skin cancer relapse; Cambodia halts exports of primates used for drug research

STAT

Top of the morning to you, and a fine one it is. Crystal clear blue skies and chilly breezes are enveloping the Pharmalot campus, where the official mascot is attempting to intimidate various creatures and the commuter traffic is whizzing by. As for us, we are busy brewing another cup of stimulation. Our choice today is the ever-so-sweet caramel apple.

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Study Sees Link Between Smartphone Screen Time, Symptoms of Mental Illness

Drug Topics

Social support and education may be the solution.

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STAT+: In bid to beat Bristol Myers, Takeda buys Nimbus’ anti-inflammatory drug for $4 billion

STAT

Takeda Pharmaceuticals said Tuesday it will spend $4 billion and offer another $2 billion in milestones for an experimental anti-inflammatory pill from Nimbus Therapeutics, the largest deal yet for a new target that has already yielded one approved drug and sparked multiple startups. Takeda will acquire a molecule that blocks TYK2, a signaling protein that affects how cells respond to common inflammatory molecules in the blood.

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The lingering menace of diethylene glycol / ethylene glycol adulteration

European Pharmaceutical Review

The World Health Organization (WHO) linked this recent incident to an Indian manufacturer, saying that the cough syrups contained “unacceptable amounts of diethylene glycol and ethylene glycol” The recent headlines linking the deaths of nearly 70 children in Gambia to diethylene glycol and ethylene glycol (DEG and EG, respectively) poisoning in a paediatric cough syrup, caused disbelief in many quarters.

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An early lesson from the Uganda Ebola vaccine trial: Shots must be ready to go before the next outbreak strikes

STAT

A clinical trial of vaccines targeting the Ebola Sudan virus is starting this week in Uganda, with first doses going into arms potentially on Tuesday. Already, though, this effort has taught the World Health Organization and partners two important lessons. They’ve learned they can get clinical trials to test countermeasures for rare but dangerous pathogens up and running far more quickly than eight years ago, when a similar effort was launched to test vaccines as Ebola Zaire raced through

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GSK to open new global headquarters

European Pharmaceutical Review

GSK have announced that its global headquarters will move from Brentford, West London to its new headquarters in central London in 2024, placing it near the capital’s fast-growing global life sciences hub, Knowledge Quarter and top academic institutions. GSK’s centrally located headquarters. The new site, currently known as the Earnshaw, is under construction and scheduled for completion in 2023.

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